[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Yunliang Zhang\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":61},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100650408","the-effect-of-brain-endurance-training-on-motor-skill-learning-in-adolescents-with-mild-mental-fatigue-100650408",false,"NCT07746557","The Effect of Brain Endurance Training on Motor Skill Learning in Adolescents With Mild Mental Fatigue","Inclusion Criteria:\n\n* Participants assessed as having mild mental fatigue using the Mental Fatigue VAS scale\n* No prior experience in learning specific motor skills\n* In good physical health, with no history of central nervous system disorders, musculoskeletal injuries, or mental health conditions\n\nExclusion Criteria:\n\n* Individuals with moderate to severe mental fatigue or no mental fatigue\n* Individuals with moderate to severe mental fatigue or no mental fatigue\n* Individuals with a history of traumatic brain injury, epilepsy, chronic headaches, ADHD, anxiety, or depression - Individuals who have sustained a musculoskeletal injury within the past month and are unable to complete standardized exercise routines\n* Individuals taking medications that affect central nervous system function on a long-term basis, or who have consumed caffeine, energy drinks, or alcohol within 24 hours prior to the experiment - Individuals with persistent sleep disorders\n* Individuals unable to cooperate in completing cognitive endurance training and motor skill tests.Individuals with a history of traumatic brain injury, epilepsy, chronic headaches, ADHD, anxiety, or depression\n* Individuals who have sustained a musculoskeletal injury within the past month and are unable to complete standardized exercise routines\n* Individuals taking medications that affect central nervous system function on a long-term basis, or who have consumed caffeine, energy drinks, or alcohol within 24 hours prior to the experiment\n* Individuals with persistent sleep disorders - Individuals unable to cooperate in completing cognitive endurance training and motor skill tests.","FEMALE","18 Years","19 Years",{"count":19,"type":20},58,"ESTIMATED","INTERVENTIONAL",[23],"NA","Objective: To investigate the effects of brain endurance training on improving motor skill learning in adolescents with mild mental fatigue. Methods: Fifty-eight adolescents experiencing mild mental fatigue were recruited. A 6-week training program was conducted using a 2 (BET group, control group) × 2 (pre- and post-Stroop task) × 3 (0, 3, 6 weeks) mixed-design experimental design. Assessments included basketball free throws, the Visual Analog Scale (VAS-MF), the 3-minute Psychomotor Vigilance Test (PVT-B), the Borg Rating of Perceived Exertion (RPE) to assess performance before and after a 30-minute Stroop task.",[26,27],"Mental Fatigue","Motor Skill Learning","NOT_YET_RECRUITING","2026-08-03",{"date":31,"type":32},"2026-08-05","ACTUAL",{"date":34,"type":20},"2026-08-02",{"date":36,"type":20},"2026-09-19",{"name":38,"class":39},"Yunliang Zhang","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":46,"targetDuration":4,"studyType":21,"phases":48,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":4},"100648776","the-effects-of-caffeine-and-vitamin-c-on-maximum-strength-and-strength-endurance-in-adolescents-with-mild-mental-fatigue-100648776","NCT07726745","The Effects of Caffeine and Vitamin C on Maximum Strength and Strength Endurance in Adolescents With Mild Mental Fatigue","Inclusion Criteria:\n\n1. Aged between 18and 19years (adolescent)\n2. Able to complete standardized 1RM maximal strength test and muscular endurance protocol for back squat and bench press\n3. Meet criteria for mild mental fatigue verified by validated scale (PVT + VAS Mental Fatigue ≥4\u002F10 or Brief Fatigue Inventory) prior to experimental session\n4. Habitual daily caffeine intake ≤ 150 mg\u002Fday (low-to-moderate habitual consumption)\n5. Non-smoker; no regular alcohol consumption\n6. Consistent strength training status: No physical training for the past 3 months, or maintenance of a consistent daily activity routine throughout the study\n7. Able to attend all scheduled testing visits, comply with pre-test restrictions (diet, sleep, exercise, supplements)\n8. Participant provides written assent; parent\u002Flegal guardian provides written informed consent\n9. Able to understand and follow verbal and written study instructions\n\nExclusion Criteria:\n\n1. History of cardiovascular disease, arrhythmia, hypertension, asthma requiring regular medication\n2. Known hypersensitivity or adverse reaction to caffeine, vitamin C\n3. Chronic neurological disorders: epilepsy, migraine disorder, ADHD with stimulant medication\n4. Current psychiatric diagnosis (anxiety, depression) receiving psychotropic medication\n5. Musculoskeletal injury in the past 3 months limiting lower\u002Fupper body maximal strength testing\n6. Regular intake of ergogenic supplements (creatine, beta-alanine, energy drinks) within 4 weeks before screening\n7. Use of any stimulants, anti-fatigue drugs, corticosteroids within 30 days prior to enrollment\n8. Chronic gastrointestinal disease, kidney stone history (vitamin C related risk)\n9. Irregular sleep-wake cycle, diagnosed sleep disorder\n10. Females: current pregnancy; regular oral contraceptive use\n11. Participated in other human intervention trials within past 8 weeks\n12. Investigator judges any condition that compromises participant safety or interferes with outcome measurements",{"count":47,"type":20},40,[23],"Objective To investigate the independent and combined effects of caffeine and vitamin C on maximal strength and strength endurance in female adolescents with mild mental fatigue.\n\nMethods A randomised, double-blind, crossover experimental design was adopted. Forty female college students presenting mild mental fatigue were recruited as participants. Each participant completed five laboratory sessions in total. The first session determined their one-repetition maximum (1RM) for bench press and back squat. The remaining four experimental sessions involved four supplement interventions administered in random order: placebo control, vitamin C (VC) alone, caffeine (CAF) alone, and combined caffeine plus vitamin C (CAF+VC). A one-week washout interval was arranged between every two supplementation trials.\n\nIn each test session, participants completed a 45-min Stroop task to induce mental fatigue prior to exercise assessments. Measurements included the Visual Analogue Scale for Mental Fatigue (VAS-MF), 1RM bench press and squat performance, as well as the maximal number of repetitions at 65% 1RM for both movements. Immediately after the strength endurance test, perceived exertion and muscle pain were rated. Blood glucose and blood lactate concentrations were sampled before and after all exercise protocols.\n\nSupplementation was administered 1 hour prior to testing: a standard caffeine dosage of 3.0 mg per kg body mass and a single 500 mg dose of vitamin C were provided for the corresponding intervention groups.",[51,52,26],"Maximum Force","Strength Endurance","2026-07-23",{"date":55,"type":32},"2026-07-27",{"date":57,"type":20},"2026-07-25",{"date":59,"type":20},"2026-09-22",{"name":38,"class":39},""]