[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of La Laguna\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":91},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100651488","oxidative-stress-and-cardiovascular-risk-in-patients-with-rheumatoid-arthritis-100651488",false,"NCT07760662","Oxidative Stress and Cardiovascular Risk in Patients With Rheumatoid Arthritis","Oxidative Stress and Cardiovascular Comorbidity in Patients With Rheumatoid Arthritis","PIFIISC23\u002F07","Inclusion Criteria:\n\n* Men or women who are not pregnant or breastfeeding.\n* Age 18 years or older and younger than 70 years.\n* Treatment with any disease-modifying antirheumatic drug, including biologic therapies.\n* For patients receiving oral corticosteroids, a prednisone dose of 10 mg or less that has remained stable for at least one month before study inclusion.\n* Ability and willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Autoimmune rheumatic disease other than RA, including systemic lupus erythematosus, mixed connective tissue disease, systemic sclerosis, or polymyositis. Sjögren syndrome associated with RA will not be an exclusion criterion.\n* Functional class IV RA with complete or substantial disability, including confinement to bed or wheelchair that prevents personal self-care.\n* History or current presence of inflammatory joint disease other than RA, such as gout, reactive arthritis, psoriatic arthritis, seronegative spondyloarthropathy, or Lyme disease.\n* Estimated glomerular filtration rate below 60 mL\u002Fmin\u002F1.73 m² or active renal disease.\n* Pregnancy or breastfeeding.\n* Evidence of severe uncontrolled concomitant cardiovascular, neurological, pulmonary (including obstructive lung disease), renal, hepatic, endocrine (including diabetes mellitus), or gastrointestinal disease, or any condition considered by the investigator likely to alter the lipid profile.\n* Body weight greater than 150 kg.\n* History of alcoholism, drug abuse, or substance misuse within six months before the screening visit.\n* Statin use will not be an exclusion criterion.","ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","OBSERVATIONAL","The pathogenic process underlying atherosclerosis resembles a chronic inflammatory response in which oxidative stress is involved. Similarly, oxidative stress is widely recognized to play an important role in the clinical course and pathogenesis of rheumatoid arthritis (RA). RA has been associated with accelerated atherosclerosis.\n\nThis cross-sectional study will include patients with RA. The primary objective is to evaluate the association between selected oxidative stress biomarkers-serum malondialdehyde levels, superoxide dismutase, and glutathione peroxidase-and the presence of subclinical atherosclerosis and carotid arterial stiffness in patients with RA. We will subsequently assess whether these molecules are related to cardiovascular disease determinants, including inflammatory dyslipidemia, insulin resistance, and beta-cell dysfunction, which may occur in this condition. This study will further explore the relationship between oxidative stress and cardiovascular disease in RA.",[25,26,27],"Rheumatoid Arthritis (RA","Oxidative Stress","Cardiovascular (CV) Risk",[29,30],"Rheumatoid arthritis","Oxidative stress","RECRUITING","2026-08-07",{"date":34,"type":35},"2026-08-12","ACTUAL",{"date":37,"type":35},"2024-01-01",{"date":39,"type":21},"2026-12",{"name":41,"class":42},"University of La Laguna","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100622922","a-convolutional-neural-network-for-difficult-biliary-cannulation-100622922","NCT07389915","A Convolutional Neural Network for Difficult Biliary Cannulation","Design and Validation of a Convolutional Neural Network to Predict Difficult Biliary Canulation: a Multicenter Study.","PRECABIDO2","Inclusion Criteria:\n\n* Age \\>18 years\n* Signed informed consent\n* Patients indicated for ERCP\n\nExclusion Criteria:\n\n* INR \\> 1.5\n* Platelets \\\u003C 50,000\u002Fmm³\n* Patients with a prior endoscopic sphincterotomy\n* Papilla of Vater not accessible via duodenoscope (gastric or duodenal stenosis due to neoplasm) or gastric surgery (Billroth II, Roux-en-Y)\n* Known pancreas divisum\n* Indication due to pancreatic duct pathology",{"count":53,"type":21},600,"The main purpose of the study is to train a convolutional neural network (CNN) to predict difficult biliary canulation (DBC) following the European Society of Gastrointestinal Endoscopy Society (ESGE). Consecutive patients undergoing an endoscopic retrograde cholangiopancreatography (ERCP) will be included in the study. Several pictures of the second portion of the duodenum including the ampulla will be taken, along with several pictures of the radiological image. Pictures prospectively collected from the study PRECABIDO (NCT06591364), a multicenter study whith the purpose of evaluating the prevalence of difficult biliary cannulation and predictive factors for difficult cannulation and cannulation failure using ESGE criteria were also used for the training of the CNN.\n\nWe will also assess:\n\nA validation of the CNN assessing the agreement between ESGE criteria and the CNN prediction.\n\nTo design a novel application based on the use of a convolutional neural network (CNN) to detect difficult biliary cannulation.\n\n.",[56],"Difficult Biliary Cannulation",[58,59,60,61],"ERCP","Difficult biliary cannulation","Convolutional neural network","CNN","NOT_YET_RECRUITING","2026-01-28",{"date":65,"type":35},"2026-02-05",{"date":67,"type":21},"2026-02-01",{"date":69,"type":21},"2027-03-31",{"name":41,"class":42},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":79,"conditions":80,"keywords":81,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":4},"100561530","prevalence-and-predictive-factors-of-difficult-biliary-cannulation-100561530","NCT06591364","Prevalence and Predictive Factors of Difficult Biliary Cannulation","Prevalence and Predictive Factors of Difficult Biliary Cannulation: a Multicenter Study","PRECABIDO",{"count":53,"type":21},"The main purpose of the study is to evaluate the prevalence of difficult biliary cannulation using endoscopic retrograde cholangiopancreatography (ERCP) according to the criteria defined by the European Society of Gastrointestinal Endoscopy (ESGE) and the American Society for Gastrointestinal Endoscopy (ASGE), as well as the predictive factors for this event in a prospective, multicenter study. Consecutive patients undergoing ERCP will be included in the study\n\nWe will also assess:\n\nEvaluate the failure of biliary cannulation in our setting. Evaluate predictive factors for difficult cannulation and cannulation failure using ESGE criteria.\n\nDesign an \"a priori\" predictive model for difficult cannulation and cannulation failure.\n\nCost study: record of materials used.",[56],[58,82,59],"Endoscopic retrograde cholangiopancreatography","2024-09-07",{"date":85,"type":35},"2024-09-19",{"date":87,"type":21},"2024-09-20",{"date":89,"type":21},"2025-10-30",{"name":41,"class":42},""]