[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of California, Santa Barbara\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":90},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,62],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":37,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":4},"100657335","thrive-at-home-a-virtual-reality-social-intervention-for-older-adults-100657335",false,"NCT07835568","Thrive at Home: A Virtual Reality Social Intervention for Older Adults","Improving Mental Health and Social Connectivity for Older Adults Through Virtual Reality-Based Social Interventions","Thrive at Home","Inclusion Criteria:\n\nPRIMARY PARTICIPANTS (OLDER ADULTS):\n\n* Aged 65 years or older.\n* Living in a private residence and receiving home care services from a participating provider, with services expected to continue for the duration of the study (approximately 4 months).\n* Montreal Cognitive Assessment (MoCA) score of 12 or above.\n* Fluent in English, sufficient to participate in group virtual reality (VR) sessions and complete verbal surveys.\n* Adequate vision and hearing to complete surveys and engage with VR experiences (mild impairments acceptable if corrected).\n* Has a family caregiver or home care professional available to support them at every VR session if the MoCA score is below 18 or the participant cannot physically manipulate the headset independently.\n\nFAMILY CAREGIVERS (OPTIONAL SUBSTUDY):\n\n* Aged 18 years or older.\n* Identifies as the primary family caregiver for an enrolled primary participant (living with or visiting the primary participant at least twice per week).\n* Fluent in English and able to complete online surveys on a personal digital device (e.g., smartphone, laptop, tablet, or computer).\n\nExclusion Criteria:\n\nPRIMARY PARTICIPANTS (OLDER ADULTS):\n\n* History of severe motion sickness or vertigo.\n* History of seizures or epilepsy.\n* Frequent and distressing hallucinations.\n* Aphasia or other communication barriers preventing verbal participation.\n* Severe disorientation or delirium.\n* Frequent and severe outbursts or emotional dyscontrol, or frequent and severe aggressive tendencies. (Typical sundowning is not exclusionary.)\n* Total vision loss not overcome by VR, or uncorrected hearing impairment that makes group conversation impracticable.\n* Residence in a senior living community or other congregate housing.\n* Presence of a harmful, aggressive, or abusive relationship with a family caregiver living in the home.\n\nFAMILY CAREGIVERS (OPTIONAL SUBSTUDY):\n\n* Presence of an aggressive or abusive relationship with the enrolled primary participant.",true,"ALL","65 Years",{"count":21,"type":22},250,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to evaluate whether a virtual reality (VR) based social platform can improve mental health and social connection for older adults who receive in-home care. Specifically, the study aims to determine if the VR program reduces loneliness, depressive symptoms, and boredom while increasing social connection and well-being among older adult participants. It also explores whether access to the VR program reduces caregiver burden and depressive symptoms for family caregivers.\n\nResearchers will compare an immediate-start group to a waitlist control group to assess whether the VR program improves outcomes compared to standard home care alone. Both groups will eventually receive the intervention. Older adult participants will use a VR headset at home to join group activities three times a week. These sessions include social activities with local peers and live-hosted group activities. A family caregiver or home care professional may be present during sessions if needed for support.\n\nOver a 12-week study period, older adult participants will complete three surveys assessing their mood, social connection, and well-being. Family caregivers of participating older adults are also invited to join an optional caregiver substudy. Caregivers who enroll in the substudy will not participate in the VR activities themselves, but will complete three surveys at the same time points over the 12 weeks to share their own well-being and caregiving experiences.",[28,29,30,31,32,33,34,35,36],"Mental Health (Depression)","Mental Health and General Well-being","Loneliness","Well Being","Caregiver Burden","Caregiver Wellbeing","Mild Cognitive Impairment(MCI)","Alzheimer Dementia (AD)","Dementia",[38,39,40,41,30,42,43,44,45,46,47,48,49],"Randomized controlled trial","Virtual reality (VR)","Older adults","Cognitive functioning","Mental health","Thriving","Social connection","Depression","Quality of life","Family caregivers","Caregiver burden","Respite care","NOT_YET_RECRUITING","2026-09-22",{"date":53,"type":54},"2026-09-25","ACTUAL",{"date":56,"type":22},"2026-10",{"date":58,"type":22},"2028-05",{"name":60,"class":61},"University of California, Santa Barbara","OTHER",{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":17,"sex":18,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":23,"phases":73,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},"100537328","lpfc-organization-in-emotion-duration-difference-estimation-100537328","NCT06276400","LPFC Organization in Emotion-Duration Difference Estimation","Lateral Prefrontal Organization in Emotion: Representational and Causal Mechanism - Duration Difference Estimation","Inclusion Criteria:\n\n* right-handed\n* between the ages of 18 and 45\n* be a fluent English speaker\n* have normal to corrected-to-normal vision.\n\nExclusion Criteria:\n\n* if they report a current or prior diagnosis of a psychiatric disorder requiring hospitalization and\u002For are currently using psychiatric medication; o If they report a history of or current neurological disease (i.e., stroke, concussion, epilepsy, major head trauma, complicated migraine);\n* If they ever had a seizure;\n* If they have a family history of epilepsy or seizure disorders;\n* If they have a history of fainting;\n* If they are sleep deprived (TMS only);\n* If they have a history of prior surgery with metal clips, implants, devices, prosthetics, cardiac or neural implants (e.g., pacemaker; neurostimulator), or cochlear implants;\n* If they are unable to safely and comfortably complete an MRI: have metal in the body, recent surgery, presence of surgically implanted devices not cleared for MRI, extreme claustrophobia, if they report tattoos of the head or neck region, non-removable metal piercing anywhere on the body\n* Women will be asked to self-report their pregnancy status and have the option to take a pregnancy test if they wish. If there is a chance a participant is pregnant, they will not be scanned.\n* As part of the newly adopted UCSB BIC prescreening procedure, participants will be asked about their history of hearing issues (including loss, hyperacuity, sensitivity to loud noises, history of tinnitus (ringing in ears), job with high noise exposure, and chronic migraines. Participants will be excluded if one or more hearing issues are reported.","18 Years","45 Years",{"count":72,"type":22},50,[25],"To support optimal behavior in daily life, goals and responses following emotional events should ideally incorporate not only the valence and intensity of prior emotional episodes but also their temporal features, such as the relative duration of positive vs. negative attributes. However, how specific brain regions contribute to the integration of temporal and emotional information and promote goal-directed response remains unknown.\n\nThe goal of this study is to examine how specific brain regions track both emotional and temporal information of dynamic emotional events to inform other related brain regions to guide goal-oriented and context-appropriate actions. The investigators will scan healthy human participants using functional MRI (fMRI) while they view emotional image sequences and track the associated emotional and temporal (duration) information, and act accordingly. The investigators will employ multivariate patterns analysis and pattern similarity analysis to identify brain regions that represent (can decode) emotion, time, and their combined signals, as well as brain regions that represent the associated action goal. In addition, to infer the causal contributions of these brain regions in forming task-relevant representations (emotion, time, and action goal), the same participants will be recruited to receive transcranial magnetic stimulation (TMS) in these regions.",[76],"Healthy",[78,79],"Emotion-time information integration in healthy participants","Neural representation of emotional events and goal action","RECRUITING","2026-04-28",{"date":83,"type":54},"2026-05-04",{"date":85,"type":54},"2024-01-29",{"date":87,"type":22},"2028-03-31",{"name":60,"class":61},1,""]