[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Medicine and Pharmacy at Ho Chi Minh City\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":671},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,40,0,25,[9,53,80,105,131,158,178,202,228,260,282,311,341,366,387,415,436,453,486,509,536,560,591,613,642],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100652720","enamel-matrix-derivative-and-xenograft-for-mandibular-molar-furcation-defects-100652720",false,"NCT07776756","Enamel Matrix Derivative and Xenograft for Mandibular Molar Furcation Defects","Efficacy of Enamel Matrix Derivative Combined With Xenograft in the Treatment of Furcation Defects in Mandibular Molars","Inclusion Criteria:\n\n* Age 18 years or older.\n* Full-mouth plaque score (FMPS) ≤ 20%.\n* Full-mouth bleeding score (FMBS) ≤ 20%.\n* Willingness to participate in the study and provide informed consent.\n* Mandibular first and\u002For second molar with a buccal Class II furcation defect classified as subgroup A2 or B2.\n* Probing pocket depth (PPD) ≥ 5 mm at the eligible furcation site.\n* Keratinized gingival height ≥ 2 mm at the eligible site.\n* No gingival recession extending apically beyond the buccal furcation roof; the furcation entrance must not be clinically exposed above the gingival margin.\n\nExclusion Criteria:\n\n* Systemic diseases or conditions that may affect periodontal treatment outcomes, including uncontrolled diabetes mellitus, heart disease requiring anticoagulant therapy, hematologic disorders, or immunodeficiency.\n* Pregnancy or breastfeeding.\n* Untreated endodontic pathology involving the study tooth.\n* Class III furcation involvement according to the Hamp classification.\n* Untreated occlusal trauma involving the study tooth.\n* Grade II tooth mobility that has not been stabilized by splinting, or Grade III tooth mobility according to the Miller classification.\n* Defective restorations at the surgical site, including overhanging, bulky, or poorly adapted restorations.","ALL","18 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled clinical trial aims to compare two regenerative surgical approaches for the treatment of mandibular molar Class II furcation defects in patients with periodontitis. Eligible furcation defects will be randomly assigned to receive either xenograft bone combined with enamel matrix derivative (EMD) or xenograft bone combined with a collagen membrane. Both approaches are used to support periodontal tissue regeneration.\n\nParticipants will be followed for approximately 7 months. The study will evaluate postoperative pain and patient-reported satisfaction, periodontal clinical parameters, changes in furcation defect volume and relative bone density on cone-beam computed tomography (CBCT), and changes in gingival crevicular fluid TWEAK levels. Clinical and radiographic outcomes will be assessed before surgery and during follow-up, including at 3 and 6 months after surgery.\n\nThe study is intended to determine whether xenograft bone combined with EMD provides clinical, radiographic, biological, and patient-reported outcomes comparable or superior to xenograft bone combined with a collagen membrane in the regenerative treatment of mandibular molar Class II furcation defects.",[27],"Class II Furcation Defect",[29,30,31,32,33,34,35,36,37,38,39],"Periodontal Regeneration","Enamel Matrix Derivative","Xenograft","Emdogain","Collagen Membrane","Class II Furcation","Mandibular Molar","Cerabone","Bio-Gide","TWEAK","TNF-like weak inducer of apoptosis (TWEAK)","RECRUITING","2026-08-17",{"date":43,"type":44},"2026-08-20","ACTUAL",{"date":46,"type":44},"2026-06-29",{"date":48,"type":21},"2027-09-30",{"name":50,"class":51},"University of Medicine and Pharmacy at Ho Chi Minh City","OTHER",1,{"id":54,"slug":55,"hasResults":12,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":52},"100652214","morphological-characteristics-of-mandibular-molar-furcation-involvement-and-efficacy-of-regenerative-surgical-treatment-100652214","NCT07770256","Morphological Characteristics of Mandibular Molar Furcation Involvement and Efficacy of Regenerative Surgical Treatment","Morphological Characteristics of Furcation Involvement in Mandibular Molars and Efficacy of Regenerative Surgical Treatment: A Cross-Sectional and Interventional Trial","Inclusion Criteria:\n\n* Patients aged 18 years or older who signed the informed consent form.\n* Diagnosed with Stage III or Stage IV periodontitis according to the 2017 AAP\u002FEFP classification.\n* Completed non-surgical periodontal therapy with full-mouth plaque score (FMPS) and bleeding on probing (FMBS) \\\u003C= 20%.\n* Presence of at least one mandibular molar with Hamp Class II furcation involvement (horizontal bone loss \\> 3 mm without through-and-through communication).\n* Target tooth requirements:\n\n  * Probing pocket depth (PPD) \\>= 5 mm.\n  * Clinical attachment loss (CAL) \\>= 3 mm.\n  * Tooth mobility \\\u003C= Grade I (Miller index).\n  * Vital pulp or adequately filled root canal treatment without periapical radiolucency.\n  * Gingival margin positioned coronal to the furcation entrance.\n  * Intact tooth structure without root fractures or furcation caries.\n\nExclusion Criteria:\n\n* Uncontrolled systemic diseases (e.g., uncontrolled diabetes, hypertension, cardiovascular disease, severe osteoporosis).\n* Pregnant or lactating women.\n* Current smokers or individuals who quit smoking less than 6 months prior to enrollment.\n* Use of antibiotics, anti-inflammatory agents, or medications affecting bone metabolism (e.g., bisphosphonates, high-dose corticosteroids, anti-resorptive drugs) within the past 3 months.\n* Previous periodontal surgery at the evaluation site within the past 6 months.\n* Target teeth presenting with:\n\n  * Miller Grade II or Grade III tooth mobility.\n  * Severe bone destruction extending to the root apex.\n  * Metallic restorations (metal crowns, amalgam fillings, or large metallic posts) causing significant scatter\u002Fartifacts on CBCT scans.\n  * Fused roots or abnormal root anatomy.",{"count":61,"type":21},98,[24],"This study consists of two components evaluating furcation involvement in mandibular molars among Stage III or Stage IV periodontitis patients. Component 1 is a cross-sectional study evaluating the prevalence and morphological characteristics of Hamp Class II furcation defects during initial screening. Component 2 is a randomized controlled clinical trial in 30 selected patients comparing the diagnostic accuracy of Cone Beam Computed Tomography (CBCT) against direct intra-operative clinical measurements, as well as evaluating the clinical and radiographic outcomes of regenerative periodontal surgery using Acellular Dermal Matrix (ADM) + Enamel Matrix Derivative (EMD) + Xenograft versus Autogenous Connective Tissue Graft (CTG) + EMD + Xenograft.",[65,66,67],"Periodontitis","Periodontitis (Stage 3)","Furcation Defects",[29,69,30,70,71],"Connective Tissue Graft","Acellular Dermal Matrix","Cone-Beam Computed Tomography","2026-08-14",{"date":74,"type":44},"2026-08-18",{"date":76,"type":44},"2026-05-02",{"date":78,"type":21},"2028-05",{"name":50,"class":51},{"id":81,"slug":82,"hasResults":12,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":52},"100651706","efficacy-of-prf-and-xenograft-in-treating-mandibular-molar-furcation-involvements-100651706","NCT07764029","Efficacy of PRF and Xenograft in Treating Mandibular Molar Furcation Involvements","Efficacy of Platelet-Rich Fibrin Combined With Xenograft in the Treatment of Mandibular Molar Furcation Involvements","Inclusion Criteria:\n\n* Patients over 18 years old\n* Patients diagnosed with periodontitis who have completed non-surgical treatment: scaling and root planing\n* Patients attending a follow-up visit at least 5 weeks after non-surgical treatment, demonstrating compliance and good oral hygiene cooperation\n* Presence of a mandibular molar with a Degree II furcation involvement according to Hamp (1975), presenting a residual periodontal pocket at the buccal site (PPD ≥ 5mm) after non-surgical treatment, and showing radiolucency in the furcation area on CBCT imaging\n* Plaque Index (PlI) \\\u003C 1 following non-surgical treatment\n* Width of keratinized gingiva ≥ 2mm\n* Teeth with furcation defects where gingival recession does not extend apically beyond the buccal furcation fornix (no supragingival furcation exposure)\n* Teeth without occlusal trauma, pulpal or periapical pathologies, and no combined periodontic-endodontic lesions\n* Degree II furcation involvement according to Hamp (1975) and Subclass A or B according to Tarnow and Fletcher (1984)\n* The defect is located apical to the interproximal alveolar bone crest on CBCT imaging\n\nExclusion Criteria:\n\n* Patients with systemic diseases affecting periodontal treatment outcomes, such as: diabetes mellitus, heart disease requiring anticoagulant therapy, blood disorders, immunodeficiency, etc\n* Pregnant or lactating patients\n* Patients who have used antibiotics or any other medications affecting periodontal treatment outcomes within the last 6 months\n* Patients who smoke tobacco.\n* Patients who have used aspirin or medications affecting blood coagulation within 2 weeks prior to the blood collection for PRF preparation\n* Patients with a history of allergy to local anesthetics\n* Defects associated with grade II tooth mobility that has not been splinted, or grade III tooth mobility according to Miller (2014)",{"count":88,"type":21},22,[24],"The purpose of this randomized controlled clinical trial is to compare the effectiveness of advanced platelet-rich fibrin (A-PRF+) combined with xenograft versus a collagen membrane combined with xenograft in the treatment of degree II furcation involvements in mandibular first molars. Adult patients with periodontitis will randomly receive either the A-PRF+ treatment or the collagen membrane treatment during periodontal flap surgery. The study will evaluate clinical periodontal healing, bone regeneration using 3D imaging (CBCT), patient comfort (pain levels and satisfaction), and changes in the TWEAK biomarker in gingival crevicular fluid over a 6-month period.",[65,67],[93,94,31,35,95,38,96,97],"A-PRF plus","A-PRF+","Guided Tissue Regeneration","biomarker","collagen membrane","2026-08-12",{"date":72,"type":44},{"date":101,"type":44},"2026-06-25",{"date":103,"type":21},"2027-06-30",{"name":50,"class":51},{"id":106,"slug":107,"hasResults":12,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":4},"100651563","home-use-dual-light-antibacterial-photodynamic-therapy-for-peri-implant-mucositis-in-full-arch-implant-prostheses-100651563","NCT07763431","Home-Use Dual-Light Antibacterial Photodynamic Therapy for Peri-Implant Mucositis in Full-Arch Implant Prostheses","Efficacy of Home-Use Dual-Light Antimicrobial Photodynamic Therapy as an Adjunct to Supportive Peri-Implant Care in Patients With Peri-Implant Mucositis Around Screw-Retained Full-Arch Implant-Supported Prostheses: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older who agree to participate and provide written informed consent.\n* Rehabilitated with a screw-retained full-arch implant-supported fixed prosthesis (All-on-4, All-on-6 or All-on-X) delivered at least 3 months before enrolment.\n* Diagnosed with peri-implant mucositis according to the 2017 World Workshop case definitions.\n* HbA1c below 7.0% and stable systemic health.\n* Non-smoker for at least the preceding 6 months.\n* Willing to attend all scheduled follow-up visits at 2 and 4 weeks and to comply with the home-use protocol.\n\nExclusion Criteria:\n\n* Disability or severe motor impairment limiting the ability to perform the oral hygiene procedures required by the study.\n* Long-term antibiotic therapy.\n* Immunodeficiency.\n* Long-term corticosteroid therapy.\n* History of organ transplantation.\n* Refusal to participate.",{"count":20,"type":21},[24],"The goal of this clinical trial is to learn whether a home-use light device helps control gum inflammation around dental implants in adults who have a full set of fixed teeth attached to implants. This gum inflammation, called peri-implant mucositis, is common and reversible, but can lead to more serious problems if it is not controlled. The device is meant to be added to the usual professional cleaning and hygiene care, not to replace it.\n\nThe main questions it aims to answer are:\n\n* Does adding the home-use light device reduce gum bleeding around the implants more than the usual care alone?\n* Does it reduce the depth of the space around the implants and the amount of harmful bacteria?\n\nResearchers will compare adults who receive the usual professional care plus the home-use light device with adults who receive the usual professional care alone, to see if the device improves gum health.\n\nParticipants will:\n\n* Receive professional cleaning and personalized instructions on how to keep their implant teeth clean at the start of the study.\n* Be placed by chance into one of two groups: usual care plus the home-use light device, or usual care alone.\n* Use the light device at home each day for 4 weeks (if in the device group)\n* Visit the clinic at the start, after 2 weeks, and after 4 weeks for gum checkups and to have bacteria samples taken.",[116,117,118,119,120,121],"Peri Implant Mucositis","Dental Implant Rehabilitation","Prosthesis and Implant Dentistry","Implant Supported Prosthesis","Photodynamic Therapy (PDT)","Antimicrobial Photodynamic Therapy","NOT_YET_RECRUITING","2026-08-10",{"date":125,"type":44},"2026-08-13",{"date":127,"type":21},"2026-09-10",{"date":129,"type":21},"2027-07-10",{"name":50,"class":51},{"id":132,"slug":133,"hasResults":12,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":146,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":157},"100634907","electroacupuncture-and-cupping-for-shoulder-tendinitis-100634907","NCT07545785","Electroacupuncture and Cupping for Shoulder Tendinitis","Effectiveness of Electroacupuncture Combined With Cupping Therapy in Patients With Shoulder Tendinitis and qi Stagnation and Blood Stasis Syndrome","Inclusion Criteria:\n\n* Patients between 18 and 70 years old.\n* Pain intensity score on the Visual Analogue Scale (VAS) between 4 and 7.\n* Diagnosis of rotator cuff and\u002For long head of the biceps tendonitis according to the guidelines issued by the Ministry of Health of Vietnam.\n* Mechanical pain that increases during movements such as abduction or raising the arm.\n* Presence of tender points at the long head of the biceps tendon or supraspinatus tendon .\n* Pain that increases during resisted contraction tests, such as the Jobe test or Palm-up test.\n* Absence of limitation in the passive range of motion of the shoulder.\n* Ultrasound findings showing a hypoechoic tendon or evidence of calcification.\n* Absence of motor weakness or paralysis.\n* Diagnosis of the TCM syndrome \"Qi Stagnation and Blood Stasis\"\n\nExclusion Criteria:\n\n* Patients who do not agree to participate in the study.\n* Diagnosis of pseudo-paralysis, acute calcific periarthritis, or frozen shoulder.\n* Shoulder pain caused by cervical nerve root lesions.\n* Shoulder pain originating from apical lung tumors, coronary artery disease, or myocardial infarction.\n* Specific joint lesions caused by infection, tuberculosis, or rheumatoid arthritis.\n* Bone pathologies including fractures, dislocations, or osteonecrosis of the humeral head.\n* Shoulder dysfunction resulting from stroke or hemiplegia.\n* Women who are pregnant.\n* Patients with mental illness.\n* Contraindications for vacuum cupping, such as acute skin inflammation, open wounds, or alcohol consumption.\n* Contraindications for electroacupuncture, including cardiac pacemakers, heart failure, or local skin ulcers.\n* Current participation in another intervention study.\n* Use of painkillers, muscle relaxants, or within the last week.\n* Use of anticoagulants or a history of hemophilia.","70 Years",{"count":140,"type":21},54,[24],"This study aims to evaluate the effectiveness of electroacupuncture combined with vacuum cupping therapy in treating simple periarthritis of the shoulder associated with the traditional medicine syndrome of Qi stagnation and blood stasis. Shoulder periarthritis is a common condition that causes pain, stiffness, and limited movement of the shoulder due to injury or inflammation of the muscles, tendons, ligaments, and surrounding soft tissues. It can interfere with daily activities such as dressing, lifting objects, sleeping, and working.\n\nElectroacupuncture is commonly used to relieve shoulder pain and improve shoulder function. Vacuum cupping therapy is another non-drug treatment that may help improve blood circulation, reduce muscle tightness, decrease pain, and improve mobility. However, there is currently limited evidence about whether combining electroacupuncture with vacuum cupping provides better results than electroacupuncture alone in patients with shoulder periarthritis and Qi stagnation-blood stasis syndrome. This study is being conducted to determine whether the combined treatment is more effective and safe.\n\nA total of 54 participants with simple shoulder periarthritis and Qi stagnation-blood stasis syndrome will be enrolled in the study. Participants will be randomly assigned to one of two groups:\n\nGroup 1: treatment with electroacupuncture alone. Group 2: treatment with electroacupuncture combined with vacuum cupping therapy.\n\nAll participants will also receive advice on shoulder exercises, posture, and daily activities to support recovery. Treatments will be performed by licensed traditional medicine practitioners.\n\nEach participant will take part in the study for two weeks. Assessments will be performed before treatment, after one week, and after two weeks. The study will evaluate:\n\nPain intensity using the Visual Analogue Scale (VAS). Shoulder pain and disability using the Shoulder Pain and Disability Index (SPADI).\n\nShoulder range of motion using the McGill-McRomi Range of Motion Index. Any side effects or unwanted events related to treatment. Possible benefits of participating in this study include reduced shoulder pain, improved movement and daily function, and close monitoring by health care professionals. Participants may also benefit from receiving non-drug therapies at no cost during the study period. The findings of this research may help improve future treatment options for patients with shoulder pain.\n\nPossible risks of electroacupuncture include mild pain at the needle site, minor bleeding, bruising, dizziness, or fainting. Possible risks of vacuum cupping include temporary discomfort, skin redness, bruising, or mild pain in the treated area. These side effects are usually mild and temporary. If any unexpected problem occurs, participants will receive prompt medical attention.\n\nParticipation in this study is completely voluntary. Participants may refuse to join or may withdraw from the study at any time without affecting their usual medical care. All personal information collected during the study will remain confidential and will only be used for research purposes.",[144,145],"Shoulder Tendinopathy","Shoulder Tendinitis",[147,148,149,145],"shoulder tendinopathy","Rotator cuff tendinitis","Long head of the biceps tendonitis","2026-08-05",{"date":123,"type":44},{"date":153,"type":44},"2026-03-01",{"date":155,"type":21},"2026-11-15",{"name":50,"class":51},2,{"id":159,"slug":160,"hasResults":12,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":22,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":52},"100650447","metronidazole--versus-tinidazole-based-bismuth-quadruple-therapy-for-helicobacter-pylori-eradication-100650447","NCT07746934","Metronidazole- Versus Tinidazole-Based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication","Comparison of Metronidazole- and Tinidazole-Based Bismuth Quadruple Regimens for Helicobacter Pylori Eradication","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Confirmed Helicobacter pylori infection\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* Gastrointestinal malignancy.\n* Previous H. pylori eradication therapy.\n* Liver cirrhosis.\n* Stage IV or V chronic kidney disease.\n* Previous gastric surgery.\n* Known allergy to any study medication.\n* Use of antibiotics within the previous 4 weeks.",{"count":166,"type":21},600,[24],"This randomized, open-label clinical trial will compare two bismuth-containing quadruple therapies for the first-line treatment of Helicobacter pylori infection. Adults aged 18 years or older with confirmed H. pylori infection who have not previously received eradication treatment will be randomly assigned in a 1:1 ratio to receive either a metronidazole-based regimen or a tinidazole-based regimen for 14 days. Both regimens will also include esomeprazole, tetracycline, and bismuth subcitrate.\n\nThe main purpose of the study is to determine whether the tinidazole-based regimen is not inferior to the metronidazole-based regimen in achieving successful H. pylori eradication. Eradication will be assessed after treatment using a carbon-13 urea breath test or an endoscopic urease test. The study will also compare adverse effects and treatment tolerability between the two groups. The results may help clinicians select the more appropriate nitroimidazole for bismuth quadruple therapy in routine clinical practice.",[170],"Helicobacter Pylori Infection","2026-07-30",{"date":150,"type":44},{"date":174,"type":21},"2026-07-27",{"date":176,"type":21},"2027-12-27",{"name":50,"class":51},{"id":179,"slug":180,"hasResults":12,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":12,"sex":17,"minAge":185,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":22,"phases":188,"briefSummary":189,"conditions":190,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":52},"100647732","high-frequency-electroacupuncture-at-cervical-huatuo-jiaji-points-combined-with-electromagnetic-field-therapy-for-cervical-spondylotic-radiculopathy-100647732","NCT07712354","High-Frequency Electroacupuncture at Cervical Huatuo Jiaji Points Combined With Electromagnetic Field Therapy for Cervical Spondylotic Radiculopathy","Efficacy of High-Frequency Electroacupuncture at Cervical Huatuo Jiaji Points Combined With Electromagnetic Field Therapy in the Treatment of Cervical Spondylotic Radiculopathy Due to Cervical Spondylosis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Written informed consent to participate in the study.\n* Male or female patients aged 30 years or older.\n* Inpatients or outpatients diagnosed with cervical spondylotic radiculopathy caused by cervical spondylosis at Ho Chi Minh City Hospital of Traditional Medicine.\n* Clinical diagnosis of cervical spondylotic radiculopathy, including:\n* Neck pain radiating to the shoulder and\u002For upper extremity.\n* Sensory disturbance and\u002For motor deficit and\u002For abnormal deep tendon reflexes consistent with the affected cervical nerve root.\n* At least one positive provocative test (Spurling test, cervical percussion\u002Fcompression test, cervical distraction test, or shoulder abduction relief test).\n* Pain intensity of at least 3 on the Visual Analog Scale (VAS).\n* Clinical evidence of cervical spine syndrome.\n* Cervical spine X-ray demonstrating at least one degenerative finding (osteophytes, intervertebral disc space narrowing, or subchondral sclerosis).\n\nExclusion Criteria:\n\n* Cervical radiculopathy caused by conditions other than cervical spondylosis.\n* Cervical myelopathy or other spinal cord disorders requiring surgical intervention.\n* Severe systemic illness, frailty, or medical conditions requiring intensive care, or suspected malignancy indicated by unexplained fever, unexplained weight loss, immunodeficiency, or cancer.\n* Contraindications to acupuncture, including skin infection or ulceration at the acupuncture site, allergy to acupuncture needles, severe needle phobia, or psychiatric disorders preventing cooperation.\n* Current treatment with strong analgesics (including paracetamol\u002Fcodeine combinations, tramadol, or strong opioids) or other therapies that may interfere with study outcomes.\n* Implanted cardiac pacemakers or other implanted electronic medical devices (e.g., neurostimulators, implantable cardioverter-defibrillators, or insulin pumps).\n* Bleeding disorders or hematologic diseases affecting coagulation.\n* Benign or malignant tumors involving the treatment area or systemic malignancy.\n* Participation in another interventional clinical trial.\n* Inability to communicate effectively in Vietnamese.\n* Pregnant women or women with suspected pregnancy.","30 Years",{"count":187,"type":21},104,[24],"Cervical spondylotic radiculopathy (CSR) is one of the most common manifestations of cervical spondylosis and is characterized by neck pain radiating to the upper extremities, sensory disturbances, restricted cervical range of motion, and functional disability. Conservative treatment is recommended as the first-line management for most patients, and electroacupuncture is widely used in Traditional Medicine to relieve pain and improve function.\n\nCervical Huatuo Jiaji (EX-B2) acupuncture points are anatomically located adjacent to the cervical spinal nerve roots and may provide more targeted therapeutic effects than conventional meridian acupuncture points. Pulsed electromagnetic field (PEMF) therapy has also been used as an adjunctive physical modality to reduce pain and facilitate functional recovery.\n\nThis randomized controlled trial aims to evaluate whether high-frequency electroacupuncture at cervical Huatuo Jiaji (EX-B2) points combined with PEMF therapy provides greater improvement in pain intensity, cervical function, and safety outcomes than conventional high-frequency electroacupuncture combined with PEMF therapy in patients with cervical spondylotic radiculopathy caused by cervical spondylosis.\n\nThe primary outcome is pain intensity measured using the Visual Analog Scale (VAS). Secondary outcomes include cervical range of motion, Neck Disability Index (NDI), and treatment-related adverse events. Clinical outcomes will be assessed at baseline, after one week of treatment, and at the end of the two-week treatment period.",[191,192,193],"Cervical Spondylosis","Neck Pain","Cervical Spondylotic Radiculopathy","2026-07-29",{"date":196,"type":44},"2026-07-31",{"date":198,"type":44},"2026-06-02",{"date":200,"type":21},"2026-09",{"name":50,"class":51},{"id":203,"slug":204,"hasResults":12,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":12,"sex":17,"minAge":209,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":22,"phases":212,"briefSummary":213,"conditions":214,"keywords":219,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":52},"100649323","accuracy-and-healing-outcomes-of-endodontic-surgery-using-a-static-surgical-guide-100649323","NCT07734987","Accuracy and Healing Outcomes of Endodontic Surgery Using a Static Surgical Guide.","Evaluation of the Accuracy and Healing Outcomes of Endodontic Surgery Using a Static Surgical Guide: A Prospective Longitudinal Cohort Clinical Trial.","Inclusion Criteria:\n\n1. Patient is aged 16 years or older.\n2. Patient possesses a healthy or stable systemic physical status classification (ASA I or II).\n3. Presence of at least one permanent tooth displaying a distinct clinical indication for apical endodontic surgery.\n4. The estimated post-resection crown-to-root ratio of the target tooth remains \\\u003C= 1.\n5. The periapical radiolucency features a well-defined maximum radiographic dimension of \\>= 5 mm on CBCT.\n6. The target tooth has no history of previous surgical root-end resection procedures.\n7. The lesion does not directly involve or impinge upon hazardous adjacent anatomical structures (e.g., the inferior alveolar nerve canal, the maxillary sinus floor, or the mental foramen).\n8. The presence of at least three stable, non-mobile permanent teeth within the same dental arch to serve as reliable anchor units to support the surgical template.\n9. Patient is fully capable and willing to provide signed written informed consent.\n\nExclusion Criteria:\n\n1. Women who are currently pregnant or breastfeeding.\n2. History of known allergy or systemic hypersensitivity to amide local anesthetics, epinephrine co-agents, or any structural resins and bioceramic materials utilized in this protocol.\n3. Extensive metal restorations, crowns, or massive fixed partial dentures adjacent to the target site that generate severe radiographic scattering artifacts, compromising CBCT measurement quality.\n4. Target tooth displays clinical evidence of a vertical root fracture, non-restorable structural crown destruction, or advanced localized periodontitis.\n5. Massive periapical pathology requiring a root-end resection length exceeding 3 mm, or necessitating excessive mechanical field widening beyond the template boundaries to achieve surgical curettage.\n6. Inadequate stability, rocking, or poor fit of the printed surgical guide during the intraoral verification phase.\n7. Patient demonstrates non-compliance or is unable to return for scheduled longitudinal follow-ups and imaging appointments.","16 Years",{"count":211,"type":21},11,[24],"The goal of this clinical trial is to evaluate the surgical accuracy and healing outcomes of endodontic surgery performed with the assistance of a 3D-printed static surgical guide in patients requiring apicoectomy.\n\nThe main questions it aims to answer are:\n\n1. What is the level of positional and angular accuracy of the actual root-end resection compared to the virtual planning when utilizing a static surgical guide?\n2. What are the postoperative pain and swelling levels reported by patients at 1, 3, and 7 days after undergoing guided endodontic surgery?\n3. What are the clinical success rates and CBCT-based radiographic healing outcomes at 6 months postoperatively?\n\nParticipants will:\n\n* Undergo a preoperative digital workflow combining CBCT data and intraoral surface scans to design a customized static surgical guide.\n* Undergo targeted endodontic surgery where a 4.5-mm trephine bur is guided through the static template to perform the osteotomy and a 3-mm root-end resection in a single step.\n* Receive retrograde root-end cavity preparation via ultrasonic tips and root-end filling using calcium aluminosilicate bioceramic paste (Well-Root PT).\n* Complete self-evaluation forms regarding pain and swelling on postoperative days 1, 3, and 7.\n* Return for follow-up examinations at 1 week (for suture removal) and at 6 months for definitive clinical evaluations, as well as follow-up multi-planar CBCT imaging to evaluate both periapical bone healing and surgical accuracy via superimposition with the baseline preoperative plan.",[215,216,217,218],"Periapical Periodontitis","Periradicular Lesion","Endodontic Treatment Failure","Postoperative Wound Healing",[220],"Static surgical guide, Endodontic surgery, Apicoectomy, Cone Beam Computed Tomography, Trephine bur, Well-Root PT, Structural accuracy, Bone healing outcomes","2026-07-24",{"date":194,"type":44},{"date":224,"type":21},"2026-07-01",{"date":226,"type":21},"2027-09",{"name":50,"class":51},{"id":229,"slug":230,"hasResults":12,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":235,"sex":17,"minAge":18,"maxAge":236,"enrollmentInfo":237,"targetDuration":4,"studyType":22,"phases":239,"briefSummary":240,"conditions":241,"keywords":243,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":52},"100622649","wound-healing-and-bacterial-adherence-with-triclosan-coated-sutures-after-mandibular-impacted-third-molar-surgery-100622649","NCT07386366","Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Third Molar Surgery","Evaluation of Soft Tissue Healing and Antibacterial Effectiveness of Triclosan-Coated Polyglactin 910 Sutures After Impacted Mandibular Third Molar Surgery: A Randomized Double-Blind Split-Mouth Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 to 35 years.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Presence of two symmetric impacted mandibular third molars with the same level of difficulty according to the Pell-Gregory and Winter classification; the difference in angulation between the two third molars is no more than 15 degrees.\n* No use of topical or systemic antibiotics for at least 4 weeks before surgery.\n* Able and willing to provide written informed consent.\n* No active infection associated with the mandibular third molar at the time of enrollment.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding.\n* Allergy to local anesthetic (2% lidocaine with 1:100,000 epinephrine) or any medications used in the study.\n* Radiographic findings suggestive of a tumor or cyst associated with the impacted mandibular third molar.\n* Participant withdraws consent or does not agree to continue participation.\n* Unable to attend scheduled follow-up visits.\n* Difference in surgical extraction time between the two procedures is 12 minutes or more.\n* Suture loss\u002Floosening before completion of the final assessment time point.",true,"35 Years",{"count":238,"type":21},14,[24],"The goal of this clinical trial is to learn if triclosan-coated absorbable stitches (polyglactin 910 sutures coated with triclosan, an antibacterial agent) help soft tissue heal better and have fewer bacteria stuck to the stitches after lower impacted wisdom tooth surgery in adults aged 18 to 35 years.\n\nThe main questions it aims to answer are:\n\n1. Does triclosan-coated polyglactin 910 suture lead to better soft-tissue wound healing than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery?\n2. Does triclosan-coated polyglactin 910 suture result in a lower oral bacterial load adhered to the suture material than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery?\n\nParticipants will:\n\n* Have surgery to remove two similar lower impacted wisdom teeth (one on each side)\n* Receive triclosan-coated stitches on one side and standard stitches on the other side, with the side assignment chosen at random\n* Return for follow-up visits on day three, day five, and day seven after surgery for healing checks, simple ratings of pain and swelling, and collection of a small stitch sample for bacterial testing.",[242,218],"Impacted Mandibular Third Molar",[244,245,246,247,248,249,250,251],"Triclosan-coated suture","Polyglactin 910","Impacted third molar surgery","Mandibular third molar","Oral surgery","Postoperative wound healing","Bacterial adhesion","Antibacterial suture","2026-07-19",{"date":254,"type":44},"2026-07-21",{"date":256,"type":44},"2025-10-07",{"date":258,"type":21},"2026-07",{"name":50,"class":51},{"id":261,"slug":262,"hasResults":12,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":12,"sex":17,"minAge":267,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":22,"phases":270,"briefSummary":271,"conditions":272,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":52},"100642572","efficacy-of-three-needle-dazhui-and-electroacupuncture-for-cervical-spondylosis-with-wind-cold-syndrome-100642572","NCT07640126","Efficacy of Three-Needle Dazhui and Electroacupuncture for Cervical Spondylosis With Wind-Cold Syndrome","Three-Needle Dazhui Combined With Electroacupuncture for Cervical Spondylotic Radiculopathy and Wind-Cold Syndrome: A Randomized, Single-Blind, Controlled Trial Evaluating Pain and Neck Disability","Inclusion Criteria:\n\n* Consent: Participants must voluntarily agree to participate and sign a written informed consent form.\n* Age: Individuals aged 18 years or older.\n* Pain Intensity: Patients with a baseline pain score of VAS ≥ 50 mm on the Visual Analog Scale.\n* Modern Medicine Diagnosis (Cervical Spondylotic Radiculopathy - CSR) Patients must meet the diagnostic criteria for CSR due to cervical spondylosis according to Decision 361\u002FQD-BYT, including:\n\n  * Cervical Spine Syndrome: Localized neck pain, restricted range of motion, and tenderness upon palpation of the spinous processes or paravertebral areas.\n\nRadicular Syndrome: Neck pain radiating to the occipital region, shoulder, arm, or hand.\n\n* Physical Examination: At least one positive result from the following tests: Bell-ringer sign, Spurling's test, Shoulder abduction test, or Cervical distraction test.\n* Imaging Criteria: X-ray findings (straight, lateral, or 3\u002F4 oblique views) showing at least one of the following:\n\n  1. Osteophytes (bone spurs) on the vertebral body.\n  2. Intervertebral disc space narrowing ≥ 25%.\n  3. Subchondral bone sclerosis.\n  4. Spondylolisthesis. - Traditional Chinese Medicine (TCM) Diagnosis (Wind-Cold Syndrome) Patients must satisfy at least one primary symptom and reach a total symptom score of ≥ 50% based on the following criteria:\n* Primary Symptoms: Pain in the neck and shoulder radiating to the arm accompanied by numbness; pain is the dominant feature; pain increases with cold and decreases with warmth.\n* Secondary Symptoms: Aversion to cold, aversion to wind, cold extremities, and presence or absence of sweating.\n* Tongue and Pulse: Pale tongue with a thin white coating; floating-tight or slow pulse.\n\nExclusion Criteria:\n\n* History of neck trauma.\n* Diagnosed with specific bone or joint diseases: Rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Down syndrome, cervical spina bifida, or Scheuermann's disease.\n* Severe neurological deficits: Progressive muscle weakness (motor loss) or acute, severe sensory loss indicating advanced nerve compression.\n* Vertebral-basilar artery syndrome: Headache, dizziness, tinnitus, loss of balance, or fatigue.\n* Autonomic nervous system disorders: Pain accompanied by tinnitus, visual disturbances, or vasomotor disorders in the occipital-shoulder region or arms.\n* Central motor neuron lesions: Presence of Hoffmann's sign, Babinski's sign, hyperreflexia, spasticity, urinary\u002Ffecal incontinence, or sexual dysfunction.\n* Symptoms suggesting systemic or malignant disease: Unexplained weight loss, fever, loss of appetite, personal or family history of malignant tumors, or diffuse pain and stiffness.\n* Symptoms suggesting infection: Fever, meningeal signs, or photophobia.\n* Symptoms suggesting serious acute medical conditions: Myocardial infarction (chest pain + sweating + shortness of breath) or arterial dissection (tearing pain sensation + headache + blurred vision).\n* Local or systemic contraindications: Infection or ulceration at the acupuncture site; patients who are exhausted, emaciated, or suffering from severe accompanying internal medical diseases.\n* Substance abuse: Alcohol or drug addiction.\n* Recent medication use (within the past month): Currently using analgesics or anti-inflammatory drugs that may affect results, such as Opioids, NSAIDs, Corticosteroids, Gabapentin, Pregabalin, or tricyclic antidepressants.\n* Other ongoing treatments: Currently undergoing other therapies such as acupressure, massage, or physical therapy for the neck area.","18 Days",{"count":269,"type":21},74,[24],"Cervical spondylosis is a prevalent health issue that significantly impacts quality of life, with Cervical Spondylotic Radiculopathy (CSR) accounting for 60-70% of cases\n\n* While modern medicine offers various treatments, the frequent use of painkillers often leads to undesirable side effects\n* In Traditional Chinese Medicine, electroacupuncture is a safe and effective method recognized by the Ministry of Health for treating this condition\n* The \"Three-Needle Dazhui\" technique is a specialized acupuncture method that simultaneously uses three needles at the Dazhui (GV14) point to strongly activate Yang Qi and dispel cold, making it particularly suitable for the Wind-Cold syndrome. This study aims to evaluate whether the combination of the Three-Needle Dazhui technique and electroacupuncture yields better results in pain reduction and functional improvement compared to electroacupuncture alone in patients with cervical spondylosis and Wind-Cold syndrome.",[191,273,192,193],"Wind-Cold Syndrome","2026-07-17",{"date":276,"type":44},"2026-07-20",{"date":278,"type":44},"2026-06-01",{"date":280,"type":21},"2028-06",{"name":50,"class":51},{"id":283,"slug":284,"hasResults":12,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":288,"eligibilityCriteria":289,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":290,"targetDuration":292,"studyType":293,"phases":4,"briefSummary":294,"conditions":295,"keywords":299,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":157},"100646053","pediatric-movement-disorders-of-unknown-etiology-in-vietnam-vpemd-100646053","NCT07695610","Pediatric Movement Disorders of Unknown Etiology in Vietnam (VPeMD)","Phenotypic and Genotypic Characterization of Pediatric Movement Disorders of Unknown Etiology in Vietnam","VPeMD","Inclusion Criteria:\n\n* Children younger than 18 years old.\n* Patients with clinically confirmed movement disorders based on direct examination and\u002For video review by at least two pediatric neurology specialists.\n* Patients with movement disorders of unknown etiology after appropriate neurological evaluation and exclusion of clear acquired causes.\n* Patients evaluated or treated at University Medical Center Ho Chi Minh City or Children's Hospital 1 during the study period.\n* Patients and\u002For legal guardians who provide written informed consent for study participation and genetic testing.\n\nExclusion Criteria:\n\n* Patients with isolated or transient primary tic disorders.\n* Patients with a confirmed acquired cause of movement disorder.\n* Patients or legal guardians who decline participation or withdraw from the study.\n* Patients with insufficient clinical information or unavailable biological samples for genetic analysis.",{"count":291,"type":21},50,"12 Months","OBSERVATIONAL","This observational patient registry aims to describe the clinical phenotypes and genetic findings of Vietnamese children with movement disorders of unknown etiology. Eligible participants are children with clinically confirmed movement disorders after evaluation by pediatric neurology specialists and after exclusion of clear acquired causes.\n\nThe study will collect clinical data, neurological examination findings, available laboratory and imaging results, and video recordings of abnormal movements when consent is provided. Blood samples will be collected for whole-exome sequencing and related genetic analysis. Genetic variants will be classified according to accepted clinical genetics standards and compared with the patients' clinical phenotypes.\n\nThe study is expected to improve understanding of the phenotypic and genotypic spectrum of pediatric movement disorders in Vietnam, support genetic counseling, and evaluate how genetic results may influence diagnosis, follow-up, prognosis, and treatment planning.",[296,297,298],"Movement Disorders in Children","Neuro Developmental Delay","Neurogenetic Disorders",[288,300,301,302],"Vietnam","Whole Exome Sequencing","Pediatric movement disorders","2026-07-08",{"date":305,"type":44},"2026-07-10",{"date":307,"type":44},"2026-04-17",{"date":309,"type":21},"2029-01-31",{"name":50,"class":51},{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":12,"sex":17,"minAge":318,"maxAge":319,"enrollmentInfo":320,"targetDuration":4,"studyType":22,"phases":322,"briefSummary":323,"conditions":324,"keywords":326,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":52},"100635440","thread-embedding-plus-auricular-acupressure-for-non-organic-insomnia-based-on-traditional-medicine-pattern-differentiation-100635440","NCT07552714","Thread Embedding Plus Auricular Acupressure for Non-Organic Insomnia Based on Traditional Medicine Pattern Differentiation","Evaluation of the Efficacy of Thread Embedding Acupuncture Combined With Auricular Acupressure Based on Traditional Chinese Medicine Clinical Syndromes in Patients With Non-Organic Insomnia","Inclusion Criteria:\n\n* Age: 40 to 75 years.\n* Cognitive Function: Mini-Mental State Examination (MMSE) score \\> 24.\n* Stable Comorbidities: Participants with hypertension or diabetes must be well-controlled with medication (Blood Pressure \\\u003C 140\u002F90 mmHg, HbA1c \\\u003C 7%) and have no changes in their medication regimen within the last 3 months.\n* Modern Medical Criteria: Diagnosis of Chronic Insomnia Disorder according to the International Classification of Sleep Disorders, 3rd Edition (ICSD-3).\n* Sleep Quality Scores: A Pittsburgh Sleep Quality Index (PSQI) score \\>= 5 and a total Insomnia Severity Index (ISI) score \\>= 10.\n* TCM Syndrome: Diagnosed with one of the following Traditional Chinese Medicine syndromes: Heart-Spleen Deficiency, Liver Qi Stagnation, or Liver Qi Stagnation with Spleen Deficiency.\n* Informed Consent: Participants must voluntarily sign the informed consent form and agree to comply with study requirements, including stool sample collection.\n\nExclusion Criteria:\n\n* Secondary Insomnia: Sleep disturbances caused by organic conditions (e.g., brain tumor, acute pain, hyperthyroidism, or severe cardiovascular disease).\n* Gastrointestinal Disorders: Current acute or chronic gastrointestinal diseases (e.g., ulcerative colitis, Crohn's disease, or acute diarrhea).\n* Specific Medications and Supplements: \\* Use of antibiotics, corticosteroids, or Probiotic\u002FPrebiotic supplements within 4 weeks prior to the study.\n* Use of Proton Pump Inhibitors (PPIs) such as Omeprazole or Esomeprazole within the last 2 weeks.\n* Regular use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as Ibuprofen, Meloxicam, or Diclofenac.\n* Medical Procedures: Enema or colonoscopy performed within 1 month prior to the study.\n* Immune Conditions: Autoimmune diseases or rheumatoid arthritis.\n* Vaccination: Vaccination (e.g., influenza vaccine) within 2 weeks prior to blood collection.\n* Advanced Chronic Diseases: Late-stage chronic conditions including renal failure (eGFR \\\u003C 45), liver failure, or stage III-IV heart failure.\n* Severe Nocturia: Urinating \\>= 3 times per night.\n* Obstructive Sleep Apnea (OSA): Patients with obesity, loud snoring, and excessive daytime sleepiness.\n* Pregnancy and Lactation: Women who are pregnant or breastfeeding.","40 Years","75 Years",{"count":321,"type":21},70,[24],"Non-organic insomnia is a prevalent disorder that significantly impairs quality of life, characterized by difficulty initiating or maintaining sleep alongside daytime functional decline. This condition is particularly common among adults facing chronic stress, which increases the risk of chronic diseases and dysregulates the Microbiota-Gut-Brain Axis (MGBA)-a bidirectional communication system between the central nervous system and the gut microbiota. Prolonged sleep deprivation and stress can trigger inflammatory responses and gut dysbiosis, which in turn exacerbate emotional and sleep disturbances. While conventional sedative-hypnotics often carry side effects and risks of dependency, traditional medicine interventions are emerging as potential sustainable solutions. This study evaluates the efficacy of thread embedding combined with auricular acupressure based on individualized traditional Chinese medicine syndrome differentiation, while clarifying the relationship between clinical sleep improvement and changes in MGBA-related inflammatory markers, specifically interleukin-6 and calprotectin.\n\nThe goal of this clinical trial is to evaluate the clinical efficacy and preliminarily investigate the mechanisms of action-via the Microbiota-Gut-Brain Axis-of individualized Traditional Chinese Medicine (targeting Heart-Spleen Deficiency and Liver Qi Stagnation syndromes) using thread embedding acupuncture combined with auricular acupressure to improve sleep quality in patients with insomnia, compared to a non-individualized protocol. The main questions it aims to answer are:\n\n* Does the combined method of thread embedding acupuncture and auricular acupressure based on syndrome differentiation improve sleep quality more effectively than the standardized protocol?\n* Is there a significant difference in the change of IL-6 and Calprotectin levels following treatment in the intervention group compared to the control group?\n* Does post-treatment clinical improvement correlate with the reduction of these inflammatory markers?\n\nParticipants will:\n\n* Receive thread embedding acupuncture sessions every 4 weeks and have ear seeds (auricular acupressure) replaced every 2 weeks . Self-massage the ear seeds for 1 to 2 minutes several times each day, especially before bedtime.\n* Complete assessments of sleep quality (PSQI, ISI) and digestive health (GSRS) every 2 weeks through week 8.\n* Provide blood and stool samples at the start and end of the study to measure inflammation markers.\n* Be monitored for any adverse effects, such as local pain, dizziness, or needle fainting, during the trial period.",[325],"Insomnia, Nonorganic",[327,328,329,330,331,332,333],"non-organic insomnia","thread embedding acupuncture","auricular acupressure","TCM Syndrome","Interleukin 6","Calprotectin","Gut-brain axis",{"date":335,"type":44},"2026-07-06",{"date":337,"type":44},"2026-05-18",{"date":339,"type":21},"2027-12",{"name":50,"class":51},{"id":342,"slug":343,"hasResults":12,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":319,"enrollmentInfo":348,"targetDuration":4,"studyType":22,"phases":350,"briefSummary":351,"conditions":352,"keywords":355,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":361,"startDateStruct":362,"completionDateStruct":363,"leadSponsor":365,"locationsCount":52},"100646874","effectiveness-of-electroacupuncture-at-xuanzhong-gb39-and-tongli-ht5-points-in-post-stroke-aphasia-100646874","NCT07684781","Effectiveness of Electroacupuncture at Xuanzhong (GB39) and Tongli (HT5) Points in Post-Stroke Aphasia","Evaluation of the Effectiveness of Electroacupuncture at Xuanzhong (GB39) and Tongli (HT5) Acupoints in Patients With Post-Stroke Aphasia","Inclusion Criteria:\n\n* Age: 18 to 75 years.\n* Diagnosis: Diagnosed with post-stroke aphasia (PSA) based on the Ministry of Health criteria or ICD-10 codes (I60-I64).\n* Cognitive and Functional State: Alert and able to cooperate with the treatment.\n* Language Assessment: Aphasia classified as moderate or mild according to the BDAE scale (scores 2-4).\n* Disease Duration: Stroke occurring 7 to 90 days prior to enrollment.\n* Language Proficiency: Native Vietnamese speaker.\n* Informed Consent: Must voluntarily sign the informed consent form and agree to comply with all study requirements.\n\nExclusion Criteria:\n\n* Non-Stroke Related Aphasia: Pre-existing aphasia or aphasia not caused by a stroke.\n* Severe Comorbidities: Severe heart, liver, or kidney failure.\n* Psychiatric\u002FCognitive Disorders: Diagnosed dementia or other mental health conditions.\n* Medical Contraindications: Presence of a pacemaker.\n* Dermatological Conditions: Infection at the targeted acupoint sites.\n* Sensory Impairment: Significant hearing or visual impairment that interferes with assessment.",{"count":349,"type":21},30,[24],"Post-stroke aphasia (PSA) is a prevalent and debilitating condition that significantly impairs communication, social participation, and quality of life, often leading to increased long-term healthcare costs and psychological burden. While speech therapy is the recommended standard of care, many patients face limitations in recovery, prompting exploration into integrative approaches. Traditional medicine, particularly electroacupuncture, has shown potential in enhancing neuro-functional recovery; however, further evidence is needed to optimize its integration with standard rehabilitative protocols. This study evaluates the clinical efficacy of electroacupuncture at the Xuanzhong (GB39) and Tongli (HT5) acupoints combined with standardized speech therapy, aiming to improve language outcomes and patient quality of life.\n\nThe goal of this clinical trial is to evaluate the clinical efficacy of electroacupuncture at the Xuanzhong (GB39) and Tongli (HT5) acupoints combined with speech therapy in patients with post-stroke aphasia, aged 18 to 75. The main questions it aims to answer are:\n\n* Does electroacupuncture at the Xuanzhong and Tongli acupoints, combined with speech therapy and standard treatment, improve language recovery more effectively than the standard protocol alone, as measured by the BDAE and ART scales?\n* Does this combined approach significantly improve the quality of life (SAQOL-39) and correlate with functional language recovery in post-stroke patients?\n\nResearchers will compare the intervention group (electroacupuncture at Xuanzhong and Tongli combined with basic treatment and speech therapy) to a control group (electroacupuncture at other acupoints combined with basic treatment and speech therapy) to see if the specific acupoint combination enhances language rehabilitation.\n\nParticipants will:\n\n* Undergo 4 weeks of electroacupuncture (once daily, 5 days per week) and speech therapy sessions.\n* Complete assessments of language function (BDAE, ART) and quality of life (SAQOL-39) at baseline, 2 weeks, 1 month, and 3 months.\n* Be monitored for any adverse effects, such as local pain, bleeding, bruising, or needle fainting, throughout the trial period.",[353,354],"Post-stroke Aphasia","PSA",[356,357,358,359,360],"Post-stroke aphasia","Electroacupuncture","Speech therapy","Language recovery","Clinical trial",{"date":335,"type":44},{"date":258,"type":21},{"date":364,"type":21},"2028-01",{"name":50,"class":51},{"id":367,"slug":368,"hasResults":12,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":4,"eligibilityCriteria":372,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":319,"enrollmentInfo":373,"targetDuration":4,"studyType":22,"phases":375,"briefSummary":376,"conditions":377,"keywords":4,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":382,"completionDateStruct":384,"leadSponsor":386,"locationsCount":4},"100637239","evaluation-of-the-therapeutic-efficacy-of-auricular-pellets-combined-with-atorvastatin-20mg-in-patients-with-dyslipidemia-and-phlegm-dampness-syndrome-100637239","NCT07624604","Evaluation of the Therapeutic Efficacy of Auricular Pellets Combined With Atorvastatin 20mg in Patients With Dyslipidemia and Phlegm-Dampness Syndrome","The Potential Efficacy of Auricular Pellets Combined With Atorvastatin 20mg in Managing Blood Lipid Levels and Improving Phlegm-Dampness Symptoms in 80 Patients With Dyslipidemia and Phlegm-Dampness Syndrome: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis: Dyslipidemia (DL), untreated or discontinued treatment for at least 1 month, and not taking drugs that induce DL.\n* Laboratory Criteria: LDL-c levels between 2.6 and 4.9 mmol\u002FL.\n* TCM Criteria:\n\nDiagnosed with Phlegm-Dampness syndrome in patients with DL according to the \"Guiding Principles for Clinical Research on Combined Traditional Chinese and Western Medicine\":\n\nPrimary symptoms: Obesity, heavy sensation in the head, chest tightness, nausea\u002Fphlegm expectoration, numbness in limbs.\n\nSecondary symptoms: Palpitations, insomnia, bland taste in the mouth, poor appetite.\n\nTongue manifestations: Enlarged\u002Fflabby tongue, greasy\u002Fslippery tongue coating. Pulse: String-taut and slippery pulse (Wiry-Slippery pulse). Diagnostic threshold: Confirmed when presenting \\>= 50% of TCM Phlegm-Dampness syndrome symptoms in patients with DL.\n\nExclusion Criteria:\n\n* Participants are non-compliant with the treatment protocol.\n* Participants decline to continue study participation for any reason (Withdrawal of consent).\n* Participants experience health events during the study and do not wish to continue participation.",{"count":374,"type":21},80,[24],"Dyslipidemia (DL) is a metabolic disorder characterized by an imbalance of blood lipid components, serving as a leading silent cause of dangerous cardiovascular diseases and increased mortality risk globally. According to the World Health Organization (WHO), cardiovascular diseases account for 32% of all deaths worldwide, with dyslipidemia playing a crucial role in the pathogenesis of 85% of fatalities caused by heart attacks and strokes. Although current management primarily relies on lifestyle modifications and lipid-lowering medications such as statins, fibrates, or niacin, some patients still encounter difficulties due to inadequate treatment response, adverse side effects, or poor long-term compliance. In this context, Traditional Chinese Medicine (TCM) therapies are increasingly being widely applied, either as monotherapy or in combination with Western medicine. Notably, auricular acupuncture-a method focusing on specific acupoints on the ear-has been recognized for its great potential in modulating lipid profiles, particularly demonstrating therapeutic efficacy in patients with Phlegm-Dampness syndrome.\n\nTheoretically and clinically, Phlegm-Dampness syndrome is inextricably linked to the pathogenesis and progression of dyslipidemia (DL); furthermore, clinical research in China indicates that the Phlegm pattern accounts for the highest proportion among the five traditional syndromes of this condition, and a greater severity of Phlegm-Dampness correlates positively with higher levels of TC and LDL-c. In terms of treatment, auricular pellets (a modality of auricular acupuncture) have been demonstrated to improve cardiovascular health by reducing TC, LDL-c, and TGR levels while elevating HDL-c in obese patients with mild-to-moderate DL. In Vietnam, however, studies evaluating the application of auricular pellets in patients with DL remain limited, primarily focusing on individuals with simple overweight or obesity without documented concurrent metabolic disorders. Notably, a study by Nguyen Vu Thien Duyen (2021) reported that a 3-acupoint formula consisting of Hunger (TGR3), Stomach (CO4), and Endocrine (CO18) effectively reduced lipid profiles to a moderate extent in obese individuals.\n\nGiven the limitations in evaluating therapeutic efficacy and the scarcity of published studies discussing the effects of lowering blood lipid profiles and alleviating Phlegm-Dampness symptoms for this specific pattern in Vietnam, the investigators conducted this study to evaluate the degree of lipid profile reduction and the clinical symptom improvement of the Phlegm-Dampness syndrome using auricular acupuncture in patients with dyslipidemia presenting with the Phlegm-Dampness syndrome.",[378],"Phlegm-Dampness Syndrome","2026-05-28",{"date":381,"type":44},"2026-06-03",{"date":383,"type":21},"2026-05-15",{"date":385,"type":21},"2026-10",{"name":50,"class":51},{"id":388,"slug":389,"hasResults":12,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":4,"eligibilityCriteria":393,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":394,"enrollmentInfo":395,"targetDuration":4,"studyType":22,"phases":397,"briefSummary":398,"conditions":399,"keywords":402,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":414,"locationsCount":52},"100639109","catgut-embedding-for-lumbar-spondylosis-with-blood-stasis-syndrome-100639109","NCT07590050","Catgut Embedding for Lumbar Spondylosis With Blood Stasis Syndrome","Evaluating the Efficacy of Catgut Embedding Therapy in Pain Relief and Quality of Life Improvement for Lumbar Spondylosis With Blood Stasis Syndrome","Inclusion Criteria:\n\n* Age and Gender: Patients aged 18 to 65 years, regardless of gender.\n* Diagnosis of Chronic Low Back Pain: Confirmed diagnosis of low back pain due to lumbar spondylosis with the following criteria:\n\n  * Clinical: Mechanical spinal pain.\n  * Radiographic (X-ray): Joint space narrowing, subchondral sclerosis, and osteophytes on the vertebral bodies.\n  * Absence of systemic symptoms such as fever, unexplained weight loss, or anemia.\n* Duration: Pain duration exceeding 3 months.\n* Pain Intensity: Visual Analog Scale (VAS) score for low back pain \\> 40 mm.\n* Traditional Medicine Diagnosis: Diagnosed with Low back pain under the \"Blood Stasis\" syndrome according to Decision No. 5013\u002FQD-BYT (2020) by the Ministry of Health: Pain occurs after heavy lifting or sudden movement. Severe localized pain, pain increases with movement\u002Fpressure. Limited range of motion. Tongue: Purple or with stasis points. Pulse: Choppy.\n* Communication: Capable of communicating fluently in Vietnamese to complete survey questionnaires.\n* Consent: Volunteers who agree to participate and sign the Informed Consent Form.\n\nExclusion Criteria:\n\n* Neurological Deficits: Patients with clinical neurological abnormalities in the lower limbs.\n* Surgical Indications: Patients with indications for spinal surgery due to severe neurological deficits.\n* Co-morbidities: Vertebral fractures, spinal inflammation\u002Finfection, malignant tumors, neuromuscular scoliosis, or degenerative neurological diseases.\n* Hypersensitivity: History of hypersensitivity or adverse reactions to electro-acupuncture or catgut embedding treatments.","65 Years",{"count":396,"type":21},66,[24],"The goal of this clinical trial is to learn if catgut embedding works to treat chronic low back pain in adults with lumbar spondylosis and \"Blood Stasis\" syndrome. The main questions it aims to answer are:\n\nDoes catgut embedding lower back pain more effectively than electro-acupuncture?\n\nDoes catgut embedding improve the daily physical activities of participants?\n\nResearchers will compare catgut embedding to electro-acupuncture to see which method works better to reduce pain and improve quality of life. All participants will also receive counseling on lifestyle changes and back exercises.\n\nParticipants will:\n\nBe randomly assigned to receive either catgut embedding (2 sessions over 4 weeks) or electro-acupuncture (20 sessions over 4 weeks).\n\nVisit the clinic for treatments and checkups.\n\nComplete surveys about their pain levels and ability to perform daily tasks at the start, at 2 weeks, and at 4 weeks.",[400,401],"Lumbar Spondylosis","Low Back Pain",[403,404,405,406,407],"Catgut Embedding","Electro-acupuncture","Polydioxanone (PDO)","Traditional Vietnamese Medicine","Blood Stasis Syndrome","2026-05-10",{"date":383,"type":44},{"date":411,"type":44},"2026-03-11",{"date":413,"type":21},"2026-10-30",{"name":50,"class":51},{"id":416,"slug":417,"hasResults":12,"nctId":418,"briefTitle":419,"officialTitle":420,"acronym":4,"eligibilityCriteria":421,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":422,"targetDuration":4,"studyType":22,"phases":423,"briefSummary":424,"conditions":425,"keywords":4,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":435,"locationsCount":52},"100639595","efficacy-of-auricular-acupressure-combined-with-antihistamines-in-patients-with-wind-heat-type-urticaria-100639595","NCT07575464","Efficacy of Auricular Acupressure Combined With Antihistamines in Patients With Wind-Heat Type Urticaria.","Evaluation of the Efficacy of Auricular Acupressure Combined With Antihistamines in Patients With Wind-Heat Type Urticaria","Inclusion Criteria:\n\n* Diagnosed with urticaria according to the international EAACI\u002FGA²LEN\u002FEuroGuiDerm\u002FAPAAACI 2022 guidelines.\n* Presenting typical clinical symptoms of urticaria.\n* Experiencing persistent itching and wheals, with an Urticaria Activity Score (UAS) indicating an itching and discomfort level of ≥ 1.\n* Diagnosed with the Wind-Heat syndrome according to Traditional Medicine criteria by a certified practitioner. Diagnosis requires the presence of main symptoms (persistent itchy rash, intense itching, bright red wheals) and at least 2 secondary symptoms (restlessness, feverish sensation, aversion to heat, sore throat, symptoms worsening with heat, thin yellow tongue coating, floating rapid pulse).\n* Voluntarily agrees to participate and signs the informed consent form.\n\nExclusion Criteria:\n\n* Having contraindications to auricular acupressure according to the Ministry of Health, including severe physical exhaustion or immunodeficiency.\n* Having skin infections, inflammation, or ulceration at the auricular acupoint areas.\n* Experiencing acute pain suspected to be of surgical origin or in an emergency condition.\n* Pregnant women.\n* Use of stimulants (alcohol, beer, coffee, tobacco) within 24 hours prior to the study intervention.\n* Severe cognitive impairment or inability to understand the study protocol.\n* History of allergy or hypersensitivity to second-generation H1 antihistamines.\n* Currently participating in another interventional clinical study.",{"count":396,"type":21},[24],"The purpose of this clinical trial is to evaluate the efficacy of auricular acupressure combined with an antihistamine (Loratadine) in treating patients diagnosed with Wind-Heat type urticaria. Participants will be randomly assigned to either the intervention group or the control group.\n\nThe purpose of this clinical trial is to evaluate the efficacy of auricular acupressure combined with an antihistamine (Loratadine) in treating patients diagnosed with Wind-Heat type urticaria. Participants will be randomly assigned to either the intervention group or the control group.\n\nThe main questions the study aims to answer are:\n\n* Does true auricular acupressure combined with Loratadine reduce urticaria symptoms (measured by the Urticaria Activity Score - UAS) more effectively than sham acupressure with Loratadine?\n* Does the intervention improve the patients' quality of life (measured by the Dermatology Life Quality Index - DLQI) better than the control treatment?\n* Are there any adverse effects associated with the auricular acupressure treatment during the intervention period?\n\nParticipants will:\n\n* Take a standard daily dose of oral Loratadine (10mg).\n* Visit the clinic once a week for 4 weeks to have Vaccaria seed patches applied to their ear (either true therapeutic points or sham points, depending on their assigned group).\n* Self-stimulate the acupoints by pressing the patches for 1 to 2 minutes, 2 to 3 times a day at home.\n* Record their daily urticaria symptoms (wheals and pruritus) using the Urticaria Activity Score (UAS).\n* Complete the Dermatology Life Quality Index (DLQI) questionnaire at the beginning and at the end of the 4-week study period.",[426,427,428],"Auricular Acupressure","Wind-Heat Urticaria","Traditional Medicine","2026-05-03",{"date":431,"type":44},"2026-05-08",{"date":433,"type":21},"2026-05-01",{"date":258,"type":21},{"name":50,"class":51},{"id":437,"slug":438,"hasResults":12,"nctId":439,"briefTitle":440,"officialTitle":441,"acronym":4,"eligibilityCriteria":442,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":138,"enrollmentInfo":443,"targetDuration":4,"studyType":22,"phases":444,"briefSummary":445,"conditions":446,"keywords":4,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":448,"startDateStruct":450,"completionDateStruct":451,"leadSponsor":452,"locationsCount":4},"100635945","efficacy-of-jins-three-needle-technique-combined-with-electroacupuncture-in-cervical-spondylosis-with-blood-stasis-syndrome-100635945","NCT07559279","Efficacy Of Jin's Three-Needle Technique Combined With Electroacupuncture In Cervical Spondylosis With Blood Stasis Syndrome","The Potential Efficacy Of Jin's Three-Needle Technique Combined With Electroacupuncture In Managing Pain And Improving Cervical Active Range Of Motion In 104 Patients With Cervical Spondylosis And Blood Stasis Syndrome: A Randomized, Single-Blind, Controlled Trial","Inclusion Criteria:\n\n* Individuals between the ages of 18 and 70 years.\n* Patients diagnosed with cervical spondylosis based on clinical symptoms (mechanical neck pain increasing with movement and decreasing at rest, continuous or episodic pain, restricted cervical movement) and subclinical criteria (at least one imaging evidence from X-ray or MRI showing cervical spondylosis).\n* Patients diagnosed with Blood Stasis syndrome according to the 2002 Guidelines for Clinical Research of New Traditional Chinese Medicines. • Diagnosis requires \\>50% of the symptoms and at least one primary symptom. Primary symptoms include onset after neck trauma, stiff neck pain increasing with movement, and a fixed pain point. Secondary symptoms include limb numbness, pale pink or dark purple tongue with stasis spots, and a string-taut or choppy pulse.\n* Individuals with an average pain score from 3 to less than 8 (3 ≤ VAS \\\u003C 8) on the Visual Analogue Scale.\n* Individuals who volunteered to participate in the study and signed a consent form.\n\nExclusion Criteria:\n\n* Patients diagnosed with acute or chronic neck pain due to specific causes (infection, tumor, osteoporosis, ankylosing spondylitis, fracture, disc herniation) or those having root compression syndrome, spinal cord compression syndrome, or vertebral artery syndrome.\n* Patients with a history of neck trauma, cervical spine fracture or surgery, congenital spinal abnormalities, or systemic bone and joint diseases.\n* Patients who have used medications affecting the study results within 1 week prior, including painkillers (Paracetamol, Tramadol, NSAIDs, Gabapentin, Pregabalin), muscle relaxants (Eperisone, Tolperisone), or traditional medicine for neck pain.\n* Patients with contraindications to electroacupuncture according to the Ministry of Health guidelines, such as cachexia, decreased resistance, pregnancy, skin infection or ulceration at acupoints, prolonged fever, dehydration, blood loss, emergency conditions, heart failure, arrhythmia, or surgical causes of neck pain.\n* Patients with mental illness or who are not fully conscious.\n* Patients with a pacemaker or metal devices such as nails or splints.\n* Patients currently using anticoagulants or having hemophilia.\n* Patients currently participating in another interventional study",{"count":187,"type":21},[24],"Neck pain is a highly prevalent condition, affecting 30% to 50% of the population, with cervical spondylosis accounting for up to 80% of these cases. The burden of cervical spondylosis continues to increase, leading to chronic mechanical pain, restricted mobility, and a significant socioeconomic impact. Treatment mainly includes non-steroidal anti-inflammatory drugs (NSAIDs), physical therapy, and traditional medicine therapies such as massage and acupuncture.\n\nJin's Three-Needle technique (specifically Cervical Three-Needle targeting Dazhu, Tianzhu, and Bailao acupoints) is a specialized acupuncture method created by Professor Jin Rui, demonstrating therapeutic effectiveness in improving local circulation and relieving neck pain. Recent studies have shown that acupuncture effectively manages pain in cervical spondylosis, especially for the Blood Stasis syndrome. Additionally, combining these specific acupoints with standard electroacupuncture and active movement exercises plays an essential role in alleviating pain and restoring cervical spine function. In practice, many practitioners apply Jin's Three-Needle technique to treat cervical spondylosis with considerable effectiveness, though it has not been thoroughly evidence-based in Vietnam for the Blood Stasis syndrome.\n\nGiven the limitations in evaluating treatment effectiveness and the lack of published research discussing the analgesic effects of Jin's Three-Needle technique for this specific syndrome in Vietnam , the investigators conducted the study to evaluate the pain reduction and range of motion improvement of Jin's Three-Needle technique combined with electroacupuncture in patients with cervical spondylosis with blood stasis syndrome.",[447],"Pain",{"date":449,"type":44},"2026-05-07",{"date":383,"type":21},{"date":385,"type":21},{"name":50,"class":51},{"id":454,"slug":455,"hasResults":12,"nctId":456,"briefTitle":457,"officialTitle":458,"acronym":4,"eligibilityCriteria":459,"healthyVolunteers":12,"sex":17,"minAge":460,"maxAge":461,"enrollmentInfo":462,"targetDuration":4,"studyType":22,"phases":464,"briefSummary":465,"conditions":466,"keywords":469,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":157},"100635837","healing-efficacy-of-diode-laser-in-lingual-frenectomy-100635837","NCT07557875","Healing Efficacy of Diode Laser in Lingual Frenectomy","Evaluation of the Healing Efficacy of Diode Laser in Lingual Frenectomy","Inclusion Criteria:\n\n* Patients aged between 3 and 6 years.\n* Diagnosed with grade 3 or grade 4 ankyloglossia according to Kotlow's classification (1999).\n* Parents or legal guardians provide informed consent for the child to participate in the study.\n* Patients and guardians agree to follow the follow-up schedule (24 hours, 3 days, 1 week, and 1 month post-surgery).\n\nExclusion Criteria:\n\n* History of allergy to local anesthetics (e.g., Lidocaine, Adrenaline).\n* Patients with systemic diseases or high-risk surgical factors (e.g., cardiovascular disease, bleeding disorders, hemophilia, epilepsy, or uncontrolled asthma).\n* Uncooperative patients who are unable to undergo the procedure under local anesthesia or fail to follow post-operative instructions.\n* Patients who withdraw from the study before completion.","3 Years","6 Years",{"count":463,"type":21},53,[24],"This study aims to compare the wound healing efficacy and postoperative experiences between the 940 nm diode laser technique and the traditional electrosurgery method for treating ankyloglossia (tongue-tie) in children aged 3 to 6 years.\n\nParticipants are randomly assigned to one of two groups: Experimental Group - Patients undergo lingual frenectomy using a 940 nm diode laser and Active Comparator Group - Patients undergo the procedure using conventional high-frequency electrosurgery.\n\nThe study evaluates several key outcomes at multiple intervals (24 hours, 3 days, 1 week, and 1 month post-surgery), including: (1) Wound Healing: Measured by the Early Wound Healing Score (EHS); (2) Pain Levels: Assessed using the Wong-Baker FACES Pain Rating Scale; (3) Bleeding Control: Evaluation of intraoperative bleeding; (4) Tongue Mobility: Measurement of free tongue length according to Kotlow's classification.\n\nThe goal is to determine if the diode laser provides superior healing, less pain, and better bleeding control compared to electrosurgery.",[467,468],"Ankyloglossia","Tongue-tie",[467,468,470,471,472,473,474,475,476,477],"Lingual frenectomy","Diode laser","Electrosurgery","Wound healing","Postoperative pain","Early Wound Healing Score (EHS)","Wong-Baker FACES Pain Rating Scale","Kotlow's classification","2026-04-22",{"date":480,"type":44},"2026-04-30",{"date":482,"type":44},"2024-10-01",{"date":484,"type":21},"2026-10-01",{"name":50,"class":51},{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":493,"targetDuration":4,"studyType":22,"phases":495,"briefSummary":496,"conditions":497,"keywords":498,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":503,"lastUpdatePostDateStruct":504,"startDateStruct":505,"completionDateStruct":506,"leadSponsor":507,"locationsCount":508},"100634776","acupuncture-with-five-shu-points-for-insomnia-in-heart-spleen-deficiency-100634776","NCT07544082","Acupuncture With Five Shu Points for Insomnia in Heart-Spleen Deficiency","Efficacy of Five Shu Point Acupuncture in the Treatment of Insomnia in Patients With Heart-Spleen Deficiency Pattern: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18 years or older who voluntarily consent to participate in the study.\n* Patients who have never used or have discontinued insomnia medication within 2 weeks prior to study enrollment.\n* Patients meeting the diagnostic criteria for insomnia according to the DSM-V of the American Psychiatric Association, specifically as follows:\n\nA. The patient complains about sleep quantity or quality, including one or more of the following symptoms: difficulty initiating sleep; difficulty maintaining sleep, characterized by frequent awakenings or trouble returning to sleep after awakening; early morning awakening with inability to return to sleep.\n\nB. Sleep difficulty occurs for at least 3 months. C. Sleep disturbance causes significant distress or impairment in social, occupational, educational, academic, behavioral, or other important areas of functioning.\n\nD. Sleep difficulty occurs at least 3 nights per week. E. Sleep difficulty occurs despite adequate opportunity for sleep. F. Insomnia is not better explained by another sleep disorder (e.g., narcolepsy, breathing-related sleep disorder, circadian rhythm sleep disorder).\n\nG. Co-existing mental disorders or medical conditions do not adequately explain the predominant complaint of insomnia.\n\nH. Insomnia is not attributable to the physiological effects of a substance.\n\n* Patients who are able to understand Vietnamese.\n* Patients meeting the diagnostic criteria for Heart-Spleen dual deficiency syndrome according to Jing Lv, requiring the presence of mandatory symptoms + 2 primary symptoms + 2 secondary symptoms + tongue and pulse findings, specifically:\n\nMandatory symptoms\n\n* Sleeplessness throughout the night, or light sleep with frequent awakening; fragmented sleep.\n* Frequent nightmares.\n* Early morning awakening with inability to fall back asleep.\n\nPrimary symptoms\n\nPalpitations, forgetfulness. Mental fatigue, poor appetite. Pale, unhealthy complexion. Secondary symptoms\n\nDizziness, blurred vision. Weakness of limbs. Abdominal distension, loose stools. Tongue and pulse findings\n\nPale tongue with thin white coating. Thin, weak, forceless pulse.\n\nExclusion Criteria:\n\n* Patients diagnosed with other sleep disorders such as sleep apnea syndrome or narcolepsy.\n* Patients previously diagnosed with neurological or psychiatric disorders (e.g., anxiety disorder, autism spectrum disorder, depression, obsessive-compulsive disorder, rapid eye movement sleep behavior disorder) prior to study enrollment.\n* Patients currently using antidepressants or psychiatric medications.\n* Patients participating in other clinical trials involving behavioral, psychological, or complementary medical interventions during the study period.\n* The patient no longer agrees to continue participation.\n* Occurrence of uncomfortable symptoms during the study, such as needle syncope, nausea, headache, dizziness, sweating, etc.\n* Significant worsening of the condition or development of new complications.\n* Non-adherence to the treatment protocol, making continuation impossible.",{"count":494,"type":21},46,[24],"This study was designed as a randomized controlled trial (RCT) with a multicenter, single-blind methodology. Participants diagnosed with insomnia attributable to the Heart-Spleen Deficiency pattern, receiving treatment at the Ho Chi Minh City Hospital of Traditional Medicine and Hospital 1A, were randomly allocated into two groups.",[325],[499,500,501,502],"Five-Shu acupoints","insomnia","acupuncture","Heart-Spleen deficiency","2026-04-19",{"date":478,"type":44},{"date":153,"type":44},{"date":127,"type":21},{"name":50,"class":51},3,{"id":510,"slug":511,"hasResults":12,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":4,"eligibilityCriteria":515,"healthyVolunteers":12,"sex":516,"minAge":18,"maxAge":517,"enrollmentInfo":518,"targetDuration":4,"studyType":293,"phases":4,"briefSummary":520,"conditions":521,"keywords":523,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":528,"lastUpdatePostDateStruct":529,"startDateStruct":531,"completionDateStruct":533,"leadSponsor":535,"locationsCount":52},"100633638","evaluating-traditional-medicine-syndromes-in-male-infertility-with-oligoasthenoteratozoospermia-100633638","NCT07529288","Evaluating Traditional Medicine Syndromes in Male Infertility With Oligoasthenoteratozoospermia","Characterization of Traditional Medicine Syndromes in Male Infertility With Oligoasthenoteratozoospermia Via Latent Tree Models","Inclusion Criteria:\n\n* Male patients aged between 18 and 60 years.\n* Diagnosed with male infertility by an andrology specialist according to World Health Organization (WHO) standards.\n* Semen analysis results meet the diagnostic criteria for Oligoasthenoteratozoospermia (OAT) syndrome.\n* Voluntary agreement to participate in the research and signed Informed Consent Form.\n\nExclusion Criteria:\n\n* Infertility caused by genetic or chromosomal abnormalities, including but not limited to: Klinefelter syndrome, Sandberg mosaic syndrome (46 XY\u002F47 XXY), or XYY syndrome.\n* Presence of structural abnormalities of the reproductive organs.\n* Patients with Azoospermia (absence of sperm in the ejaculate) as defined by WHO 2021 standards.\n* Use of medications affecting spermatogenesis within the last 3 months, including: cannabinoids, hydantoins, valproate, anabolic steroids, cimetidine, colchicine, spironolactone, nitrofurantoin, sulfasalazine, or calcium channel blockers.\n* Inability to understand or answer survey questions due to physical or mental limitations (e.g., mutism, deafness, intellectual disability, coma, or being on a ventilator in the ICU).\n* Lack of cooperation during the clinical examination and interview process.","MALE","60 Years",{"count":519,"type":21},300,"The goal of this observational study is to identify and evaluate the characteristics of Traditional Medicine (TM) syndromes in men aged 18 to 60 with male infertility and oligoasthenoteratozoospermia (OAT) syndrome. The main questions it aims to answer are:\n\n* What are the common Traditional Medicine syndromes and symptoms associated with male infertility based on Traditional Medicine literature?\n* What are the specific Traditional Medicine syndromes and symptoms found in men with OAT syndrome at Binh Dan Hospital when analyzed using Latent Tree Models?\n\nThe research will be conducted in two phases:\n\n* Phase 1 (Literature Review): Researchers will collect and analyze Traditional Medicine texts to list the symptoms and syndromes related to male infertility. This phase will help create a standardized clinical survey.\n* Phase 2 (Clinical Survey): Researchers will recruit 300 male participants with OAT syndrome.\n\n  * Participants will answer a survey questionnaire about their Traditional Medicine symptoms.\n  * Researchers will apply Latent Tree Models (a mathematical approach) to the collected data to objectively classify the TM syndromes.",[522],"Male Infertility With OAT",[524,525,526,527],"Traditional Medicine Pattern","OAT","Male Infertility","Oligoasthenoteratozoospermia","2026-04-09",{"date":530,"type":44},"2026-04-14",{"date":532,"type":44},"2026-01-14",{"date":534,"type":21},"2026-09-30",{"name":50,"class":51},{"id":537,"slug":538,"hasResults":12,"nctId":539,"briefTitle":540,"officialTitle":541,"acronym":4,"eligibilityCriteria":542,"healthyVolunteers":235,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":543,"targetDuration":4,"studyType":22,"phases":545,"briefSummary":546,"conditions":547,"keywords":550,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":555,"completionDateStruct":557,"leadSponsor":559,"locationsCount":52},"100632929","xuong-tan-lac-than-exercise-for-range-of-motion-and-muscle-endurance-100632929","NCT07520071","\"Xuong Tan Lac Than\" Exercise for Range of Motion and Muscle Endurance","Assessment of Changes in Range of Motion and Muscle Endurance After Practicing the \"Xuong Tan Lac Than\" Exercise in Healthy Volunteers","INCLUSION CRITERIA\n\n* Aged 18 years or older\n* Voluntarily agree to participate in the study\n* Vital signs within normal limits,\n\nEXCLUSION CRITERIA\n\n* Participants with concomitant internal or surgical medical conditions\n* Refusal to participate in the study at any time\n* Inability to perform or complete the assessment procedures\n* Engaging in vigorous physical activity within 2 days prior to the study participation",{"count":544,"type":21},34,[24],"The goal of this clinical trial is to learn the effects of the \"Xuong tan lac than\" exercise on range of motion and muscle endurance in healthy volunteers. The main questions it aims to answer are:\n\n* Does practicing the \"Xuong tan lac than\" exercise improve joint range of motion (cervical spine, lumbar spine, shoulder, elbow, wrist, knee, and ankle)?\n* Does the exercise improve muscle endurance around these joints?\n\nParticipants will:\n\n* Perform the \"Xuong tan lac than\" exercise for 12 weeks (5 days per week, once daily).\n* Be trained to perform the exercise correctly before starting the intervention.\n* Undergo assessments of joint range of motion and muscle endurance at baseline and after 2, 4, 8, and 12 weeks.",[548,549],"Healthy","Physical Fitness",[551,552],"Traditional Vietnamese exercise","Xuong tan lac than","2026-04-06",{"date":528,"type":44},{"date":556,"type":44},"2026-01-15",{"date":558,"type":21},"2026-09-01",{"name":50,"class":51},{"id":561,"slug":562,"hasResults":12,"nctId":563,"briefTitle":564,"officialTitle":565,"acronym":4,"eligibilityCriteria":566,"healthyVolunteers":12,"sex":17,"minAge":567,"maxAge":209,"enrollmentInfo":568,"targetDuration":4,"studyType":22,"phases":570,"briefSummary":571,"conditions":572,"keywords":575,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":586,"completionDateStruct":588,"leadSponsor":590,"locationsCount":52},"100631487","recombinant-tropomyosin--and-hemocyanin-specific-ige-in-children-with-suspected-shrimp-allergy-100631487","NCT07501325","Recombinant Tropomyosin- and Hemocyanin-Specific IgE in Children With Suspected Shrimp Allergy","Diagnostic Value of Recombinant Tropomyosin- and Hemocyanin-Specific IgE for the Diagnosis of IgE-Mediated Shrimp Allergy in Children in Vietnam","Inclusion Criteria:\n\n* Children aged 1 to 16 years.\n* Evaluated at the Allergy Unit of Children's Hospital 1.\n* Clinical history suggestive of IgE-mediated shrimp allergy based on EAACI 2023 criteria, including at least 1 typical allergic symptom (urticaria, angioedema, vomiting, abdominal pain, diarrhea, cough, wheezing, dyspnea, or hypotension), symptom onset within 2 hours after shrimp ingestion, and recurrence on at least 2 separate exposures.\n* Parent or legal guardian able to provide written informed consent; child assent obtained when appropriate.\n\nExclusion Criteria:\n\n* Acute illness at the time of enrollment or challenge, including acute respiratory infection, acute gastrointestinal infection, or acute asthma exacerbation.\n* Severe chronic disease, including malignancy, severe liver or kidney disease, primary immunodeficiency, or significant heart disease affecting hemodynamic status.\n* Mental or behavioral disorder that prevents completion of study procedures.\n* Use of immunosuppressive medication (oral corticosteroids, cytotoxic drugs, or biologic agents) within 4 weeks before enrollment, or intravenous immunoglobulin within the previous 3 months.\n\nExclusion Criteria:\n\n* Acute illness at the time of enrollment or challenge, including acute respiratory infection, acute gastrointestinal infection, or acute asthma exacerbation; participants may be rescheduled after recovery.\n* Severe chronic disease, including malignancy, severe liver or kidney disease, primary immunodeficiency, or significant heart disease affecting hemodynamic status.\n* Mental or behavioral disorder that prevents completion of study procedures.\n* Use of immunosuppressive medication (oral corticosteroids, cytotoxic drugs, or biologic agents) within 4 weeks before enrollment, or intravenous immunoglobulin within the previous 3 months.","1 Year",{"count":569,"type":21},129,[24],"This study will evaluate whether blood tests that measure IgE antibodies to two shrimp proteins, tropomyosin and hemocyanin, can help diagnose shrimp allergy in children. Children with suspected IgE-mediated shrimp allergy will undergo oral food challenge, skin prick testing, and blood sampling. Oral food challenge results will be used as the reference standard to determine whether these tests can accurately identify true shrimp allergy and help improve diagnosis in clinical practice.",[573,574],"Food Hypersensitivity","Shellfish Allergy",[576,577,578,579,580,581,574,582,573,583],"Oral Food Challenge","Skin Prick Test","Tropomyosin","Hemocyanin","Specific IgE","Recombinant Allergen","Children","Shrimp Allergy","2026-03-31",{"date":553,"type":44},{"date":587,"type":21},"2026-04",{"date":589,"type":21},"2028-04",{"name":50,"class":51},{"id":592,"slug":593,"hasResults":12,"nctId":594,"briefTitle":595,"officialTitle":596,"acronym":4,"eligibilityCriteria":597,"healthyVolunteers":12,"sex":516,"minAge":18,"maxAge":4,"enrollmentInfo":598,"targetDuration":600,"studyType":293,"phases":4,"briefSummary":601,"conditions":602,"keywords":604,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":606,"lastUpdatePostDateStruct":607,"startDateStruct":609,"completionDateStruct":610,"leadSponsor":612,"locationsCount":52},"100630400","a-survey-of-traditional-medicine-pattern-identification-in-patients-with-erectile-dysfunction-100630400","NCT07487181","A Survey of Traditional Medicine Pattern Identification in Patients With Erectile Dysfunction","Traditional Medicine Pattern Distribution in Patients With Erectile Dysfunction: A Cross-sectional Study","Inclusion Criteria:\n\n* Individuals aged 18 years or older who were diagnosed with erectile dysfunction by a clinical physician at Binh Dan Hospital between January 2026 and August 2026.\n* Willing to participate in the study and provide informed consent.\n\nExclusion Criteria:\n\n* Unable to understand the questionnaire.\n* Unable to complete all the study questions.\n* Patients who do not wish to continue participating in the study.",{"count":599,"type":21},375,"1 Day","Erectile dysfunction (ED) is a common condition that significantly affects quality of life, psychological well-being, and interpersonal relationships. In Traditional Medicine, ED is classified into different syndrome patterns, which are essential for guiding individualized treatment; however, evidence on their distribution and associated factors in Vietnam remains limited. This cross-sectional study aims to determine the distribution of Traditional Medicine syndrome patterns in patients with ED and to evaluate their associations with demographic characteristics, clinical features, psychological status, and lifestyle factors, thereby providing evidence to support improved diagnosis and integrative treatment approaches.",[603],"Erectile Dysfunctions",[524,603,605],"IIEF-5","2026-03-17",{"date":608,"type":44},"2026-03-23",{"date":532,"type":44},{"date":611,"type":21},"2026-08-31",{"name":50,"class":51},{"id":614,"slug":615,"hasResults":12,"nctId":616,"briefTitle":617,"officialTitle":618,"acronym":619,"eligibilityCriteria":620,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":621,"targetDuration":4,"studyType":22,"phases":623,"briefSummary":624,"conditions":625,"keywords":628,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":634,"lastUpdatePostDateStruct":635,"startDateStruct":637,"completionDateStruct":639,"leadSponsor":641,"locationsCount":52},"100628318","immediate-implant-placement-with-autogenous-maxillary-tuberosity-graft-in-the-esthetic-zone-100628318","NCT07460076","Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone","Clinical and Esthetic Outcomes of Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone: A Prospective Case Series","TUBERO-IMPLANT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Patients requiring single implant placement in the maxillary esthetic zone\n* Indication for immediate implant placement following tooth extraction\n* Presence of a buccal bone defect requiring augmentation with an autogenous maxillary tuberosity bone graft\n* Adequate oral hygiene and ability to maintain postoperative care\n* Willingness to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* Uncontrolled sHistory of radiotherapy in the head and neck region ystemic diseases\n* History of radiotherapy in the head and neck region\n* Active periodontal disease or untreated oral infection\n* Heavy smoking (more than 10 cigarettes per day)\n* Pregnancy or lactation\n* Severe parafunctional habits\n* Insufficient bone volume preventing implant placement with the planned protocol\n* Patients unable to attend follow-up visits",{"count":622,"type":21},15,[24],"Immediate implant placement in the esthetic zone is often associated with buccal bone deficiency, which may compromise esthetic outcomes and long-term implant stability. Autogenous bone graft harvested from the maxillary tuberosity provides corticocancellous bone with favorable biological properties and may help reconstruct the buccal bone plate during immediate implant placement.\n\nThis prospective case series aims to evaluate the clinical and esthetic outcomes of immediate implant placement combined with autogenous maxillary tuberosity graft in the esthetic zone. The primary outcomes include buccal bone thickness measured on cone-beam computed tomography (CBCT), facial soft tissue thickness measured clinically, and the pink esthetic score (PES) after implant restoration.",[626,627],"Alveolar Bone Loss","Esthetic Zone Implant Rehabilitation",[629,630,631,632,633],"Immediate Implant Placement","Maxillary Tuberosity Graft","Autogenous Bone Graft","Dental Implant","Pink Esthetic Score","2026-03-04",{"date":636,"type":44},"2026-03-10",{"date":638,"type":44},"2026-01-01",{"date":640,"type":21},"2026-11",{"name":50,"class":51},{"id":643,"slug":644,"hasResults":12,"nctId":645,"briefTitle":646,"officialTitle":647,"acronym":4,"eligibilityCriteria":648,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":649,"targetDuration":4,"studyType":22,"phases":651,"briefSummary":652,"conditions":653,"keywords":654,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":663,"lastUpdatePostDateStruct":664,"startDateStruct":666,"completionDateStruct":668,"leadSponsor":670,"locationsCount":4},"100627214","cyanoacrylate-adhesive-in-impacted-mandibular-third-molars-surgery-100627214","NCT07445724","Cyanoacrylate Adhesive in Impacted Mandibular Third Molars Surgery","Evaluation of Soft Tissue Healing and Microbiological Status in Patients Undergoing Surgical Extraction of Impacted Mandibular Third Molars Using Cyanoacrylate Adhesive","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Patients presenting with bilateral mandibular third molars indicated for extraction, with the same level of surgical difficulty according to the Pell-Gregory classification, and an angulation difference between the two teeth not exceeding 15° according to the Winter classification on panoramic radiographs.\n* No use of local or systemic antibiotics within 2 weeks prior to surgery.\n* Absence of serious systemic diseases such as coagulation disorders or uncontrolled diabetes, and no acute infection at the extraction site.\n* Patients who agree to participate in the study after receiving clear explanation and counseling.\n\nExclusion Criteria:\n\n* Patients who are uncooperative in providing necessary information or who decline to continue participation in the study.\n* A difference in surgical duration between the two sides exceeding 12 minutes, or the occurrence of intraoperative complications.\n* Patients with known hypersensitivity or allergy to any materials used in the study, such as lidocaine local anesthetic, cyanoacrylate adhesive, or suture materials.",{"count":650,"type":21},23,[24],"The goal of this randomized clinical trial is to evaluate whether cyanoacrylate tissue adhesive can improve postoperative outcomes compared with conventional silk sutures in patients undergoing surgical removal of impacted mandibular third molars.\n\nThe main questions it aims to answer is: Is there a difference in wound healing support, soft-tissue conditions, and microbiological outcomes at the surgical site of impacted mandibular third molar extraction between closure with conventional sutures and cyanoacrylate tissue adhesive? Researchers will compare cyanoacrylate tissue adhesive with conventional silk sutures to determine whether the adhesive provides superior postoperative recovery and periodontal outcomes.\n\nParticipants will:\n\n* Undergo surgical extraction of an impacted mandibular third molar.\n* Receive wound closure using either cyanoacrylate tissue adhesive or conventional silk sutures.\n* Be followed postoperatively for assessment of pain, swelling, trismus, soft-tissue healing, and periodontal measurements at specified time points.",[242],[655,656,657,658,474,659,660,661,662,248],"impacted mandibular third molar","Cyanoacrylate tissue adhesive","Silk suture","Wound closure","Soft-tissue healing","Periodontal healing","Oral microbiota","Randomized controlled trial","2026-02-25",{"date":665,"type":44},"2026-03-03",{"date":667,"type":21},"2026-03",{"date":669,"type":21},"2026-12",{"name":50,"class":51},""]