[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Groningen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":77},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100647903","replication-meaning-centered-intervention-for-internalizing-symptoms-100647903",false,"NCT07714954","Replication: Meaning-centered Intervention for Internalizing Symptoms","Testing the Efficacy of a Meaning-centered Intervention for Individuals Who Tend to Feel Down or Anxious: a Replication","Inclusion Criteria:\n\n* heightened internalizing symptoms (depression and\u002For anxiety symptoms) as indicated by PHQ-4 score of 2 or above on either the anxiety or depression subscale\n\nExclusion Criteria:\n\n* receiving psychotherapeutic treatment for a depressive or anxiety disorder\n* suicidality","ALL","18 Years",{"count":19,"type":20},140,"ESTIMATED","INTERVENTIONAL",[23],"NA","Young adults who experience depression and\u002For anxiety symptoms (i.e., internalizing symptoms) will be randomly allocated to a six-session meaning-centered intervention condition or a waitlist condition. Both conditions receive the same questionnaires at baseline, post assessment (intervention condition: immediately after the final session; waitlist: four weeks after baseline), and follow-up.\n\nThe researchers hypothesize that a meaning-centered intervention for individuals with internalizing symptoms will increase participants' meaning in life and reduce their internalizing symptoms at post assessment and 4-week follow-up when compared to a waitlist condition.",[26],"Depression and\u002For Anxiety Symptoms",[28,29,30,31,32],"meaning in life","meaning-centered intervention","internalizing symptoms","depression symptoms","anxiety symptoms","NOT_YET_RECRUITING","2026-08-11",{"date":36,"type":37},"2026-08-14","ACTUAL",{"date":39,"type":20},"2026-10",{"date":41,"type":20},"2028-02",{"name":43,"class":44},"University of Groningen","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100537574","pt-stress-study-predicting-treatment-success-and-dealing-with-non-response-in-the-treatment-of-ptsd-100537574","NCT06279598","PT-STRESS Study: Predicting Treatment Success and Dealing With Non-response in the Treatment of PTSD","PT-STRESS Study: A Two-phase RCT Aimed at Predicting Treatment Success and Dealing With Non-response in the Treatment of PTSD; by Alternating Between Two Trauma-focused Treatments (EMDR\u002FPE) or by Switching to Interpersonal Therapy (IPT)","PT-STRESS","Inclusion Criteria:\n\n* Adults between the ages of 18 and 65 who were classified with a primary diagnosis of PTSD (based on the DSM-5 criteria).\n* Adults who are willing to participate in the study (informed consent)\n\nExclusion Criteria:\n\n* Insufficient proficiency in the Dutch language.\n* Patients who cannot follow the treatment protocol (for example due to prolonged absence) are excluded from the study.\n* Patients who use medication that is not stable. If properly set to the last prescribed medication by the doctor there will be advised to continue and referably not change the medication and its dose during treatment, unless necessary in connection with side effects, crisis, etc.\n* Patients that already received an evidence-based form of trauma-oriented treatment for PTSD in the past year and for sufficient treatment duration, in accordance to the Dutch professional practice guidelines (reference: Akwa GGZ (2020, December 1). GGZ Standaarden. Psychotrauma- en stressorgerelateerde stoornissen. Retrieved September 29, 2022, from https:\u002F\u002Fwww.ggzstandaarden.nl\u002Fzorgstandaarden\u002Fpsychotrauma-en-stressorgerelateerde-stoornissen\u002Fintroductie).\n* Patients with serious suicidality that requires acute intervention and structural addition of additional treatment interventions.\n* Patients with an intellectual disability.\n* Patients with a serious addiction as a comorbid problem.\n* Patients with an acute mania or a psychotic state.","65 Years",{"count":55,"type":20},442,[23],"The aim of this study is to increase understanding of the effectiveness and efficiency of psychological treatment for adult patients with posttraumatic stress disorder -PTSD- and to make it more personalized.\n\nKey questions:\n\n1. Which predictors of treatment success influence treatment outcome of patients with PTSD who receive the three psychotherapeutic treatments investigated in this study?\n2. Which specific moderators can be identified with regard to the different psychotherapies (Eye Movement Desensitization and Reprocessing -EMDR-; Prolonged Exposure -PE-; and Interpersonal Psychotherapy -IPT- in the second phase)?\n3. In patients with PTSD, does offering another proven effective form of trauma-focused psychotherapy (PE after EMDR, or EMDR after PE) improve symptoms following insufficient response to a first trauma-focused treatment?\n4. Is switching from a trauma-focused therapy to a non-trauma-focused treatment (IPT) a more effective strategy for dealing with non-response to a first proven effective psychotherapeutic treatment compared to switching to another trauma-focused therapy?\n5. Are there differences in treatment tolerance and differences in dropout rates between PE, EMDR and IPT?\n\nSecondary goals:\n\n* Investigating the extent to which therapist allegiance to a specific therapy method affects outcomes;\n* Investigating whether the quality of therapy implementation or the treatment integrity ('adherence\u002F competence') affects treatment outcomes;\n* Investigating how much the quality of the therapeutic alliance influences outcomes.\n\nParticipants receive treatment and will complete questionnaires. The study is conducted in two phases. Its aim is to compare two different trauma-focused treatments (EMDR and PE) for patients with PTSD to one another and with a nontrauma-focused psychotherapy (IPT) and to investigate possible predictors and moderators for treatment success. Patients will first be randomized to PE or EMDR in the first treatment phase. After this first phase, non-responders are re-randomized for a second phase of treatment. They receive either the alternative phase 1 trauma-focused psychotherapy or IPT as non-trauma-focused therapy. In phase 1 researchers will compare the PE and EMDR group to see which treatment is most effective for whom. In phase 2 researchers will compare the trauma-focused treatments (PE and EMDR group) with the nontrauma-focused treatment (IPT group) to see which treatment is most effective for whom.",[59],"Stress Disorders, Post-Traumatic",[61,62,63,64,65,66],"Psychotherapy","Trauma","Prolonged Exposure","Eye Movement Desensitization Reprocessing","Interpersonal Psychotherapy","Trauma-focused Cognitive Behavioral Therapy","RECRUITING","2024-02-25",{"date":70,"type":37},"2024-02-28",{"date":72,"type":37},"2024-01-01",{"date":74,"type":20},"2032-08-31",{"name":43,"class":44},1,""]