[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University Hospital, Grenoble\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":660},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,157,0,25,[9,46,75,99,130,165,185,216,239,266,285,321,344,368,388,411,434,464,485,512,530,552,580,615,642],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100652688","effectiveness-of-a-communication-training-program-in-improving-the-handling-of-calls-for-suspected-cardiac-arrest-at-samu-centre-15-100652688",false,"NCT07776990","Effectiveness of a Communication Training Program in Improving the Handling of Calls for Suspected Cardiac Arrest at SAMU-Centre 15.","Effectiveness of a Communication Training Program in Improving the Handling of Calls for Suspected Cardiac Arrest at SAMU-Centre 15. A Multicenter, Randomized Controlled Stepped-Wedge Implementation Trial","COM-ARM","Inclusion Criteria:\n\n* Out-of-hospital cardiac arrest of presumed medical origin in an adult patient diagnosed during the phone call to the 15 emergency dispatch center\n\nNon Inclusion Criteria:\n\n* Minor patients,\n* Calls initially handled by another emergency call center or a healthcare professional,\n* Calls regarding cardiac arrest for which CPR has already been initiated at the time the call is made to the 15 center,\n* Obvious or known pregnancy at the time of enrollment.\n* Persons protected under Articles L1121-6 and L1121-8 of the Public Health Code (CSP).","ALL","18 Years",{"count":21,"type":22},987,"ESTIMATED","INTERVENTIONAL",[25],"NA","Each year, France's emergency response services-the SAMU (15) and the fire department (18)-handle 31 million and 19 million calls, respectively. The effectiveness of this system depends on the call centers' ability to obtain location information, prioritize responses, assess the severity of each call, and dispatch appropriate emergency resources.\n\nCardiac arrest (CA) affects 40,000 people in France each year who call on this service. The survival rate decreases by 7 to 10% for every minute that elapses between cardiac arrest and the start of cardiopulmonary resuscitation (CPR). Early CPR performed by bystanders is associated with a survival rate 2-3 times higher than CPR initiated only after emergency responders arrive on the scene. CPR assisted by SAMU-Centre 15 dispatchers (T-CPR) is a way to provide CPR to patients before emergency responders arrive on the scene and is recommended as early as possible to improve survival. According to the American Heart Association (AHA) guidelines, the timing of the initiation of the chain of survival is considered high quality if T-CPR is initiated within 90 seconds.\n\nStudies show that recognizing a cardiac arrest (CA) over the phone is often difficult for several reasons, including communication challenges, the caller's stress, and the presence of abnormal breathing.\n\nEmergency medical dispatchers (EMDs) receive very little training on communication strategies, particularly those needed to optimally manage stressed and sometimes difficult callers. Interventions to improve communication have proven effective among healthcare professionals. These methods included face-to-face training, blended learning programs, simulation-based teamwork exercises, and communication techniques adapted from aviation. Standardized scripting systems have been shown to improve the speed of decision-making and the dispatch of emergency response teams. These scripts depend on the quality of the information provided by the caller and the caller's ability to communicate effectively with the EMD.\n\nThe objective of this study will be to evaluate the effect of a communication training program for Centre-15 emergency medical dispatchers on calls for cardiac arrest.",[28],"Cardiac Arrest (CA)",[30,31,32],"Cardiac Arrest","Dispatcher","Cardiopulmonary Resuscitation","NOT_YET_RECRUITING","2026-08-17",{"date":36,"type":37},"2026-08-20","ACTUAL",{"date":39,"type":22},"2026-10-01",{"date":41,"type":22},"2028-08",{"name":43,"class":44},"University Hospital, Grenoble","OTHER",10,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100651621","quality-of-life-of-patients-after-rectal-cancer-resection--100651621","NCT07764120","Quality of Life of Patients After Rectal Cancer Resection .","Quality of Life at 3 Years of Patients Treated by Abdominoperineal Resection or Rectal Resection and Coloanal Anastomosis for Cancer of the Lower Rectum.","QRAAP","Inclusion Criteria:\n\n* Patients over 18 years\n* Patient operated on for adenocarcinoma of the lower rectum without metastasis\n* Total mesorectal excision (TME) surgery for cancer\n* Patients who underwent coloanal anastomosis or abdominoperineal amputation, regardless of the method and approach, between January 2005 and December 2021\n* Patients' information and non-opposition\n\nExclusion Criteria:\n\n* Double localisation of colorectal cancer during surgery\n* Resection of another organ due to invasion (T4 tumours)\n* Chemotherapy for recurrence or metastasis during follow-up\n* Surgical complication of coloanal anastomosis requiring permanent stoma",{"count":55,"type":22},22,"OBSERVATIONAL","Surgical treatment of cancer of the lower rectum by resection and coloanal anastomosis or abdominoperineal resection in both cases exposes the patient to significant functional digestive sequelae (anal incontinence or permanent stoma), and also to urinary and sexual consequences, which have a major impact on quality of life.\n\nLocally advanced rectal cancers leading to one or the other of these two procedures have practically the same characteristics: always fairly large cancers, located in the distal third of the rectum, in most cases requiring neoadjuvant chemoradiotherapy and a temporary or permanent stoma.\n\nRecent surgical advances and improved adjuvant therapy are increasingly steering patients toward \"at all costs\" sphincter preservation, sometimes at the expense of quality of life.\n\nAbdominoperineal resection with permanent ostomy is classically believed to have a detrimental effect on quality of life compared with resection and low anastomosis. Very few studies have compared these two procedures in terms of long-term functional results and quality of life. Most of them are small and\u002For retrospective case series, involve heterogeneous populations, or use questionable methodology.\n\nAs randomized patients between sacrifice or preservation of the anus, seem not ethical, the study propose to compare in a prospective single-center study two very close populations of patients presenting advanced cancer of the lower rectum after chemoradiotherapy, treated by abdominoperineal resection or resection and coloanal anastomosis, with the objective to determine long-term quality of life.\n\nMost studies, including the recent prospective one, showed no substantial difference between the two procedures in terms of quality of life or functional difficulties. With the caveat of the biases, sphincter conservation would nevertheless seem that is associated with a better quality of life.The aim of this single-centre retrospective study is to compare the quality of life over more than three years in a population of patients with locally advanced lower rectal cancer who underwent surgery after chemoradiotherapy, either rectal resection and coloanal anastomosis or abdominoperineal amputation.\n\nThis study might conclude that one procedure is superior to the other in terms of quality of life and help to choose the best technique, which could lead to substantial changes in the management of advanced cancers of the lower rectum.",[59],"Rectal Cancer",[61,62,63,64,65,66],"Rectal cancer","abdominoperineal resection","rectal resection","coloanal anastomosis","quality of life","genitourinary disorders","2026-08-11",{"date":69,"type":37},"2026-08-13",{"date":71,"type":22},"2026-08",{"date":73,"type":22},"2026-11-30",{"name":43,"class":44},{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},"100650207","study-on-the-management-of-comisa-100650207","NCT07743931","Study on the Management of COMISA","COMISA-PEC","Inclusion Criteria:\n\n* Adult patient diagnosed with COMISA, defined by an apnea-hypopnea index (AHI) ≥ 15 events\u002Fhour and an Insomnia Severity Index (ISI) score ≥ 15, newly diagnosed and naïve to CPAP therapy and daridorexant treatment (no treatment for \\> 5 years).\n* Prescription of continuous positive airway pressure (CPAP) therapy combined with a prescription of daridorexant.\n* Patient has provided informed consent to participate in the study.\n* Patient is affiliated with a national health insurance system.\n\nExclusion Criteria:\n\n* Severe hepatic impairment (contraindication to daridorexant treatment).\n* Refusal of CPAP therapy and\u002For refusal of daridorexant treatment.\n* Individuals covered under Articles L1121-5 to L1121-8 of the French Public Health Code.\n* Staff members who have a hierarchical relationship with the principal investigator.\n* Any patient who, in the opinion of the investigator, would be unable to comply with study procedures or the study schedule.","75 Years",{"count":84,"type":22},150,[25],"COMISA, the combination of obstructive sleep apnea (OSA) and insomnia, is a frequent and burdensome condition. Many patients with OSA experience clinically significant insomnia symptoms, and a substantial proportion of individuals with chronic insomnia also meet criteria for OSA. This comorbidity is associated with more severe symptoms, more complex diagnostic pathways, and reduced adherence to continuous positive airway pressure (CPAP) therapy. This study aims to better understand COMISA and evaluate whether adding daridorexant to CPAP treatment can improve treatment adherence and overall patient outcomes.",[88,89,90],"Obstructive Sleep Apnea (OSA)","Insomnia","COMISA","2026-07-31",{"date":93,"type":37},"2026-08-04",{"date":71,"type":22},{"date":96,"type":22},"2029-02",{"name":43,"class":44},4,{"id":100,"slug":101,"hasResults":12,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":12,"sex":18,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":126,"leadSponsor":128,"locationsCount":129},"100650080","urinary-and-sexual-symptoms-in-patients-with-hirschsprung-disease-100650080","NCT07742436","Urinary and Sexual Symptoms in Patients With Hirschsprung Disease","Medium- and Long-Term Urinary and Sexual Outcomes in Patients Who Underwent Surgery for Hirschsprung Disease in the Auvergne-Rhône-Alpes Region and at Marseille University Hospital Between 2000 and 2018","UroSexH","Inclusion Criteria:\n\n* Biopsy-confirmed Hirschsprung disease treated surgically between 2000 and 2018, regardless of the pull-through technique used.\n* Surgery performed at one of the five participating university hospitals (Grenoble, Lyon, Saint-Étienne, Clermont-Ferrand, or Marseille).\n* Male or female participants.\n* Aged 7 to 25 years at the time of study inclusion.\n* No objection to participation obtained from the participant or, for minors, from the legal representative, in accordance with French regulations.\n* Affiliation with the French national health insurance system.\n\nExclusion Criteria:\n\n* Syndromic Hirschsprung disease (e.g., Down syndrome, Waardenburg syndrome, or Multiple Endocrine Neoplasia type 2).\n* Total colonic aganglionosis.\n* Small-bowel aganglionosis.\n* Major congenital urogenital malformation unrelated to Hirschsprung disease (e.g., bladder exstrophy or posterior urethral valves).\n* Deceased before study inclusion.\n* Unable to be contacted despite repeated attempts.\n* Individuals not eligible for biomedical research under Articles L1121-5 to L1121-8 of the French Public Health Code.","7 Years","25 Years",{"count":110,"type":22},556,"Hirschsprung disease is a rare congenital disorder affecting the gastrointestinal tract of newborns. It is caused by the absence of enteric ganglion cells in a segment of the large intestine, preventing normal bowel function and leading to intestinal obstruction. The only effective treatment is surgical, usually performed during the first months or years of life, and consists of resecting the affected bowel segment and reconnecting the healthy intestine.\n\nAdvances in surgical techniques have enabled most children with Hirschsprung disease to achieve normal growth and development. However, surgery is performed in an anatomical region containing nerves and structures that are essential for normal bladder and sexual function. Although previous studies have demonstrated that some patients continue to experience long-term bowel dysfunction after surgery, the potential long-term effects on urinary function and sexual health during childhood, adolescence, and adulthood remain insufficiently investigated.\n\nThe primary objective of this study is to determine the prevalence and characteristics of long-term urinary symptoms in patients who underwent surgery for Hirschsprung disease during early childhood. Secondary objectives are to assess sexual function, overall quality of life, and long-term bowel function. In addition, the investigators aim to compare these outcomes according to the surgical technique used, as several operative approaches are currently available and none has yet been shown to be superior in preventing long-term sequelae.\n\nthe investigators hypothesize that a clinically relevant proportion of patients-approximately 10%-experience persistent urinary symptoms years after surgery, despite these symptoms being infrequently assessed and rarely included in routine long-term follow-up.\n\nThis study is intended for individuals aged 7 to 25 years who underwent surgery for Hirschsprung disease between 2000 and 2018 at one of the five participating university hospitals: Grenoble, Lyon, Saint-Étienne, Clermont-Ferrand, and Marseille. Eligible participants will be contacted by telephone and invited to participate. Those who provide informed consent (and assent\u002Fparental consent when applicable) will receive a secure email link to complete online questionnaires assessing urinary symptoms, sexual function (when age-appropriate), quality of life, and bowel function. These validated questionnaires have been widely used in previous studies and require approximately 15-20 minutes to complete. No study visits, medical examinations, or additional follow-up are planned as part of this research; participation consists solely of completing the questionnaires.\n\nThe findings of this study will improve our understanding of the long-term urinary and sexual sequelae associated with Hirschsprung disease surgery. Ultimately, they may contribute to the development of more systematic long-term postoperative follow-up strategies, enabling earlier identification and improved management of urinary and sexual dysfunction in children as they progress through adolescence and into adulthood.",[113],"Hirschsprung Disease",[113,115,116,117,118,119,120,121],"Lower Urinary Tract Symptoms","Sexual Dysfunction","Quality of Life","Pediatric Surgery","Long-Term Outcome","Multicenter Study","Bowel Function","2026-07-28",{"date":124,"type":37},"2026-08-03",{"date":71,"type":22},{"date":127,"type":22},"2027-02",{"name":43,"class":44},5,{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":137,"sex":18,"minAge":19,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":147,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":164},"100648991","reper-age-reorganization-of-visuo-cognitive-functions-based-on-peripheral-vision-with-aging-100648991","NCT07727369","RePer-AGE: Reorganization of Visuo-cognitive Functions Based on Peripheral Vision With Aging","RePer-AGE","Inclusion Criteria:\n\n* Healthy young adults aged 18 to 30 years or healthy older adults aged 60 to 85 years.\n* Normal or corrected-to-normal visual acuity.\n* No ophthalmological disease affecting visual function.\n* For participants aged 60 years or older: Mini-Mental State Examination (MMSE) score ≥23.\n* Affiliated with a national health insurance system.\n* Written informed consent.\n\nNon inclusion Criteria:\n\n* Individuals protected under French regulations governing research involving human participants.\n* Employees or individuals under the direct authority of the investigators.\n* History of neurological or psychiatric disorders likely to affect visual or cognitive functions.\n* Current treatment likely to alter visual function or vigilance.\n* MRI contraindications (metallic implants, pacemaker, severe claustrophobia, or other MRI safety contraindications) for participation in the MRI arm only.",true,"85 Years",{"count":140,"type":22},160,[25],"The RePer-AGE study investigates how central and peripheral vision contribute to visual recognition and how these mechanisms change with normal aging. The study is based on the hypothesis that peripheral vision provides rapid global information that supports visual recognition through predictive mechanisms. Healthy young adults (18-30 years) and older adults (60-85 years) will undergo visual psychophysical testing, ophthalmological examinations, and, for a subset of participants, functional magnetic resonance imaging (fMRI). The results are expected to improve our understanding of age-related changes in visuo-cognitive functions and provide reference data for future studies on age-related visual disorders.",[144,145,146],"Aging","Visual Perception","Cognition",[148,149,150,151,152,153,154,155],"Healthy Aging","Peripheral vision","Central vision","Visual recognition","Predictive processing","Psychophysics","Retinal sensitivity","fMRI","2026-07-21",{"date":158,"type":37},"2026-07-27",{"date":160,"type":22},"2026-09-01",{"date":162,"type":22},"2030-09",{"name":43,"class":44},1,{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":23,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":184,"locationsCount":4},"100648783","effect-of-high-flow-humidified-oxygen-on-ventilatory-work-during-the-spontaneous-breathing-trial-100648783","NCT07724392","Effect of High-Flow Humidified Oxygen on Ventilatory Work During the Spontaneous Breathing Trial","OTRAVAIL","Inclusion Criteria:\n\n* Adult patient, of legal age\n* On invasive mechanical ventilation for more than 48 hours\n* With at least one criterion indicating a high risk of extubation failure:\n\n  * Age \\> 65 years\n  * Chronic respiratory disease\n  * Chronic cardiac disease\n* Capable of undergoing a mechanical ventilation weaning test (\"weaning criterion\"):\n\n  * Respiratory rate \\\u003C 35 bpm\n  * Adequate oxygenation:\n\n    * SpO₂ ≥ 90% with FiO₂ ≤ 40% and PEEP ≤ 8 cm H₂O\n    * Or PaO₂\u002FFiO₂ ≥ 150 with PEEP ≤ 8 cm H₂O\n  * Effective cough\n  * Patient is alert (RASS score -2 to +1), without sedation\n  * Hemodynamically stable or on the minimum effective dose\n* Patient has an invasive arterial pressure catheter for arterial blood sampling\n* Informed consent signed by a family member\n* Patient is enrolled in or eligible for a social security program\n\nExclusion Criteria:\n\n* Resuscitation-associated neuromyopathy\n* History of neuromuscular disease\n* Admission for a neurological condition\n* Subjects currently excluded from another study,\n* Persons referred to in Articles L1121-5 through L1121-8 of the CSP (corresponding to all protected persons: pregnant women, women in labor, breastfeeding mothers, persons deprived of liberty by judicial or administrative decision, persons receiving psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 who are not covered by the provisions of Article L. 1121-8, persons admitted to a health or social care facility for purposes other than research, minors, and persons subject to a legal protection order or unable to give informed consent).\n* Staff members who report to the principal investigator",{"count":173,"type":22},30,[25],"Weaning from mechanical ventilation (MV) accounts for a significant portion of the total MV duration, and failure to extubate or delayed extubation increases complications (particularly Ventilator-Associated Pneumonia (VAP)) and mortality. Standard tests (T-piece, Spontaneous Ventilation with Inspiratory Assistance (SV-IA)) have not demonstrated clear superiority, and the T-piece is still widely used despite its limitations. High-flow oxygen (HFO) may reduce ventilatory work and facilitate secretion clearance; however, there is a lack of physiological data in humans with an endotracheal tube in place. This study aims to address this gap prior to a subsequent clinical evaluation.\n\nAn experimental, prospective, single-center, 3-period crossover study with randomized sequence order and single-blind design (primary endpoint assessment and statistical analysis were conducted in a blinded manner).",[177],"Spontaneous Breathing Trial in ICU","2026-07-20",{"date":180,"type":37},"2026-07-24",{"date":182,"type":22},"2027-01",{"date":182,"type":22},{"name":43,"class":44},{"id":186,"slug":187,"hasResults":12,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":195,"briefSummary":196,"conditions":197,"keywords":199,"overallStatus":207,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":215},"100581668","machine-learning-assisted-electrochemical-profiling-to-provide-early-identification-of-bloodstream-infections-pathogens-100581668","NCT06853301","Machine Learning Assisted Electrochemical Profiling to Provide Early Identification of Bloodstream Infections Pathogens","Towards a Smart Blood Culture Bottle: Machine Learning Assisted Electrochemical Profiling to Provide Early In-situ Identification of Bloodstream Infections Pathogens","E-MOC","Inclusion Criteria:\n\n* patient requiring a blood culture sample as standard of care procedure\n* body weight \\> 50 Kg\n* Patient for whom the collection of 2 to 4 additional blood culture bottles is feasible, depending on venous access\n* patient who has not objected to participation in the project\n\nExclusion Criteria:\n\n* Patient protected under the French Public Health Code (pregnant or breastfeeding women, patients under guardianship or curatorship, hospitalized under constraint, or deprived of liberty)\n* patients with ongoing antibiotic treatment at the time of sampling",{"count":194,"type":22},200,[25],"In the context of a bacteremia, although significant progress has been made in speeding up pathogen identification once a blood culture bottle turns positive, few cost-effective solutions have been proposed to improve the earlier stages of the process-specifically, from blood collection to bottle positivity. The investigators propose that transport time could be leveraged to grow and identify bacteria, enabling faster access to actionable results through innovative technologies. This project aims to develop a bacterial identification database by analyzing the electrochemical profile of bacteria growing within the blood culture bottle, using machine learning.",[198],"Bacteremia Sepsis",[200,201,202,203,204,205,206],"Rapid identification","Positive blood culture","Electrochemical profiling","Machine learning","Artificial intelligence","Bacteremia","Database","RECRUITING",{"date":209,"type":37},"2026-07-22",{"date":211,"type":37},"2026-07-13",{"date":213,"type":22},"2028-01",{"name":43,"class":44},2,{"id":217,"slug":218,"hasResults":12,"nctId":219,"briefTitle":220,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":137,"sex":18,"minAge":19,"maxAge":223,"enrollmentInfo":224,"targetDuration":4,"studyType":23,"phases":226,"briefSummary":227,"conditions":228,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":164},"100644490","methodological-study-of-exercise-and-hypoxic-conditions-in-healthy-subjects-100644490","NCT07671638","Methodological Study of Exercise and Hypoxic Conditions in Healthy Subjects","ExHyp","Inclusion Criteria:\n\n* Healthy male or female volunteers\n* Aged 18-55\n* Body Mass Index \\\u003C30 kg\u002Fm²\n* Participants covered by a social security scheme\n* Participants capable of signing an informed consent form\n* Negative pregnancy test and highly effective contraception for women of childbearing age\n\nExclusion Criteria:\n\n* Cardiorespiratory, metabolic and neurological disorders, or other conditions assessed during the inclusion consultation that may affect physiological responses to exercise or hypoxia\n* Pharmacological treatment taken during the study, other than oral or implantable contraceptive medication for female volunteers of childbearing age","55 Years",{"count":225,"type":22},305,[25],"The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during inhalation of a gas mixtures with various oxygen contents (similar to exposure at high altitude).",[229,230,231],"Healthy Subjects (HS)","Exercise","Hypoxia","2026-07-17",{"date":156,"type":37},{"date":235,"type":22},"2026-09-15",{"date":237,"type":22},"2032-03-31",{"name":43,"class":44},{"id":240,"slug":241,"hasResults":12,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":23,"phases":249,"briefSummary":250,"conditions":251,"keywords":253,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":164},"100647901","abdominal-massage-after-colon-surgery-for-cancer-100647901","NCT07713472","Abdominal Massage After Colon Surgery for Cancer","Benefits of Abdominal Massage After Colon Surgery for Cancer Following an ERAS Protocol (MATRAC_Ter): a Multicenter, Prospective, Randomized Clinical Trial","MATRAC_Ter","Inclusion Criteria:\n\n* Adults programmed to undergo surgery involving right, transverse or left colectomy due to cancer with anastomosis, regardless the approach (laparoscopy.\n* Laparotomy and Robot-assisted). Patients must be able to follow the colorectal surgery unit's ERAS protocol.\n* All included patients are required to have signed a study specific written informed consent form prior to inclusion in the trial.\n\nExclusion Criteria:\n\n* Patients required emergency surgery (obstruction or peritonitis),\n* A stoma for whatever reason,\n* Rectal cancer,\n* BMI \\> 40,\n* Psychiatric disorders,\n* An associated procedure, extensive resection,\n* Pregnancy, deprivation of liberty by judicial or administrative decision, or being under legal protection and patients with a hierarchical link to the principal investigator.",{"count":248,"type":22},225,[25],"Postoperative ileus is a transient gastrointestinal dysmotility following abdominal surgery that leads to bloating, abdominal distention, visceral pain, nausea, vomiting, and delayed passage of flatus and stool. This paralytic state lasts longer when surgery involves the distal rather than the proximal digestive tract. Its incidence following colorectal surgery is between 10% and 30%. The main factors of postoperative ileus include age, predisposed constipation, method of anesthesia, type of surgical approach, perioperative analgesia, inflammatory reactions, and the psychopathology of the patient.\n\nEnhanced recovery after surgery (ERAS) provides patients with optimal means to counteract or minimize the deleterious effects of surgery, in particular toward minimizing postoperative ileus. Expert consensus among surgeons, anesthesiologists, physiotherapists, dieticians, and other team members has been reached that stated 24 clinical statements concerning preoperative, peroperative and postoperative periods that should be included in current rehabilitation programs in colorectal surgery.\n\nIn China, massage, a 3000-year-old therapy guided by the theory of Yin and Yang, is widely used to treat various diseases. Chapelle and Bowe showed that abdominal massage reduced experimental postoperative ileus in a rat model and suggested that the effect was due to the attenuation of inflammation.\n\nAbdominal massage has not widely been applied after colorectal surgery. Due to the scarcity of literature on abdominal massage, it has never been considered to be part of ERAS recommendations in colorectal surgery. Nevertheless, massage involving profound maneuvering of the viscera through abdominal palpation and breathing has been used as part of the local postoperative protocol in our department for many years with interesting results, and no complication has been reported. To our knowledge, only one study has explored the effect of mechanical abdominal massage on the duration of ileus after colectomy.\n\nThe aim of this prospective, multicenter randomized controlled trial (RCT) is to compare return of intestinal transit using the GI-2 criteria as defined by the time to first defecation and time to tolerance of solid food following the operation in two groups of patients following an ERAS protocol for colonic cancer surgery, one with and the other without early postoperative abdominal massage.",[252],"Colonic Cancer",[254,255,256,257,258],"Postoperative ileus","Surgery","Colonic cancer","Abdominal massage","Physiotherapy","2026-07-16",{"date":178,"type":37},{"date":262,"type":22},"2026-07",{"date":264,"type":22},"2028-08-31",{"name":43,"class":44},{"id":267,"slug":268,"hasResults":12,"nctId":269,"briefTitle":270,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":273,"enrollmentInfo":274,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":276,"conditions":277,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":279,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":164},"100647119","large-scale-evaluation-of-a-clinical-decision-tree-for-the-management-of-low-energy-thoracic-and-lumbar-vertebral-compression-fractures-100647119","NCT07706439","Large-Scale Evaluation of a Clinical Decision Tree for the Management of Low-Energy Thoracic and Lumbar Vertebral Compression Fractures.","PALMTREE","Inclusion Criteria:\n\n* Age \\> 50 years\n* One or more low-energy vertebral compression fractures (LEVCFs) confirmed by MRI\n* Fractures located between T7 and L5\n* Compression fractures classified as A1.1, A1.2, or A1.3 according to the Magerl classification \\[15\\]\n* Management in accordance with the clinical decision tree\n* Vertebroplasty performed by an interventional radiologist, orthopedic surgeon, or neurosurgeon\n* Vertebral augmentation performed by an orthopedic surgeon or neurosurgeon, with or without navigation assistance\n* Conservative treatment consisting of a lumbar brace worn during daytime, with duration individualized according to the patient's needs, and physiotherapy initiated between 45 and 90 days after treatment, including core stabilization, stretching, and strengthening of the posterior muscle chain and abdominal muscles, based on active rehabilitation rather than manual therapy (no massage therapy).\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women\n* Individuals under administrative or judicial supervision\n* Age \\\u003C 50 years or \\> 90 years\n* Pathological vertebral fracture\n* Presence of other osteoporotic fractures during the study follow-up period (6 months)\n* Non-compliance with the clinical decision tree\n* Dementia or cognitive impairment preventing data collection at the final follow-up (telephone interview), assessed using the Mini-Cog test (score \\\u003C 3 = exclusion)\n* Refusal to participate during the telephone interview or inability to provide non-opposition (e.g., under legal guardianship)","100 Years",{"count":275,"type":22},400,"Percutaneous vertebroplasty is widely used for low-energy vertebral compression fractures, but its clinical benefits remain debated. Studies and meta-analyses have reported mixed results, while complications occur in a significant proportion of patients, highlighting the importance of careful patient selection. To standardize management, a clinical decision tree was developed based on patient age, MRI findings, pain severity (VAS), and radiological deformity.",[278],"Thoracolumbar Low-energy Vertebral Compression Fractures",{"date":232,"type":37},{"date":281,"type":22},"2026-07-15",{"date":283,"type":22},"2027-07-15",{"name":43,"class":44},{"id":286,"slug":287,"hasResults":12,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":12,"sex":293,"minAge":19,"maxAge":4,"enrollmentInfo":294,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":296,"conditions":297,"keywords":312,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":316,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":320,"locationsCount":4},"100645943","quality-of-life-of-patients-who-have-undergone-bilateral-mastectomy-100645943","NCT07699913","Quality of Life of Patients Who Have Undergone Bilateral Mastectomy","Psychological Experience, Quality of Life, and Patient Satisfaction Following Bilateral Breast Reconstruction After Prophylactic or Therapeutic Mastectomy, Using the BREAST-Q Questionnaire.","RM BREAST Q","Inclusion Criteria:\n\n* Female sex\n* Age ≥ 18 years\n* Bilateral mastectomy\n* Breast reconstruction between January 1, 2015, and January 1, 2026\n* No objection to the study\n\nExclusion Criteria:\n\n* Individual under guardianship or curatorship, or deprived of liberty\n* Reconstruction not completed by January 1, 2026.","FEMALE",{"count":295,"type":22},115,"The investigators therefore aim to determine whether the type of mastectomy (preventive in a high-risk patient or therapeutic in a patient with a history of cancer), as well as the timing (immediate or delayed) and type of breast reconstruction, influence the quality of life and satisfaction of patients who have undergone bilateral mastectomy. The goal of this observational study is thus to measure and compare the quality of life of patients who have undergone bilateral mastectomy using the BREAST-Q questionnaire.",[298,299,300,301,302,303,304,305,306,307,308,309,310,311],"Surgery Date","Age","BMI","Height","Weight","Smoking Status","Hormone Therapy","Chemotherapy","Radiotherapy","Postoperative Complications","Type of Reconstruction (Flap or Implant)","Timing of Reconstruction","Type of Mastectomy (Prophylactic or Therapeutic)","BRCA Mutation",[313,314,315],"Comparative","observational","retrospective",{"date":281,"type":37},{"date":318,"type":22},"2026-07-10",{"date":36,"type":22},{"name":43,"class":44},{"id":322,"slug":323,"hasResults":12,"nctId":324,"briefTitle":325,"officialTitle":325,"acronym":326,"eligibilityCriteria":327,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":328,"targetDuration":330,"studyType":56,"phases":4,"briefSummary":331,"conditions":332,"keywords":334,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":341,"leadSponsor":343,"locationsCount":4},"100645581","pilot-study-to-study-the-time-between-pleuropulmonary-ultrasound-and-antibiotic-therapy-prescription-in-patients-admitted-to-the-emergency-department-for-suspected-pneumonia-100645581","NCT07703852","Pilot Study to Study the Time Between Pleuropulmonary Ultrasound and Antibiotic Therapy Prescription in Patients Admitted to the Emergency Department for Suspected Pneumonia","PRE-EPPA","Inclusion Criteria:\n\n* Patient over 18 years admitted the the emergency department of Grenoble Alpes University Hospital with respiratory symptoms (cough and\u002For dyspnea, fever).\n* No objection by the subject to the study\n* Affiliated to the french social security system (or equivalent)\n\nExclusion Criteria:\n\n* Patient admitted to a life-threatening emergency\n* Patient already on antibiotic therapy on admission\n* Patient excluded from another study\n* Patient with respiratory signs following chest trauma\n* Unable to communicate or non-french speaking patients or those with impaired comprehension or consciousness\n* Protected persons referred to in articles L1121-6 and L1121-8 of French public health code (deprived of liberty, tutorship or curatorship)\n* The patient already enrolled in the study",{"count":329,"type":22},15,"1 Day","Pneumonia is a common pathology with significant morbidity and mortality. It is recommended in his diagnostic approach to perform either a chest X-ray or a pleuropulmonary ultrasound. Previous studies have shown the advantages of ultrasound in terms of diagnostic performance cost and patient irradiation. However, it remains little used in clinical practice.",[333],"Pneumonia",[333,335,336],"Pleuropulmonary ultrasound","Antibiotic","2026-07-09",{"date":339,"type":37},"2026-07-14",{"date":211,"type":22},{"date":342,"type":22},"2026-09-30",{"name":43,"class":44},{"id":345,"slug":346,"hasResults":12,"nctId":347,"briefTitle":348,"officialTitle":348,"acronym":349,"eligibilityCriteria":350,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":351,"enrollmentInfo":352,"targetDuration":4,"studyType":23,"phases":354,"briefSummary":355,"conditions":356,"keywords":359,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":367,"locationsCount":98},"100645875","evaluation-of-the-feasibility-and-efficacy-of-a-chronic-brain-computer-interface-for-speech-rehabilitation-in-patients-with-locked-in-syndrome-lis-100645875","NCT07698496","Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS)","SpeechBCI","Inclusion Criteria:\n\na. Male or female between 18 and 65 years old b. French speaking person c. Person in locked in syndrome with a severe speech disorder following either: i. A subcortical stroke ii. Amyotrophic Lateral Sclerosis. d. Person with stable clinical state (esp. regarding respiratory state) e. Person able to read on a screen (sufficient eye movement control) f. Negative plasma pregnancy test for women of childbearing potential\\* g. Highly effective or at least acceptable\\*\\* contraception for women of childbearing potential.\n\nh. Persistence of localizing signals of language function proven by functional MRI.\n\ni. Person able to perform a simple BCI task with MEG j. Person with a neuropsychological profile evaluated by psychiatrist as compatible with sustain BCI training k. Informed consent to participate in the obtained using their usual means and code of communication (residual vocalizations, eye-blinking code, pictograms, eye tracking, alphabet chart, etc.), in the presence of their trusted person or curator who is accustomed to communicating with them using this means.\n\nl. Person affiliated to the French social security system or beneficiary of such a system\n\nExclusion Criteria:\n\nPatients with any of the following criteria cannot be included in this investigation:\n\n1. Severe cognitive disorders assessed after a neuropsychological evaluation\n2. Deafness\n3. Continuous assisted ventilation\n4. Contraindication to intracranial surgery\n5. Contra-indication to MRI (1.5T), CT-scan or their related contrast agent injection or MEG examinations.\n6. Anatomical brain MRI showing structural abnormalities in the cortical areas of language\n7. Functional impairment of language cortical areas on MRI\n8. Auditory evoked potential showing hearing impairment\n9. Person with a skull shape incompatible with one WIMAGINE implant on each hemisphere\n10. Persons referred to in Articles L1125-7 of the Public Health Code and article 64 of MDR(corresponding to all protected persons: pregnant women, women in labor, breastfeeding mothers, minors, persons deprived of liberty by judicial or administrative decision.","65 Years",{"count":353,"type":22},3,[25],"Eighteen million people worldwide are affected by speech disorders. Locked-in syndrome (LIS) represents the most extreme form of communication disability resulting from motor impairment. In France, the Association du Locked-In Syndrome (ALIS) reports approximately 500 individuals with LIS, most of whom live at home. The quality of life of people with LIS depends strongly on their ability to communicate, and speech synthesis is the mode of communication restoration most desired by individuals with LIS. Several surveys have shown that improving communication abilities in these individuals leads to a significant improvement in their quality of life as well as that of their caregivers.\n\nNatural speech allows the production of an average of 150 words per minute. Non-invasive communication methods, whether based on residual motor function (eye-blink code) or on brain-machine or brain-computer interfaces (Brain-Computer Interface, BCI) using scalp electroencephalographic (EEG) signals, involve a high cognitive load and have low efficiency (spelling only a few letters per minute). Invasive BCIs for speech rehabilitation aim to overcome the limitations of non-invasive devices (cognitive overload and slow speech rate). The intention to act (the act of speaking) is predicted by an algorithm based on the direct decoding of neuronal activity from the sensorimotor cortex (the area where articulatory muscles are represented).\n\nTo date, studies testing speech rehabilitation BCIs in humans remain rare. A subdural electrocorticographic (ECoG) invasive BCI enabled speech decoding (words and sentences from a limited repertoire) for chronic use (2 years). Real-time control of an on-screen cursor allowing spelling of up to 90 letters per minute (equivalent to text messaging) has also been achieved using an intracortical invasive BCI (Utah Array). Very recently, up to 60 words per minute were produced using an intracortical invasive BCI (Utah Array) implanted in the ventral premotor cortex, although with a connector potentially contaminated by acoustic audio feedback. Furthermore, these devices still rely on transcutaneous connectors, which may be sources of infection and prevent routine daily-life use.\n\nIn summary, there is currently no fully implantable, wireless invasive \"speech BCI\" with real-time speech synthesis suitable for long-term home use. The present study will use an intracranial extradural invasive BCI combined with a speech synthesizer, with the aim of developing a communication tool suitable for everyday use. More specifically, the SpeechBCI protocol will propose two complementary BCI approaches in the same subject: a speech BCI (primary objective, BCI\\_PAROLE device) and a cursor BCI (secondary objective). Both BCIs will use the WIMAGINE intracranial epidural system, enabling ECoG signal acquisition with a very limited risk of infection and brain injury and providing signals that are more stable over time compared with intracortical or subdural ECoG devices that retain transcutaneous connectors. These systems will allow long-term and ecological use, as the WIMAGINE implant is wireless and offers excellent long-term signal stability. The WIMAGINE implant has already been successfully tested for controlling an exoskeleton in a tetraplegic subject (operational for over 6 years) and very recently for controlling walking in real-life conditions via a spinal cord stimulator in a paraplegic individual.\n\nThe BCI\\_PAROLE device will integrate a speech synthesizer providing real-time auditory feedback to the speaker. The BCI-CURSEUR device will allow the subject to control an on-screen cursor to access various communication functionalities (web access, emails, chats, etc.). This will provide a complementary communication solution to real-time speech production.\n\nThe hypothesis of this stydy is that the intention to speak (attempted speech) will be decoded by the BCI\\_PAROLE device in individuals with LIS because, as with limb paralysis, paralysis of articulatory and phonatory muscles does not prevent the corresponding cortical map from producing specific signals. Similarly, the BCI-CURSEUR device will decode the intention to move a cursor and perform actions on a computer screen.\n\nNeuronal electrical signals will be recorded bilaterally from the ventral motor cortex (representation of lips, cheeks, tongue, palate, and larynx-the vocal tract) and from the dorsal part of the motor cortex (larynx and hand, the latter for controlling a two-degree-of-freedom cursor), using a total of 128 electrodes (64 on each cerebral hemisphere). The implant will be optimally positioned over speech motor areas using preoperative functional imaging in order to optimize speech decoding by the BCI\\_PAROLE device.",[357,358],"Locked in Syndrome","ALS (Amyotrophic Lateral Sclerosis)",[360],"Locked in syndrom, Speech disorders, Brain-computer interface, BCI, speech rehabilitation","2026-07-07",{"date":211,"type":37},{"date":364,"type":22},"2026-10-10",{"date":366,"type":22},"2031-09-30",{"name":43,"class":44},{"id":369,"slug":370,"hasResults":12,"nctId":371,"briefTitle":372,"officialTitle":372,"acronym":373,"eligibilityCriteria":374,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":375,"enrollmentInfo":376,"targetDuration":4,"studyType":23,"phases":377,"briefSummary":378,"conditions":379,"keywords":4,"overallStatus":207,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":387,"locationsCount":164},"100629664","implantable-brain-computer-interface-for-upper-limb-recovery-after-stroke-100629664","NCT07477613","Implantable Brain-Computer Interface for Upper-Limb Recovery After Stroke","BCI4STROKE-Arm","Inclusion Criteria:\n\n1. Male or female, 18-70 years-old included\n2. Hemispheric ischemic stroke (\\> 1.5 cm on 2 imaging slices): cortical and\u002For subcortical lesion\n3. No decompressive craniectomy procedure performed\n4. Single unilateral stroke occurred 6 months to 18 months ago\n5. Disabling motor deficit of upper limb\n6. Patient able to follow a rehabilitation program\n7. Written consent to participate in the study from the patient and his\u002Fher legal representative\n8. Person affiliated to the social security system or beneficiary of such a system\n9. Highly effective or at least acceptable birth control method for women of childbearing potential\n\nExclusion Criteria:\n\n1. Contraindication for Magnetic Resonance Imaging (MRI), Computed Tomography (CT-scan), Positron Emission Tomography (PET-scan)\n2. Contraindication for Transcranial Magnetic Stimulation (TMS), Electroencephalography (EEG), Magnetoencephalography (MEG)\n3. Contraindication for general anesthesia and for the surgery (such as thrombocytopenia, …)\n4. Severe leukoaraiosis\n5. Previous stroke (symptomatic deficit)\n6. Pre-existing dementia or significant cognitive deficits (MoCA)\n7. Intolerance to electrical stimulation\n8. Major spasticity in the upper limb (4 or 5 in the scale of Modified Ashworth Scale - MAS)\n9. Lesions on the scalp area, skin infections or dermatitis\n10. Epileptiform focus, even without clinical repercussions\n11. A health status, any clinical condition (eg, short life expectancy, and coexisting disease) or other characteristic that precludes appropriate diagnosis, treatment, or follow-up in the trial\n12. Presence of brain implants of metal clips and\u002For brain stimulators\n13. Severe dystonia\u002Finvoluntary movements\n\nPatients with any of the following criteria cannot be included in this investigation:\n\n1. Contraindication for MRI, CT-scan, PET-scan\n2. Contraindication for TMS, EEG, MEG\n3. Contraindication for general anesthesia and for the surgery (such as thrombocytopenia, …)\n4. Severe leukoaraiosis\n5. Previous stroke (symptomatic deficit)\n6. Pre-existing dementia or significant cognitive deficits (MoCA)\n7. Intolerance to electrical stimulation\n8. Major spasticity in the upper limb (4 or 5 in the scale of Modified Ashworth Scale - MAS)\n9. Lesions on the scalp area, skin infections or dermatitis\n10. Epileptiform focus, even without clinical repercussions\n11. A health status, any clinical condition (eg, short life expectancy, and coexisting disease) or other characteristic that precludes appropriate diagnosis, treatment, or follow-up in the trial\n12. Presence of brain implants of metal clips and\u002For brain stimulators\n13. Severe dystonia\u002Finvoluntary movements\n14. Persons referred to in Articles L1121-5 to L1121-7 of the French Public Health Code (CSP), corresponding to all protected persons: pregnant women, women in labor, breastfeeding mothers, individuals deprived of liberty by judicial or administrative decision, individuals undergoing psychiatric care under Articles L.3212-1 and L.3213-1 who are not covered by Article L.1121-8, individuals admitted to a healthcare or social institution for purposes other than research, and minors.\n\nMoreover, patient will not be included for implantation (exclusion criteria), if he is not eligible for a BCI rehabilitation protocol, as determined by the clinical team after multimodal selection tests. As examples, it can be due to:\n\n1. No existing residual corticospinal tracts proven tractography and\u002For Motor Evoked Potential (MEP)\n2. Unability to control a BCI or unwillingness to follow a BCI rehabilitation program, assessed by MEG-BCI\n3. Unability to activate any residual motor regions during motor imagery assessed by EEG and functional MRI (fMRI)\n4. Shape of the skull in the implantation site not concordant with the WIMAGINE implant, assessed by anatomical MRI","70 Years",{"count":45,"type":22},[25],"The clinical investigation will take place in three phases:\n\n* A pre-selection\u002Fselection phase to ensure that the patient (lesion, symptoms, ability of our tools to detect your movement intentions, etc.) is suitable for a six-month intensive rehabilitation program using Brain-Machine Interface.\n* A second phase, consisting of implementing the intensive rehabilitation program, first in the traditional manner, without the Brain-Machine Interface (2 to 5 weeks), then, after implantation, with the Brain-Machine Interface (6 months).\n* During the third phase, only follow-up visits will be scheduled to ensure the longevity of the implants and the maintenance of the motor progress achieved through rehabilitation.",[380],"Stroke","2026-07-02",{"date":361,"type":37},{"date":384,"type":37},"2026-04-08",{"date":386,"type":22},"2031-04-08",{"name":43,"class":44},{"id":389,"slug":390,"hasResults":12,"nctId":391,"briefTitle":392,"officialTitle":392,"acronym":393,"eligibilityCriteria":394,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":395,"targetDuration":330,"studyType":56,"phases":4,"briefSummary":397,"conditions":398,"keywords":400,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":405,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":4},"100646622","blood-pressure-measured-on-the-arm-with-different-layers-of-clothing-versus-on-the-bare-arm-in-patients-at-grenoble-alpes-university-hospital-100646622","NCT07687771","Blood Pressure Measured on the Arm With Different Layers of Clothing Versus on the Bare Arm in Patients at Grenoble Alpes University Hospital","PA-COUCHE","Inclusion Criteria:\n\n* Patient over 18 years admitted to the emergency department of Grenoble University Hospital\n* No objection by the subject to the study\n* Affiliated to the French social security system (or equivalent)\n\nExclusion Criteria:\n\n* Physical inability to collect BP at the admission in the emergency department (pain, arm wound)\n* Technical inability to collect BP at the admission in the emergency department (incompatible size of the cuffs)\n* Medical or surgical contraindication to repeated blood pressure measurement on both arms\n* Patient who received antihypertensive treatment within the hour prior to measurements\n* Unable to communicate or non-french speaking patients or those with impaired comprehension or consciousness\n* Protected persons referred to in articles L1121-6 and L1121-8 of French public health code (deprived of liberty, tutorship or curatorship)\n* The patient already enrolled in the study",{"count":396,"type":22},161,"Blood pressure (BP) is an essential physiological parameter for assessing patient condition. In pre-hospital emergency situations it is measured at the arm over the patient's clothing when the patient cannot be undressed.\n\nHowever there is no study proving the reliability of this measurement compared to measurement according to recommendations (blood pressure cuff).\n\nThis lack of proof could lead to misinterpretation when measurement conditions are not optimal.",[399],"Blood Pressure",[401,402,403],"Blood Pressure measurement","Bar Arm","Sleeve","2026-06-30",{"date":361,"type":37},{"date":407,"type":22},"2026-08-01",{"date":409,"type":22},"2027-01-30",{"name":43,"class":44},{"id":412,"slug":413,"hasResults":12,"nctId":414,"briefTitle":415,"officialTitle":415,"acronym":416,"eligibilityCriteria":417,"healthyVolunteers":137,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":418,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":420,"conditions":421,"keywords":4,"overallStatus":207,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":428,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":164},"100642858","clinical-performance-and-multitasking-in-anesthesia--a-simulation-based-study-100642858","NCT07615582","Clinical Performance and Multitasking in Anesthesia : a Simulation-based Study","FOCUS","Inclusion Criteria:\n\n* Anesthesiology and intensive care resident or attending physician\n* Written informed consent\n\nExclusion Criteria:\n\n* None",{"count":419,"type":22},35,"Cognitive failure under multitasking conditions has been demonstrated in various settings, including healthcare. However, in anesthesiology, the impact of multitasking on clinical performance has not yet been fully characterized.\n\nThe objective of our study is to evaluate the impact of multitasking on anesthesiologists' clinical performance in a simulated setting.",[422,423,424,425,426,427],"Multitasking Behavior and Multitasking Ability","Clinical Performance","Simulation Training","Simulation Based Medical Education","Clinical Reasoning","Anesthesia",{"date":381,"type":37},{"date":430,"type":37},"2026-06-09",{"date":432,"type":22},"2026-12",{"name":43,"class":44},{"id":435,"slug":436,"hasResults":12,"nctId":437,"briefTitle":438,"officialTitle":439,"acronym":440,"eligibilityCriteria":441,"healthyVolunteers":12,"sex":18,"minAge":442,"maxAge":4,"enrollmentInfo":443,"targetDuration":4,"studyType":23,"phases":445,"briefSummary":446,"conditions":447,"keywords":451,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":459,"completionDateStruct":461,"leadSponsor":463,"locationsCount":164},"100644047","acute-muscular-and-vascular-responses-to-a-single-session-of-exercise-with-bfr-in-copd-100644047","NCT07668921","Acute Muscular and Vascular Responses to a Single Session of Exercise With BFR in COPD","Blood Flow Restriction (BFR): a Novel Approach to Potentiate the Effects of Rehabilitative Exercise Training in COPD? Study of Acute - Muscular, and Vascular - Responses to a Single Session of Exercise With BFR","2BFREE_aigu","Inclusion Criteria:\n\n* Negative pregnancy test and use of an acceptable contraceptive method throughout the study duration for women of childbearing potential\n* Established COPD defined as obstructive ventilatory defect (FEV1\u002FFVC \\\u003C 0.70 or below the 5th percentile)\n* Resting lung hyperinflation defined as functional residual capacity \\> 2.5 z-scores according to the Global Lung Function Initiative (GLI)\n* Clinical stability of COPD for at least 3 months, with no recent exacerbation requiring treatment modification\n* Covered by a national health insurance system\n* Able and willing to provide written informed consent\n\nNon-inclusion Criteria:\n\n* Presence of a medical device incompatible with magnetic stimulation\n* Inability to perform an exercise test on a cycle ergometer\n* Any usual contraindication to exercise testing, including:\n\n  * Recent myocardial infarction (3-5 days)\n  * Unstable coronary insufficiency\n  * Severe stenotic valvular disease\n  * Uncontrolled arrhythmia with hemodynamic instability\n  * Recent unexplained syncope\n  * Uncontrolled heart failure\n  * Uncontrolled arterial hypertension (systolic blood pressure ≥200 mmHg and\u002For diastolic blood pressure ≥110 mmHg at rest)\n  * Acute thromboembolic disease and\u002For pulmonary edema\n* Conditions contraindicating the use of blood flow restriction (BFR), including:\n\n  * Coagulation disorder\n  * Peripheral neuropathy\n  * Uncontrolled hypertension (\\>160\u002F100 mmHg)\n  * Peripheral arterial disease\n  * History of venous thrombosis\n  * Intensive care unit stay within the last 3 months\n* Participation in another study during an exclusion period\n* Inability to be contacted in case of emergency\n* Individuals covered under Articles L1121-5 to L1121-8 of the French Public Health Code (protected populations, including pregnant or breastfeeding women, prisoners, minors, individuals under legal protection, psychiatric inpatients, etc.)\n* Staff members with a hierarchical relationship with the principal investigator","45 Years",{"count":444,"type":22},40,[25],"Exercise training is a cornerstone of pulmonary rehabilitation (PR) in patients with chronic obstructive pulmonary disease (COPD). However, some patients derive limited benefits from conventional exercise programs. Previous studies suggest that the magnitude of exercise-induced muscle fatigue is associated with training effectiveness, with patients unable to develop significant muscle fatigue (\"non-fatiguers\") showing smaller improvements in functional capacity and quality of life.\n\nBlood flow restriction (BFR) exercise consists in performing physical exercise while applying external pressure to the proximal part of the exercising limb, thereby reducing oxygen delivery to the muscles and limiting metabolite clearance. This approach has been shown to induce significant muscular adaptations despite the use of low exercise intensities. Because exercise intensity in COPD patients is often constrained by ventilatory limitations, BFR training may enhance muscle adaptations while reducing respiratory stress, potentially improving the effectiveness of PR.\n\nThe primary objective of this monocentric randomized crossover study is to compare lower-limb muscle fatigue induced by a single exercise session performed with BFR versus a standard exercise session in patients with COPD.",[448,449,450],"Control Condition","Pulmonary Disease (COPD), Chronic Obstructive","Blood Flow Restriction Training (BFRT)",[452,453,454,455,456],"Muscle Fatigue","COPD","Aerobic exercise","Resistance exercise","Blood Flow Restriction Training","2026-06-25",{"date":404,"type":37},{"date":460,"type":22},"2026-11",{"date":462,"type":22},"2028-12",{"name":43,"class":44},{"id":465,"slug":466,"hasResults":12,"nctId":467,"briefTitle":468,"officialTitle":468,"acronym":469,"eligibilityCriteria":470,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":471,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":473,"conditions":474,"keywords":476,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":481,"completionDateStruct":482,"leadSponsor":484,"locationsCount":4},"100645038","one-year-prognostic-impact-of-microcirculation-assessed-by-nh-imr-angio-in-patients-hospitalized-for-acute-myocarditis-100645038","NCT07676201","One-year Prognostic Impact of Microcirculation Assessed by NH IMR Angio in Patients Hospitalized for Acute Myocarditis","MICROMYOC","Inclusion Criteria:\n\n* Male or female patients over the age of 18.\n* Patients hospitalized between June 2015 and July 2025.\n* Patients who presented with chest pain and at least 1 diagnostic criterion; or, in the absence of chest pain, at least 2 of the following diagnostic criteria:\n\n  * Electrocardiographic abnormalities (ST-segment elevation or depression, T-wave inversions, conduction disturbances such as type 3 atrioventricular block),\n  * Elevated troponin levels,\n  * Abnormal kinematics on echocardiography.\n* Associated with MRI findings of ≥2 tissue abnormalities (edema, hyperemia, myocardial fibrosis).\n* Coronary angiography performed during the initial hospitalization\n* Patient enrolled in or eligible for a social security program.\n* Patient who has expressed consent to participate.\n\nExclusion Criteria:\n\n* Absence of coronary artery disease confirmed by coronary angiography\n* Myocarditis secondary to immunotherapy\n* Presence of documented coronary artery disease (coronary angiography or cardiac CT)\n* Presence of cardiomyopathy (hypertrophic cardiomyopathy, dilated cardiomyopathy)\n* Infiltrative heart disease (sarcoidosis or cardiac amyloidosis)\n* Severe valvular heart disease\n* Takotsubo syndrome\n* Constrictive or chronic pericarditis\n* Loeffler's endocarditis\n* Left ventricular noncompaction\n* Cardiac tumor\n* Pulmonary embolism\n* Coronary spasm\n* Patients covered by Articles L1121-5 through L1121-8 of the Public Health Code (pregnant women, women in labor, and breastfeeding women; persons deprived of their liberty by judicial or administrative decision; adults under guardianship)",{"count":472,"type":22},106,"The goal of this observational study is to evaluate the association between post-coronary angiography IMR and medium-term clinical prognosis in patients with acute myocarditis. The main question it aims to answer is:\n\nIs there a correlation between impaired microcirculation and the occurrence of serious clinical events in this population of patients?",[475],"Myocarditis Acute",[477,478],"NH IMR","Coronary catheterization","2026-06-23",{"date":404,"type":37},{"date":281,"type":22},{"date":483,"type":22},"2026-10-15",{"name":43,"class":44},{"id":486,"slug":487,"hasResults":12,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":491,"eligibilityCriteria":492,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":138,"enrollmentInfo":493,"targetDuration":4,"studyType":23,"phases":495,"briefSummary":496,"conditions":497,"keywords":499,"overallStatus":207,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":511,"locationsCount":164},"100633716","treatment-failure-of-continuous-positive-airway-pressure-cpap-in-patients-with-obstructive-sleep-apnea-syndrome-osa-a-trial-comparing-polysomnography-and-the-sunrise-device-to-drive-treatment-adjustment-decisions-100633716","NCT07530302","Treatment Failure of Continuous Positive Airway Pressure (CPAP) in Patients With Obstructive Sleep Apnea Syndrome (OSA): A Trial Comparing Polysomnography and the Sunrise Device to Drive Treatment-Adjustment Decisions.","Treatment Failure of Continuous Positive Airway Pressure (CPAP) in Patients With Obstructive Sleep Apnea Syndrome (OSA): A Randomized Controlled Trial Comparing Polysomnography and the Sunrise Device to Drive Treatment-Adjustment Decisions.","SUNCPAP","Inclusion Criteria:\n\n* Adults aged 18 to 85 years\n* Patients treated with Resmed CPAP\n* Residual apnea-hypopnea index under CPAP (rAHI(CPAP) \\> 10 events\u002Fhour)\n* Access to a smartphone and home internet connection, and ability to use a mobile application\n* Signed informed consent\n* Affiliated with, or beneficiary of, a national health insurance program\n\nExclusion Criteria:\n\n* Severe chronic obstructive or restrictive pulmonary disease, with or without supplemental oxygen\n* Unstable cardiovascular disease or severe heart failure requiring hospitalization within the past 3 months, or meeting New York Heart Association (NYHA) class III or IV criteria\n* Conditions affecting mandibular condyle rotation or temporomandibular joint function\n* Refusal to shave excessive facial hair when required for proper placement of the Sunrise device\n* Participation in another interventional clinical study or currently within an exclusion period of another study\n* Individuals who, in the investigator's judgment, are unlikely to comply with study procedures or requirements\n* Individuals who cannot be contacted in case of emergency\n* Persons protected under French Public Health Code articles L1121-5, L1121-6, and L1121-8 (including pregnant or breastfeeding women, persons deprived of liberty, individuals under psychiatric care under articles L.3212-1 or L.3213-1, individuals admitted to healthcare or social institutions for reasons other than research, and persons under legal protection or unable to provide informed consent)\n* Staff members with a hierarchical relationship to the principal investigator",{"count":494,"type":22},105,[25],"The goal of this clinical trial is to determine whether treatment-adjustment decisions based on one night of home monitoring with the Sunrise device are comparable to decisions based on one night of in-laboratory polysomnography (PSG) in adults with obstructive sleep apnea (OSA) who remain insufficiently controlled with continuous positive airway pressure (CPAP) therapy.\n\nThe main questions it aims to answer are:\n\n* Do Sunrise-based assessments lead to similar therapeutic decisions as PSG-based assessments?\n* Are residual apnea-hypopnea indices measured by Sunrise comparable to those measured by PSG?\n\nParticipants will complete both assessment sequences in a randomized cross-over design. They will:\n\n* Use the Sunrise device for several nights with and without CPAP.\n* Undergo one night of PSG with and without CPAP.\n* Have their CPAP therapy reviewed based on the results of each assessment method.",[498],"Sleep Apnea Syndrome, Obstructive",[500,501,502,503],"Obstructive sleep apnea","Randomized","Cross-over","CPAP","2026-06-15",{"date":506,"type":37},"2026-06-17",{"date":508,"type":37},"2026-06-10",{"date":510,"type":22},"2029-09",{"name":43,"class":44},{"id":513,"slug":514,"hasResults":12,"nctId":515,"briefTitle":516,"officialTitle":516,"acronym":517,"eligibilityCriteria":518,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":273,"enrollmentInfo":519,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":520,"conditions":521,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":526,"completionDateStruct":527,"leadSponsor":529,"locationsCount":4},"100642401","vertebral-augmentation-and-percutaneous-fixation-for-thoracolumbar-burst-fractures-requiring-corpectomy-100642401","NCT07645092","Vertebral Augmentation and Percutaneous Fixation for Thoracolumbar Burst Fractures Requiring Corpectomy","EXVERCOR","Inclusion Criteria:\n\n* Adult patient at the time of the fracture.\n* Patient who underwent posterior fixation (+1\u002F-1 levels) combined with anterior vertebral augmentation:\n\nFracture with a Load Sharing Classification (LSC) score ≥ 7 Single vertebral level involved Percutaneous surgery\n\n* Preoperative CT scans (thoracic and lumbar spine)\n* Postoperative CT scans (thoracic and lumbar spine)\n\nExclusion Criteria:\n\n* Persons deprived of liberty by judicial or administrative decision, or persons under legal protection measures.\n* Non-inclusion criteria include:\n\nPerformance of a laminectomy Pathological fractures Fractures classified as type C or B2 according to the AO Spine classification Presence of severe scoliosis Neurological deficit More than one vertebral fracture",{"count":173,"type":22},"This study evaluates minimally invasive vertebral augmentation combined with percutaneous fixation for the treatment of severe thoracolumbar burst fractures. Traditionally, fractures with a Load Sharing Classification (LSC) score ≥7 require corpectomy, which is associated with significant morbidity. Newer techniques, such as vertebral expansion devices, may restore vertebral height and alignment while reducing the need for invasive anterior procedures. This study aims to assess their effectiveness in this population.",[522],"Thoracolumbar Burst Fractures","2026-06-08",{"date":525,"type":37},"2026-06-12",{"date":504,"type":22},{"date":528,"type":22},"2027-06-15",{"name":43,"class":44},{"id":531,"slug":532,"hasResults":12,"nctId":533,"briefTitle":534,"officialTitle":534,"acronym":535,"eligibilityCriteria":536,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":537,"targetDuration":4,"studyType":23,"phases":538,"briefSummary":539,"conditions":540,"keywords":542,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":546,"lastUpdatePostDateStruct":547,"startDateStruct":548,"completionDateStruct":549,"leadSponsor":551,"locationsCount":164},"100642452","characterization-of-the-involvement-of-the-subthalamic-nucleus-during-wakefulness-and-sleep-in-parkinsons-disease-contribution-of-deep-brain-stimulation-100642452","NCT07637955","Characterization of the Involvement of the Subthalamic Nucleus During Wakefulness and Sleep in Parkinson's Disease: Contribution of Deep Brain Stimulation","SLEEP-STN","Inclusion Criteria:\n\n* Adult patients with Parkinson's disease, followed at Grenoble University Hospital, for whom surgery to implant deep brain stimulation electrodes in the subthalamic nucleus is indicated\n* Patients agreeing to be implanted with a Medtronic PERCEPT stimulator (routine care)\n* Patients who have given and signed informed consent\n* Patients covered by social security or a similar scheme\n\nExclusion Criteria:\n\n* Individuals who do not understand\u002Fspeak French (prevents completion of questionnaires)\n* Any condition that, in the investigator's opinion, will prevent the participant from successfully or safely completing the study procedures (i.e., dementia, severe depression, etc.)\n* Subjects on exclusion from another study\n* Protected persons (Articles L1121-5 to L1121-8 of the French Public Health Code)",{"count":329,"type":22},[25],"Sleep-wake disturbances are common in Parkinson's disease. These disturbances are associated with a decline in patients' quality of life and a poor prognosis. This clinical research project follows a study conducted in non-human primates that began in 2017 at the Grenoble Institute of Neuroscience. In this study, the investigators confirmed the existence of sleep-wake behavior disturbances in the macaque model of the disease, and the investigators characterized their nature and expression. These disturbances were founded to be very similar to those observed in patients with Parkinson's disease. The investigators then explored the involvement of different brain structures, potentially targets for deep brain stimulation, in sleep-wake behavior under healthy conditions and dopamine depletion (Parkinson's disease model). Among the deep brain stimulation targets being explored, the subthalamic nucleus (STN), still under investigation in this preclinical program, is a promising candidate for deep brain stimulation because this nucleus is strongly implicated in motor behavior and, more recently, in sleep\u002Fwake behavior. An ongoing study in non-human primates shows that it is possible to identify states of alertness based on STN activity, and an automatic detection algorithm is currently being evaluated.\n\nFurthermore, this study will allow for the characterization of sleep\u002Fwake behavioral disturbances (diurnal and nocturnal) in patients with Parkinson's disease. Finally, this study will enable a correlation analysis between disease severity and sleep\u002Fwake disturbances.",[541],"Parkinson Disease",[543,544,545],"Parkinson's disease (PD)","Subthalamic nucleus (STN)","Sleep-wake disturbances","2026-06-04",{"date":508,"type":37},{"date":262,"type":22},{"date":550,"type":22},"2029-07",{"name":43,"class":44},{"id":553,"slug":554,"hasResults":12,"nctId":555,"briefTitle":556,"officialTitle":556,"acronym":557,"eligibilityCriteria":558,"healthyVolunteers":137,"sex":18,"minAge":559,"maxAge":560,"enrollmentInfo":561,"targetDuration":563,"studyType":56,"phases":4,"briefSummary":564,"conditions":565,"keywords":567,"overallStatus":207,"whyStopped":4,"lastUpdateSubmitDate":572,"lastUpdatePostDateStruct":573,"startDateStruct":575,"completionDateStruct":577,"leadSponsor":579,"locationsCount":164},"100621227","the-monument-test--a-new-tool-for-assessing-the-ability-to-name-and-identify-unique-entities-tedimo-100621227","NCT07367880","The Monument Test : A New Tool for Assessing the Ability to Name and Identify Unique Entities. (TeDIMO)","TeDIMO","Inclusion criteria :\n\n* Alzheimer's disease:\n\n  * Age ≥ 50 years and older\n  * Possible or probable diagnosis of Alzheimer's disease according to the revised criteria of Mac Khann et al., 2011.\n  * Score 18≤ MMSE ≤26\n* Controls:\n\n  * Age ≥ 50 years and older\n  * MMSE score ≥ 26 For all subjects\n  * No objection from the participant\n\nExclusion criteria\n\n* Alzheimer's disease:\n\n  * Persons referred to in Articles L1121-5 to L1121-8 of the CSP\n* Controls:\n\n  * Memory complaints\n  * Persons referred to in Articles L1121-5 to L1121-8 of the CSP For all subjects\n  * Significant neurological or psychiatric history\n  * Taking psychotropic medication (neuroleptics)\n  * Poor command of the French language, comprehension difficulties\n  * Significant hearing or visual impairments (diplopia, nystagmus, scotoma, etc.)\n  * Insufficient exposure to the media and\u002For socio-cultural knowledge (questionnaire) ; Deficit in face recognition (Benton Face Recognition Test)","50 Years","95 Years",{"count":562,"type":22},220,"1 Month","The goal of this study is to show a significant difference in performance between 2 groups of participants (healthy elderly people vs. people with Alzheimer Disease) in an identification and naming task involving famous monuments.",[566],"Alzheimer s Disease",[568,569,570,571],"unique entities","denomination","identification","landmarks","2026-05-22",{"date":574,"type":37},"2026-05-26",{"date":576,"type":37},"2026-02-23",{"date":578,"type":22},"2032-02-01",{"name":43,"class":44},{"id":581,"slug":582,"hasResults":12,"nctId":583,"briefTitle":584,"officialTitle":584,"acronym":585,"eligibilityCriteria":586,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":587,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":589,"conditions":590,"keywords":600,"overallStatus":207,"whyStopped":4,"lastUpdateSubmitDate":572,"lastUpdatePostDateStruct":608,"startDateStruct":610,"completionDateStruct":612,"leadSponsor":614,"locationsCount":164},"100619680","study-of-the-serotype-and-genotype-of-bk-virus-in-kidney-transplant-recipients-and-their-donors-to-identify-individuals-at-risk-of-nephropathy-100619680","NCT07347769","Study of the Serotype and Genotype of BK Virus in Kidney Transplant Recipients and Their Donors to Identify Individuals at Risk of Nephropathy","TYPIK","Inclusion Criteria:\n\n* Kidney transplant patients with a first positive BK virus viral load in urine. - BK virus viral load in urine \\> 3 log copies\u002FmL.\n* More than 3 months post-transplant and less than 2 years post-transplant.\n* Men or women aged 18 years and older.\n* Followed up at Grenoble Alpes University Hospital.\n* Affiliated with social security or beneficiary of such a scheme.\n* Patients who are not opposed to the TYPIK study.\n\nExclusion Criteria:\n\n* Expected renal graft survival is \\\u003C 6 months, estimated by an eGFR \\\u003C 15 mL\u002Fmin\u002F1.73 m² at the time of BKPyV viruria\n* Patients who object to the use of their data and\u002For samples for research purposes\n* Subjects who are excluded from another study\n* Subjects under administrative or judicial supervision",{"count":588,"type":22},100,"The aim of this observational study is to characterize the urinary replication of BK polyomavirus (BKV) in kidney transplant recipients. Although BKV reactivation after transplantation is well established, the origin of the replicating virus remains uncertain. Current evidence suggests that BKV detected in recipients may originate either from the transplanted kidney (donor-derived) or from viral reactivation in the recipient. The evaluation of new biomarkers to predict BKV replication are needed.\n\nThis study seeks to address the following key questions:\n\n* Origin of the replicating virus: Is the BKV detected in the recipient identical to the virus originating from the donor kidney?\n* Host immune response and viral genotype: Is there an association between the recipient's immune response and the genotype of the replicating BKV?\n* Differences in immune response according to viral replication profile: Does the immune response differ between patients presenting isolated BKV viruria and those with both viruria and viremia?\n* Can new biomarkers help predict BKV replication and viremia?\n\nPatients will be grouped according to their BKV replication profile:\n\nGroup 1: patients with BKV viruria without viremia Group 2: patients with both BKV viruria and viremia Comparisons between these two groups will help identify whether different viral genotypes or immune responses are associated with systemic dissemination (viremia).\n\nKidney transplant recipients will be included if they present BKV viruria during their post-transplant follow-up. Additional blood samples will be collected during scheduled follow-up visits at the university hospital. These visits are part of routine clinical care, and no extra visits will be required specifically for the study.",[591,592,593,594,595,596,597,598,599],"Nephropathy","Opportunistic Viral Infection","Polyoma Virus Nephropathy","BK Nephropathy","BK Viremia; BKV DNAemia","BK Virus Infection","BK Polyomavirus","Immune Response","Neutralizing Antibodies",[601,602,603,604,605,606,607],"TTV","BK polyomavirus","neutralizing antibodies","ELISPOT BKV","genotype","miRNA BKV","urinary chimiokine",{"date":609,"type":37},"2026-05-27",{"date":611,"type":37},"2026-03-11",{"date":613,"type":22},"2030-09-11",{"name":43,"class":44},{"id":616,"slug":617,"hasResults":12,"nctId":618,"briefTitle":619,"officialTitle":619,"acronym":620,"eligibilityCriteria":621,"healthyVolunteers":12,"sex":18,"minAge":622,"maxAge":4,"enrollmentInfo":623,"targetDuration":4,"studyType":23,"phases":624,"briefSummary":625,"conditions":626,"keywords":628,"overallStatus":207,"whyStopped":4,"lastUpdateSubmitDate":572,"lastUpdatePostDateStruct":636,"startDateStruct":637,"completionDateStruct":639,"leadSponsor":641,"locationsCount":353},"100568925","role-of-actg2-variants-in-smooth-muscle-determination-and-function-in-pediatric-intestinal-pseudo-obstruction-100568925","NCT06687564","Role of ACTG2 Variants in Smooth Muscle Determination and Function in Pediatric Intestinal Pseudo-obstruction.","SMOOTH-PIPO","Inclusion Criteria:\n\nPIPO Population:\n\n1. Minor or adult patient ≥ 4 years of age\n2. Patient with PIPO before age 18\n3. Male or female\n4. Patient with PIPO meeting at least 2 of the ESPGHAN criteria (Thapar et al 2018) and carrying the R178, R257, R40 or A136 mutation of the ACTG2 gene.\n5. Patient whose assent has been obtained and whose legal guardians have given their written informed consent\n6. Patient affiliated to the French Social Security system or benefiting from an equivalent plan\n\nWT population:\n\n\\- iPS cell lines MS573 or WT8288 or 202CT or SD378M, from the Nantes University Hospital biological collection and generated from samples from control patients without POIC who have consented to donate their samples.\n\nExclusion Criteria:\n\nPIPO population :\n\n1. Patients with a history of radiotherapy treatment\n2. Patient with lymphocyte lineage damage","4 Years",{"count":98,"type":22},[25],"The primary objective of this study is to describe the transcriptional impact of R178, R257, R40 or A136 variants of the ACTG2 gene on iPS differentiation mechanisms up to organoids derived from PIPO patient samples versus those derived from control \u002F WT patients (generation of IPS from cultured cell lines), at different stages of their experimental ex vivo development.",[627],"PIPO",[627,629,630,631,632,633,634,635],"CIPO","ACTG2","pseudo-obstruction","organoid","iPS","Pediatric Intestinal Pseudo-Obstruction","Chronic Intestinal Pseudo-obstruction",{"date":609,"type":37},{"date":638,"type":37},"2026-02-04",{"date":640,"type":22},"2032-02-03",{"name":43,"class":44},{"id":643,"slug":644,"hasResults":12,"nctId":645,"briefTitle":646,"officialTitle":646,"acronym":647,"eligibilityCriteria":648,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":649,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":650,"conditions":651,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":653,"lastUpdatePostDateStruct":654,"startDateStruct":656,"completionDateStruct":658,"leadSponsor":659,"locationsCount":164},"100626899","qualitative-exploration-of-key-symptoms-of-stricturing-crohns-disease-toward-the-development-of-a-clinical-assessment-score-100626899","NCT07441629","Qualitative Exploration of Key Symptoms of Stricturing Crohn's Disease: Toward the Development of a Clinical Assessment Score.","SYMCROHNS","Inclusion Criteria:\n\n* Adult patient (≥ 18 years old).\n* With a confirmed diagnosis of Crohn's disease.\n* Presenting a stricturing form of the disease (confirmed clinically, endoscopically, radiologically, or surgically).\n* Followed in a hospital department managing inflammatory bowel diseases (IBD).\n* Clinically stable at the time of the interview (not experiencing an acute episode requiring urgent hospitalization).\n* Able to understand and speak French, in order to participate in a qualitative interview.\n\nExclusion Criteria:\n\n* Current hospitalization for a severe Crohn's disease flare, acute intestinal obstruction, or any situation requiring urgent medical care.\n* Severe cognitive impairment, communication deficits, or acute psychiatric disorder preventing understanding of the interview or reliable expression of experiences.\n* Major uncontrolled medical comorbidity (e.g., active cancer under treatment, severe heart failure) making the interview inappropriate or likely to confound symptom interpretation.\n* Technical inability to participate in an interview (no access to the proposed modalities: unable to travel, no access to videoconference if a remote interview is required).\n* Pregnant women\n* Persons deprived of their liberty\n* Persons receiving psychiatric care\n* Persons admitted to a healthcare or social institution\n* Adults subject to a legal protection measure\n* Persons unable to express their consent",{"count":329,"type":22},"The goal of this qualitative study is to identify and better understand the symptoms of stricturing Crohn's disease in order to inform the development of more appropriate clinical evaluation scores. This study focuses on adult patients diagnosed with stricturing Crohn's disease who are followed in hospital gastroenterology departments.\n\nThe main questions it aims to answer are:\n\n* Which symptoms are perceived by patients as the most specific and significant features of stenosing Crohn's disease?\n* Which symptoms are perceived by patients as early warning signs of a stenosing flare?\n* How does stenosing Crohn's disease impact daily life, mental health, and quality of life, and what coping strategies do patients use to manage symptoms and limit their impact?\n\nParticipants will:\n\n* Take part in a one-hour individual semi-structured interview, conducted in person (at the hospital, at home, or in another agreed location) or by videoconference\n* Have the interview audio-recorded for transcription and qualitative analysis\n* Be offered the opportunity to review and validate the transcript and summary of their interview before final anonymized analysis",[652],"Crohn Disease (CD)","2026-05-18",{"date":655,"type":37},"2026-05-20",{"date":657,"type":22},"2026-05",{"date":460,"type":22},{"name":43,"class":44},""]