[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Zeynep Serra Kalkan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100653779","evaluation-of-temporomandibular-disorders-during-pregnancy-100653779",false,"NCT07791173","Evaluation of Temporomandibular Disorders During Pregnancy","Inclusion Criteria:\n\n* Aged 18-40 years\n* Singleton, healthy pregnancy\n* Presenting to the Obstetrics and Gynecology outpatient clinic during the first trimester (weeks 8-12)\n* No history of systemic rheumatic disease, chronic pain syndrome, or serious psychiatric illness\n* No prior orthodontic treatment\n* Written informed consent after being informed about the purpose and scope of the study\n\nExclusion Criteria:\n\n* Prior treatment for temporomandibular disorders (splint, botulinum toxin, surgery, etc.)\n* History of maxillofacial trauma or temporomandibular joint surgery\n* Systemic rheumatic disease, connective tissue disease, or chronic pain syndrome\n* Use of systemic corticosteroids or hormone replacement therapy\n* Pregnancy achieved through assisted reproductive techniques (e.g., IVF)\n* Refusal to consent to blood sampling or questionnaire administration\n* Language barrier preventing understanding and completion of Turkish-language questionnaires","FEMALE","18 Years","40 Years",{"count":19,"type":20},60,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate how temporomandibular disorders (TMD) - a condition affecting the jaw joint and chewing muscles - change during pregnancy. The same pregnant women will be assessed twice: once in the first trimester (weeks 8-12) and again in the third trimester (weeks 28-32). At each visit, researchers will examine jaw function and pain, and collect blood samples to calculate inflammation markers from routine complete blood counts. Where participants additionally consent, blood samples will also be used to measure hormone levels (estrogen and progesterone). Participants will also complete questionnaires about pain, stress and jaw-related habits. The goal is to better understand whether hormonal and inflammatory changes during pregnancy are associated with the development or worsening of TMD symptoms.",[24,25],"Temporomandibular Disorders (TMD)","Pregnancy",[27,25,28,29,30,31,32,33],"Temporomandibular Joint Disorders","DC\u002FTMD","Estrogen","Progesterone","Systemic Immune-Inflammation Index","Chronic Pain","Prospective Cohort Study","NOT_YET_RECRUITING","2026-08-25",{"date":37,"type":38},"2026-08-27","ACTUAL",{"date":40,"type":20},"2026-09",{"date":42,"type":20},"2027-05",{"name":44,"class":45},"Zeynep Serra Kalkan","OTHER",""]