[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acanthosis-nigricans\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acanthosis-nigricans":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100651411","phase-1-efficacy-and-safety-of-fractional-carbon-dioxide-laser-plus-topical-metformin-in-treatment-of-acanthosis-nigricans-100651411",false,"NCT07760181","Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans","Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans: A Comparative Study","Inclusion Criteria:\n\n* \\- male or female patients aged 18-50 years\n* clinically \\& dermoscopy diagnosed acanthosis nigricans involving the neck\n* skin types iii-v\n* stable systemic condition for at least 3 months\n* willingness to comply with study protocol and follow-up\n\nExclusion Criteria:\n\n* \\- pregnancy or lactation\n* malignancy-associated acanthosis nigricans\n* active skin infection or inflammatory dermatosis at the treatment site\n* history of keloid or hypertrophic scar formation\n* photosensitivity disorders\n* use of topical or systemic treatment for acanthosis nigricans within the last 4 weeks\n* previous laser treatment to the neck within the last 6 months",true,"ALL","18 Years","50 Years",{"count":21,"type":22},34,"ESTIMATED","INTERVENTIONAL",[25],"PHASE1","evaluate and compare the clinical Efficacy \\& Safety Of Fractional Carbon Dioxide (Co₂) Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans.",[28],"Acanthosis Nigricans","NOT_YET_RECRUITING","2026-08-07",{"date":32,"type":33},"2026-08-12","ACTUAL",{"date":35,"type":22},"2026-08-10",{"date":37,"type":22},"2027-09-10",{"name":39,"class":40},"Al-Azhar University","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":57,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100541588","clinical-association-between-obstructive-sleep-apnea-facial-pigmentation-and-vasovagal-symptoms-100541588","NCT06331819","Clinical Association Between Obstructive Sleep Apnea, Facial Pigmentation, and Vasovagal Symptoms.","Clinical Association Between Obstructive Sleep Apnea (OSA) and Facial Pigmentation, and the Relation Between OSA and Vasovagal Symptoms With Resulting Smoking Tendency and the Effect of Treatment in Patients Referred for Sleep Study.","VasOSA","Inclusion Criteria:\n\n* Patients within age limit who agree to participate and sign the consent form.\n\nExclusion Criteria:\n\n* Patients with prior diagnosis of obstructive sleep apnea by sleep study.",{"count":50,"type":22},200,"OBSERVATIONAL","The goal of this prospective cohort study is to study patients referred for sleep study by in-lab polysomnography in the Jordan University Hospital and the Jordan Hospital or with an at-home sleep study kit. The main aims are:\n\n* To prospectively obtain demographic and clinical information of patients referred for a sleep study.\n* To determine the diagnostic value of facial discoloration as potential marker for obstructive sleep apnea to increase detection rate for the condition.\n* To establish a correlation between obstructive sleep apnea and vasovagal symptoms with resulting increased smoking tendency and study the effect of treatment on the disorders.\n* To determine the association between timing of appearance of obstructive sleep apnea symptoms and initiation of smoking.",[54,55,56,28],"Obstructive Sleep Apnea","Vasovagal Syncope","Smoking",[54,55,58,28,59,60,61],"Facial Discoloration","Smoking Cessation","Jordan","In-Lab Polysomnography","RECRUITING","2024-09-07",{"date":65,"type":33},"2024-09-19",{"date":67,"type":33},"2024-03-10",{"date":69,"type":22},"2026-03-01",{"name":71,"class":40},"Jordan Collaborating Cardiology Group",1]