[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Vasiliki Samartzi\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100658109","esmolol-versus-dexmedetomidine-for-opioid-sparing-in-laparoscopic-gynecological-surgery-100658109",false,"NCT07846722","Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery","The Impact of Intraoperative Esmolol and Dexmedetomidine Administration on Opioid Consumption in Laparoscopic Gynecological Procedures: A Double-blinded Randomized Study","Inclusion Criteria:\n\n* adult patients\n* American Society of Anesthesiologists (ASA) classification I-II\n* Laparoscopic hysterectomy\n\nExclusion Criteria:\n\n* body mass index (BMI) \\>35 kg\u002Fm2\n* β-blocker administration preoperatively\n* systematic use of analgesic agents preoperatively\n* chronic pain syndromes preoperatively\n* neurological or psychiatric disease on treatment\n* pregnancy\n* severe hepatic or renal disease\n* history of cardiovascular diseases\u002F arrhythmias\u002F conduction abnormalities\n* hemodynamic instability\n* patients with a known malignancy or undergoing surgery for oncological reasons\n* known allergy to a local anesthetic\n* drug or alcohol abuse\n* language or communication barriers\n* lack of informed consent","FEMALE","20 Years","70 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in patients undergoing laparoscopic hysterectomy.",[27,28,29,30,31,32],"Pain, Acute Post-Operative","Dexmedetomidine","Analgesia","Esmolol","Nociceptive Pain","Laparoscopic Hysterectomy","RECRUITING","2026-09-22",{"date":36,"type":37},"2026-09-29","ACTUAL",{"date":39,"type":37},"2026-07-15",{"date":41,"type":21},"2027-02-01",{"name":43,"class":44},"Vasiliki Samartzi","OTHER",""]