[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Università degli Studi di Trento\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":104},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100645608","ai-driven-processing-and-analysis-of-glioma-imaging-data-100645608",false,"NCT07703761","AI-driven Processing and Analysis of Glioma Imaging Data","AI-driven Processing and Analysis of Glioma Imaging Data EUCAIM Database Contribution by the Italian Brain Glioma Initiative Italian Title: Elaborazione ed Analisi Supportata Dall'Intelligenza Artificiale di Immagini di Risonanza Magnetica di Gliomi Cerebrali","GLIOMAID","Inclusion Criteria:\n\n* Imaging (MRI) of confirmed glioma diagnosis in the period 2019-2024, for whom cancer types and stages, from diagnosis to post-treatment are available\n* Having undergone a full brain tumor resection operation, followed or not by treatment with RT or CHT\n* Adults aged 18 to 60 years\n* Informed consent available, when possible and applicable\n\nExclusion Criteria:\n\n* Poor quality or artifact-laden MRI images\n* Lack of a minimal set of clinical information\n* Explicit refusal of consent (if possible to obtain)\n* Age under 18 years or over 60 years","ALL","18 Years","60 Years",{"count":21,"type":22},700,"ESTIMATED","OBSERVATIONAL","GLIOMAID is a scientific research project focused on improving how brain tumors, specifically gliomas, are diagnosed and managed. It uses Artificial Intelligence (AI) to analyze MRI brain scans and patient data. The project collects existing clinical information and imaging from glioma patients to build AI models that support doctors in making better and faster treatment decisions.Gliomas, especially high-grade ones, are among the most common and challenging brain tumors. Many patients have poor survival chances, and diagnosis often requires invasive procedures like biopsies.\n\nDespite medical advances, current treatments have limited effectiveness. Better non-invasive diagnostic tools are urgently needed to:\n\n* Detect tumors earlier.\n* Predict how aggressive they are.\n* Help doctors plan the most effective treatments. The GLIOMAID study aims to reduce the need for invasive diagnostics by creating AI tools that interpret brain scans with high accuracy.\n\nPrimary Objectives\n\n* Create Italy's First Glioma Imaging Database This database will store anonymized MRI scans and clinical records from around 700 patients.\n* Improve Early Detection Develop AI systems to identify brain tumors earlier from MRI scans.\n* Automate Tumor Mapping Use AI to outline tumors on MRI images to assist with surgical planning and treatment follow-up.\n* Non-Invasive Tumor Characterization Train AI models to predict tumor type and severity without needing a biopsy.\n\nSecondary Objectives\n\n* Study how well AI tools fit into research and future clinical workflows.\n* Test how well AI can predict changes in tumors over time.\n\nLead Institution: University of Trento and Santa Chiara Hospital, Trento (Prof. Silvio Sarubbo, Principal Investigator).\n\nPartner Hospitals: 7 neurosurgery and neuro-oncology centers across Italy.\n\nInclusion Criteria\n\n* Adults aged 18-60 with a confirmed glioma diagnosis (from 2019 to 2024).\n* Patients who had surgical tumor removal, with or without further treatment (e.g., chemotherapy, radiotherapy).\n* MRI scans and basic clinical data must be available.\n\nExclusion Criteria\n\n* Poor quality or incomplete MRI scans.\n* Missing essential clinical information.\n* If consent is explicitly refused (when it can be obtained).\n\nClinical Data\n\n* Age, sex, diagnosis date.\n* Tumor type and genetic information.\n* Treatments received (surgery, chemo, radiation).\n* Patient outcomes (e.g., survival, tumor progression).\n\nImaging Data\n\n* Pre- and post-operative MRI scans (T1, T2, FLAIR).\n* Segmented images highlighting tumor areas and post-surgery cavities.\n* Time points: before surgery, up to 6 months post-op, and during follow-up.\n\nAll data is pseudonymized (no personal identifiers) and securely stored.\n\nExpected Results\n\n* Faster, more accurate diagnosis.\n* More personalized treatment planning.\n* Reduced need for invasive biopsies.\n\nBenefits for Patients and Doctors Patients: Earlier diagnosis, less invasive procedures, better treatment outcomes.\n\nDoctors: Improved decision-making tools, automated image analysis, consistent data for treatment planning.",[26,27],"Glioma","Glioma (Diagnosis)",[29,30,31,32,33,34],"Ai","clinical decision support","MRI","brain tumor","computer-assisted diagnosis","outcome prediction","RECRUITING","2026-07-09",{"date":38,"type":39},"2026-07-14","ACTUAL",{"date":41,"type":39},"2026-01-21",{"date":43,"type":22},"2031-01-01",{"name":45,"class":46},"Università degli Studi di Trento","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":47},"100645665","promoting-psychophysical-well-being-in-children-and-adolescents-with-visual-impairment-100645665","NCT07703150","Promoting Psychophysical Well-being in Children and Adolescents With Visual Impairment","Promoting the Psychophysical Well-Being of Children and Adolescents With Visual Impairment","VIPPSTAR_UNITN","Inclusion Criteria:\n\n* Aged 10 to 17 years.\n* Diagnosis of Visual Impairment (VI), defined as a congenital or acquired impairment of visual functioning that cannot be corrected solely through the use of glasses or contact lenses.\n* Ability to participate in the exercise protocol, with adapted instructions or support where necessary.\n\nExclusion Criteria:\n\n* Presence of severe neurological, orthopaedic, or cardiac conditions that contraindicate moderate physical exercise.\n* Current pregnancy.\n* Conditions preventing the safe use of wearable devices, such as severe skin allergies or incompatible medical devices.","10 Years","17 Years",{"count":59,"type":22},20,"INTERVENTIONAL",[62],"NA","Visual impairment (VI) has significant implications not only for visual functioning, but also for the motor development, psychological well-being, and social participation of children and adolescents. Despite the fundamental role of physical activity in promoting health, autonomy, and quality of life, young people with VI still participate to a limited extent in structured physical activity programmes, owing to the lack of adapted interventions supported by robust scientific evidence. The European VIPPSTAR project (Horizon Europe 2024), conducted at the University of Trento, aims to address this gap through the development and validation of an integrated system of educational and rehabilitation interventions designed to promote the motor, physiological, and psychosocial competences of children and adolescents with VI.\n\nThis study marks the transition from the validation of the exercise battery in a controlled setting, carried out during the first phase of the VIPPSTAR project, to its implementation in participants' everyday environments. The aim is to assess its effectiveness, sustainability, and impact on psychophysical and relational well-being.\n\nThe study has a longitudinal, non-profit experimental design and will involve 20 children and adolescents with VI aged 10-17 years (50% female and 50% male), recruited through lower- and upper-secondary schools in the Autonomous Province of Trento participating in the project.\n\nThe intervention programme lasts 12 weeks and is divided into two blocks. During Block 1 (8 weeks), participants will complete the motor exercise battery twice weekly in the school setting, under the supervision of Abilnova educators. Sessions will take place twice a week, last approximately 45-60 minutes, and will be accompanied by fortnightly group meetings with classmates aimed at promoting social inclusion. During Block 2 (4 weeks), participants will perform the exercises at home, with the aim of consolidating the skills acquired and promoting autonomy in carrying out physical activity exercises, while continuing the fortnightly peer sessions at school.\n\nThe effectiveness of the programme will be evaluated using a pre-post design (T0-T1), with an intermediate assessment at the end of Block 1 (T0.5). An integrated assessment system will be used, including ComfTech® wearable devices for continuous monitoring of physiological parameters, such as heart rate, respiratory rate, body temperature, SpO₂, and ECG; video systems for the assessment of motor and postural performance; standardised questionnaires assessing quality of life and social participation; and structured observation grids during peer sessions. Data will be transmitted to the AVATAR system, a conversational system developed within the project, which processes physiological and kinematic information in real time. AVATAR does not operate autonomously and does not make medical decisions.\n\nThe results will contribute to validating an adapted, sustainable, and transferable exercise battery, laying the foundations for large-scale applications in clinical, educational, and rehabilitation settings, with potentially significant benefits for the quality of life and autonomy of young people with VI.",[65,66,67],"Visual Impairment","Cerebral Visual Impairment","Visual Impairments",[69,65,70,71,72],"Physical Activity","Psychophysical Well-being","Physiological Monitoring","Social Inclusion","NOT_YET_RECRUITING","2026-07-08",{"date":38,"type":39},{"date":77,"type":22},"2027-01-01",{"date":79,"type":22},"2028-08-31",{"name":45,"class":46},{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":17,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":60,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":47},"100643212","potenziamente-a-digital-executive-function-training-intervention-for-healthy-aging-in-the-elderly-population-100643212","NCT07639203","PotenziaMente: A Digital Executive Function Training Intervention for Healthy Aging in the Elderly Population","Inclusion Criteria:\n\nCognitively healthy adults aged 65 to 75 years. Montreal Cognitive Assessment (MoCA) equivalent score ≥ 1, according to Italian normative values.\n\nExclusion Criteria:\n\nHistory of current or previous neurological or neuropsychiatric disorders.",true,"65 Years","75 Years",{"count":91,"type":22},60,[62],"The study, entitled \"PotenziaMente: Cognitive Training in Aging,\" is a clinical trial designed to evaluate the effectiveness of an individualized tablet-based cognitive training program targeting executive functions (e.g., planning, cognitive flexibility, and problem solving) in healthy older adults. Executive functions are higher-order cognitive processes that support adaptive functioning in daily life and influence other cognitive domains, such as memory. The primary aim of the study is to enhance cognitive performance, specifically executive functioning, in neurologically healthy adults aged 65 to 75 years. A secondary aim is to compare the effects of two different delivery modalities of the same cognitive training program: home-based self-administration via tablet versus supervised tablet-based training in the presence of a trained researcher. Participants will undergo cognitive assessments at baseline (pre-training), immediately after the intervention (post-training), and at a 3-month follow-up.\n\nThis is a randomized parallel-group interventional clinical trial without masking. Participants are randomly assigned to one of two groups: a home-based cognitive training condition, in which they perform an individualized tablet-based cognitive training program targeting executive functions independently at home via a tablet application without direct supervision, or a supervised cognitive training condition, in which they perform the same individualized tablet-based cognitive training under the supervision of a trained researcher in a controlled environment. The intervention consists of two sessions per week, 1 hour per session, for 4 consecutive weeks, delivered via tablet-based exercises. The study uses a parallel assignment model with a prospective design and a primary purpose of treatment (cognitive enhancement and prevention of cognitive decline).\n\nThe primary outcome is the change in executive functioning from baseline to post-intervention, assessed using standardized neuropsychological tests. Secondary outcomes include between-group differences (home-based vs. supervised) in executive functioning, changes in global cognitive functioning from baseline to post-intervention, and maintenance of cognitive effects at the 3-month follow-up.",[95,96],"Aging and Cognitive Health","Healty",{"date":98,"type":39},"2026-07-10",{"date":100,"type":39},"2024-09-17",{"date":102,"type":22},"2026-09",{"name":45,"class":46},""]