[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Universidad Europea de Valencia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":157},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,82,108,136],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100646964","efficacy-of-dbt-live-an-identity-skills-training-program-for-borderline-personality-disorder-100646964",false,"NCT07684872","Efficacy of \"DBT-LIVE\", an Identity Skills Training Program, for Borderline Personality Disorder.","Efficacy of \"DBT-LIVE\", an Identity Skills Training Program, for Borderline Personality Disorder: Study Protocol for a Randomized Controlled Trial.","Inclusion Criteria:\n\n* Being 16 years old or more.\n* Having the diagnosis of Borderline Personality Disorder.\n* Currently receiving treatment or follow-up care at the recruitment center mentioned above.\n* Signing the informed consent form to participate in the study; in the case of minors, consent must be provided by parents or legal guardians.\n\nExclusion Criteria:\n\n* Individuals with severe conditions that may interfere with participation in the research-such as psychosis, schizophrenia, or intellectual disability.\n* Individuals with high substance use who are not in optimal condition to follow the treatment program.\n* Individuals who present an imminent risk of suicide or who are not in adequate psychological condition to participate in the program.","ALL","16 Years",{"count":19,"type":20},112,"ESTIMATED","INTERVENTIONAL",[23],"NA","The main objective of this project is to adapt and evaluate the LIVE Skill module in the Spanish population. LIVE Skill is a psychological intervention protocol specifically designed to address identity disturbances in individuals with Borderline Personality Disorder (BPD). The project aims to examine its effectiveness in reducing identity disturbances, emotional regulation difficulties, and suicidal behavior, as well as in improving self-compassion, meaning in life, and personality functioning. In addition, the efficiency and feasibility of the program will be assessed by evaluating its acceptability among both patients and professionals, and its dissemination will be promoted to maximize its clinical impact.\n\nThe methodology includes a sample of approximately 112 individuals diagnosed with BPD, recruited through the Valencian Association for Personality Disorders (ASVA-TP), who will be allocated into two groups. The project is structured into five studies. First, a qualitative pilot feasibility study will be conducted with approximately 30 participants through focus groups and interviews in order to refine the intervention protocol. The second study will describe the randomized clinical trial protocol, including the interventions and assessment procedures. Subsequently, a randomized controlled trial (RCT) will be carried out, comparing LIVE Skill with treatment as usual (TAU), with assessments conducted at pre-treatment, post-treatment, and six-month follow-up. Following the trial, a qualitative evaluation will be undertaken to identify treatment facilitators and barriers. Finally, the psychometric validation of the questionnaires used in the study will be conducted.\n\nThe protocol will collect sociodemographic data and measures of identity, emotional regulation, self-compassion, meaning in life, suicidal ideation and behavior, personality functioning, as well as treatment acceptability and feasibility. Participants will provide informed consent and complete an initial assessment to confirm eligibility according to the inclusion and exclusion criteria.",[26,27],"Treatment 1:Dialectical Behavior Therapy (DBT)","Treatment as Usual",[29,30,31,32,33,34],"DBT","dialectical behavior therapy","skills","identity","LIVE","borderline personality disorder","NOT_YET_RECRUITING","2026-07-02",{"date":38,"type":39},"2026-07-06","ACTUAL",{"date":41,"type":20},"2027-01-01",{"date":43,"type":20},"2028-12-31",{"name":45,"class":46},"Universidad Europea de Valencia","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":47},"100641581","combined-manual-therapy-and-percutaneous-neuromodulation-for-moderate-carpal-tunnel-syndrome-100641581","NCT07654621","Combined Manual Therapy and Percutaneous Neuromodulation for Moderate Carpal Tunnel Syndrome","Combined Manual Therapy and Percutaneous Neuromodulation Versus Postsurgical Rehabilitation for Moderate Carpal Tunnel Syndrome: Protocol for a Non-Randomized Controlled Trial","MANUCTS","Inclusion Criteria:\n\n* Adults aged 30 to 50 years.\n* Clinical diagnosis of moderate carpal tunnel syndrome confirmed by nerve conduction studies according to the American Association of Electrodiagnostic Medicine criteria.\n* Symptoms persisting for at least 3 months.\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Previous surgery for carpal tunnel syndrome in the affected hand (experimental group only).\n* Severe carpal tunnel syndrome requiring urgent surgical intervention.\n* History of wrist fracture or major upper-limb trauma affecting the study limb.\n* Pregnancy.\n* Diabetes mellitus or other systemic diseases associated with peripheral neuropathy.\n* Cervical radiculopathy or other neurological disorders affecting the upper limb.\n* Rheumatoid arthritis or other inflammatory arthropathies involving the wrist.\n* Previous corticosteroid injection for carpal tunnel syndrome within the last 3 months.\n* Contraindications to percutaneous neuromodulation (e.g., pacemaker, active infection at the treatment site, bleeding disorders, or anticoagulant therapy when considered clinically inappropriate).\n* Inability to comply with the study protocol or follow-up assessments.","30 Years","50 Years",{"count":59,"type":20},150,[23],"Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy and can cause pain, numbness, tingling, and functional impairment of the hand. Although surgical decompression is considered an effective treatment for moderate CTS, there is increasing interest in conservative therapeutic strategies that may improve symptoms and function while avoiding surgery.\n\nThe aim of this multicenter non-randomized controlled trial is to evaluate the effectiveness of a combined intervention consisting of manual therapy and ultrasound-guided percutaneous neuromodulation compared with conventional postsurgical rehabilitation in patients with moderate CTS.\n\nParticipants allocated to the experimental group will receive a standardized multimodal physiotherapy program including manual therapy techniques and ultrasound-guided percutaneous neuromodulation, whereas participants in the control group will undergo standard rehabilitation following carpal tunnel release surgery. The primary outcome will be symptom severity and functional status assessed with the Boston Carpal Tunnel Questionnaire. Secondary outcomes will include pain intensity, nerve conduction parameters, ultrasound measures, hand strength, patient-reported outcomes, and adverse events.\n\nThe findings of this study are expected to provide evidence regarding the potential role of combined conservative treatment as an alternative therapeutic strategy for patients with moderate carpal tunnel syndrome.",[63],"Carpal Tunnel Syndrome",[63,65,66,67,68,69,70,71,72,73],"Manual Therapy","Percutaneous Neuromodulation","Physical Therapy","Rehabilitation","Median Nerve","Peripheral Neuropathy","Ultrasound-Guided Intervention","Conservative Treatment","Upper Limb","2026-06-12",{"date":76,"type":39},"2026-06-17",{"date":78,"type":20},"2026-07",{"date":80,"type":20},"2028-01",{"name":45,"class":46},{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":103,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":107,"locationsCount":47},"100641547","multimodal-conservative-intervention-versus-surgery-for-chronic-refractory-plantar-fasciopathy-100641547","NCT07654660","Multimodal Conservative Intervention Versus Surgery for Chronic Refractory Plantar Fasciopathy","Study Protocol for a Multicenter Controlled Trial Comparing Multimodal Conservative Intervention Versus Surgical Management in Chronic Refractory Plantar Fasciopathy","Inclusion Criteria:\n\n* Adults aged 30 to 65 years.\n* Diagnosis of chronic refractory plantar fasciopathy with symptom duration greater than 6 months.\n* Failure of at least two previous conservative treatments, each lasting at least 12 weeks.\n* Foot Function Index (FFI) total score ≥45 points.\n* Resting pain intensity ≥4\u002F10 on the Visual Analog Scale (VAS).\n* Plantar fascia thickness ≥4 mm at the calcaneal insertion confirmed by ultrasound.\n* Ability to provide written informed consent and comply with study procedures.\n\nExclusion Criteria:\n\n* Previous foot surgery on the affected side.\n* Calcaneal stress fracture.\n* Glycated hemoglobin (HbA1c) \\>7.5%.\n* Inability or unwillingness to comply with study procedures or follow-up assessments.","65 Years",{"count":91,"type":20},120,[23],"Chronic refractory plantar fasciopathy is a common musculoskeletal condition that can cause persistent heel pain and functional limitations despite conservative treatment. When symptoms do not improve, patients often face the decision between continuing non-surgical management or undergoing surgery. However, direct comparative evidence between these treatment strategies is limited.\n\nThis multicenter controlled trial aims to compare the effectiveness of a multimodal conservative intervention consisting of manual therapy and ultrasound-guided percutaneous neuromodulation with endoscopic plantar fascial release followed by standard postoperative rehabilitation in adults with chronic refractory plantar fasciopathy.\n\nA total of 120 participants will be allocated to treatment groups according to their informed treatment preference within a shared decision-making process. The primary outcome will be the change in the Foot Function Index (FFI) after 6 weeks. Secondary outcomes include pain intensity, health-related quality of life, treatment adherence, adverse events, and exploratory neurophysiological measures. The results are expected to provide evidence to support clinical decision-making and optimize the management of patients with chronic refractory plantar fasciopathy.",[95],"Chronic Refractory Plantar Fasciopathy",[97,98,65,66,99,100,101,72,68,102],"Plantar Fasciopathy","Plantar Fasciitis","Endoscopic Plantar Fasciotomy","Foot Function Index","Heel Pain","Comparative Effectiveness",{"date":76,"type":39},{"date":105,"type":20},"2026-12",{"date":80,"type":20},{"name":45,"class":46},{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":115,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":21,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":47},"100637677","effects-of-dry-needling-in-athletes-with-subacromial-pain-syndrome-100637677","NCT07621016","Effects of Dry Needling in Athletes With Subacromial Pain Syndrome","Effects of Dry Needling on Proprioception, Dynamic Stability, Strength, Pain Perception, and Disability in Athletes With Subacromial Pain Syndrome","Inclusion Criteria:\n\n* Men and women aged between 18 and 40 years.\n* Clinical diagnosis of subacromial pain syndrome (SAPS) according to the Dutch Orthopaedic Association criteria: presence of a painful arc and at least two positive tests among the following: Hawkins-Kennedy test, Neer sign, Jobe test, Drop Arm test, or Gerber test.\n* Participation in sports involving predominant upper-limb activity between 2 and 4 hours per week.\n\nExclusion Criteria:\n\n* Previous surgery involving the upper extremities.\n* Diagnosis of specific shoulder pathologies other than SAPS at the time of the study.\n* Receipt of medical or physiotherapy treatment within the month prior to the intervention.\n* Needle phobia or refusal to receive dry needling treatment.\n* Presence of vestibular disorders, balance impairments, or vascular alterations that could interfere with study measurements.\n* Confirmed or suspected pregnancy.","18 Years","40 Years",{"count":118,"type":20},40,[23],"The goal of this clinical trial is to evaluate whether dry needling combined with therapeutic exercise improves shoulder proprioception in amateur athletes with subacromial pain syndrome. The study will also assess its effects on dynamic stability, strength, pain, and functional disability.\n\nThe main questions this study aims to answer are:\n\nDoes dry needling improve shoulder proprioception compared with therapeutic exercise alone? Does dry needling improve dynamic shoulder stability and muscle strength? Does dry needling reduce pain and upper limb disability?\n\nResearchers will compare a group receiving dry needling plus therapeutic exercise with a group performing therapeutic exercise alone to determine whether the combined intervention produces better outcomes.\n\nParticipants will:\n\nBe randomly assigned to one of the two treatment groups. Perform a home-based therapeutic exercise program for 3 weeks. Complete assessments of proprioception, dynamic stability, strength, pain, and functional disability before and after the intervention.",[122],"Subacromial Pain Syndrome",[124,125,126,127],"subacromial pain syndrome","dry needling","shoulder proprioception","shoulder pain","2026-06-03",{"date":130,"type":39},"2026-06-05",{"date":132,"type":20},"2026-06",{"date":134,"type":20},"2027-03",{"name":45,"class":46},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":115,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":21,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":4},"100522265","cbt-for-adult-inmates-with-adhd-100522265","NCT06080373","CBT for Adult Inmates With ADHD","Formulation-Based Cognitive-Behavioral Therapy Compared to an Active Control and a Waitlist in Adult Inmates With ADHD: A Randomized Controlled Trial","Inclusion Criteria:\n\n* To have signed written informed consent to participate in the study\n* To be between 18 and 65 years of age\n* To meet the DSM-5 diagnostic criteria for ADHD (American Psychiatric Association, 2013)\n* To have been convicted of at least one crime under Spanish or German criminal law\n* To have been incarcerated for at least six months and three or fewer years since the completion of the conviction at the time of eligibility assessment.\n\nExclusion Criteria:\n\n* To have a severe personality disorder, psychotic disorder, or pervasive developmental disorder as their primary diagnosis, as the intervention would not meet their clinical needs\n* To have an IQ of 80 or less, as measured by a standardized IQ test (Raven et al., 1993), due to the complexity of the cognitive components in the CBT program\n* To have participated in a previous psychological intervention for ADHD;\n* To not be fluent in Spanish or German, depending on the study site.",{"count":144,"type":20},111,[23],"Background Recent literature suggests that ADHD is a risk factor for the development of antisocial behavior that is more severe and persistent than in community and other psychiatric populations. The combination of stimulant medication and psychotherapy (particularly cognitive-behavioral therapy, CBT) is considered an evidence-based intervention for adults with ADHD. In contrast, few studies have evaluated the efficacy of medication in adult prisoners with ADHD, and the literature on the efficacy of psychotherapy is virtually nonexistent. Therefore, this article presents the protocol of a trial that will assess the efficacy of a formulation-based CBT program for inmates with ADHD.\n\nMethods The study has a multicenter randomized controlled trial design. After screening and recruitment, participants will be randomly assigned to the CBT intervention, a general offender treatment program, or a waitlist. Pre- and post-treatment self-report and clinician-report assessments, as well as 6- and 12-month follow-up assessments will be conducted. These will include both clinical (e.g., ADHD symptoms, depression and anxiety symptoms, self-esteem, alcohol\u002Fdrug abuse, treatment adherence, quality of life) and criminological (e.g., recidivism and risk of recidivism) measures. Linear mixed models will be used to assess differences between groups.\n\nDiscussion This study may be the first to evaluate the efficacy of a psychotherapy intervention in adult inmates with ADHD. It is expected that addressing the specific needs of ADHD would not only result in the previously reported clinical improvements (e.g., reduction in ADHD and comorbidity symptoms), but also reduce the risk and rate of recidivism compared to the general intervention or no intervention. However, the design may be limited by the difficulties inherent in the prison setting and in following up the sample after release.",[148],"Attention Deficit Hyperactivity Disorder","2026-04-29",{"date":151,"type":39},"2026-05-06",{"date":153,"type":20},"2027-09",{"date":155,"type":20},"2029-09",{"name":45,"class":46},""]