[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Strathclyde\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":148},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,72,96,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100659000","examining-a-new-insomnia-treatment-for-people-living-with-secondary-breast-cancer-100659000",false,"NCT07859098","Examining a New Insomnia Treatment for People Living With Secondary Breast Cancer.","Feasibility and Acceptability of a CBT-based Insomnia Intervention for People With Secondary Breast Cancer: a Mixed Methods Randomized Control Trial","ESTABLISH","Inclusion Criteria:\n\n1. Have a diagnosis of secondary breast cancer;\n2. Have a prognosis of greater than 6 months;\n3. Be aged 18 years or over;\n4. Be willing and able to provide informed consent;\n5. Meet screening criteria for chronic insomnia, defined as dissatisfaction with sleep quality and\u002For duration accompanied by associated night-time or daytime symptoms, occurring at least three nights per week for a minimum of three months (assessed by a score of \\\u003C16 on the Sleep Condition Indicator).\n\nExclusion Criteria:\n\n1. Report active suicidal ideation and\u002For recent suicide attempts (measured via item 9 of the Patient Health Questionnaire-9);\n2. Are currently receiving, or have completed within the previous 6 months, CBTi or specific components (e.g., sleep restriction therapy, stimulus control, or cognitive therapy) delivered in a live or one-to-one format OR those who participated in the co-production workshop study to develop the intervention;\n3. Individuals who are currently receiving inpatient hospital treatment, or who are scheduled for inpatient hospital admission during the study intervention period;\n4. Individuals with severe pain that is poorly controlled and\u002For significantly interferes with the individual's ability to engage safely with the study intervention;","ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this trial is to evaluate an intervention designed to improve insomnia and sleep in people living with secondary breast cancer. The study will assess whether the intervention is feasible and acceptable to deliver and participate in, and whether it may improve sleep and related outcomes.\n\nThe main questions the study aims to answer are:\n\n1. Is it feasible to recruit people with secondary breast cancer to take part in the trial?;\n2. Is the intervention feasible for people with secondary breast cancer to use and complete?;\n3. Is the intervention acceptable to participants?;\n4. Does the intervention improve sleep, fatigue, quality of life, and mental health?;\n\nParticipants will be allocated to one of two groups:\n\n1. Intervention group: Participants will be invited to attend five weekly sessions with a trained facilitator to receive the intervention.\n2. Control group: Participants will receive a Sleep Hygiene Education self-help resource to use over a five-week period.\n\nParticipants will complete questionnaires, sleep diaries, and sleep monitoring using a wearable device at three time points: before treatment, immediately after the five-week treatment period, and three months after treatment.\n\nParticipants will also be invited to provide feedback about their experiences of taking part in the study and the intervention through either an interview or survey.\n\nThe results will be used to determine whether the intervention is feasible and acceptable and whether there is evidence of potential benefits for sleep and other outcomes. The findings will help determine whether further research of the intervention is warranted and if there is further intervention development work required.",[27,28],"Insomnia","Breast Cancer Metastatic Breast Cancer",[27,30,31,32,33],"Secondary breast cancer","Metastatic breast cancer","Cognitive Behavioural Therapy for Insomnia","CBT-I","NOT_YET_RECRUITING","2026-09-29",{"date":37,"type":38},"2026-10-05","ACTUAL",{"date":40,"type":21},"2026-09-24",{"date":42,"type":21},"2027-12-31",{"name":44,"class":45},"University of Strathclyde","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100620668","effect-of-technology-enriched-rehabilitation-after-stroke-100620668","NCT07360613","Effect of Technology Enriched Rehabilitation After Stroke","A Pilot Evaluation of the Effectiveness and Economic Impact of a Multi-Technology Rehabilitation Programme for Sub-acute Stroke Patients","EFTERS","Inclusion Criteria:\n\n* Diagnosis of new stroke by NHS Lanarkshire physician\n* More than 48 hours since stroke event\n* Deemed medically fit for rehabilitation by medical staff\n* Deemed to require rehabilitation\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Acutely medically unwell\n* Active cardiac disease, such as unstable angina\n* Active delirium\u002Fsignificant levels of confusion\n* Seizure within past 7 days\n* Individual currently being managed under the Adults with Incapacity Act, unless the responsible medic has noted within the document that the individual has capacity to consent to rehabilitation research\n* Known pregnancy",{"count":56,"type":21},62,[24],"The Biomedical Engineering Dept, University of Strathclyde, co-creates rehabilitation technology. In 2023-2024 a clinical study (NCT06787768) was conducted to understand the feasibility of a multi-technology approach to rehabilitation early after stroke. This was successful and leads to the next phase which is to gather preliminary evidence of the effectiveness of this approach by monitoring change in the mobility of patients who receive this intervention compared with usual care which will be gathered through a data linkage project (tracking the outcomes from matched patients from other parts of Scotland who receive usual care).",[60,61],"Stroke","Rehabilitation",[61,63,60],"Technology","2026-01-16",{"date":66,"type":38},"2026-01-22",{"date":68,"type":21},"2026-04",{"date":70,"type":21},"2028-07",{"name":44,"class":45},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100587430","community-rollout-of-technology-enriched-rehabilitation-after-stroke-an-implementation-study-100587430","NCT06928285","Community Rollout of Technology Enriched Rehabilitation After Stroke: An Implementation Study","CROFTERS","Inclusion Criteria:\n\n* Diagnosis of stroke\n* Currently well\n* Suitable for rehabilitation (motor\u002Fciommunication and or\u002Fcognitive impairment(\n* Able to attend the programme for two hours at least twice a week\n* Able to follow instructions in English and follow provide verbal and\u002For written feedback\n\nExclusion Criteria:\n\n* Absolute contradictions to physical activity\n* Recent (6 weeks) deterioration in health\n* Change in medication\n* Currently unwell",{"count":80,"type":21},120,[24],"The minimum guideline recommendations for rehabilitation after stroke are not being met. This compromises individual recovery and increasing the global burden of disability. A multi-technology solution, co-created with people living with stroke, has been shown to be feasible in both sub-acute and chronic populations but has not been implemented as an integrated rehabilitation service.\n\nThe aim of this implementation study is to assess the ability of a technology enriched model of rehabilitation to deliver guideline recommendations in a range of NHS and local authority settings that provide rehabilitation services to stroke survivors at different stages of their recovery. The findings will be used to co-create a scalable, adaptable, and sustainable model that meets rehabilitation guidelines.",[60],[85,86,87],"rehabilitation","technology","implementation","2025-04-07",{"date":90,"type":38},"2025-04-15",{"date":92,"type":21},"2025-08-01",{"date":94,"type":21},"2028-03-01",{"name":44,"class":45},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":104,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":46},"100584868","amper-proof-of-concept-study-100584868","NCT06894953","AMPER Proof of Concept Study","Proof of Concept Study of the Personalised AMPER System (Agent-based Memory Prosthesis to Encourage Reminiscing).","AMPER","Inclusion Criteria:\n\n\\- Diagnosis of probable Alzheimer's disease of mild to moderate severity according to DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) and NINCS-ADRAD (National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association) criteria.\n\n* Age 50 or older\n* Sensory (visual and auditory), language, and physical abilities adequate to perform assessments (corrective aids allowed).\n* ACE III score between 20 and 82 (inclusive) (or equivalent score on MMSE (between 14 and 24, based on Law et al., 20123 equivalence data) or MOCHA (between 14 and 24 (based on Pendleberry et al., 2011 equivalence data).\n* Having a caregiver or family member who can attend all visits, perform assessments, and supervise administration of study.\n\nExclusion Criteria:\n\n* Medical records indicate AD patients with the visual variant or having colour vision deficits.\n* Medical records indicate a CT or MRI within 24 months prior to screening that indicates a diagnosis other than probable Alzheimer's disease.\n* Medical records indicate any significant neurological disease other than probable AD (e.g. Parkinson's disease, Huntington's disease, brain tumor, normal pressure hydrocephalus, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, history of stroke, or history of head injury requiring hospitalization).\n* On review of medical records, no clinically significant abnormal findings on previous physical examination, medical history, or clinical laboratory results that would indicate an alternative diagnosis.\n* Current history of major psychiatric disorder (e.g. Major depression) (as indicated on medical records)\n* History of substance misuse (as indicated on medical records).","50 Years",{"count":106,"type":21},40,[24],"The AMPER (Agent-based Memory Prosthesis to Encourage Reminiscing) system has been built to help people with Alzheimer's disease by improving their memory recall and quality of life. Alzheimer's often leads to the loss of autobiographical memories, which can affect a person's sense of identity. AMPER seeks to address this by creating a digital memory aid that uses an engaging, animated character on a tablet to help individuals with Alzheimer's reminisce about their past. By presenting personally relevant stories, images, audio, and videos, the character helps trigger memories and encourages interaction with caregivers.\n\nThis is proof of concept study using a randomised controlled trial methodology. Twenty participants will be randomised to the control and 20 randomised to the intervention condition. The intervention group will use a personalised version of the AMPER app with tailored content and the control group will use a non-personalised version without specific adaptations. Over 12 weeks, participants will use the app at home with their caregivers. Researchers will measure changes in their memory and cognitive abilities before and after these 12 weeks.\n\nThe primary goal is to see if personalised reminiscence improves the perceived quality of the reminiscence experience and autobiographical memory ability compared to the same app with a non-personalised approach. This will be measured using a combination of automatically gathered app use data and weekly caregiver feedback. Secondary goals are to investigate any difference between participants in the intervention and control condition in their technology acceptance, quality of life, self-esteem, everyday functioning and cognitive ability.\n\nFeedback from this research will help refine AMPER and inform future studies, with the ultimate goal of creating a widely accessible tool that supports memory and well-being in Alzheimer's patients. Table 1 provides a summary of the study.",[110],"Alzheimer's Dementia (AD)",[112,113,114,115,116,117],"Azheimer's disease","Dementia","Reminiscence","Reminiscence technology","Assistive technology","Intelligent Virtual Agent","2025-03-19",{"date":120,"type":38},"2025-03-25",{"date":122,"type":21},"2025-04-01",{"date":124,"type":21},"2026-02-28",{"name":44,"class":45},{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":136,"phases":4,"briefSummary":137,"conditions":138,"keywords":139,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":145,"leadSponsor":147,"locationsCount":4},"100578088","gait-recovery-after-stroke-100578088","NCT06806748","Gait Recovery After Stroke","Observational Study of Recovery of Gait in Sub-acute Hemiplegic Stroke Patients","GRAS","Inclusion Criteria:\n\n* aged 18 or older\n* diagnosis of a first occurrence of stroke by consultant stroke physician\n* Medically stable\n* referred for rehabilitation\n* functional ambulatory category of 1 and over\n\nExclusion Criteria:\n\n* acute skin condition\n* transient ischemic stroke\n* comorbidities that may interfere with walking function, such as Parkinson's disease or lower limb amputation\n* severe communication impairments or delirium",{"count":135,"type":21},36,"OBSERVATIONAL","The purpose of this observational study is to track the recovery of stance duration symmetry during the first 6 months after stroke using wearable sensors and explore the influence of stroke specific factors (time since stroke, stroke type, location and paretic side).",[60],[140],"Observational, gait, symmetry","2025-01-28",{"date":143,"type":38},"2025-02-04",{"date":92,"type":21},{"date":146,"type":21},"2027-05-10",{"name":44,"class":45},""]