[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Vietnam Military Medical University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":110},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100640272","effectiveness-of-live-motile-sperm-sorting-device-on-ivf-outcomes-in-advanced-paternal-age-100640272",false,"NCT07605182","Effectiveness of Live Motile Sperm Sorting Device on IVF Outcomes in Advanced Paternal Age","Evaluation of the Effectiveness of Live Motile Sperm Sorting Device on In Vitro Fertilization Outcomes in Advanced Paternal Age Group","IVF","Inclusion Criteria:\n\n* Male partners aged ≥ 40 years\n* Semen analysis: volume ≥ 1.4 mL, sperm concentration ≥ 6 million\u002FmL, progressive motility (PR) ≥ 20% after 3-5 days of abstinence.\n* Female partners with ≥ 5 mature (MII) oocytes retrieved.\n* Couples undergoing ICSI with PGT-A and elective single embryo transfer (eSET).\n* Willingness to participate and sign informed consent.\n\nExclusion Criteria:\n\n* Azoospermia, surgical sperm retrieval, or use of cryopreserved sperm.\n* Female uterine or ovarian conditions severely affecting IVF outcomes.\n* Use of donor sperm or donor oocytes","ALL","40 Years",{"count":20,"type":21},378,"ESTIMATED","INTERVENTIONAL",[24],"NA","Male infertility contributes significantly to infertility, particularly in advanced paternal age men where sperm DNA fragmentation is increased. Conventional density gradient centrifugation may induce oxidative stress and sperm damage. LensHooke® CA0 is a centrifugation-free sperm sorting device designed to improve sperm quality and reduce DNA fragmentation. This prospective comparative study evaluates the effectiveness of CA0 versus conventional density gradient centrifugation on post-processing sperm quality, DNA fragmentation index, blastocyst formation, euploid embryo rate, and clinical pregnancy outcomes in IVF\u002FICSI cycles involving men aged 40 years or older",[27,28,29],"Male Infertility","Advanced Paternal Age","Assisted Reproductive Technology",[31,32,33,34],"DNA fragmentation","Advanced paternal age","ICSI","LensHooke CA0","RECRUITING","2026-08-18",{"date":38,"type":39},"2026-08-20","ACTUAL",{"date":41,"type":39},"2026-07-15",{"date":43,"type":21},"2027-12-30",{"name":45,"class":46},"Vietnam Military Medical University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":47},"100652396","225-iu-versus-300-iu-starting-fsh-dose-in-ppos-for-good-prognosis-women-100652396","NCT07772375","225 IU Versus 300 IU Starting FSH Dose in PPOS for Good-Prognosis Women","A Randomized Controlled Trial Comparing 225 IU Versus 300 IU Starting Doses of Follicle-Stimulating Hormone in Progestin-Primed Ovarian Stimulation for Women With Good Prognosis","FSH-PPOS","Inclusion Criteria:\n\n* Female patient or oocyte donor aged \\\u003C35 years.\n* Body mass index (BMI) between 18 and 25 kg\u002Fm².\n* Normal ovarian reserve, defined by:\n\n  * Antral follicle count (AFC) ≥8 on ultrasound; and\n  * AMH level between 1.5 and 4.5 ng\u002FmL.\n* First IVF treatment cycle.\n* Controlled ovarian stimulation using a progestin-primed ovarian stimulation (PPOS) protocol with recombinant FSH and dydrogesterone.\n* Indication for in vitro fertilization using intracytoplasmic sperm injection (ICSI).\n* Indication for extended embryo culture to the blastocyst stage.\n* Willingness to participate in the study and provision of written informed consent.\n\nExclusion Criteria:\n\n* Polycystic ovary syndrome (PCOS) diagnosed according to the Rotterdam criteria, currently referred to as polyendocrine metabolic ovarian syndrome (PMOS).\n* Structural abnormalities of the ovaries.\n* Ovarian endometriosis.\n* Medical or gynecological conditions that may affect ovarian response to controlled ovarian stimulation.\n* Indication for luteinizing hormone (LH) supplementation during controlled ovarian stimulation.\n* Poor sperm quality, cryptozoospermia, surgically retrieved sperm (PESA, TESE, or microTESE), cryopreserved sperm, or donor sperm.\n* Indication for artificial oocyte activation (AOA) or rescue ICSI (R-ICSI).","FEMALE","18 Years","34 Years",{"count":60,"type":21},380,[24],"This randomized controlled trial will compare two starting doses of follicle-stimulating hormone (FSH), 225 IU and 300 IU, during progestin-primed ovarian stimulation (PPOS) in women undergoing in vitro fertilization (IVF) who have a good reproductive prognosis. Participants will be randomly assigned to receive either 225 IU or 300 IU of FSH at the start of ovarian stimulation. The study will evaluate whether the starting FSH dose affects oocyte and embryo outcomes, with blastocyst formation as the primary outcome. Other outcomes will include oocyte morphology, fertilization, embryo development, and embryo quality. The findings may help determine an appropriate starting FSH dose for women with a good prognosis undergoing IVF using the PPOS protocol.",[64,65],"Infertility (IVF Patients)","Infertility Assisted Reproductive Technology",[67,68,69,70,71],"Progestin-primed ovarian stimulation","PPOS","FSH dose","Embryo quality","blastulation","NOT_YET_RECRUITING","2026-08-17",{"date":75,"type":39},"2026-08-19",{"date":77,"type":21},"2026-08-15",{"date":79,"type":21},"2029-08-31",{"name":45,"class":46},{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":97,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":47},"100572430","the-impact-of-peep-guided-electrical-impedance-tomography-on-oxygenation-and-pulmonary-mechanics-in-moderate-to-severe-ards-100572430","NCT06733168","The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS","PEEP","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Intubated moderate and severe ARDS according to the New Global Definition (PaO2\u002FFiO2 ≤200 mmHg).\n* Used continuous sedation with or without paralysis.\n\nExclusion Criteria:\n\n* Presence of pneumothorax that is either undrained or newly occurred.\n* Unstable hemodynamics with a mean arterial pressure \\\u003C 60 mmHg and unresponsive to resuscitation measures, and\u002For heart rate \\\u003C 60 bpm.\n* Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application).\n* Pregnancy.\n* Severe neuromuscular disease.",{"count":89,"type":21},76,[24],"Acute respiratory distress syndrome (ARDS) in its moderate to severe forms is associated with high mortality. Mechanical ventilation (MV) remains the cornerstone of ARDS management but carries a significant risk of ventilator-induced lung injury (VILI). Positive end-expiratory pressure (PEEP), a fundamental component of MV, is widely utilized in clinical practice; however, optimal PEEP selection for patients with moderate to severe ARDS remains a complex and unresolved challenge. Electrical impedance tomography (EIT), a bedside imaging modality that evaluates regional ventilation distribution, offers a means of individualizing PEEP settings in mechanically ventilated patients. By balancing the competing risks of alveolar overdistension and collapse, EIT facilitates precision in PEEP titration. This study compares the impact of EIT-guided PEEP selection versus the conventional low FiO2-PEEP table on blood oxygenation and pulmonary mechanics.",[93,94,95,96],"Acute Respiratory Syndrome Distress","Positive End-Expiratory Pressure","Mechanical Ventilation","Electrical Impedance Tomography (EIT)",[98,95,94,99,100,101],"Acute respiratory syndrome distress","electrical impedance tomography","blood oxygenation","pulmonary mechanics","2024-12-09",{"date":104,"type":39},"2024-12-13",{"date":106,"type":39},"2024-08-15",{"date":108,"type":21},"2026-12-30",{"name":45,"class":46},""]