[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"accidental-fallsprevention--control\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:accidental-fallsprevention--control":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100649736","neural-cognitive-and-biomechanical-determinants-of-falls-in-older-adults-100649736",false,"NCT07739056","Neural, Cognitive, and Biomechanical Determinants of Falls in Older Adults","Neural, Cognitive, and Biomechanical Determinants of Falls in Older Adults: A Two-Phase Multimodal Investigation With a Phenotype-Guided Rehabilitation Trial","Inclusion Criteria:\n\n* Participants must meet all of the following criteria:\n\n  * Age ≥ 65 years\n  * Community-dwelling\n  * Ability to ambulate independently (with or without assistive device)\n  * Ability to understand instructions and provide informed consent\n\nParticipants will be stratified into fall-risk categories based on established criteria:\n\n* High fall risk: history of ≥1 fall in the previous 12 months and\u002For impaired functional performance (e.g., TUG \\> 13.5 s or BBS ≤49)\n* Low\u002Fno fall risk: no falls and preserved functional mobility These criteria are consistent with previously published fall-prevention trials.\n\nExclusion Criteria:\n\n* Participants will be excluded if they have:\n\n  * Neurological conditions affecting gait or balance (e.g., stroke, Parkinson's disease)\n  * Severe musculoskeletal disorders limiting mobility\n  * Severe cognitive impairment (e.g., inability to follow instructions or MoCA \\\u003C 18)\n  * Uncontrolled cardiovascular or metabolic conditions\n  * Current participation in structured rehabilitation programs\n  * Contraindications to EEG, EMG, or fNIRS measurements",true,"ALL","65 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial with an embedded observational phase is to evaluate whether a phenotype-guided, personalized rehabilitation program can improve fall risk and underlying neural control mechanisms in older adults aged ≥65 years, including both high and low fall-risk individuals.\n\nThe main questions it aims to answer are:\n\nDo older adults at high fall risk exhibit altered neural, neurocognitive, and biomechanical profiles compared with low\u002Fno fall-risk individuals? Does personalized rehabilitation guided by neurophysiological and neurocognitive profiles result in greater reductions in fall risk and improvements in motor control compared with conventional rehabilitation?\n\nResearchers will compare personalized phenotype-guided rehabilitation to conventional evidence-based fall-prevention exercise to determine whether targeted, mechanism-based intervention leads to superior clinical and mechanistic outcomes.\n\nParticipants will:\n\nUndergo a comprehensive multimodal assessment including neurophysiological (EEG, EMG), neurocognitive (fNIRS, dual-task testing), and biomechanical (gait and balance) measures Be classified into fall-risk and neurophysiological control profiles based on assessment results (Phase 2 - high fall-risk participants only) be randomly assigned to either personalized rehabilitation or conventional rehabilitation Attend supervised exercise sessions 2-3 times per week for 8-12 weeks Complete gait, balance, and cognitive-motor assessments before and after the intervention Record falls prospectively using monthly fall diaries and follow-up monitoring over 3-6 months",[27],"Accidental Falls\u002FPrevention & Control",[29,30,31,32,33,34],"Fall risk","Older adults","Balance","Neural control","Cognitive-motor integration","Phenotype-guided therapy","NOT_YET_RECRUITING","2026-07-27",{"date":38,"type":39},"2026-07-31","ACTUAL",{"date":41,"type":21},"2026-12-31",{"date":43,"type":21},"2028-12-31",{"name":45,"class":46},"University of Sharjah","OTHER"]