[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Fribourg\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":170},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,55,85,113,141],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100652287","hyperventilation-effects-on-bodily-self-consciousness-100652287",false,"NCT07769710","Hyperventilation Effects on Bodily Self-Consciousness","HYPERSELF","Inclusion Criteria:\n\n* Healthy adult aged 18-55 years\n* Able to provide written informed consent\n* Normal or corrected-to-normal vision\n* Sufficient German or English to follow instructions and complete questionnaires\n* Tolerates the \\~5-minute VR-guided hyperventilation test at screening\n\nExclusion Criteria:\n\n* Cardiovascular or cerebrovascular disease posing a risk during hyperventilation (e.g., myocardial infarction or stroke within 12 months, significant\u002Funstable cardiac disease, heart failure, uncontrolled\u002Fsevere hypertension, aneurysm, Moyamoya)\n* Respiratory disease (asthma, COPD, restrictive lung disease, pulmonary fibrosis, recent severe lung infection, dyspnoea at rest)\n* Haematological disease (sickle cell disease or trait, severe anaemia)\n* Neurological disease (epilepsy or seizures, severe\u002Frecurrent migraine, neurodegenerative disorder)\n* Psychiatric disorder (panic or severe anxiety disorder, psychosis or schizophrenia, severe bipolar disorder, acute major depression, acute addiction)\n* Metabolic disease (Type 1 or poorly controlled Type 2 diabetes, BMI \\> 35)\n* Pregnancy (confirmed by urine test at screening) or planned pregnancy during the study period\n* Medication affecting respiration or brain function\n* Physical inability to cooperate or to remain seated for the \\~188-minute experimental visit\n* Insufficient understanding of study procedures and risks\n* Intolerable reaction to the hyperventilation tolerance test at screening",true,"ALL","18 Years","55 Years",{"count":21,"type":22},35,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study examines how voluntary fast, deep breathing (hyperventilation) affects the way healthy adults perceive their own body. Participants wear a virtual-reality (VR) headset and see a virtual body; a glowing halo around it either pulses exactly in time with their own breathing or is time-shifted. During the study, breathing, heart activity, blood-oxygen level, the carbon-dioxide content of exhaled air, and brain activity (EEG, measured non-invasively from the scalp) are recorded continuously, and participants complete questionnaires about their experience.\n\nThe aim is to understand whether and how altered breathing changes the interplay between what people see and what they feel inside their body, and thereby the sense of being located within one's own body. The study uses a 2×2 within-subjects design crossing Breathing (normal vs. hyperventilation) with Visual synchrony (synchronous vs. asynchronous), with the asynchronous and normal-breathing conditions serving as within-subject controls.\n\nNo medication is administered and no medical device is being tested; the instruments used serve only for monitoring and measurement. Participation involves a screening visit (including a short, \\~5-minute guided-hyperventilation tolerance test) and an experimental visit.",[28,29,30],"Bodily Self-Consciousness","Interoception","Healthy Volunteers",[32,33,34,35,36,37,38,39,40,41],"hyperventilation","bodily self-consciousness","full-body illusion","respiratory-visual synchrony","interoception","virtual reality","EEG","heartbeat-evoked potential","altered states of consciousness","breathwork","NOT_YET_RECRUITING","2026-08-12",{"date":45,"type":46},"2026-08-18","ACTUAL",{"date":48,"type":22},"2026-09-01",{"date":50,"type":22},"2027-07-31",{"name":52,"class":53},"University of Fribourg","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":54},"100647604","investigating-the-neurophysiology-of-the-motor-system-and-the-feasibility-of-vagus-nerve-stimulation-in-functional-neurological-disorder-fnd-100647604","NCT07710677","Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND)","Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND): a Randomized, Sham-controlled Study","TMS-VNS","Inclusion Criteria for FND patients:\n\n* Over 18 years of age.\n* Capable of judgement.\n* Willing to participate in the study (by signing the informed consent form).\n* FND diagnosis by a certified neurologist or psychiatrist.\n* Motor FND symptoms in the upper limb in the form of tremor or weakness.\n* Participating in physiotherapy for FND.\n\nExclusion Criteria for FND patients:\n\n* Severe neuropsychiatric comorbidities.\n* Pregnancy or breastfeeding.\n* Prior knowledge on the effects of attention on the motor system.\n* Prior history of epilepsy or epileptic seizures in the person and their family.\n* Severe claustrophobia.\n* Implanted medical devices.\n* Ear anatomy incompatible with the taVNS device (e.g. cauliflower ear).\n* Previous use of taVNS.\n* Substance abuse.\n* Simultaneous participation in another investigation involving an investigational drug or a MD.\n* Enrolment of the PI and their dependent persons.\n\nInclusion Criteria for healthy volunteers:\n\n* Over 18 years of age.\n* Capable of judgement.\n* Willing to participate in the study (by signing the informed consent form).\n\nExclusion Criteria for healthy volunteers:\n\n* Neurological or neuropsychiatric or movement disorders.\n* Pregnancy or breastfeeding.\n* Prior knowledge on the effects of attention on the motor system.\n* Prior history of epilepsy or epileptic seizures in the person and their family.\n* Substance abuse.\n* Simultaneous participation in another investigation involving an investigational drug or a MD.\n* Enrolment of the PI and their dependent persons.",{"count":64,"type":22},68,[25],"This clinical study will test if adding a non-invasive stimulation of the vagus nerve through the ear during physiotherapy brings an improvement to FND (Functional Neurological Disorder) patients with motor symptoms.\n\nFirst, the investigators will test the normal functioning of the motor regions of the brain in FND patients and in healthy volunteers for comparison, using a painless method called TMS (Transcranial Magnetic Stimulation). Then, the investigators will further test how brain regions communicate with each other in FND patients, using fMRI (functional Magnetic Resonance Imaging, also painless). Additionally, the investigators will ask both FND patients and healthy volunteers to answer questions about their health and wellbeing, and will assess the exact symptoms of FND patients. The FND patients will then be assigned to two groups randomly, and neither they nor the researchers will know in which group they are. Both groups will do 5 sessions of their usual physiotherapy - one group with a real stimulation of the vagus nerve, and the other group with a fake stimulation. This is important to obtain reliable results. At the end, both groups of patients will be tested again to see if the way brain regions communicate with each other has changed. They will also answer again questions about their health and wellbeing, and their symptoms will be assessed again, to see if any changes happen. The results of the two groups of patients will be compared to isolate the effects of vagus nerve stimulation from the effects of physiotherapy alone.",[68,69],"Functional Neurological Disorder","Motor Symptoms",[68,71,72,73,74,75,76],"FND","vagus nerve stimulation","VNS","TMS","fMRI","motor","2026-07-16",{"date":79,"type":46},"2026-07-17",{"date":81,"type":22},"2026-07-01",{"date":83,"type":22},"2028-12-01",{"name":52,"class":53},{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":92,"targetDuration":94,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},"100647364","the-comet-study-a-prospective-cohort-of-medical-residents-to-assess-professional-personal-and-psychological-trajectories-of-residents-in-general-internal-medicine-100647364","NCT07707453","The COMET Study: a Prospective COhort of MEdical residenTs to Assess Professional, Personal and Psychological Trajectories of Residents in General Internal Medicine","COMET","Inclusion Criteria:\n\nResident physician in general internal medicine employed at a participating study site or annex centre during the recruitment period Written informed consent\n\nExclusion Criteria:\n\nNot providing direct patient care Severe mental or physical condition precluding informed consent or compliance with the protocol",{"count":93,"type":22},800,"5 Years","OBSERVATIONAL","Introduction.\n\nSwitzerland, like most Western countries, faces a paradox: an ageing, multimorbid population needs general internal medicine (GIM) physicians more than ever, yet fewer young doctors choose - and stay in - the specialty. Career decisions during residency are intertwined with well-being, mental and physical health, and work-life balance, and distress in training has been associated with depression, burnout, attrition and poorer patient care. Longitudinal data following GIM residents across these domains, and linking them to actual career trajectories, are lacking. The COMET study establishes a multicentre prospective cohort of GIM residents to fill this gap.\n\nMethods and analysis.\n\nCOMET is a prospective, open, multicentre cohort conducted in the departments of (general) internal medicine of Fribourg Hospital (HFR, four sites), Bern University Hospital (Inselspital) and Lausanne University Hospital (CHUV). All GIM residents providing direct patient care are eligible (≈334 residents; expected enrolment ≥267, assuming 80% participation). Participants complete an annual online survey (REDCap; French or German) at baseline and for at least four years, covering sociodemographics; job characteristics; career intentions and 24 factors for or against a GIM career; well-being (Physician Well-Being Index, Professional Fulfillment Index, quality of life, work-life balance); mental health (CES-D, Perceived Stress Scale, Maslach Burnout Inventory, Questionnaire of Cognitive and Affective Empathy); and physical health (step counts, physical activity, fatigue, sleep, healthcare utilisation). Primary endpoints are the longitudinal course of well-being and distress (PWBI, PFI, CES-D) and residents' career trajectory. Analyses combine descriptive statistics, mixed-effects and regression models, and comparisons with the population-based CoLaus\\|PsyCoLaus cohort.",[98,99,100,101,102,103],"Burnout Syndrome","Depression Disorder","Insomnia","Perceived Stress","Fatigue Symptom","Empathy","RECRUITING","2026-07-15",{"date":77,"type":46},{"date":108,"type":46},"2025-08-01",{"date":110,"type":22},"2031-12-31",{"name":52,"class":53},3,{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":23,"phases":124,"briefSummary":125,"conditions":126,"keywords":128,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":54},"100601662","influence-of-tea-extract-on-maximal-voluntary-knee-contraction-following-downhill-jogging-100601662","NCT07113405","Influence of Tea Extract on Maximal Voluntary Knee Contraction Following Downhill Jogging","The Influence of Tea Extract on Maximal Voluntary Knee Contraction After 30 Minutes of Downhill Jogging: a Randomized, Double-blind, Placebo-controlled Study","ITMVC-DJ","Inclusion Criteria:\n\n* Signed written informed consent\n* Aged between 18-40 years\n* Healthy subjects\n\nExclusion Criteria:\n\n* Any type of food allergy (e.g. nuts)\n* Health-related problems according to the \"Physical Activity Readiness Questionnaire (PAR-Q)\n* Current injury of the lower extremities\n* Serious clinical back pain or current back injuries\n* Orthopedic disorders\n* Cardiovascular diseases\n* Current Intake of blood-thinning medication\n* Current Intake of anti-inflammatory medication","40 Years",{"count":123,"type":22},60,[25],"In this research project, we want to investigate whether the combined intake of proteins and tea extract has an influence on muscle regeneration compared to the sole intake of proteins or a placebo product. In the study, you will be randomly assigned to one of 3 groups. Neither the research group nor you will know which group you are assigned to. The study lasts 5 days for you as a participant. During these 5 days you will have to attend a total of 5 appointments in our laboratory. The groups differ only in the intake of the regeneration product, otherwise all measurements and appointments are identical. You will jog downhill for 30 minutes on the first day in order to strain your muscles. In order to be able to draw conclusions about the regeneration of your muscles, we will carry out the following measurements on all 5 days: Blood sampling at the fingertip, ultrasound of the thigh muscle, pain tolerance of the thigh muscle, strength tests of the thigh muscle, muscle function of the thigh muscle and jumping performance.",[127],"Muscle Recovery",[129,130,131,132],"Protein","muscle recovery","Tea extract","EIMD","2026-05-01",{"date":135,"type":46},"2026-05-04",{"date":137,"type":46},"2025-12-01",{"date":139,"type":22},"2026-12-30",{"name":52,"class":53},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":149,"minAge":18,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":152,"briefSummary":153,"conditions":154,"keywords":159,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":54},"100589790","confocal-histolog-scanner-in-routine-breast-conserving-surgery-chib-100589790","NCT06958991","Confocal Histolog Scanner in Routine Breast-Conserving Surgery (CHiB)","Confocal Histolog Scanner in Routine Breast-Conserving Surgery","CHiB","Inclusion Criteria:\n\n* Adult female Subject ≥18 years old.\n* Subject scheduled for breast conserving surgery of invasive and\u002For in-situ ductal and lobular carcinoma.\n* Subject is able to read, understand and sign the informed consent.\n\nExclusion Criteria:\n\n* Subject with planned mastectomy\n* Subject does not speak French- Subject with planned tumor-adapted breast reduction\n* Subject is pregnant\u002F lactating. Subjects pregnant\u002Flactating are excluded because such subjects are presenting additional risks during the surgery and they are also rare.\n* Participation in any other clinical study that would affect data acquisition.","FEMALE",{"count":151,"type":22},100,[25],"The clinical performance study is collecting data from the use of a CE mark product used within the scope of its intended purpose to intraoperatively visualize tissue specimen. The subjects are not submitted to invasive and burdensome procedures compared to the standard of care surgical practices and regular use of the CE mark product.",[155,156,157,158],"Breast Cancer Invasive","Breast Cancer Surgery","Lumpectomy","Confocal Laser Endomicroscopy",[160,161],"breast cancer surgery","confocal microscopy","2025-11-22",{"date":164,"type":46},"2025-11-25",{"date":166,"type":46},"2025-06-01",{"date":168,"type":22},"2026-09-30",{"name":52,"class":53},""]