[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Science and Technology, Yemen\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100658128","i-prf-and-microneedling-with-or-without-vitamin-c-for-gingival-phenotype-augmentation-100658128",false,"NCT07848035","Injectable Platelet-Rich Fibrin and Microneedling With or Without Vitamin C for Gingival Phenotype Augmentation.","Effect of Injectable Platelet-Rich Fibrin Combined With Microneedling, With and Without Local Vitamin C Injection, on Gingival Phenotype Augmentation: A Randomized Split-Mouth Controlled Clinical Trial.","Inclusion Criteria:\n\n* Systemically healthy female participants.\n* Age 18 to 65 years.\n* Thin gingival phenotype (\\\u003C1.5 mm).\n* No known blood disorders.\n* Good oral hygiene.\n\nExclusion Criteria:\n\n* Pregnancy.\n* Use of medications known to cause gingival enlargement.\n* History of trauma from occlusion or bruxism.\n* Previous soft-tissue grafting or other periodontal soft-tissue surgery at the study sites.\n* Heavy smoking (\\>10 cigarettes per day).\n* Known allergy or hypersensitivity to vitamin C.\n* Use of vitamin C supplementation within the previous 2 months.","FEMALE","18 Years","65 Years",{"count":20,"type":21},27,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized split-mouth clinical trial will evaluate whether adding locally injected vitamin C to injectable platelet-rich fibrin (i-PRF) and microneedling improves gingival tissue thickness and keratinized tissue width in women with a thin gingival phenotype in the lower front teeth region.\n\nEach participant will receive i-PRF and microneedling on both sides of the lower anterior region. One side will additionally receive vitamin C, while the opposite side will receive normal saline as a placebo. The treatment will be repeated after 4 weeks. Gingival measurements will be taken at baseline, 3 months, and 6 months after the second treatment session. Patient satisfaction will also be assessed during follow-up.",[27],"Thin Gingival Phenotype",[29,30,31,32,33,34,35],"Gingival phenotype","Gingival thickness","Keratinized tissue width","Gingival augmentation","Injectable platelet-rich fibrin","Microneedling","Vitamin C","NOT_YET_RECRUITING","2026-10-01",{"date":39,"type":40},"2026-10-06","ACTUAL",{"date":42,"type":21},"2026-10",{"date":44,"type":21},"2027-07",{"name":46,"class":47},"University of Science and Technology, Yemen","OTHER",""]