[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"abdominal-wall-defect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:abdominal-wall-defect":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,53,77,97,134],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100648811","risk-factors-for-mesh-infection-after-abdominal-wall-reconstruction-100648811",false,"NCT07725718","Risk Factors for Mesh Infection After Abdominal Wall Reconstruction","Risk Factors for Mesh-Related Infection in Abdominal Wall Reconstruction: A Single-Centre Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Adults aged ≥18 years.\n* Undergoing elective or urgent abdominal wall reconstruction with implantation of synthetic, biosynthetic or biological mesh for a ventral, incisional, parastomal or complex abdominal wall defect.\n* Able and willing to provide written informed consent and to attend scheduled follow-up.\n\nExclusion Criteria:\n\n* Suture-only repair without mesh.\n* Inguinal or femoral (groin) hernia repair.\n* Active systemic sepsis or established intra-abdominal mesh infection at the time of index surgery.\n* Mesh placed solely for a non-reconstructive indication (e.g. temporary abdominal closure or planned re-look without definitive reconstruction).\n* Estimated life expectancy \\\u003C 12 months or inability to complete the minimum follow-up.\n* Patient declines participation.","ALL","18 Years",{"count":19,"type":20},420,"ESTIMATED","OBSERVATIONAL","Abdominal wall reconstruction (AWR) with mesh is the standard repair for ventral, incisional, parastomal and complex abdominal wall defects, but mesh-related infection remains one of its most serious complications - prolonging hospital stay, often requiring reoperation or removal of the mesh, and increasing the risk of hernia recurrence. Reported infection rates vary widely, and the independent contribution of individual risk factors remains uncertain, in large part because much of the existing evidence comes from retrospective series with inconsistent outcome definitions.\n\nThis single-centre, prospective observational cohort study will enrol consecutive adults undergoing elective or urgent AWR with synthetic, biosynthetic or biological mesh at a tertiary referral hernia unit. Participants will be followed for 12 months on a fixed schedule (7-10 days, 30 days, 90 days, 6 months and 12 months). Using internationally accepted, prespecified definitions of mesh infection and surgical site occurrence, the study will collect up to 18 candidate patient, defect, operative and perioperative risk factors and analyse them by multivariable logistic regression to identify the independent predictors of mesh-related infection within 90 days of surgery.\n\nSecondary aims are to describe the incidence, timing, microbiology and management (salvage versus explantation) of mesh infection; to report surgical site occurrences and reoperation; and to derive an exploratory risk-stratification model. The findings are intended to support preoperative risk assessment, targeted patient optimisation, informed mesh and technique selection, and shared decision-making. The study is designed and reported in accordance with the STROBE statement.",[24,25,26,27,28,29],"Incisional Hernia","Ventral Hernia","Parastomal Hernia","Abdominal Wall Defect","Surgical Wound Infection","Prosthesis-Related Infections (Mesh Infection)",[31,32,33,34,35,36,37,38,39],"Mesh infection","Abdominal wall reconstruction","Surgical site occurrence (SSO)","SSO requiring procedural intervention (SSOPI)","Risk factors","Prosthetic mesh","Component separation \u002F transversus abdominis release","Hernia recurrence","Surgical site infection","RECRUITING","2026-08-16",{"date":43,"type":44},"2026-08-18","ACTUAL",{"date":46,"type":44},"2026-08-15",{"date":48,"type":20},"2028-08-15",{"name":50,"class":51},"Minia University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":52},"100544317","extraperitoneal-plasty-vs-intraperitoneal-onlay-mesh-in-ventral-hernia-repair-100544317","NCT06367309","ExtrAperitoneaL Plasty vs Intraperitoneal oNlay mEsh in Ventral Hernia Repair","ExtrAperitoneaL Plasty vs Intraperitoneal oNlay mEsh in Ventral Hernia Repair - the Randomized Controlled ALPINE Trial","ALPINE","Inclusion Criteria:\n\n* Patient age \\>18 years\n* Informed consent obtained\n* Primary or incisional ventral hernia\n* Epigastric, umbilical or infraumbilical ventral hernias with transversal diameter \\>1cm and \\\u003C\u002F= 4cm, +\u002F- rectus diastasis which doesn't demand specific treatment\n* If multiple hernias: cumulative transversal diameter \\\u003C\u002F= 4cm\n* Considered eligible for minimally-invasive approach\n\nExclusion Criteria:\n\n* Subxyphoidal or suprapubic hernias\n* precedent hernia treatment with mesh placement in the retromuscular space\n* liver disease defined by the presence of ascites\n* end-stage renal disease requiring dialysis\n* need of an emergency surgery\n* pregnancy\n* need of rectus diastasis treatment intraoperatively\n\nCriteria for participating surgeons\n\n\\- Each participating surgeon has performed 20 or more laparoscopic IPOM procedures and 20 or more eTEP procedures.",{"count":62,"type":20},138,"INTERVENTIONAL",[65],"NA","This study investigates on the effect of two different operative techniques to treat abdominal wall hernias.\n\nThe goal of this clinical trial is to learn if the eTEP (Extended totally extraperitoneal repair) technique leads to a better outcome than the IPOM (Intraperitoneal onlay mesh) technique.\n\nThe main questions it aims to answer are:\n\n* pain after the operation\n* rate of complications\n* rate of recurrence and reoperations\n* quality of life.\n\nParticipants will:\n\nEither be operated using the eTEP or the IPOM technique. Be followed up either in person or via email \u002F phone call at day 1, day 7, day 14, 6 weeks, 6 months, 1, 3 and 5 years after the surgery to asses the above-stated main and some more outcomes.",[25,27],"2026-07-23",{"date":70,"type":44},"2026-07-24",{"date":72,"type":44},"2024-07-01",{"date":74,"type":20},"2031-12-31",{"name":76,"class":51},"University Hospital, Basel, Switzerland",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":63,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":90,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},"100544086","open-versus-robotic-retromuscular-repair-in-medium-to-large-ventral-hernias-100544086","NCT06364306","oPen Versus RobotIc retrOmuscular Repair in Medium to Large Ventral Hernias","oPen Versus RobotIc retrOmuscular Repair in Medium to Large Ventral Hernias - the PRIOR Multicentre Randomized Controlled Trial","PRIOR","Inclusion Criteria:\n\n* Patient age \\>18 years\n* Informed consent obtained\n* Transverse diameter of ventral hernia \\>4cm - 15cm\n* Eligible to open and minimally-invasive surgery according to preoperative anaesthetic assessment\n\nExclusion Criteria:\n\n* precedent hernia treatment with mesh placement in the retromuscular space\n* precedent anterior or posterior component separation or transversus abdominis release (TAR)\n* active wound infection\n* current cancer diagnosis\n* presence of ileostomy, colostomy or ileal conduit\n* liver disease defined by the presence of ascites\n* end-stage renal disease requiring dialysis\n* need of an emergency surgery\n* pregnancy\n\nCriteria for participating surgeons Each participating surgeon has performed 20 or more OVHR and RVHR.",{"count":86,"type":20},140,[65],"This study investigates on the effect of two different operative techniques to treat large abdominal wall defects.\n\nThe goal of this clinical trial is to learn if the minimally-invasive, robotically-assisted ventral hernia repair (RVHR) leads to a better outcome than the open ventral hernia repair (OVHR).\n\nThe main questions it aims to answer are:\n\nlength of stay after the operation rate of complications rate of recurrence and reoperations quality of life.\n\nParticipants will:\n\nEither be operated using the RVHR or OVHR will be followed up either in person or via email \u002F phone call at day 7, day 30, 6 months, 1, 3 and 5 years after the surgery to asses the above-stated main and some more outcomes.",[25,24,27],{"date":70,"type":44},{"date":92,"type":44},"2026-07-14",{"date":94,"type":20},"2033-12-31",{"name":76,"class":51},3,{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":105,"minAge":17,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":109,"conditions":110,"keywords":114,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":4},"100624264","patient-reported-outcomes-in-women-with-postpartum-abdominal-wall-insufficiency-ppawis-100624264","NCT07407374","Patient-Reported Outcomes in Women With Postpartum Abdominal Wall Insufficiency (PPAWIS)","A Prospective Observational Cohort Study of Quality of Life, Body Image, and Sexual Function in Women With Postpartum Abdominal Wall Insufficiency Syndrome (PPAWIS) Using Patient-Reported Outcome Measures","EMPOWER","Inclusion Criteria:\n\n* Female, age 18-65 years\n* Postpartum status: at least 6 months after last delivery\n* Clinical diagnosis of postpartum abdominal wall insufficiency syndrome (PPAWIS), defined by abdominal wall dysfunction symptoms and\u002For significant quality-of-life impact, with supportive findings on physical examination and\u002For imaging (e.g., diastasis recti and\u002For related abdominal wall insufficiency features)\n* Receiving routine clinical care for PPAWIS at the study site (surgical)\n* Able and willing to provide informed consent and complete patient-reported outcome questionnaires at baseline and follow-up\n\nExclusion Criteria:\n\n* Current pregnancy\n* Planned pregnancy during the follow-up period (up to 12 months), if expected to interfere with outcome assessment\n* Inability to complete questionnaires due to cognitive impairment or insufficient language proficiency in the validated questionnaire language version\n* Severe uncontrolled psychiatric condition that, in the investigator's opinion, would prevent informed consent or reliable questionnaire completion\n* Participation in another interventional study that could materially affect patient-reported outcomes related to abdominal wall function during the follow-up period","FEMALE","65 Years",{"count":108,"type":20},30,"Postpartum abdominal wall insufficiency syndrome (PPAWIS) is a multidimensional condition that may affect physical function, quality of life, body image, and sexual health in women after childbirth. Anatomical findings alone do not fully explain symptom burden or patient experience.\n\nThis prospective observational cohort study will collect validated patient-reported outcome measures (PROMs) from women with PPAWIS receiving routine care. PROMs will be assessed at baseline and during follow-up to describe symptom burden and changes over time. The study aims to improve understanding of the patient-centered impact of PPAWIS and to support development of standardized assessment pathways in clinical practice.",[111,27,112,113],"Diastasis Recti and Weakness of the Linea Alba","Postpartum Complication","Abdominal Wall Anomaly",[115,116,117,118,119,120,121,122,123],"PROMs","postpartum abdominal wall insufficiency","PPAWIS","patient-reported outcomes","sexual function","women's health","core stability","quality of life","abdominal wall reconstruction","NOT_YET_RECRUITING","2026-02-05",{"date":127,"type":44},"2026-02-12",{"date":129,"type":20},"2026-02-20",{"date":131,"type":20},"2027-01-01",{"name":133,"class":51},"Swissmed Hospital",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":106,"enrollmentInfo":141,"targetDuration":4,"studyType":63,"phases":142,"briefSummary":143,"conditions":144,"keywords":151,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":52},"100309634","abdominal-wall-transplant-100309634","NCT03310905","Abdominal Wall Transplant","Abdominal Wall Transplantation for the Reconstruction of Abdominal Wall Defects as Adjunct to Abdominal Solid Organ Transplantation","Inclusion Criteria:\n\n* Candidates between 18-65 years old\n* Willingness and legal ability to give consent\n* Abdominal Wall in combination with another organ transplant: they must be eligible for the non-vascularized composite allograft organ transplant at Duke\n\nExclusion Criteria:\n\n* Malignancy at evaluation or history of malignancy that precludes transplantation\n* Pregnancy: Women who are of childbearing potential must have a negative serum pregnancy test within 48 hours of transplant and agree to use reliable contraception with two contraceptive methods for a minimum of 2 years following abdominal wall transplantation. Subjects seeking to become pregnant following 2 years will be made aware during the consent process that the effect of pregnancy on the transplanted abdominal wall and vice versa is unknown.\n* Medical exclusion criteria for general anesthesia\n* Ongoing substance abuse or history of untreated substance abuse",{"count":5,"type":20},[65],"The purpose of this protocol is to determine the safety and efficacy of abdominal wall transplantation as a treatment for the reconstruction of abdominal wall defects. Abdominal wall transplantation may be performed alone or in combination with another transplant.",[145,146,147,27,148,149,150],"Transplant;Failure,Kidney","Transplant; Failure, Liver","Transplant; Failure, Bowel","Abdominal Wall Fistula","Abdominal Wall Hernia","Abdominal Wall Injury",[152,153,154,155],"Research","Transplant","Abdominal Wall","Hernia","2026-01-05",{"date":158,"type":44},"2026-01-07",{"date":160,"type":44},"2018-05-01",{"date":162,"type":20},"2028-06-01",{"name":164,"class":51},"Duke University"]