[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Unidade Local de Saude Sao Jose\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100659524","metabolomics-in-subarachnoid-hemorrhage-100659524",false,"NCT07865182","Metabolomics in Subarachnoid Hemorrhage","New Predictive Models for Subarachnoid Hemorrhage - an Exploratory Study on Metabolomics","NeuroMetas","Inclusion Criteria:\n\n* Age 18 years or older\n* Diagnosis of acute spontaneous (non-traumatic) subarachnoid hemorrhage\n* Admission to the Neurocritical Care and Trauma Unit of ULS São José\n\nExclusion Criteria:\n\n* Traumatic subarachnoid hemorrhage\n* Death before ICU admission\n* Refusal of informed consent by the patient or legal representative","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","1 Year","OBSERVATIONAL","The goal of this observational study is to learn whether blood and cerebrospinal fluid markers, combined with clinical, imaging and brain monitoring data, can help predict the outcome of adults with spontaneous subarachnoid hemorrhage (bleeding around the brain not caused by trauma) admitted to the neurocritical care unit of Unidade Local de Saúde São José, in Lisbon, Portugal.\n\nThe main questions it aims to answer are:\n\nWhich substances (metabolites) in blood and cerebrospinal fluid are associated with death and with long-term disability after subarachnoid hemorrhage? Can a prediction model combining these markers with clinical and monitoring data predict the patient's recovery one year after hospital discharge?\n\nParticipants will receive standard care as decided by their treating physicians; the study will not change any diagnostic or treatment decision. In addition to routine care, participants will have small extra samples of blood and cerebrospinal fluid collected on days 1, 3 and 7 after the onset of the hemorrhage. Cerebrospinal fluid will only be collected from drains already in place for clinical reasons, and no additional invasive procedures will be performed. Samples will be stored in a biobank for metabolomic analysis. Participants will be assessed one year after hospital discharge to evaluate their recovery.",[26,27],"Subarachnoid Haemorrhage (SAH)","Delayed Cerebral Ischemia",[29,30,31,32,33,34,35,36,37],"metabolomics","biomarkers","prognosis","clinical prediction model","cerebrospinal fluid","Fourier Transform Infrared Spectroscopy","Multimodal Neuromonitoring","Neurocritical Care","Glasgow Outcome Scale-Extended","RECRUITING","2026-10-02",{"date":41,"type":42},"2026-10-08","ACTUAL",{"date":44,"type":42},"2025-05-01",{"date":46,"type":21},"2027-10",{"name":48,"class":49},"Unidade Local de Saude Sao Jose","OTHER",""]