[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Xinghua Liu\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":69},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100648021","exploring-the-feasibility-and-effectiveness-of-a-mied-based-adolescent-mindfulness-intervention-group-for-youth-with-emotional-distress-100648021",false,"NCT07715916","Exploring the Feasibility and Effectiveness of a MIED-Based Adolescent Mindfulness Intervention Group for Youth With Emotional Distress","Inclusion Criteria:\n\n* Age 12-18 years, minors (junior and senior high school level; special note: individuals who exceed the age criterion due to dropout or leave of absence but are still in junior or senior high school may be included if they meet all other inclusion criteria).\n* PHQ-9 total score 10-19 or GAD-7 total score 10-14 (either criterion is sufficient, indicating mild to moderate depressive or anxiety symptoms).\n* Informed consent from both the participant and their parent\u002Flegal guardian.\n\nExclusion Criteria:\n\n* PHQ-9 total score ≥20 or GAD-7 total score ≥15, or clinical diagnosis of anxiety or depressive disorder (if severe depression or anxiety, referral to individual therapy is recommended).\n* PHQ-9 item 9 score ≥2 and clinical interview confirming active suicidal ideation or plan.\n* Presence of psychotic symptoms, bipolar disorder, or severe self-harm behaviors (requiring medical treatment).\n* Currently receiving other systematic psychotherapy.\n* Severe cognitive or developmental disorders that prevent understanding of group content.\n* Unable to use a smartphone (affecting use of AI-assisted tools).","ALL","12 Years","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","Background: Adolescent emotional distress (anxiety and depressive symptoms) is rising globally. The detection rate of depression risk among Chinese middle and high school students reaches 24.6%, with anxiety risk at 18.1%. These conditions show high comorbidity, high recurrence, and high disability rates, seriously affecting adolescents' academic performance, social relationships, and quality of life. Mindfulness-Based Interventions (MBIs) have shown significant effects in children and adolescent populations; meta-analyses indicate a moderate effect size on adolescent internalizing problems (Hedges' g = 0.47). Group-based adolescent mindfulness interventions are feasible, as the group format improves efficiency, reduces costs, and provides social support. However, existing research still has limitations in cultural adaptation and systematic intervention design. The MIED (Mindfulness Intervention for Emotional Distress) systematic theory was developed by researcher Liu Xinghua based on MBSR\u002FUP. Its core theory is the \"Diamond Model\" of emotional distress, identifying four core maintenance mechanisms: engagement in life, distress tolerance regulation, emotional behavior regulation, and cognitive flexibility enhancement. Adult studies on MIED have shown significant improvements in emotional distress symptoms, but no specialized research has been conducted in adolescent populations.\n\nMethods: This study is a feasibility exploratory study employing a single-group pre-post design, planning to recruit 24-30 adolescents aged 12-18 years with emotional distress, to undergo an 8-week MIED adolescent mindfulness intervention group. Data will be collected at multiple time points: baseline, after session 4, after session 8, and at 1-month follow-up.\n\nObjectives: The primary objective is to evaluate the feasibility of the MIED-based adolescent mindfulness intervention group (recruitment feasibility, retention feasibility, implementation feasibility, acceptability, and safety). The secondary objective is to preliminarily assess the intervention's effectiveness on outcomes such as anxiety, depression, and stress, estimate effect sizes, and provide methodological preparation for subsequent large-scale randomized controlled trials (RCTs).",[26],"Emotional Distress",[26,28,29,30,31,32],"Adolescent","Mindfulness Intervention Group","Feasibility","Effectiveness","MIED-based","NOT_YET_RECRUITING","2026-07-20",{"date":36,"type":37},"2026-07-21","ACTUAL",{"date":34,"type":20},{"date":40,"type":20},"2027-05-31",{"name":42,"class":43},"Xinghua Liu","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":15,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},"100643870","mindfulness-intervention-for-emotional-distress-mied-in-patients-with-gerd-100643870","NCT07667894","Mindfulness Intervention for Emotional Distress (MIED) in Patients With GERD","Effects of an Online Mindfulness-Based Emotion Intervention on Symptoms and Emotional Distress in Patients With Gastroesophageal Reflux Disease: A Multicenter Randomized Waitlist-Controlled Trial","Inclusion Criteria\n\nParticipants must meet all of the following criteria:\n\n1. Aged 18 to 65 years.\n2. GERD-Q score of 8 or higher.\n3. Willingness to maintain a relatively stable usual treatment regimen during the study unless medically indicated changes are required.\n4. Ability to use a smartphone, computer, or tablet to participate in the online program and complete online questionnaires.\n5. Willingness to comply with course training and follow-up assessments.\n6. Ability to understand the study and provide written or electronic informed consent.\n\nExclusion Criteria\n\nParticipants meeting any of the following criteria will be excluded:\n\n1. Alarm symptoms or high suspicion of serious organic disease, including but not limited to progressive dysphagia, hematemesis, melena, unexplained weight loss, anemia, recurrent vomiting, or persistent chest pain without exclusion of cardiovascular risk.\n2. Current or previous severe esophageal organic disease or gastrointestinal malignancy.\n3. History of anti-reflux surgery, partial gastrectomy, or other upper gastrointestinal surgery that may substantially affect reflux symptom assessment.\n4. GERD-Q score greater than 15, or symptoms judged by the study physician to be extremely severe and requiring priority medical evaluation or intensified treatment.\n5. Current uncontrolled severe mental disorder, such as schizophrenia, manic episode of bipolar disorder, acute severe depressive episode, or severe substance use disorder.\n6. Current suicide risk, operationalized as a score greater than 1 on item 9 of the PHQ-9.\n7. Previous systematic participation in MIED, mindfulness-based stress reduction, mindfulness-based cognitive therapy, or another structured mindfulness program.","65 Years",{"count":53,"type":20},500,[23],"The goal of this multicenter randomized waitlist-controlled clinical trial is to evaluate whether an online Mindfulness-Based Intervention for Emotional Distress (MIED) can reduce emotional distress and reflux-related symptoms in adults with gastroesophageal reflux disease (GERD). GERD is a common chronic gastrointestinal condition that is frequently accompanied by anxiety, depressive symptoms, stress, and impaired quality of life.\n\nThe main questions this study aims to answer are:\n\nCan online MIED reduce emotional distress in patients with GERD?\n\nCan online MIED reduce reflux-related symptoms and improve reflux-related quality of life?\n\nAre changes in psychological processes, such as distress tolerance, cognitive flexibility, experiential avoidance, emotional behaviors, and life engagement, associated with improvements in emotional distress and reflux symptoms?\n\nResearchers will compare participants receiving online MIED with participants in a waitlist control group receiving usual medical care and health management to determine whether online MIED leads to greater improvement over time.\n\nParticipants will:\n\ncomplete screening and baseline assessments;\n\nbe randomly assigned to either the online MIED intervention group or the waitlist control group;\n\nif assigned to the intervention group, complete an 8-week online MIED program with one session per week;\n\ncontinue necessary usual medical care during the study, while keeping medication use stable when possible;\n\ncomplete online questionnaires at baseline, during the intervention, after the intervention, and at 3, 6, 12, and 24 months after the intervention;\n\nreport information on reflux symptoms, emotional distress, quality of life, sleep, stress, resilience, life satisfaction, healthcare use, intervention adherence, and adverse events.",[57,26],"Gastroesophageal Reflux Disease",[26,57,59],"Mindfulness Intervention for Emotional Distress","2026-06-19",{"date":62,"type":37},"2026-06-25",{"date":64,"type":20},"2026-07-01",{"date":66,"type":20},"2028-05-15",{"name":42,"class":43},15,""]