[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Wah Medical college , POF hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":77},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100654477","phase-4-efficacy-of-topical-lidocaine-gel-vs-oral-duloxetine-for-painful-diabetic-peripheral-neuropathy-100654477",false,"NCT07800468","Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy","Comparison of the Efficacy of Topical Lidocaine Gel Versus Oral Duloxetine in the Treatment of Painful Diabetic Peripheral Neuropathy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged 30 to 70 years\n* Confirmed type 2 diabetes mellitus (as per WHO 2019 criteria) for at least 1 year\n* HbA1c \\\u003C or = 10% (or documented stable glycemic control over the preceding 3 months)\n* Diagnosis of painful diabetic peripheral neuropathy (PDPN) with a DN4 score \\> or = 4\u002F10\n* Baseline Numeric Rating Scale (NRS) pain score \\>= 4\u002F10 (moderate-to-severe pain)\n* Willing and able to provide written informed consent\n\nExclusion Criteria:\n\n* Known hypersensitivity or contraindication to lidocaine or duloxetine\n* Current use of other neuropathic pain medications (gabapentinoids, tricyclic antidepressants, opioids, or topical capsaicin) within 4 weeks of enrollment\n* Significant hepatic impairment (ALT or AST \\> 3 times the upper limit of normal)\n* Severe renal impairment (eGFR \\\u003C 30 mL\u002Fmin\u002F1.73 m²)\n* Active skin lesions, open wounds, or dermatological conditions at the intended application site on the feet\n* Pregnant or lactating females\n* Other causes of peripheral neuropathy (e.g., alcohol-related, hypothyroidism, vitamin B12 deficiency, or Charcot-Marie-Tooth disease)","ALL","30 Years","70 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The goal of this clinical trial is to learn if topical lidocaine gel can effectively reduce pain intensity compared to oral duloxetine in adult patients (aged 30-70 years) with type 2 diabetes suffering from painful diabetic peripheral neuropathy. The main questions it aims to answer are:\n\nIs there a significant difference in the reduction of pain intensity (measured by the Numeric Rating Scale) between topical lidocaine 2% gel and oral duloxetine after 8 weeks of treatment?\n\nHow does the safety and tolerability profile of topical lidocaine gel compare with oral duloxetine in this patient population?\n\nResearchers will compare Group A (Topical Lidocaine 2% gel applied to the affected areas of both feet twice daily) to Group B (Oral Duloxetine 60 mg taken once daily) to see if topical lidocaine provides comparable pain relief to oral duloxetine with a reduction in systemic adverse drug reactions.\n\nParticipants will:\n\nComplete a baseline clinical assessment, including nerve pain evaluation using the DN4 questionnaire and rating their pain severity on the Numeric Rating Scale (NRS).\n\nBe randomly assigned to receive either topical lidocaine 2% gel applied twice daily to both feet or oral duloxetine capsules (30 mg once daily for 2 weeks, then escalated to 60 mg once daily) for 8 consecutive weeks.\n\nMaintain their existing routine antidiabetic medications throughout the study.\n\nAttend an interim safety check visit at Week 4 to report and document any side effects or adverse drug reactions.\n\nAttend a final evaluation visit at Week 8 to record their post-treatment NRS pain score and complete safety reporting.",[27,28,29],"Painful Diabetic Neuropathy (PDN)","Diabetic Neuropathies","Type 2 Diabetes",[31,32,33,34,35,36,37],"Topical Lidocaine Gel","Duloxetine","Neuropathic Pain","Diabetic Peripheral Neuropathy","Numeric Rating Scale (NRS)","DN4 Questionnaire","Analgesics","NOT_YET_RECRUITING","2026-08-28",{"date":41,"type":42},"2026-09-02","ACTUAL",{"date":44,"type":21},"2026-12-01",{"date":46,"type":21},"2027-04-01",{"name":48,"class":49},"Wah Medical college , POF hospital","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100642291","phase-4-comparison-of-intraperitoneal-bupivacaine-and-saline-irrigation-for-pain-relief-after-laparoscopic-cholecystectomy-100642291","NCT07650760","Comparison of Intraperitoneal Bupivacaine and Saline Irrigation for Pain Relief After Laparoscopic Cholecystectomy","Comparison of Intraperitoneal Bupivacaine and Normal Saline Irrigation for Postoperative Pain Relief After Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* • Adult consented patients of any gender aged 18 to 60 years Fit to undergo elective laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* • Patients who had developed choledocholithiasis or pancreatitis pre-operatively\n\n  * Where conversion to open cholecystectomy is needed intraoperatively\n  * Pregnant or lactating\n  * Inability to express pain appropriately, like in psychiatric disorders\n  * With any contraindication to the use of bupivacaine or normal saline, e.g., hypersensitivity","18 Years","60 Years",{"count":60,"type":21},106,[24],"This randomized clinical trial compared intraperitoneal irrigation of bupivacaine(a local anesthetic) vs a control group receiving normal saline for relief of post operative pain following laparoscopic gallbladder surgery. A total of 106 patients divided into two equal groups, with one group receiving bupivacaine and the other treated using normal saline(control).Previous studies on the subject found that bupivacaine significantly reduced postoperative pain. Although conventional intravenous analgesics remain widely used, bupivacaine may be a better option, especially in difficult surgical cases.",[64],"Postoperative Pain",[66],"laparoscopic cholecystectomy","RECRUITING","2026-06-13",{"date":70,"type":42},"2026-06-16",{"date":72,"type":21},"2026-07-01",{"date":74,"type":21},"2026-12",{"name":48,"class":49},1,""]