[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Science Ho Chi Minh City\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":47},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100654249","thread-embedding-acupuncture-as-an-adjunct-to-proton-pump-inhibitor-therapy-for-gastroesophageal-reflux-disease-100654249",false,"NCT07797959","Thread-Embedding Acupuncture as an Adjunct to Proton Pump Inhibitor Therapy for Gastroesophageal Reflux Disease","Efficacy and Safety of Thread-Embedding Acupuncture as an Adjunct to Proton Pump Inhibitor Therapy in Patients With Gastroesophageal Reflux Disease and Liver-Stomach Stagnation-Heat Syndrome: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18 to 60 years.\n* Diagnosed with gastroesophageal reflux disease (GERD) with a GerdQ score ≥8 and typical heartburn and\u002For regurgitation occurring at least 2 days per week, and considered eligible for proton pump inhibitor therapy according to the ACG 2013 guideline.\n* Meets the diagnostic criteria for Liver-Stomach Heat Stagnation Syndrome according to the 2017 expert consensus on traditional medicine syndrome differentiation for GERD.\n* No previous diagnosis of GERD within the past 8 weeks.\n* Voluntarily agrees to participate in the study and provides written informed consent.\n\nExclusion Criteria:\n\n* Presence of alarm symptoms, including dysphagia, odynophagia, palpable lymph nodes or mass, unintentional weight loss, family history of gastrointestinal malignancy, gastrointestinal bleeding, anemia, or persistent nausea\u002Fvomiting.\n* Structural gastrointestinal disease confirmed by endoscopy, including esophageal malignancy or other significant organic lesions.\n* Current use of medications that may influence GERD assessment or treatment, including glucocorticoids, NSAIDs, bisphosphonates, prostaglandins, oral contraceptives, antifungal agents, or sedative medications.\n* Use of proton pump inhibitors, H2-receptor antagonists, or prokinetic agents within the previous 14 days.\n* History of hypersensitivity to proton pump inhibitors or absorbable catgut\u002Fthread material.\n* Skin inflammation, infection, or other dermatologic disease at or around the intended thread-embedding sites.\n* Current pregnancy or breastfeeding.\n* Currently participating in another interventional clinical study.","ALL","18 Years","60 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate the effectiveness of thread-embedding acupuncture combined with omeprazole in patients with gastroesophageal reflux disease (GERD) presenting with the traditional medicine pattern of Liver-Stomach constraint-heat. Participants will receive either thread-embedding acupuncture combined with omeprazole or the comparator treatment according to the study protocol. Clinical outcomes will be assessed to determine the effectiveness and safety of the intervention.",[27,28],"GERD","Gastroesophageal Reflux Disease",[30,31,32,33,34],"Liver-Stomach constraint-heat","Traditional medicine","Acupoint catgut embedding","Thread-embedding acupuncture","Omeprazole","RECRUITING","2026-08-28",{"date":38,"type":39},"2026-09-01","ACTUAL",{"date":41,"type":39},"2026-04-15",{"date":43,"type":21},"2026-09-18",{"name":45,"class":46},"University of Science Ho Chi Minh City","OTHER",""]