[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"achilles-tendon-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:achilles-tendon-pain":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,53,82,109,141],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100630103","extracorporeal-shockwave-therapy-and-platelet-rich-plasma-for-midportion-achilles-tendinopathy-100630103",false,"NCT07483320","Extracorporeal Shockwave Therapy and Platelet-Rich Plasma for Midportion Achilles Tendinopathy","A Randomized Controlled Trial Evaluating the Influence of Physical Therapy, Shockwave Therapy, Platelet Rich Plasma or Combined Treatment in the Management of Midportion Achilles Tendinopathy","Inclusion Criteria:\n\n* Age 18-65 years\n* Diagnosis of unilateral midportion Achilles tendinopathy\n* Symptoms present for more than 3 months\n* VISA-A score \\\u003C80 at baseline\n* Pre-injury physical activity level ≥3 on the Physical Activity Scale\n* Ability to participate in rehabilitation program\n\nExclusion Criteria:\n\n* Symptoms present for less than 3 months\n* Prior PRP injection or ESWT treatment to the Achilles tendon within 3 months\n* Other lower extremity musculoskeletal injury affecting function\n* Symptomatic arthritis affecting the ankle or foot\n* Rheumatologic disease or connective tissue disorder\n* Coagulopathy or anticoagulant therapy affecting platelet function\n* Neuropathy affecting pain perception\n* Known cardiac condition contraindicating treatment\n* Poorly controlled diabetes (HbA1c \\>9.0)\n* Pregnancy","ALL","18 Years","65 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","Midportion Achilles tendinopathy is a common cause of pain and functional limitation in both athletes and the general population. Progressive tendon loading programs are considered first-line treatment but do not lead to satisfactory outcomes in all patients. Extracorporeal shockwave therapy (ESWT) and platelet-rich plasma (PRP) injections are commonly used interventions for refractory symptoms, yet evidence supporting their combined use is limited particularly in treating Achilles tendon disorders.\n\nThis randomized controlled trial will evaluate the effectiveness of a standardized exercise program alone or in combination with PRP injection, ESWT, or both therapies in active adults with midportion Achilles tendinopathy. Participants will be randomized to one of four treatment groups and followed for six months. The primary outcome will assess changes in Achilles tendon symptoms and function using the Victorian Institute of Sport Assessment-Achilles (VISA-A) score. Secondary outcomes will include patient-reported outcomes, physical function testing, ultrasound tendon structure measures, and gait biomechanics.",[27,28,29,30,31,32],"Achilles Injuries Tendon","Achilles Tendinopathy (AT)","Achilles Tendinitis, Left Leg","Achilles Tendinitis, Right Leg","Achilles Tendon Pain","Achilles Tendonitis",[34,35,36,37,38,39],"PRP","platelet rich plasma","extracorporeal shockwave","focus shockwave","radial pressure waves","rehabilitation","NOT_YET_RECRUITING","2026-07-24",{"date":43,"type":44},"2026-07-27","ACTUAL",{"date":46,"type":21},"2026-08-01",{"date":48,"type":21},"2028-05-30",{"name":50,"class":51},"Spaulding Rehabilitation Hospital","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100646870","achilles-tendinopathy-the-effect-of-shockwave-treatment-100646870","NCT07685509","Achilles Tendinopathy; the Effect of Shockwave Treatment","Comparison of Two Treatment Methods for Achilles Tendon Pain With a Focus on Pain, Function, Vascular Ingrowth, Immune Cell Response, and Cell Composition","Inclusion Criteria:\n\n* Women and men over 18 years of age who seek care for load-related pain in the midportion of the Achilles tendon or at the Achilles tendon insertion at a Physiotherapy Clinic in Primary Care, at the Physiotherapy Department at Sahlgrenska University Hospital\u002FMölndal, or at the Orthopedic Department at Sahlgrenska University Hospital\u002FMölndal.\n* Symptoms must have been present for one month or longer.\n* Symptoms may be present in one or both Achilles tendons.\n\nExclusion Criteria:\n\n* Unwillingness to receive shockwave therapy.\n* Previous shockwave therapy for Achilles tendon pain within the past year.\n* Neurological disease, significant cardiac conditions, increased bleeding tendency, treatment with anticoagulant medication, pregnancy, or presence of a tumor in the foot.\n* Corticosteroid injection in the foot within the past six months.\n* Reduced sensation, acute inflammation, or any wound around the heel.\n* Inability to understand or speak Swedish.",{"count":61,"type":21},200,[24],"BACKGROUND Achilles tendinopathy-pain in the Achilles tendon-is a common and often long-lasting condition that limits physical activity and performance, and also affects work capacity and quality of life. The pain is localized either to the mid- portion of the tendon or at its insertion into the calcaneus. Although individually tailored exercise is the first-line treatment, symptoms persist in many patients, highlighting the need for adjunctive therapies.\n\nAIM This interdisciplinary and innovative research project aims to evaluate the effect of shockwave therapy in Achilles tendinopathy, both in cases where the pain is located in the mid-portion of the tendon and where it is situated at the tendon's insertion. In addition to assessing effects on pain and function, the study will examine the impact on calcifications, neovascularization (evaluated via Doppler ultrasound), and-uniquely-systemic immunological effects, with a focus on NK cells in the blood, an area that remains largely unexplored. METHOD This is a randomized controlled trial (RCT) with four arms, including 200 patients divided into two groups based on pain location. Half of the participants will receive adjunctive shockwave therapy in six sessions, in addition to exercise following the protocol by Silbernagel et al. The primary outcome measure is self-reported pain assessed using the Numeric Rating Scale (NRS) 0-10 at 12 months.\n\nSecondary outcomes include function, assessed through patient-reported outcomes (Victorian Institute of Sport Assessment-Achilles Swedish version, VISA-AS), calf muscle strength and endurance, and jumping ability using a validated test battery. Neovascularization and tendon cross-sectional area will be evaluated using ultrasound\u002FDoppler.\n\nIn a sub-cohort, immune cell composition in blood will be analyzed using flow cytometry before and after treatment. For patients undergoing surgery, tissue samples will also be collected for cellular composition analysis.\n\nSIGNIFICANCE This project has the potential to improve treatment strategies, reduce the need for surgery, and generate entirely new knowledge about the relationship between local tissue pathology and systemic immune responses.",[28,65,31],"Achilles Tendon",[67,68,69,70,71],"Achilles Tendinopathy","Shockwave","Insertional Achilles Tendinopathy","Exercise","Heel-rise","2026-07-01",{"date":74,"type":44},"2026-07-06",{"date":76,"type":21},"2026-09-01",{"date":78,"type":21},"2031-12-31",{"name":80,"class":81},"Vastra Gotaland Region","OTHER_GOV",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":90,"targetDuration":91,"studyType":92,"phases":4,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100618345","cuhk-achilles-tendon-disorder-registry-100618345","NCT07330414","CUHK Achilles Tendon Disorder Registry","AT Registry","Inclusion Criteria:\n\n* Adults (\\>18 years of age)\n\nExclusion Criteria:\n\n* Any physical or psychological comorbidity that would impair the ability to complete study assessments (e.g., significant neurological deficits) or preclude the provision of informed consent.\n* Concomitant diseases that severely affect lower limb function or assessment (e.g., severe osteoarthritis of the knee or hip, prior lower limb amputation, peripheral vascular disease, active rheumatoid arthritis, lower limb paralysis, etc.)",true,{"count":61,"type":21},"5 Years","OBSERVATIONAL","This is a long-term research registry for patients with Achilles tendon disorders (like tears, chronic pain, or ruptures) as well as healthy adults without tendon problems. The goal is to collect detailed information over time to understand which treatments work best for different people, identify risk factors for injury, and improve overall care. Adults over 18, both with and without Achilles tendon conditions, are eligible to join. Participants will attend several assessment visits at the Prince of Wales Hospital over the first year (at the start, 6 weeks, 3, 4, 6, and 12 months) for physical tests, ultrasounds, and questionnaires. After the first year, follow-up continues with annual online questionnaires for up to five years. The main measure is a standard questionnaire about tendon pain and function (VISA-A). The study aims to use this information to guide better, more personalized rehabilitation strategies, improve patient outcomes, and reduce long-term disability. All participation is voluntary and requires written consent.",[95,65,31],"Achilles Tendon Injury",[97,98,99],"Achilles tendinopathy","Achilles tendon rupture","Achilles tendinitis","2025-12-28",{"date":102,"type":44},"2026-01-09",{"date":104,"type":21},"2026-01-15",{"date":106,"type":21},"2030-12-30",{"name":108,"class":51},"Chinese University of Hong Kong",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":121,"conditions":122,"keywords":123,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":140},"100572709","progressive-achilles-loading-via-clinician-e-support-100572709","NCT06736795","Progressive Achilles Loading Via Clinician E-support","Progressive Achilles Loading Via Clinician E-support (PACE)","PACE","Inclusion Criteria:\n\n* Pain localized to the Achilles tendon (insertion or midportion)\n* AT pain greater than or equal to 3\u002F10 with tendon-loading exercise\n\nExclusion Criteria:\n\n* Younger than 18 years of age or older than 60 years of age\n* BMI \\> 45 kg\u002Fm2\n* Pain primarily due to a differential diagnosis, including paratendonitis, bursitis (retrocalcaneal or subcutaneous), posterior ankle impingement or os trigonum, irritation or neuropathy of the sural nerve, plantaris tendon involvement)\n* Presence of a partial Achilles tendon tear or rupture on imaging or a history of Achilles tendon rupture that was verified by surgical or conservative management\n* Attended physical therapy for AT in the past 3 months\n* History of steroid injection to lower extremity tendons\u002Ffascia, ESWT or any injection to the Achilles tendon region in the past 3 months\n* History of taking fluoroquinolones in the past 6 months\n* History of surgery or invasive procedure for AT on side enrolling for treatment\n* Diagnosed systemic conditions affecting the foot and ankle (e.g., rheumatoid arthritis, ankylosing spondylitis), endocrine disorder with complications (e.g., uncontrolled Type I or II diabetes, diabetic peripheral neuropathy), connective tissue disorder (e.g., Marfan's syndrome, Ehlers Danlos), or pregnancy\n* At high risk for falls (four step square test \\>15 seconds)\n* Refusal of randomization or unable or uninterested in completing virtual visits with a webcam or smart phone or completing quizzes and surveys","60 Years",{"count":119,"type":21},160,[24],"This is a randomized controlled trial with individuals who have Achilles tendon pain. This study is designed to identify an effective rehabilitation program for Achilles tendon pain that expands access to care for military personnel and to predict treatment response. Limited or delayed access to healthcare can exacerbate the severity of pain and duration of disability due to AT. This is particularly relevant for individuals deployed to battlefield settings or are being seen in busy military treatment facilities. Therefore, it is crucial to identify efficient and effective treatment pathways that maximize healthcare access and facilitate a rapid and pain-free return to full duty.",[31,67],[124,125,126,127,128,129],"ultrasound imaging","tendon health","pain","exercise","physical therapy","education","RECRUITING","2025-10-01",{"date":133,"type":44},"2025-10-07",{"date":135,"type":44},"2025-08-20",{"date":137,"type":21},"2028-07",{"name":139,"class":51},"Ruth Chimenti",2,{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":52},"100457791","effects-of-low-load-resistance-training-with-blood-flow-restriction-in-patients-with-achilles-tendinopathy-100457791","NCT05241197","Effects of Low-load Resistance Training With Blood Flow Restriction in Patients With Achilles Tendinopathy","Inclusion Criteria:\n\n* Clinical diagnosis of unilateral MAT.\n* Achilles pain \\> 3 months.\n* Age ranging between 18 to 50 years, both genders.\n* Read and speak Spanish well enough to provide informed consent and follow study instructions.\n* Can attend in-clinic treatments 2-3 x weekly for the next 12 weeks.\n\nExclusion Criteria:\n\n* Any ankle or foot surgery.\n* History of Achilles rupture.\n* Heel pain in the last 3 months.\n* Systemic disorders\u002Fdiseases.\n* History of deep venous thrombosis, hypertension or blood clotting disorder.\n* Body mass index \\> 30kg\u002Fm2.\n* Self-report of pregnancy.\n* Drug use (local steroid injection or systemic fluoroquinolones).\n* Pain \\\u003C 2\u002F10 of average pain on NPRS.\n* VISA A score \\> 90%.\n* Unable to perform any of the exercises of the study.","50 Years",{"count":149,"type":21},52,[24],"Midportion Achilles tendinopathy (MAT) is a common overuse injury of the lower extremity characterized by the presence of pain, restricted function and interruption of sport activities. Conservative management of MAT has been suggested as the first line of treatment. Actually, there are several exercise programs with beneficial effects on pain and function among which high load training stands out. However, this training modality is inherently difficult to implement in certain populations and pathological conditions due to their inability to tolerate this mechanical stress. In this sense, low load training with blood flow restriction (BFR-LLT) emerges as an effective option in producing hypertrophic adaptations with low intensities (30% 1RM). However, this training modality has not yet been studied in tendon pathology. The aim of this study is to evaluate the potential clinical effects of BFR-LLT in comparison with HLT in patients with chronic MAT.",[67,31,153],"Tendon Injuries",[155,156],"Blood Flow Restriction","Rehabilitation","2024-12-03",{"date":159,"type":44},"2024-12-06",{"date":161,"type":44},"2022-04-29",{"date":163,"type":21},"2026-08",{"name":165,"class":51},"University of Gran Rosario"]