[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of the State of Santa Catarina\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":135},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,52,81,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100649437","telerehab-br-cardiovascular-rehabilitation-models-trial-100649437",false,"NCT07734831","TELEREHAB-BR: Cardiovascular Rehabilitation Models Trial","TELEREHAB-BR: A Pragmatic Randomized Controlled Trial Comparing Traditional, Hybrid Cardiac Telerehabilitation, and Usual Care Models of Cardiovascular Rehabilitation","TELEREHAB-BR","Inclusion Criteria:\n\n* Diagnosis of coronary artery disease (CAD), including patients with or without acute coronary syndrome (ACS), with or without ST-segment elevation, who were hospitalized for clinical management, percutaneous coronary intervention (PCI), or coronary artery bypass grafting (CABG).\n* Patients with heart failure and left ventricular ejection fraction (LVEF) \\>20%. New York Heart Association (NYHA) functional class I-III.\n* Clinically stable patients without limiting angina.\n* Patients who meet the study eligibility criteria and provide informed consent to participate.\n\nExclusion Criteria:\n\n* Decompensated severe heart failure.\n* Unstable angina.\n* Atrial fibrillation with rapid ventricular response.\n* Myocarditis, recent embolism, or thrombophlebitis.\n* Disabling musculoskeletal disorders that preclude participation in the exercise program.\n* History of cardiac arrest with disabling neurological sequelae.\n* Any decompensated medical condition that precludes participation in the study.\n* More than 2 months since hospital discharge before screening.\n* No access to the internet via smartphone or computer.\n* Unable to access or use the online intervention platform.\n* Absence of a caregiver or companion available at home during participation in the study.","ALL","35 Years","80 Years",{"count":21,"type":22},219,"ESTIMATED","INTERVENTIONAL",[25],"NA","Introduction:\n\nCardiovascular diseases remain the leading cause of mortality worldwide. Despite the proven effectiveness of cardiac rehabilitation (CR) programs, adherence remains unsatisfactory, especially in public healthcare systems such as the Brazilian Unified Health System (Sistema Único de Saúde - SUS), due to logistical, geographical, and socioeconomic barriers. In this context, cardiac telerehabilitation (CTR) has emerged as a promising alternative, with effectiveness comparable to traditional center-based cardiac rehabilitation.\n\nHowever, evidence regarding hybrid cardiac telerehabilitation models applicable to the Brazilian context, using simple and low-cost technologies, remains scarce.\n\nObjectives:\n\nTo investigate adherence and its effects on the effectiveness, safety, and maintenance of exercise practice across different models of cardiac rehabilitation, with emphasis on the development and implementation of a hybrid cardiac telerehabilitation (HCTR) model adapted to the Brazilian context.\n\nThe primary outcome will be adherence to the exercise program, defined as participation in at least 75% of the proposed sessions during the 12-week intervention.\n\nSecondary outcomes will include estimated cardiorespiratory fitness, functional capacity, functional mobility, handgrip strength, and health-related quality of life.\n\nAdverse events, digital health literacy, exercise maintenance, hospitalizations, and benefits and barriers to exercise will be evaluated as exploratory variables.\n\nMethods:\n\nThis is a pragmatic, single-center, three-arm parallel randomized clinical trial consisting of hybrid cardiac telerehabilitation (HCTR), traditional center-based cardiac rehabilitation (TCR), and a usual care (UC) group.\n\nA total of 219 participants with coronary artery disease, with or without acute coronary syndrome, and\u002For stable heart failure, who are eligible for Phase II cardiac rehabilitation and receiving care through the Brazilian Unified Health System (Sistema Único de Saúde - SUS), will be enrolled.All participants will undergo standardized clinical and functional assessments at baseline, post-intervention, and short-term follow-up.\n\nClinical screening and exercise stress testing will be performed at the Santa Catarina Institute of Cardiology (Instituto de Cardiologia de Santa Catarina - ICSC), whereas physical assessments and interventions will be conducted at the Center for Cardio-Oncology and Exercise Medicine (Núcleo de Cardio-Oncologia e Medicina do Exercício - NCME), State University of Santa Catarina (UDESC).\n\nThe intervention will last 12 weeks, followed by an additional 12-week short-term follow-up period.\n\nParticipants allocated to the HCTR group will receive a hybrid intervention consisting of face-to-face sessions, synchronous sessions supervised through videoconferencing, and remotely monitored asynchronous activities.\n\nParticipants in the TCR group will participate exclusively in supervised face-to-face sessions, whereas participants in the UC group will receive usual clinical care, including conventional clinical guidance and an educational booklet.\n\nStudy Significance:\n\nThis clinical trial aims to generate evidence regarding adherence, effectiveness, safety, and maintenance of exercise practice across different models of cardiac rehabilitation. Furthermore, it seeks to provide evidence to support the development and implementation of a hybrid cardiac telerehabilitation model adapted to the Brazilian context and the Brazilian Unified Health System (SUS), contributing to expanding access to cardiac rehabilitation through accessible digital technologies.",[28,29,30],"Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))","Chronic Heart Failure","Acute Coronary Syndromes (ACS)",[32,33,34,35,36,37,38],"Coronary Artery Disease","Heart Failure","Cardiac Rehabilitation","Telerehabilitation","Exercise Therapy","Health Literacy","Exercise Adherence","NOT_YET_RECRUITING","2026-07-24",{"date":42,"type":43},"2026-07-29","ACTUAL",{"date":45,"type":22},"2026-08-03",{"date":47,"type":22},"2028-07",{"name":49,"class":50},"University of the State of Santa Catarina","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":51},"100629025","high-intensity-progressive-inspiratory-muscle-training-in-class-iii-obesity-and-obstructive-sleep-apnea-100629025","NCT07469280","High-Intensity Progressive Inspiratory Muscle Training in Class III Obesity and Obstructive Sleep Apnea","High-Intensity Progressive Inspiratory Muscle Training in Class III Obesity and Obstructive Sleep Apnea: Study Protocol for a Prospective Nonconcurrent Multiple-Baseline Single-Case Experimental Design With Stability-Based Phase Transition","Inclusion Criteria: -Adults (≥18 years).\n\n* Of both genders.\n* Class III obesity (BMI \\> 40 kg\u002Fm²).\n* Diagnosis of OSA.\n* Without neurological conditions that would prevent them from responding to the study assessments.\n\nExclusion Criteria:\n\n* Systemic diseases (pulmonary, cardiac or renal).\n* Are using medications that may affect muscle performance.\n* Are currently using CPAP therapy.\n* Conditions that could compromise adherence to the study protocol.","18 Years",{"count":61,"type":22},10,[25],"The purpose of this study is to evaluate the feasibility and effects of a 12-week high-intensity progressive Inspiratory Muscle Training (IMT) program in individuals with Class III obesity (BMI ≥ 40 kg\u002Fm²) and obstructive sleep apnea (OSA). Using a single-case experimental design (SCED) with multiple baselines, the study will investigate whether this respiratory intervention can reduce the severity of sleep apnea, as measured by the Apnea-Hypopnea Index (AHI), and improve inspiratory muscle strength and sleep quality. Participants will perform daily training sessions using a resistive loading device (POWERbreathe), with intensity progressing from 40% to 90% of their maximum inspiratory pressure.",[65,66,67],"Obesity, Class III","Sleep Apnea, Obstructive","Inspiratory Muscle Training",[69,70,71,72],"Class III obesity","Inspiratory muscle training","Obstructive sleep apnea","Single-case experimental design","2026-03-18",{"date":75,"type":43},"2026-03-23",{"date":77,"type":22},"2026-05-01",{"date":79,"type":22},"2027-12-01",{"name":49,"class":50},{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":17,"minAge":59,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":51},"100553359","myofascial-reorganization-on-performance-and-biomechanical-viscoelastic-and-thermographic-properties-of-athletes-100553359","NCT06485063","Myofascial Reorganization on Performance, and Biomechanical, Viscoelastic, and Thermographic Properties of Athletes","Effects of Myofascial Reorganization on Running Performance, and Lower Limb Biomechanical, Viscoelastic, and Thermographic Properties of Triathletes: a Randomized Clinical Trial.","Inclusion Criteria:\n\n* Athletes\n* Age between 18 and 45 years\n* 2 years of competitive experience\n* Non-smokers\n* Training at least 3 times\u002Fweek intending to compete in at least local competitions\n* No presenting lower limb surgery in the last 12 months\n* Not presenting lower limb injury in the last 6 months\n* Not presenting cerebellar diseases that limit sportive practice\n* Not presenting brain diseases that limit sportive practice\n* Not presenting musculoskeletal diseases that limit sportive practice\n* Not presenting signs of rhabdomyolysis\n* Not presenting systemic conditions that limit sportive practice\n* Not presenting metabolic that limits sports practice\n* Not presenting autoimmune conditions;\n* Not presenting cardiac conditions.\n\nExclusion Criteria:\n\n* Not accomplishing 83,3% (10 of 12 sessions) of the proposed experimental\u002Fplacebo protocol\n* Not presenting themselves on the re-test day\n* Developing a lower limb musculoskeletal injury during the study's ongoing period.\n* Developing a back injury during the study's ongoing period?\n* Developing central or peripheral nervous system conditions during the study's ongoing period.",true,"45 Years",{"count":91,"type":22},60,[25],"This is a two-group randomized clinical trial (includes an experimental and a placebo group) to verify the effects of the Myofascial Reorganization (RMF) compared to the placebo-RMF technique on running performance and thermographic, biomechanical, and viscoelastic proprieties of lower limbs of male triathletes. Data collection will be carried out one week before the first intervention session, and one week after the last intervention session. Anthropometric characteristics (height and weight), lower limbs, and biomechanical, viscoelastic, and thermographic properties will be collected before any exercise tests. After this, the athlete will be submitted to: a 10-minute protocol to verify running economy on the treadmill, followed by an incremental test on the treadmill, and a time to exhaustion test. Evaluation procedures will carried out one week before (0 weeks) and one week after (7th week) the experimental\u002Fplacebo intervention. Intervention sessions will occur during six weeks, twice a week, each session lasting up to 30 minutes.",[95],"Healthy",[97,98,99,100],"athletes","performance","healthy","fascia","RECRUITING","2024-06-26",{"date":104,"type":43},"2024-07-03",{"date":106,"type":43},"2024-04-15",{"date":108,"type":22},"2025-12-31",{"name":49,"class":50},{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":121,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":4},"100520339","effects-of-intradialytic-aerobic-exercise-in-chronic-kidney-patients-100520339","NCT06055283","Effects of Intradialytic Aerobic Exercise in Chronic Kidney Patients","Effects of Intradialytic Aerobic Exercise on Peripheral Muscle Function, Functional Status and Motivation in Chronic Kidney Patients: A Randomized Controlled Clinical Trial","IAECKD","Inclusion Criteria:\n\n* diagnosis of chronic kidney disease undergoing renal replacement therapy via hemodialysis\n* aged 20 to 65 years\n* low body mass index at overweight (21 kg\u002Fm2 to 29.9 kg\u002Fm2)\n* regular renal replacement therapy via hemodialysis for 6 months, without acute complications related to the diagnosis and\u002For comorbidities for the period of 3 months prior to the evaluation and intervention.\n\nExclusion Criteria:\n\n* patients who do not reach a score equal to or above 20 assessed by the Mini Mental State Examination\n* severe heart failure according to the New York Heart Association classification\n* musculoskeletal alteration that prevents the correct execution of the assessment activities\n* who have participated in other exercise protocols in the last 6 months prior to the present study\n* patients who show signs of clinical instability during the hemodialysis procedure or after training for two consecutive sessions will be excluded throughout the protocol.","65 Years",{"count":120,"type":22},90,[25],"The goal of this clinical trial is to evaluate the effects of intradialytic aerobic exercise on muscle capacity, functionality and motivation of patients with chronic kidney disease undergoing hemodialysis.\n\nThe main question it aims to answer are:\n\n• Is intradialytic aerobic exercise at moderate intensity effective in improving peripheral muscle function, functional status and motivation in patients with chronic kidney disease?",[124],"Chronic Kidney Diseases",[126],"Chronic Kidney Disease","2023-09-19",{"date":129,"type":43},"2023-09-26",{"date":131,"type":22},"2023-11",{"date":133,"type":22},"2026-12-31",{"name":49,"class":50},""]