[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Baghdad\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":678},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,46,0,25,[9,46,72,98,125,147,185,212,244,264,289,312,335,368,389,419,450,475,496,525,543,569,596,633,655],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100652715","comparative-study-between-leg-massage-and-vibration-on-cramps-and-comfort-for-patients-undergoing-hemodialysis-100652715",false,"NCT07777354","Comparative Study Between Leg Massage and Vibration on Cramps and Comfort for Patients Undergoing Hemodialysis","Inclusion Criteria:\n\n* patients on maintenance HD for ≥3 months who experienced lower extremity muscle cramps.\n\nExclusion Criteria:\n\n* Exclusion criteria included acute illness, lower extremity wounds\u002Finfections, deep vein thrombosis, severe neuropathy, and cognitive impairment. All participants provided written informed consent.","ALL","20 Years","60 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"NA","This planned randomized controlled trial will enroll 164 patients undergoing hemodialysis to compare the effectiveness of leg massage versus vibration therapy on muscle cramps and patient comfort. Participants will be randomly assigned to one of three groups: a massage group receiving 20-minute lower extremity massage sessions, a vibration group receiving 10-minute vibration therapy, or a control group receiving standard care only. All interventions will be administered three times per week for two weeks (six sessions). The study will evaluate cramp frequency, cramp severity using a Visual Analog Scale, sleep quality through the Pittsburgh Sleep Quality Index, and patient comfort scores. Both interventions are expected to significantly reduce cramp frequency and severity compared to standard care, with massage anticipated to show superior benefits for sleep quality and home-based cramp reduction, while vibration is expected to provide better immediate comfort during dialysis sessions. No serious adverse events are predicted. The findings will help healthcare providers offer personalized, evidence-based non-pharmacological options to improve quality of life for hemodialysis patients.",[27,28],"Hemodialysis","Renal Failure , Chronic",[30,31,32,33,27],"Leg massage","Vibration","Cramps","Comfort","NOT_YET_RECRUITING","2026-08-18",{"date":37,"type":38},"2026-08-20","ACTUAL",{"date":40,"type":21},"2026-09-10",{"date":42,"type":21},"2026-12-12",{"name":44,"class":45},"University of Baghdad","OTHER",{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":12,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100625070","effect-of-cartoon-projection-and-ball-squeezing-on-pain-during-venipuncture-in-children-100625070","NCT07417852","Effect of Cartoon Projection and Ball Squeezing on Pain During Venipuncture in Children","Effect of Immersive Cartoon Projection and Ball Squeezing on Pain During Venipuncture Among Children: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Children aged 4-12 years\n* Requiring venipuncture for routine blood testing\n* Able to watch cartoon video during procedure\n* Parental consent obtained\n\nExclusion Criteria:\n\n* Developmental delay preventing cooperation\n* Severe anxiety disorder\n* Visual impairment\n* Non-English\u002FArabic speaking parents","2 Years","12 Years",{"count":56,"type":21},120,[24],"The goal of this clinical trial is to learn which distraction method works better to reduce needle pain in children aged 4-12 years during blood draws.\n\nThe main questions it aims to answer are:\n\n* Does watching cartoon videos lower children's pain more than squeezing a stress ball?\n* Which method do parents prefer for their children?\n\n  120 children will be randomly assigned to watch cartoons or squeeze a ball while nurses draw blood. Pain will be measured using a 0-10 pain scale right after the needle.\n\nThis study will help nurses choose the best way to make blood draws less painful for children.",[60],"Venipuncture Pain",[62],"Pediatric pain, venipuncture, distraction, cartoon projection , Ball squeezing","2026-08-05",{"date":65,"type":38},"2026-08-10",{"date":67,"type":21},"2026-09",{"date":69,"type":21},"2027-01",{"name":44,"class":45},1,{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":12,"sex":16,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":71},"100625069","effect-of-toy-nebulizer-versus-distraction-cards-on-childrens-fear-and-parental-satisfaction-during-nebulization-therapy-a-comparative-study-100625069","NCT07417839","(Effect of Toy Nebulizer Versus Distraction Cards on Children's Fear and Parental Satisfaction During Nebulization Therapy: A Comparative Study","Inclusion Criteria:Children aged 3-6 years receiving nebulization therapy for the first time due to acute respiratory conditions (e.g., asthma or bronchitis).\n\n2\\. Presence of at least one parent (preferably the mother) during the procedure who is capable of evaluation and communication in Arabic or Kurdish.\n\n3\\. Children who are alert and able to cooperate (absence of severe pain or any condition preventing basic communication).\n\n4\\. Voluntary written informed consent obtained from the parents and assent from the child (where applicable).\n\n\\-\n\nExclusion Criteria:Prior history of nebulization therapy (to ensure the fear response is not conditioned by past experiences).\n\n2\\. Children with cognitive, neurological, or developmental disabilities, or severe chronic illnesses (e.g., terminal cancer).\n\n3\\. Parental inability to complete fear or satisfaction questionnaires due to disability or illiteracy.\n\n4\\. Refusal to participate by the child or parent, or the presence of emergency conditions requiring immediate life-saving intervention.\n\n\\-","3 Years","6 Years",{"count":56,"type":21},[24],"Goal To compare the effectiveness of a toy nebulizer versus distraction cards in reducing fear among children during nebulization therapy while improving parental satisfaction.\n\nAim To evaluate and measure children's fear levels and parents' satisfaction when using toy nebulizers compared to distraction cards in nebulization sessions.\n\nNull hypothesis: (Hᴏ) There is no statistically significant difference in fear levels among children, and parental satisfaction scores in in the toy nebulizer, distraction cards, and control groups.\n\nAlternative hypothesis: (H₁) There is a statistically significant difference in fear levels among children, and parental satisfaction scores in the toy nebulizer, distraction cards, and control groups.",[84],"Fear is a Common Psychological Response Undergoing Medical Procedures,Act From Uncertainty, Anticipation of Pain, Loss of Control, Previous Negative Experiences",[86,87,88],"\"nebulization therapy\"","\"fear\"","\"distraction card\"","RECRUITING","2026-07-30",{"date":92,"type":38},"2026-08-03",{"date":94,"type":38},"2026-04-08",{"date":96,"type":21},"2026-08-01",{"name":44,"class":45},{"id":99,"slug":100,"hasResults":12,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":106,"sex":16,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":71},"100647860","ehbm-based-intervention-on-collegians-adherence-to-oral-health-behaviors-ehbm--caohb-100647860","NCT07715773","EHBM-Based Intervention on Collegians' Adherence to Oral Health Behaviors (EHBM- CAOHB)","Efficacy of the Expanded Health Belief Model-Based Intervention on Collegians' Adherence to Oral Health Behaviors: A Randomized Controlled Trial","RCT","Inclusion Criteria: The study included\n\n* Male and female students aged 18-25 years.\n* Enrolled as undergraduate students.\n* Willing to participate and provide informed consent.\n\nExclusion Criteria: Students were excluded if they were\n\n* Students with orthodontic appliances or removable prostheses.\n* Recent comprehensive dental treatment.\n* Female students which are pregnant or lactating.\n* Recent contribution in another oral-health behavioral trial or structured oral-health program.",true,"18 Years","25 Years",{"count":110,"type":21},166,[24],"This study aims to evaluation of collegians adherence to oral health behavers and to examine the efficacy of the Expanded Health Belief Model-based intervention in enhancing oral health behaviors among collegians.",[114],"Oral Health Behavior Change",[116],"Oral Health Behavior","2026-07-19",{"date":119,"type":38},"2026-07-21",{"date":121,"type":38},"2026-03-24",{"date":123,"type":21},"2026-12-01",{"name":44,"class":45},{"id":126,"slug":127,"hasResults":12,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":12,"sex":16,"minAge":133,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":138,"conditions":139,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":141,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":71},"100647639","3d-printed-reverse-twin-block-for-class-iii-malocclusion-100647639","NCT07710391","3D Printed Reverse Twin Block for Class III Malocclusion","Effectiveness of a Novel 3D Printed Reverse Twin Block in The Management of Maxillary Deficiency of Class III Malocclusion: A Randomized Clinical Trial","3DRTB","Inclusion Criteria:\n\n1. The age group selected is mixed dentition group 8-13 years with residual potential maxillary growth. Patient maturity will be assessed using the Cervical Vertebral Maturation (CVM) method on lateral cephalogram, patients in CS1-CS3 stages will be included to ensure remaining maxillary growth.\n2. Presence of permanent first molar with lower anterior teeth to retain the appliance.\n3. Skeletal\u002Fdental class III tendency with anterior cross bite or reverse overjet: a. Clinically the overjet is equal or less than zero up to -3 mm.\n\n   b. Cephalometric ANB angle equal or less than zero up to -3 degrees and Wits appraisal ≤ -2.\n4. Prescence of unilateral or bilateral posterior crossbite.\n5. Mild to moderate anterior crowding.\n6. Acceptable oral hygiene baseline defined by oral hygiene index (OHI). -\n\nExclusion Criteria:\n\n1. Patients with cleft lip and palate and\u002For craniofacial anomalies.\n2. History of previous orthopedic and\u002For orthodontic treatment.\n3. Presence of uncontrolled systemic disease or medically compromised status.\n4. Uncooperative patient\u002Fparents.","8 Years","13 Years",{"count":136,"type":21},30,[24],"This RCT aims to evaluate the effectiveness of a novel 3D printed reverse twin block appliance in the management of maxillary deficiency in growing patients having class III malocclusion. The clinical outcomes of this appliance will be compared with the conventional reverse twin block appliance over 6 months treatment period.\n\nprimary objective is evaluating of the effectiveness of 3DRTB in correcting sagittal discrepancies due to maxillary deficiency in class III malocclusion compared to conventional one while secondary objectives are assessment of transverse and vertical jaw relationship produced by 3DRTB compared to CRTB and to evaluate the soft tissue profile of class III patients and to evaluate the maxillary and mandibular incisor inclination, also assessment of patient perception with both appliances by using questionnaire and finally to assess the impact of 3DRTB on oral health compared to CRTB by using oral hygiene index.",[140],"Class III Malocclusion",{"date":119,"type":38},{"date":143,"type":38},"2026-06-10",{"date":145,"type":21},"2027-06-30",{"name":44,"class":45},{"id":148,"slug":149,"hasResults":12,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":22,"phases":158,"briefSummary":159,"conditions":160,"keywords":164,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":71},"100646188","standard--and-micro-dose-rhbmp-2-for-implant-stability-marginal-bone-loss-and-postoperative-sequelae-a-double-blind-randomized-controlled-trial-100646188","NCT07696299","Standard- and Micro-Dose rhBMP-2 for Implant Stability, Marginal Bone Loss, and Postoperative Sequelae: A Double-Blind Randomized Controlled Trial","Comparative Evaluation of Standard- and Micro-Dose Recombinant Human BMP-2 on Implant Stability, Marginal Bone Loss, and Postoperative Sequelae: A Double-Blind Randomized Controlled Trial","SMBMP","Inclusion Criteria:\n\n* Patients aged 20 to 55 years requiring a single dental implant for a single tooth missing in the posterior mandible (strictly limited to one implant per patient to prevent clustering effects and intra-subject correlation).\n\nPatients must be systemically healthy or medically well-controlled, categorized as ASA I or ASA II according to the American Society of Anesthesiologists classification.\n\nSurgical sites must exhibit D2 or D3 bone quality with adequate residual alveolar bone volume (minimum 6 mm width and 10 mm height).\n\nPatients must maintain optimal oral hygiene, suitable for a prosthetically driven implant treatment workflow.\n\nExclusion Criteria:\n\n* Patients presenting with uncontrolled systemic conditions (e.g., unmanaged diabetes mellitus, active osteoporosis).\n\nA history of radiotherapy or chemotherapy in the maxillofacial region. Current heavy smoking habits (\\>10 cigarettes per day). Active and untreated periodontal disease. Pregnancy or lactation.","55 Years",{"count":157,"type":21},60,[24],"This study will compare the effect of standard-dose and micro-dose recombinant human bone morphogenetic protein-2 (rhBMP-2) with a placebo control on dental implant stability in the posterior mandible. Sixty patients requiring a single dental implant will be randomly assigned to one of three groups: standard-dose rhBMP-2, micro-dose rhBMP-2, or sterile saline only. Implant stability will be measured using Resonance Frequency Analysis at baseline, 2 weeks, 4 weeks, and 12 weeks. Marginal bone loss, peri-implant bone density, ectopic bone formation, and postoperative sequelae including swelling, pain, trismus, and soft tissue healing will also be evaluated during follow-up. The aim is to determine whether micro-dose rhBMP-2 can improve implant stability while reducing postoperative complications compared with the standard dose.",[161,162,163],"Tooth Loss \u002F Rehabilitation","Dental Implant","Osseo-Integrated Implants",[165,166,162,167,168,169,170,171,172,173,174,175,176],"rhbmp-2","Recombinant Human Bone Morphogenetic Protein-2","Implant Stability","Micro-dose","Standard-dose","Osstell","Resonance Frequency Analysis","ISQ","Marginal Bone Loss","Peri-implant Bone Density","Posterior Mandible","Randomized Controlled Trial","2026-07-06",{"date":179,"type":38},"2026-07-10",{"date":181,"type":21},"2026-12",{"date":183,"type":21},"2028-12",{"name":44,"class":45},{"id":186,"slug":187,"hasResults":12,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":12,"sex":16,"minAge":192,"maxAge":193,"enrollmentInfo":194,"targetDuration":4,"studyType":22,"phases":196,"briefSummary":197,"conditions":198,"keywords":201,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":71},"100642864","orthodontic-treatment-outcomes-of-self-ligating-system-compared-to-clear-aligner-system-100642864","NCT07638397","Orthodontic Treatment Outcomes of Self Ligating System Compared to Clear Aligner System","Orthodontic Treatment Outcomes of Self Ligating System Compared to Clear Aligner System : A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Good oral and general health; no systemic conditions affecting bone metabolism or pain perception.\n2. Age range between 16-32 years.\n3. Presence of full permanent dentition except the third molars.\n4. Class I canine and molar relationship moderate crowding in both arches (6-8 mm) requiring fixed orthodontic treatment.\n5. Without previous orthodontic treatment\u002F functional appliances.\n\nExclusion Criteria:\n\n1. Patients will be excluded from enrollment if they have a substantial skeletal discrepancy necessitating orthognathic surgery.\n2. Patient with class Ⅱ , Ⅲ malocclusion.\n3. Patient with external or internal root resorption.\n4. Patients with poor oral hygiene or active periodontal disease.\n5. 90o or more degree of tooth rotation.","16 Years","32 Years",{"count":195,"type":21},42,[24],"This study is a multi-center, prospective, parallel-group randomized controlled trial designed to compare the orthodontic treatment outcomes of a passive self-ligating bracket system (Damon Ultima) versus a clear aligner system. The primary objective is to evaluate and compare the total orthodontic treatment duration between the two systems in patients with Angle Class I malocclusion and moderate crowding. Secondary objectives include assessing alignment efficiency, patient pain perception at multiple time intervals, dental arch dimension changes, root volume loss percentage, and overall treatment quality using the American Board of Orthodontics Objective Grading System (ABO-OGS).",[199,200],"Angle Class I Maloclussion","Dental Crowding",[202,203],"Damon ultima","clear aligner","2026-07-03",{"date":206,"type":38},"2026-07-07",{"date":208,"type":21},"2026-09-15",{"date":210,"type":21},"2028-08-20",{"name":44,"class":45},{"id":213,"slug":214,"hasResults":12,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":106,"sex":16,"minAge":219,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":22,"phases":223,"briefSummary":224,"conditions":225,"keywords":228,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":243},"100643395","clinical-performance-of-direct-printed-versus-thermoformed-aligners-100643395","NCT07637227","Clinical Performance of Direct-Printed Versus Thermoformed Aligners","Clinical Performance of In-Office Directly Printed Versus Thermoformed Aligners: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Adult patient with an age range of 15-30 with fully erupted all permanent dentitions excluding third molars, and a willingness to participate in the trial.\n2. Angle Class I non-extraction cases, presented with mild crowding or spacing (\\\u003C5 mm) and dental rotation \\\u003C30° .\n3. Good oral hygiene; no active caries\u002Fperiodontal disease, no history of trauma or root resorption.\n\nExclusion Criteria:\n\n1. Pregnancy, smoking, and systemic conditions affecting bone remodeling.\n2. Subject with poor oral hygiene, using simplified oral hygiene index (OHI-S ≥ 3.1 ) (Greene \\& Vermillion, 1963).\n3. Patient with malposed lower second molars (need orthodontic alignment).\n4. Allergy to materials used (resins, plastics, solvents).\n5. History of trauma, root resorption, and dilacerated roots.\n6. Previous extraction or history of previous orthodontic treatment.","15 Years","30 Years",{"count":222,"type":21},34,[24],"The goal of this study is to evaluate and compare the clinical effectiveness of in-office directly 3D-printed clear aligners versus conventional multilayered thermoformed aligners.\n\nThe main question it aims to answer is:\n\nDoes the use of in-office direct-printed shape-memory aligners result in superior clinical effectiveness, compared to established multilayer thermoformed aligner systems?\n\nResearchers will compare a Direct-Printed Aligner (DPA) group using Senertek Clear-A V2 resin to a Thermoformed Aligner (TFA) group using Zendura FLX multilayer sheets to see if the additive manufacturing process improves clinical outcomes and patient satisfaction.\n\nParticipants will:\n\n* Undergo initial records including intraoral digital scans, photos, and a panoramic radiograph for treatment planning.\n* Wear their assigned clear aligners (either direct-printed or thermoformed) for at least 22 hours per day, changing them every 7 days.\n* Attend follow-up appointments every 5 weeks.",[226,200,227],"Angle Class I Malocclusion","Tooth Spacing",[229,230,231,232,233,234],"In office aligners","3D printed aligners","Thermoformed Aligners","Tooth movement","Photopolymer Resin","Pain","2026-06-05",{"date":237,"type":38},"2026-06-09",{"date":239,"type":21},"2026-06",{"date":241,"type":21},"2027-10",{"name":44,"class":45},3,{"id":245,"slug":246,"hasResults":12,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":12,"sex":16,"minAge":107,"maxAge":18,"enrollmentInfo":251,"targetDuration":4,"studyType":22,"phases":253,"briefSummary":254,"conditions":255,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":71},"100643222","effect-of-medication-adherence-based-digital-intervention-on-fatigue-severity-weight-and-thyroid-hormone-regulation-100643222","NCT07636681","Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone Regulation","Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone Regulation in Patients With Hypothyroidism: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults (≥18 years) with primary hypothyroidism.\n* On stable levothyroxine therapy for at least 3 months.\n* Able to read, understand study instructions\n* capable of using basic mobile applications\n* poor medication adherence, clinically significant fatigue, documented weight fluctuations and abnormal thyroid hormone\n\nExclusion Criteria:\n\n* Secondary hypothyroidism or recent thyroidectomy\u002Fradioactive iodine therapy.\n* Pregnancy or breastfeeding woman.\n* Severe psychiatric disorders or cognitive impairment\n* significant visual or hearing deficits\n* Serious comorbidities affecting medication adherence (e.g., chronic disease, renal, or hepatic disease).\n* take dietary supplements or medications that interfere with levothyroxine absorption.",{"count":252,"type":21},80,[24],"1. To evaluate the effect of a medication adherence-based digital intervention on fatigue severity in patients with hypothyroidism.\n2. To assess the effect of a medication adherence-based digital intervention on weight in patients with hypothyroidism.\n3. To investigate the effect of a medication adherence-based digital intervention on thyroid hormone regulation in patients with hypothyroidism.",[256],"Hypothyroidism","2026-06-03",{"date":237,"type":38},{"date":260,"type":21},"2026-06-01",{"date":262,"type":21},"2026-12-30",{"name":44,"class":45},{"id":265,"slug":266,"hasResults":12,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":270,"eligibilityCriteria":271,"healthyVolunteers":106,"sex":16,"minAge":107,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":22,"phases":274,"briefSummary":275,"conditions":276,"keywords":278,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":286,"leadSponsor":288,"locationsCount":4},"100639409","suraa-campaign-for-stroke-awareness-in-primary-health-care-centers-100639409","NCT07578259","SURA'A Campaign for Stroke Awareness in Primary Health Care Centers","\"Effectiveness of a One-Week Multifaceted SURA'A Consultation-Based Campaign on Stroke Awareness and Intention to Seek Help Among Adults in Primary Health Care Centers","SURA'A","Inclusion Criteria\n\nParticipants will be eligible if they:\n\n1. Age\n\n   * Adults aged ≥18 years residing in Diwaniyah.\n2. Residence o Living in Diwaniyah communities for at least 6 academic months prior to the study.\n3. Access to Primary Health Centers (PHCs)\n\n   * Attending in selected primary health centers where the SURA'A campaign will be implemented.\n4. Cognitive ability\n\n   o Able to understand and answer the survey questions in Arabic.\n5. Consent o Willing to provide informed consent to participate in pre- and post- awareness intervention assessments.\n\nAvailability for follow-up\n\no Agree to participate in both baseline (pre-campaign) and follow-up (post-campaign) assessments.\n\nExclusion Criteria\n\nParticipants will be excluded if they:\n\n1. Have a previous confirmed diagnosis of stroke (to avoid bias in baseline awareness).\n2. Severe cognitive impairment\n\n   * Have diagnosed dementia, severe mental illness, or cognitive impairment that prevents reliable responses.\n3. Communication barriers\n\n   o Cannot communicate in Arabic or has severe hearing\u002Fspeech impairment that prevents participation.\n4. Health professionals o Physicians, nurses, paramedics, or students of medical and health colleges (to avoid overestimation of awareness).\n5. Temporary visitors\n\n   o Non-residents or individuals visiting Diwaniyah temporarily.\n6. Refusal or withdrawal o Decline to participate or withdraw at any stage of the study.",{"count":273,"type":21},350,[24],"This study aims to evaluate the effectiveness of a one-week multifaceted Stroke Urgency Recognition, and Action Awareness (SURA'A) consultation-based campaign in increasing stroke awareness and the intention to seek emergency medical help among adults. The research will be conducted at primary health care centers to determine if this specific educational approach can improve the community's response to stroke symptoms.",[277],"Stroke",[279,280,281,282],"Stroke Awareness","Intention to Seek Help","Primary Health Care Centers","Health Campaign",{"date":284,"type":38},"2026-06-04",{"date":143,"type":21},{"date":287,"type":21},"2027-04-10",{"name":44,"class":45},{"id":290,"slug":291,"hasResults":12,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":106,"sex":297,"minAge":219,"maxAge":298,"enrollmentInfo":299,"targetDuration":4,"studyType":22,"phases":301,"briefSummary":302,"conditions":303,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":311,"locationsCount":4},"100639032","ttm-based-intervention-for-weight-management-among-high-school-female-students-100639032","NCT07604649","TTM-Based Intervention for Weight Management Among High School Female Students","Efficacy of the Transtheoretical Model of Change-Based Intervention on Weight Management Behavior Among High School Female Students: A Randomized Controlled Trial","TTM-WMHSFS-RCT","Inclusion Criteria:\n\n* Female high school students\n* Age 15-19 years\n* Overweight or obese according to Body Mass Index (BMI) criteria\n* Enrolled in high school morning classes\n* Willing to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* Students below high school level (e.g., middle school students)\n* Students with physical disabilities that prevent participation in physical activity\n* Students with chronic medical conditions affecting body weight or study participation","FEMALE","19 Years",{"count":300,"type":21},154,[24],"To examine the efficacy of a Transtheoretical Model (TTM)-based intervention in improving weight management behaviors.\n\n1. To identify if the student age, body mass index (BMI) and socioeconomic status can predict WMB.\n2. To investigate the difference in students' WMB between groups of grade, liven arrangement, socioeconomic class, and BMI.",[304],"Weight Management","2026-05-19",{"date":307,"type":38},"2026-05-22",{"date":309,"type":21},"2026-10-10",{"date":287,"type":21},{"name":44,"class":45},{"id":313,"slug":314,"hasResults":12,"nctId":315,"briefTitle":316,"officialTitle":317,"acronym":318,"eligibilityCriteria":319,"healthyVolunteers":12,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":320,"targetDuration":4,"studyType":22,"phases":322,"briefSummary":323,"conditions":324,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":331,"completionDateStruct":332,"leadSponsor":334,"locationsCount":71},"100638155","development-of-biofunctional-3d-printed-orthodontic-aligners-with-antimicrobial-and-remineralizing-properties-100638155","NCT07603427","Development of Biofunctional 3D-Printed Orthodontic Aligners With Antimicrobial and Remineralizing Properties","Development of Biofunctional 3D Printed Orthodontic Aligners Enriched With Remineralizing and Anti-microbial Agents","3D-BIOALIGN","Inclusion Criteria:\n\n* Extracted human teeth obtained for reasons unrelated to this study (e.g., orthodontic or periodontal indications).\n* Teeth collected after obtaining ethical approval from the Research Ethics Committee.\n* Teeth free from visible cracks, fractures, restorations, or developmental defects.\n\nExclusion Criteria:\n\n* \\- Teeth with caries, restorations, cracks, fractures, or structural defects.\n* Teeth extracted due to pathological conditions affecting enamel or dentin integrity.\n* Teeth with unknown extraction history",{"count":321,"type":21},400,[24],"Clear orthodontic aligners are widely used due to their esthetics and patient comfort; however, prolonged wear may promote biofilm accumulation and enamel demineralization. This laboratory-based (in vitro) study aims to develop and evaluate a novel directly 3D-printed orthodontic aligner resin modified with antimicrobial and remineralizing agents.\n\nThe study will investigate the incorporation of dimethylaminohexadecyl methacrylate (DMAHDM) as an antibacterial agent and amorphous calcium phosphate (ACP) as a remineralizing component into a 3D-printed aligner resin. Modified and unmodified resin specimens will be fabricated and assessed for antimicrobial activity, ion release, and enamel remineralization potential using extracted human teeth.\n\nIn addition, the mechanical and physical properties of the experimental aligner materials, including shape memory behavior, deflection, tensile strength, translucency, and water sorption, will be evaluated to ensure clinical suitability.\n\nThis study does not involve human participants and is conducted entirely in vitro. The findings are expected to contribute to the development of biofunctional orthodontic aligners that actively inhibit bacterial growth and support enamel health without compromising material performance",[325,326,327,328],"Orthodontic Aligner Material","Enamel Demineralization","Dental Biofilm Formation","Clear Aligner Material Properties","2026-05-15",{"date":307,"type":38},{"date":260,"type":21},{"date":333,"type":21},"2027-02-01",{"name":44,"class":45},{"id":336,"slug":337,"hasResults":12,"nctId":338,"briefTitle":339,"officialTitle":340,"acronym":4,"eligibilityCriteria":341,"healthyVolunteers":12,"sex":16,"minAge":107,"maxAge":342,"enrollmentInfo":343,"targetDuration":4,"studyType":22,"phases":345,"briefSummary":346,"conditions":347,"keywords":352,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":367,"locationsCount":243},"100640437","effect-of-different-breathing-techniques-on-dyspnea-and-cardiopulmonary-parameters-among-patients-after-open-heart-surgery-100640437","NCT07591987","Effect of Different Breathing Techniques on Dyspnea and Cardiopulmonary Parameters Among Patients After Open Heart Surgery","Effect of Segmental Breathing Versus Active Cycle Breathing Techniques on Dyspnea and Cardiopulmonary Parameters Among Patients After Open Heart Surgery: Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age 18-75 years.\n* Scheduled for elective open-heart surgery.\n* Can understand instructions and perform Segmental breathing and Active cycle breathing techniques.\n* Stable preoperative hemodynamic condition.\n\nExclusion Criteria:\n\n* Emergency cardiac surgeries.\n* Patients with pre-existing severe pulmonary disease (e.g., COPD, asthma, restrictive lung disease, Atelectasis, and Tuberculosis).\n* Neurological disorders affecting breathing effort.\n* Patients with rib fractures, recent thoracic trauma, or contraindications for coughing maneuvers.\n* Inability to provide informed consent (cognitive impairment, language barrier).","75 Years",{"count":344,"type":21},99,[24],"Open heart surgery is often associated with postoperative pulmonary complications, reduced lung expansion, dyspnea, and impaired cardiopulmonary function. Breathing exercises are commonly used after surgery to improve lung ventilation, enhance oxygenation, and support respiratory recovery. However, limited evidence is available comparing the effectiveness of segmental breathing exercises and active cycle breathing technique (ACBT) in patients after open heart surgery.\n\nThis randomized controlled trial will compare the effects of segmental breathing exercises and ACBT on dyspnea and cardiopulmonary parameters in adults undergoing open heart surgery. Participants will be randomly assigned to either the segmental breathing exercise group, the ACBT group, or the standard care group during the postoperative period following extubation.\n\nCardiopulmonary parameters, including oxygen saturation, respiratory rate, heart rate, and blood pressure, as well as dyspnea severity and postoperative pulmonary complications, will be assessed before and after the interventions.\n\nThe findings of this study may help identify the most effective breathing exercise technique for improving respiratory outcomes, reducing postoperative pulmonary complications, and supporting evidence-based postoperative rehabilitation after cardiac surgery.",[348,349,350,351],"Dyspnea","Cardiopulmonary Dysfunction","Postoperative Respiratory Dysfunction","Coronary Artery Disease",[353,354,355,356,357,358,359,348,360],"Open Heart Surgery","Cardiac Surgery","Breathing Exercises","Segmental Breathing Exercises","Active Cycle Breathing Technique","Postoperative Patients","Adult Patients","Cardiopulmonary Parameters","2026-05-14",{"date":363,"type":38},"2026-05-18",{"date":365,"type":38},"2026-01-02",{"date":309,"type":21},{"name":44,"class":45},{"id":369,"slug":370,"hasResults":12,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":374,"eligibilityCriteria":375,"healthyVolunteers":106,"sex":297,"minAge":4,"maxAge":4,"enrollmentInfo":376,"targetDuration":4,"studyType":22,"phases":378,"briefSummary":379,"conditions":380,"keywords":382,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":384,"startDateStruct":385,"completionDateStruct":386,"leadSponsor":388,"locationsCount":4},"100639980","simulation-based-training-on-immediate-newborn-care-100639980","NCT07591974","Simulation-Based Training on Immediate Newborn Care","Effectiveness of Newborn Simulation-Based Training on Self Efficacy and Practices of Midwives in Immediate Newborn Care","SBT-Newborn","Inclusion Criteria:\n\n1. Active work in the delivery room or emergency wards\n2. Direct involvement in labor, delivery, or immediate neonatal care.\n3. Minimum of one year of experience in maternity care\n4. No advanced immediate newborn care training in the past year\n\nExclusion Criteria:\n\n1. Less than one year of maternity care experience\n2. Participation in advanced immediate newborn care courses within the past",{"count":377,"type":21},100,[24],"This study aims to evaluate the effectiveness of simulation-based training on improving self-efficacy and clinical practices of midwives in providing immediate newborn care. It is a quasi-experimental study conducted among midwives working in healthcare settings to assess the impact of training on their knowledge, confidence, and practical performance in newborn care immediately after delivery.",[381],"Newborn Care",[383],"Simulation- based training, midwives, immediate newborn care, self efficacy",{"date":363,"type":38},{"date":260,"type":21},{"date":387,"type":21},"2027-01-31",{"name":44,"class":45},{"id":390,"slug":391,"hasResults":12,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":395,"eligibilityCriteria":396,"healthyVolunteers":12,"sex":16,"minAge":107,"maxAge":397,"enrollmentInfo":398,"targetDuration":4,"studyType":22,"phases":400,"briefSummary":401,"conditions":402,"keywords":405,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":416,"leadSponsor":418,"locationsCount":71},"100628920","combined-mirror-therapy-and-soft-robotic-glove-for-hand-recovery-after-stroke-100628920","NCT07467915","Combined Mirror Therapy and Soft Robotic Glove for Hand Recovery After Stroke","Effect of Combining Mirror Therapy With Soft Robotic Glove on Hand Function Recovery in Post-Stroke Hemiplegic Patients: A Randomized Controlled Trial","MT-SRG","Inclusion Criteria:\n\nAdults aged 18-70 years with first-ever ischemic or hemorrhagic stroke confirmed by imaging (CT or MRI)\n\nModerate upper limb motor impairment (Fugl-Meyer Assessment Upper Extremity \\[FMA-UE\\] score 20-50)\n\nAbility to follow simple instructions (Six-Item Cognitive Impairment Test, 6CIT)\n\nAbility to sit independently for at least 30 minutes\n\nMedically stable and cleared to participate in rehabilitation interventions\n\nWillingness to provide informed consent and adhere to the study protocol\n\nExclusion Criteria:\n\nSevere upper limb spasticity (Modified Ashworth Scale ≥ 3)\n\nCognitive or psychiatric disorders interfering with participation\n\nOther neurological or musculoskeletal conditions affecting upper limb function (e.g., Parkinson's disease, multiple sclerosis, fractures)\n\nPrior exposure to intensive Mirror Therapy or Soft Robotic Gloves\n\nVisual impairment that cannot be corrected with glasses or contact lenses\n\nUncontrolled cardiovascular or other medical conditions that would prevent safe participation","70 Years",{"count":399,"type":21},104,[24],"Post-stroke hemiplegia frequently results in impaired upper limb function, which significantly affects independence and quality of life. Various rehabilitation approaches have been developed to improve motor recovery, including mirror therapy and robotic-assisted training. Mirror therapy uses visual feedback to stimulate neural plasticity and enhance motor recovery, while soft robotic gloves assist repetitive hand movements and facilitate functional training.\n\nThis randomized controlled trial aims to investigate the effect of combining mirror therapy with a soft robotic glove on hand function recovery in patients with post-stroke hemiplegia. Participants will be randomly assigned to different intervention groups receiving mirror therapy, soft robotic glove training, combined therapy, or conventional rehabilitation.\n\nThe primary outcome will assess improvement in upper limb motor function using validated clinical assessment tools. Secondary outcomes will evaluate functional hand performance and activities of daily living. The findings of this study may contribute to improving rehabilitation strategies for stroke survivors and provide evidence for integrating innovative rehabilitation technologies into clinical practice.",[277,403,404],"Hemiplegia","Upper Limb Motor Impairment",[406,407,408,409,410,411],"Mirror Therapy","Soft Robotic Glove","Stroke Rehabilitation","Hand Function Recovery","Upper Limb Rehabilitation","Post-Stroke Hemiplegia","2026-05-08",{"date":414,"type":38},"2026-05-13",{"date":94,"type":38},{"date":417,"type":21},"2026-12-17",{"name":44,"class":45},{"id":420,"slug":421,"hasResults":12,"nctId":422,"briefTitle":423,"officialTitle":424,"acronym":425,"eligibilityCriteria":426,"healthyVolunteers":12,"sex":16,"minAge":79,"maxAge":107,"enrollmentInfo":427,"targetDuration":4,"studyType":22,"phases":428,"briefSummary":429,"conditions":430,"keywords":433,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":448,"locationsCount":449},"100624107","effect-of-coughing-exercises-versus-incentive-spirometry-on-respiratory-function-and-recovery-in-children-after-cardiac-surgery-100624107","NCT07405333","Effect of Coughing Exercises Versus Incentive Spirometry on Respiratory Function and Recovery in Children After Cardiac Surgery.","Effect of Coughing Exercises Versus Incentive Spirometry on Respiratory Outcomes and Postoperative Recovery Among Children Undergoing Cardiac Surgery.","CEXIS","Inclusion Crit\n\n* Children aged 6 to 18 years scheduled for elective cardiac surgery.\n* Postoperative extubation within 24 hours and judged clinically stable to begin respiratory therapy.\n* Hemodynamically stable.\n\nExclusion Criteria:\n\n* Pre-existing moderate-to-severe chronic lung disease requiring baseline oxygen therapy.\n* Neuromuscular disorders significantly impairing cough\u002Finspiratory effort.\n* Emergency surgery, ongoing major bleeding.\n* Prolonged mechanical ventilation \\>72 hours or tracheostomy on admission.",{"count":344,"type":21},[24],"This study examines the effects of coughing exercises and incentive spirometry (IS) on lung function and recovery in children who undergo heart surgery. The main goals are to see:\n\nHow coughing exercises and IS affect breathing and lung function after surgery? How these exercises influence overall recovery after surgery? Children who participate will be randomly assigned to one of three groups: coughing exercises, IS, or standard care. Those in the exercise groups will perform their assigned breathing exercises every 3 hours for the first 3 days after surgery. Daily check-ups will be conducted to monitor their progress, lung function, and oxygen levels.\n\nThe study will measure breathing ability, oxygen levels, and recovery milestones to find out which method is most effective in preventing lung complications and helping children recover faster.",[431,350,432],"Congenital Heart Disease (CHD)","Postoperative Recovery After Cardiac Surgery",[434,435,436,437,438,439,440],"Coughing Exercises","Incentive Spirometry","Congenital Heart Disease","Respiratory Function","Recovery","cardiac surgery","pediatric","2026-05-07",{"date":443,"type":38},"2026-05-12",{"date":445,"type":38},"2025-12-07",{"date":447,"type":21},"2026-10-07",{"name":44,"class":45},4,{"id":451,"slug":452,"hasResults":12,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":4,"eligibilityCriteria":456,"healthyVolunteers":12,"sex":16,"minAge":219,"maxAge":4,"enrollmentInfo":457,"targetDuration":4,"studyType":22,"phases":459,"briefSummary":460,"conditions":461,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":466,"lastUpdatePostDateStruct":467,"startDateStruct":469,"completionDateStruct":471,"leadSponsor":473,"locationsCount":474},"100617438","comparative-outcomes-of-damon-ultima-vs-pitts-21-pro-bracket-systems-100617438","NCT07318623","Comparative Outcomes of Damon Ultima vs Pitts 21 Pro Bracket Systems","Comparative Evaluation of Treatment Outcomes Between Damon Ultima and Pitts 21 Pro Bracket Systems; A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Presence of full permanent dentition except the third molars.\n2. Class I with moderate crowding requiring fixed appliance therapy and don't need extraction.\n3. Good dental hygiene and periodontal health.\n4. Good general health; no systemic conditions affecting bone metabolism or pain perception.\n5. Normal crown size and shape.\n6. No prior orthodontic treatment.\n7. Patient has a normal level of vitamin D3 in testing (Vit D3 serum level should be \\>30).\n\nExclusion Criteria:\n\n* Severe skeletal discrepancies requiring orthognathic surgery, craniofacial anomalies). Patients with active periodontal disease or medically compromised patients.",{"count":458,"type":21},40,[24],"Title Comparative Evaluation of Treatment Outcomes between Damon Ultima and Pitts 21 Pro Bracket Systems; A Randomized Clinical Trial Abstract Background: The primary advantages of self-ligation brackets include faster archwire removal and ligation, reduced or eliminated need for chairside assistance, secure archwire engagement, and lower bracket-archwire friction, which collectively contribute to a substantial reduction in resistance to sliding and are theorized to enhance the efficiency of initial tooth alignment. This randomized controlled trial (RCT) will be conducted to assess differences in treatment outcomes with these two different self-ligation bracket systems.\n\nSubjects\u002FMaterials and Methods: This randomized clinical trial included 40 participants with full permanent dentition (excluding third molars) exhibiting Angle Class I malocclusion with moderate crowding. Patients who were scheduled to undergo orthodontic treatment were allocated into two groups: Damon Ultima and Pitts 21 Pro. The total treatment duration will be measured in months from the bonding day to the completion of treatment, in addition to the number of visits.\n\nPre-treatment, post-alignment, and post-treatment records were obtained, including intraoral scans (IOS) for assessing alignment efficiency and arch parameters. Periapical radiographs of the upper and lower incisors were taken before and after treatment to measure the amount of root resorption. Treatment outcomes were evaluated using the American Board of Orthodontics (ABO) grading system. Additionally, pain perception and patient treatment perception were assessed.",[462,463,464,465],"Orthodentic Appliances","Orthodontic Pathological Resorption of External Root","Orthodontic Pain","Orthodontic Brackets","2026-05-01",{"date":468,"type":38},"2026-05-04",{"date":470,"type":21},"2026-05-31",{"date":472,"type":21},"2028-03",{"name":44,"class":45},2,{"id":476,"slug":477,"hasResults":12,"nctId":478,"briefTitle":479,"officialTitle":480,"acronym":4,"eligibilityCriteria":481,"healthyVolunteers":106,"sex":16,"minAge":54,"maxAge":482,"enrollmentInfo":483,"targetDuration":4,"studyType":22,"phases":485,"briefSummary":486,"conditions":487,"keywords":489,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":466,"lastUpdatePostDateStruct":492,"startDateStruct":493,"completionDateStruct":494,"leadSponsor":495,"locationsCount":71},"100615378","a-novel-remineralizing-self-etch-primer-for-orthodontic-bracket-bonding-100615378","NCT07291830","A Novel Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding","Clinical Effectiveness of a Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Full permanent dentition including incisors, canines, premolars, and molars (excepting 3rd molars;\n* Teeth with sound, non-carious buccal enamel and no pretreatment with chemical agents such as hydrogen peroxide,\n* No previous orthodontic treatment with fixed appliances.\n\nExclusion Criteria:\n\n* Participants unable to give informed consent,\n* Had craniofacial anomalies,\n* Require orthognathic surgery as part of their treatment,\n* Had congenital enamel defects.","35 Years",{"count":484,"type":21},45,[24],"This randomized clinical trial aims to evaluate the clinical effectiveness of a remineralizing self-etch primer used for orthodontic bracket bonding. The study compares bonding performance, enamel surface effects, and clinical outcomes between the experimental primer and the conventional bonding protocol,verify the potential remineralization effect, and examine the amount of adhesive remnants left on enamel over a period of 6 months.",[488,326],"White Spot Lesions",[490,491],"Orthodontic Bracket Bonding","Self-Etch Primers",{"date":441,"type":38},{"date":329,"type":21},{"date":262,"type":21},{"name":44,"class":45},{"id":497,"slug":498,"hasResults":12,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":502,"eligibilityCriteria":503,"healthyVolunteers":106,"sex":16,"minAge":504,"maxAge":505,"enrollmentInfo":506,"targetDuration":4,"studyType":22,"phases":507,"briefSummary":508,"conditions":509,"keywords":512,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":518,"lastUpdatePostDateStruct":519,"startDateStruct":521,"completionDateStruct":523,"leadSponsor":524,"locationsCount":71},"100620787","clear-orthodontic-expander-versus-hyrax-100620787","NCT07362160","Clear Orthodontic Expander Versus Hyrax","Evaluating the Clinical Performance of a Novel Clear Orthodontic Expander Versus Hyrax: A Randomized Clinical Trial","COE-Hyarx","Inclusion Criteria:\n\n1. Patients' age at the start of treatment will range from 10-14 years.\n2. Unstable unilateral or bilateral posterior crossbite due to maxillary constriction.\n3. The first molars are fully erupted.\n4. Good oral health free from caries and periodontal problems at the start of treatment.\n5. Good general health.\n\nExclusion Criteria:\n\n1. Patients with obvious facial asymmetry.\n2. Patients with orofacial cleft.\n3. Patients with previous orthodontic treatment.\n4. Patients with bad oral habits.\n5. Patients with active periodontal disease.","10 Years","14 Years",{"count":458,"type":21},[24],"This study will be conducted to evaluate the effectiveness of a clear expander fabricated from 2-mm biocompatible polyethylene terephthalate glycol (PETG) thermoforming material integrated with an expansion screw in achieving dental and skeletal expansion in adolescent patients, compared with the conventional Hyrax expander.",[510,511],"Malocclusion","Narrow Maxilla",[513,514,515,516,517],"clear expander","hyrax","clinical trial","adolescent","thermoplastic material","2026-04-17",{"date":520,"type":38},"2026-04-22",{"date":522,"type":38},"2026-02-01",{"date":333,"type":21},{"name":44,"class":45},{"id":526,"slug":527,"hasResults":12,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":4,"eligibilityCriteria":531,"healthyVolunteers":106,"sex":16,"minAge":219,"maxAge":482,"enrollmentInfo":532,"targetDuration":4,"studyType":22,"phases":534,"briefSummary":535,"conditions":536,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":518,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":542,"locationsCount":71},"100615543","pain-control-during-braces-removal-using-transcutaneous-electrical-nerve-stimulation-and-high-frequency-vibration-100615543","NCT07293975","Pain Control During Braces Removal Using Transcutaneous Electrical Nerve Stimulation and High-Frequency Vibration","Assessment of Transcutaneous Electrical Nerve Stimulation and High-Frequency Vibration for Pain Control During Bracket Debonding: A Clinical Trial Study","Inclusion Criteria:\n\n1. Patients scheduled for fixed orthodontic appliance removal.\n2. Permanent dentition present, including both anterior and posterior teeth.\n3. Age between 15-35 years.\n4. Ability to provide informed consent and comply with study procedures.\n5. General health adequate for routine orthodontic care.\n6. No history of regular or recent medication intake within the preceding 24 hours, including painkillers, corticosteroids, or anti-flu drugs.\n\nExclusion Criteria:\n\n1. Patients with craniofacial anomalies, systemic conditions affecting pain perception, or taking medications influencing nociception.\n2. Teeth with extensive restorations or prostheses that prevent standard bracket debonding.\n3. Patients with known allergy or contraindication to TENS or vibration devices.\n4. Pregnant women.\n5. Active periodontal disease, including gingival recession or tooth mobility exceeding Grade I.\n6. Excessive gingival overgrowth that may impede debonding or influence study outcomes.",{"count":533,"type":21},90,[24],"This study aims to find the best method to reduce pain during braces removal. We are comparing transcutaneous electrical nerve stimulation (TENS), high-frequency vibration, and a control group with no additional intervention.\n\nPeople who have completed orthodontic treatment and need their braces removed can take part. Participants will be randomly assigned to one of the three groups. The vibration device will be applied during the braces removal, while TENS will be applied just before the procedure.\n\nBefore the procedure, participants' anxiety will be measured using the Modified Dental Anxiety Scale (MDAS). During and after the procedure, pain will be assessed using a Visual Analog Scale (VAS) from 0 to 100, and participants will rate their satisfaction using a Numerical Rating Scale (NRS) from 0 to 10.\n\nThe purpose of this research is to help orthodontists identify the method that makes braces removal less uncomfortable, more tolerable, and more satisfying for patients.",[464],{"date":538,"type":38},"2026-04-20",{"date":540,"type":38},"2026-01-01",{"date":67,"type":21},{"name":44,"class":45},{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":4,"eligibilityCriteria":549,"healthyVolunteers":12,"sex":16,"minAge":107,"maxAge":397,"enrollmentInfo":550,"targetDuration":4,"studyType":22,"phases":551,"briefSummary":552,"conditions":553,"keywords":555,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":561,"lastUpdatePostDateStruct":562,"startDateStruct":564,"completionDateStruct":566,"leadSponsor":568,"locationsCount":71},"100631199","effect-of-local-application-of-1-metformin-gel-on-implant-stability-and-peri-implant-bone-density-a-randomized-controlled-study-100631199","NCT07497568","Effect of Local Application of 1% Metformin Gel on Implant Stability and Peri-implant Bone Density: A Randomized Controlled Study","Effect of Local Application of 1% Metformin Gel on Implant Stability and Peri-implant Bone Density: A Randomized Controlled Clinical Study","Inclusion Criteria:\n\n* 1\\) Patients age at least 18 years old. 2) Patient with partial edentulous teeth bounded areas that need dental implant for teeth replacement.\n\n  3\\) Adequate bone volume for implant placement (at least 5 mm width - 10 mm height).\n\n  4\\) Ability to tolerate conventional surgical and restorative procedures. 5) Patients who are willing to comply the study and give their consent.\n\nExclusion Criteria:\n\n\\- 1) Active infection or inflammation in the implant zone. 2) Presence of any uncontrolled systemic diseases. 3) Patient with history of chemotherapy or radiotherapy. 4) Patient had undergone bone grafting and soft tissue procedures prior to implant surgery.\n\n5\\) Patient had undergone tooth extraction at the implant site less than 6 months prior to implant surgery.",{"count":222,"type":21},[24],"This randomized controlled clinical study aims to evaluate the effect of local application of 1% metformin gel on implant stability and peri-implant bone density. Patients requiring dental implants will be randomly allocated into two groups: a control group and a test group receiving metformin gel. Implant stability will be assessed using resonance frequency analysis, and bone density will be evaluated using CBCT imaging. The outcomes will be compared over a follow-up period to determine the effectiveness of metformin in enhancing osseointegration",[162,554],"Stability",[556,557,558,559,560],"dental implant","CBCT","Metformin","bone density","RFA","2026-03-23",{"date":563,"type":38},"2026-03-27",{"date":565,"type":38},"2025-11-01",{"date":567,"type":21},"2027-06-01",{"name":44,"class":45},{"id":570,"slug":571,"hasResults":12,"nctId":572,"briefTitle":573,"officialTitle":574,"acronym":4,"eligibilityCriteria":575,"healthyVolunteers":12,"sex":16,"minAge":107,"maxAge":576,"enrollmentInfo":577,"targetDuration":4,"studyType":22,"phases":579,"briefSummary":580,"conditions":581,"keywords":582,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":588,"lastUpdatePostDateStruct":589,"startDateStruct":591,"completionDateStruct":593,"leadSponsor":595,"locationsCount":71},"100618585","hard-tissue-augmentation-with-or-without-connective-tissue-graft-in-immediate-esthetic-implants-100618585","NCT07333534","Hard Tissue Augmentation With or Without Connective Tissue Graft in Immediate Esthetic Implants","Effectiveness of Hard Tissue Augmentation With or Without Connective Tissue Graft Following Immediate Dental Implants in the Esthetic Zone: A Randomized Controlled Study","Inclusion Criteria:\n\n* Patients with a non-restorable tooth or a remaining root without signs of acute infection in the maxillary esthetic zone.\n* The failing tooth is an incisor, canine or first bicuspid in the maxilla bounded by natural sound teeth.\n* Sufficient bone (\\>4 mm) apically and palatally to allow for proper implant positioning with sufficient primary stability (≥35 N cm).\n* Sufficient mesial-distal and interocclusal space for placement of the implant and definitive restoration.\n\nExclusion Criteria:\n\n* Patients with systemic conditions affecting bone healing (e.g., uncontrolled diabetes).\n* Teeth with current acute periapical infection.\n* Dehiscence of the labial (facial) bone plate after extraction.\n* Signs of uncontrolled periodontal disease.\n* Heavy smokers and vulnerable groups (pregnant females and decision-impaired individuals).\n* History of head and neck radiation therapy.","65 Years",{"count":578,"type":21},28,[24],"This randomized controlled study is aimed to evaluate the esthetic, clinical, and radiographic outcomes following the placement of immediate single-tooth implant with hard and soft tissue augmentation.\n\nSubjects will randomly assigned to one of two groups:\n\n* Group A (control group) receiving an immediate single-tooth implant in the esthetic zone with bone augmentation only.\n* Group B (study group) receiving an immediate single-tooth implant in the esthetic zone with bone augmentation and connective tissue graft (CTG).\n\nThe main questions it aims to answer is:\n\nIs there is a significant difference in the esthetic outcome between bone augmentation alone and bone augmentation combined with connective tissue graft after immediate dental implant in the esthetic zone?",[162],[583,584,585,586,587],"immediate implant","maxillary esthetic zone","CTG","jumping gap","bone augmentation","2026-03-12",{"date":590,"type":38},"2026-03-13",{"date":592,"type":38},"2025-12-20",{"date":594,"type":21},"2026-07-01",{"name":44,"class":45},{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":601,"acronym":602,"eligibilityCriteria":603,"healthyVolunteers":12,"sex":16,"minAge":604,"maxAge":605,"enrollmentInfo":606,"targetDuration":4,"studyType":22,"phases":608,"briefSummary":609,"conditions":610,"keywords":614,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":627,"startDateStruct":629,"completionDateStruct":630,"leadSponsor":632,"locationsCount":71},"100628319","premature-infant-oral-motor-intervention-vs-pacifier-for-oral-feeding-transition-in-preterm-infants-100628319","NCT07460089","Premature Infant Oral Motor Intervention vs. Pacifier for Oral Feeding Transition in Preterm Infants","The Effect of the Premature Infant Oral Motor Intervention Versus Pacifier Use in the Transition to Oral Feeding in Preterm Infants","PIOMI","Inclusion Criteria:\n\n1. \\- Preterm infants born at 26-32 weeks of gestational age\n2. \\- Clinically stable (no mechanical ventilation, no major congenital anomalies, no necrotizing enterocolitis)\n3. \\- Birth weight ≥1000 grams\n4. \\- Informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n1. Orofacial malformations (e.g., cleft lip, cleft palate)\n2. Neurological impairment affecting sucking ability (e.g., intraventricular hemorrhage grade III or IV, periventricular leukomalacia)\n3. Infants who received any prior structured oral motor intervention\n4. Major congenital anomalies or genetic syndromes affecting feeding or development\n5. Infants requiring surgical interventions during the study period\n6. Lack of parental consent","1 Day","28 Days",{"count":607,"type":21},150,[24],"This study compares three approaches to help premature babies learn to feed by mouth: a special mouth exercise program (called PIOMI), using a pacifier, and standard care. Premature babies often have difficulty feeding because their sucking, swallowing, and breathing are not yet coordinated, which can lead to longer hospital stays. The study will include 150 premature infants born between 26 and 32 weeks of pregnancy at a hospital in Thi Qar. Babies will be randomly placed into one of three groups: one group will receive a many-day mouth exercise program, another will use a pacifier for many days, and the third will receive routine care. We will measure how quickly each baby learns to feed fully by mouth, how long they stay in the hospital, how much weight they gain, and their feeding skills. The results may help improve care for premature babies and reduce the time they spend in the hospital.",[611,612,613],"Feeding Difficulties","Sucking Behavior","Premature",[615,616,617,611,612,602,618,619,620,621,622,623,624,625],"Premature Infant","Preterm Infant","Oral Feeding","Pacifier Use","Non-nutritive Sucking","Oral Motor Intervention","Neonatal Intensive Care","NICU","Feeding Transition","Weight Gain","Length of Hospital Stay","2026-03-06",{"date":628,"type":38},"2026-03-10",{"date":628,"type":21},{"date":631,"type":21},"2026-05-30",{"name":44,"class":45},{"id":634,"slug":635,"hasResults":12,"nctId":636,"briefTitle":637,"officialTitle":638,"acronym":4,"eligibilityCriteria":639,"healthyVolunteers":12,"sex":16,"minAge":107,"maxAge":4,"enrollmentInfo":640,"targetDuration":4,"studyType":22,"phases":641,"briefSummary":643,"conditions":644,"keywords":646,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":648,"startDateStruct":650,"completionDateStruct":652,"leadSponsor":654,"locationsCount":71},"100628241","phase-4-radiographical-histomorphometrical-and-biomarker-analysis-after-maxillary-sinus-augmentation-utilizing-xenograft-particulate-bone-graft-mixed-with-parathyroid-hormone-100628241","NCT07459075","Radiographical, Histomorphometrical and Biomarker Analysis After Maxillary Sinus Augmentation Utilizing Xenograft Particulate Bone Graft Mixed With Parathyroid Hormone","Radiographical, Histomorphometrical and Biomarker Analysis After Maxillary Sinus Augmentation Utilizing Xenograft Particulate Bone Graft Mixed With Parathyroid Hormone: A Randomized Controlled Study","Inclusion criteria\n\n* Healthy individuals without any systemic disease\u002Flocal pathological lesion at the sinus zone that compromise the bone healing potential.\n* Fair to good oral hygiene.\n* Patient's age ≥ 18 years.\n* The RBH was 3 mm or less. Atrophic edentulous posterior maxillary ridge (missing tooth or teeth in the sinus zone), with adequate ridge width (≥ 5 mm) to accommodate an average DI diameter and to gain primary implant stability.\n* Healed planned implant insertion site.\n\nExclusion criteria\n\n* Medically compromised patients with any of the following conditions that could interfere with normal healing potential or osseointegration such as uncontrolled diabetes mellitus, currently on chemotherapy, corticosteroid or bisphosphonate, radiotherapy of the head and neck in the past 2 years, bleeding disorders, ongoing pregnancy, thyroid hormones problems and psychiatric disorders.\n* The RBH ˃ 3 mm.\n* Thickness of the SM ˃ 5 mm.\n* Maxillary sinusitis (acute and chronic) or any other pathologies in the MS.\n* Previous MS surgery.\n* Heavy smoking ˃ 20 cigarettes daily and\u002For alcohol abuse.\n* Parafunctional habits such as severe bruxism and clenching.",{"count":136,"type":21},[642],"PHASE4","This study aimed the to investigate the beneficial effect of combining PTH with bovine-derived bone graft bone in maxillary sinus augmentation.\n\nThere is limited information available about the effect of PTH on maxillary sinus augmentation to achieve a clear understanding of PTH's efficacy in bone regeneration and bone remodelling through radiological, clinical, biomarker, histological and histomorphometric assessment .\n\nObjectives\n\n1. Evaluation of the bone density at the planned implants sites using cone beam computed tomography (CBCT).\n2. Histomorphometry examination of maxillary sinus bone to measure (bone trabeculae, connective tissue, osteoblast, osteocyte) after healing 4 months after augmentation.\n3. Osteopontin as biomarker analysis for bone regeneration and osteoblast activity.\n4. Evaluate the primary stability of implant in upper posterior area filled with PTH (1 34) and bovine-derived bone graft compared to bovine-derived bone graft alone.",[645],"Maxillary Sinus Augmentation",[647],"bone regeneration; bone grafts; orthopaedics; dental implant, PTH.",{"date":649,"type":38},"2026-03-09",{"date":651,"type":38},"2025-05-01",{"date":653,"type":21},"2026-11",{"name":44,"class":45},{"id":656,"slug":657,"hasResults":12,"nctId":658,"briefTitle":659,"officialTitle":660,"acronym":4,"eligibilityCriteria":661,"healthyVolunteers":12,"sex":16,"minAge":107,"maxAge":4,"enrollmentInfo":662,"targetDuration":4,"studyType":22,"phases":663,"briefSummary":664,"conditions":665,"keywords":667,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":672,"startDateStruct":673,"completionDateStruct":675,"leadSponsor":677,"locationsCount":71},"100628239","phase-4-effect-of-ibuprofen-on-acute-inflammatory-response-after-one-stage-periodontal-therapy-100628239","NCT07459049","\"Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy\"","Efficacy Of Ibuprofen In Reducing Acute Inflammatory Response Following One Stage Non- Surgical Periodontal Therapy (A Randomized Clinical Trial )","Inclusion Criteria:\n\n1. systemically healthy patients.\n2. having a minimum of 20 teeth.\n3. Generalized unstable periodontitis.\n4. Pocket depth \\[≥ 4 mm\\].\n5. All included participants should be adults aged more than 18 years .\n6. smokers and non smokers\n\nExclusion Criteria:\n\n1. Allergy or hypersensitivity to Ibuprofen or other NSAIDs.\n2. current systemic anti-inflammatory or antibiotic therapy (\\\u003C3 months).\n3. peptic ulcer disease.\n4. recent periodontal therapy (\\\u003C3 months).\n5. Asthma.\n6. Renal impairment .\n7. Hepatic impairment.\n8. Severe cardiac disease (heart failure, hypertension (.\n9. Bleeding disorders (e.g., hemophilia) or patients taking anticoagulants .\n10. Any participant who had known or suspected high risk for tuberculosis, hepatitis B or HIV infections.\n11. pregnant or lactating females.\n12. those being unable to provide written informed consent.",{"count":136,"type":21},[642],"The goal of this ( Clinical Trial ) is to evaluate the efficacy of Ibuprofen in reducing acute inflammatory response (hs-CRP, ProCT, IL-6) after one hour and one week following one stage non surgical periodontal therapy.\n\nThe main question it aims to answer is:\n\n\"Does Ibuprofen effectively reduce the acute inflammatory response ( hs-CRP, ProCT, IL-6) following one-stage non-surgical periodontal therapy?\"",[666],"Periodontitis",[668,669,670,671],"Ibuprofen","Acute inflammatory response","One stage periodontal therapy","Non-surgical periodontal therapy",{"date":649,"type":38},{"date":674,"type":38},"2025-12-01",{"date":676,"type":21},"2026-08",{"name":44,"class":45},""]