[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"achilles-tendon\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:achilles-tendon":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,77,102,123],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100646870","achilles-tendinopathy-the-effect-of-shockwave-treatment-100646870",false,"NCT07685509","Achilles Tendinopathy; the Effect of Shockwave Treatment","Comparison of Two Treatment Methods for Achilles Tendon Pain With a Focus on Pain, Function, Vascular Ingrowth, Immune Cell Response, and Cell Composition","Inclusion Criteria:\n\n* Women and men over 18 years of age who seek care for load-related pain in the midportion of the Achilles tendon or at the Achilles tendon insertion at a Physiotherapy Clinic in Primary Care, at the Physiotherapy Department at Sahlgrenska University Hospital\u002FMölndal, or at the Orthopedic Department at Sahlgrenska University Hospital\u002FMölndal.\n* Symptoms must have been present for one month or longer.\n* Symptoms may be present in one or both Achilles tendons.\n\nExclusion Criteria:\n\n* Unwillingness to receive shockwave therapy.\n* Previous shockwave therapy for Achilles tendon pain within the past year.\n* Neurological disease, significant cardiac conditions, increased bleeding tendency, treatment with anticoagulant medication, pregnancy, or presence of a tumor in the foot.\n* Corticosteroid injection in the foot within the past six months.\n* Reduced sensation, acute inflammation, or any wound around the heel.\n* Inability to understand or speak Swedish.","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"NA","BACKGROUND Achilles tendinopathy-pain in the Achilles tendon-is a common and often long-lasting condition that limits physical activity and performance, and also affects work capacity and quality of life. The pain is localized either to the mid- portion of the tendon or at its insertion into the calcaneus. Although individually tailored exercise is the first-line treatment, symptoms persist in many patients, highlighting the need for adjunctive therapies.\n\nAIM This interdisciplinary and innovative research project aims to evaluate the effect of shockwave therapy in Achilles tendinopathy, both in cases where the pain is located in the mid-portion of the tendon and where it is situated at the tendon's insertion. In addition to assessing effects on pain and function, the study will examine the impact on calcifications, neovascularization (evaluated via Doppler ultrasound), and-uniquely-systemic immunological effects, with a focus on NK cells in the blood, an area that remains largely unexplored. METHOD This is a randomized controlled trial (RCT) with four arms, including 200 patients divided into two groups based on pain location. Half of the participants will receive adjunctive shockwave therapy in six sessions, in addition to exercise following the protocol by Silbernagel et al. The primary outcome measure is self-reported pain assessed using the Numeric Rating Scale (NRS) 0-10 at 12 months.\n\nSecondary outcomes include function, assessed through patient-reported outcomes (Victorian Institute of Sport Assessment-Achilles Swedish version, VISA-AS), calf muscle strength and endurance, and jumping ability using a validated test battery. Neovascularization and tendon cross-sectional area will be evaluated using ultrasound\u002FDoppler.\n\nIn a sub-cohort, immune cell composition in blood will be analyzed using flow cytometry before and after treatment. For patients undergoing surgery, tissue samples will also be collected for cellular composition analysis.\n\nSIGNIFICANCE This project has the potential to improve treatment strategies, reduce the need for surgery, and generate entirely new knowledge about the relationship between local tissue pathology and systemic immune responses.",[26,27,28],"Achilles Tendinopathy (AT)","Achilles Tendon","Achilles Tendon Pain",[30,31,32,33,34],"Achilles Tendinopathy","Shockwave","Insertional Achilles Tendinopathy","Exercise","Heel-rise","NOT_YET_RECRUITING","2026-07-01",{"date":38,"type":39},"2026-07-06","ACTUAL",{"date":41,"type":20},"2026-09-01",{"date":43,"type":20},"2031-12-31",{"name":45,"class":46},"Vastra Gotaland Region","OTHER_GOV",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":71,"leadSponsor":73,"locationsCount":76},"100642048","morphological-and-mechanical-assessment-in-the-achilles-tendon-after-radiofrequency-stimulation-in-runners-100642048","NCT07648199","Morphological and Mechanical Assessment in the Achilles Tendon After Radiofrequency Stimulation in Runners","Morphological and Mechanical Changes in the Achilles Tendon After the Application of INDIBA® Therapy in Healthy Runners: A Pre-post Quasi-experimental Study","RFAchillesRun","Inclusion Criteria:\n\n* Adults aged 18-65\n* Runners with at least one year of regular practice.\n* Must not have suffered any ligament, bone, tendon, or muscle injury in the lower limb or lumbar region during the last year.\n\nExclusion Criteria:\n\n* History of lower limb surgery, rheumatic or neuromuscular diseases or pregnancy\n* Contraindication for radiofrecuency treatment.\n* Athletes with visual, auditory, or any other impairment that may affect their cognitive ability to understand the test.",true,"65 Years",{"count":58,"type":20},19,[23],"448 kHz capacitive-resistive monopolar radiofrequency is an emerging physiotherapy technique whose usefulness and clinical relevance still need to be investigated. This study is a pre-post quasi-experimental study in which several variables will be measured before and immediately after 448 kHz capacitive resistive monopolar radiofrequency. It aims to analyze the morphological and mechanical changes in the Achilles tendon following the intervention in healthy runners.",[62,27],"Achilles Tendon Injury",[64,65,66],"Achilles tendon","Radiofrecuency","Physiotherapy","2026-06-14",{"date":69,"type":39},"2026-06-17",{"date":36,"type":20},{"date":72,"type":20},"2026-07-30",{"name":74,"class":75},"University of Malaga","OTHER",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":84,"targetDuration":85,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100618345","cuhk-achilles-tendon-disorder-registry-100618345","NCT07330414","CUHK Achilles Tendon Disorder Registry","AT Registry","Inclusion Criteria:\n\n* Adults (\\>18 years of age)\n\nExclusion Criteria:\n\n* Any physical or psychological comorbidity that would impair the ability to complete study assessments (e.g., significant neurological deficits) or preclude the provision of informed consent.\n* Concomitant diseases that severely affect lower limb function or assessment (e.g., severe osteoarthritis of the knee or hip, prior lower limb amputation, peripheral vascular disease, active rheumatoid arthritis, lower limb paralysis, etc.)",{"count":19,"type":20},"5 Years","OBSERVATIONAL","This is a long-term research registry for patients with Achilles tendon disorders (like tears, chronic pain, or ruptures) as well as healthy adults without tendon problems. The goal is to collect detailed information over time to understand which treatments work best for different people, identify risk factors for injury, and improve overall care. Adults over 18, both with and without Achilles tendon conditions, are eligible to join. Participants will attend several assessment visits at the Prince of Wales Hospital over the first year (at the start, 6 weeks, 3, 4, 6, and 12 months) for physical tests, ultrasounds, and questionnaires. After the first year, follow-up continues with annual online questionnaires for up to five years. The main measure is a standard questionnaire about tendon pain and function (VISA-A). The study aims to use this information to guide better, more personalized rehabilitation strategies, improve patient outcomes, and reduce long-term disability. All participation is voluntary and requires written consent.",[62,27,28],[90,91,92],"Achilles tendinopathy","Achilles tendon rupture","Achilles tendinitis","2025-12-28",{"date":95,"type":39},"2026-01-09",{"date":97,"type":20},"2026-01-15",{"date":99,"type":20},"2030-12-30",{"name":101,"class":75},"Chinese University of Hong Kong",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":108,"targetDuration":4,"studyType":21,"phases":110,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":4},"100608133","validity-and-reliability-of-calf-raise-tests-in-patients-with-achilles-tendon-rupture-and-lateral-ankle-sprain-100608133","NCT07197593","Validity and Reliability of Calf Raise Tests in Patients With Achilles Tendon Rupture and Lateral Ankle Sprain","General Inclusion Criteria:\n\n* Signed informed consent\n* Aged 18-65 years\n* German or English speaking\n\nInclusion Criteria:\n\nLAS individuals: Unilateral LAS 4-16 weeks post-injury diagnosed by a physician as LAS, supination trauma, ankle distortion or ligamentous ankle injury.\n\nATR individuals: Unilateral ATR 6- 24 months post-injury\u002Fsurgery (surgical or conservative treatment).\n\nHealthy controls: Matched to Patients by Group Level: Physical Activity, Age and Gender.\n\nExclusion Criteria:\n\nLAS individuals: Medial Ligament injuries (Grade II or III) ATR individuals: Previous ATR\n\nGeneral Exclusion Criteria:\n\n* Chronic Ankle Instability (defined by symptoms such as giving way, perceived instability and at least one LAS within the last 6 months)\n* Previous ATR\n* Other lower limb injury and\u002For surgery in the last year (e.g. fractures, ligament reconstructions or other conditions resulting in ≥ 6 months of sports inactivity)\n* Impaired motor function of the lower limb due to neurovascular or neurological diseases\n* Vestibular or visual disturbances\n* Or any other pathoanatomic abnormality that would affect motor performance (e.g. foot arthrodesis, toe amputation\u002Fmissing toes or other conditions such as joint deformities, severe chronic pain).",{"count":109,"type":20},70,[23],"This study aims to evaluate the validity and reliability of clinically used Calf Raise Test parameters (collected with the \"the Calf Raise App\") between patients with Lateral Ankle Sprain or Achilles Tendon Repair and healthy controls.",[27,113],"Ankle Sprain","2025-09-22",{"date":116,"type":39},"2025-09-29",{"date":118,"type":20},"2025-10-01",{"date":120,"type":20},"2026-05-31",{"name":122,"class":75},"Schulthess Klinik",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":130,"minAge":17,"maxAge":131,"enrollmentInfo":132,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":143,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":76},"100532564","effects-of-the-menstrual-cycle-on-triceps-surae-properties-in-women-100532564","NCT06214442","Effects of the Menstrual Cycle on Triceps Surae Properties in Women","Effects of Menstrual Cycle Phases on Plantar Flexor Neuromechanical Properties and Achilles Tendon Mechanical Properties of Eumenorrheic Women and Hormonal Contraception Users","Inclusion Criteria:\n\n* Inclusion criteria for the group of eumenorrheic women\n\n  * Being eumenorrheic with a regular menstrual cycle lasting between 21 and 35 days during the last 6 months prior to study participation.\n  * Body Mass Index between 20 and 25 kg\u002Fm2.\n  * Normal ankle function and range of motion.\n  * Do not use hormonal contraception of any kind or supplements hormones for at least the 6 months prior to the study.\n  * No complaints of pain or history of lower limb injury.\n  * In view of the COVID-19 pandemic, have completed vaccination will be used as an inclusion criteria.\n  * For the physically active group, practice regular physical exercise at least 3 times a week for the past 6 months.\n  * For the sedentary group, not practicing regular physical exercise in the last 6 months.\n\nInclusion criteria for the group users of hormonal oral contraception:\n\n* Body Mass Index between 20 and 25 kg\u002Fm2.\n* Normal ankle function and range of motion.\n* Make use of any method of oral hormonal contraception (compressed).\n* Make use of combined oral hormonal contraception with estrogen and progesterone (ethinylestradiol + Drospirenone) for at least 6 months before participating in the study.\n* Do not use other hormone supplements for at least 6 months prior to the study.\n* No complaints of pain or presence of pathologies in the lower limb\n* In view of the COVID-19 pandemic, have completed vaccination will be used as an inclusion criteria.\n* For the physically active group, practice regular physical exercise at least 3 times a week for the past 6 months.\n* For the sedentary group, not practicing regular physical exercise in the last 6 months\n\nExclusion Criteria:\n\nExclusion Criteria for eumenorrheic and contraception hormonal groups:\n\nHealth problems - contraindication to maximal effort exercise. Additionally, the following subjects will be excluded:\n\n* Women who have anovulatory cycles or phase lutea deficiency.\n* Women in early menopause.\n* Pregnant or lactating women.\n* Women with oligomenorrhea (menstrual cycles longer than 35 days, or delay of menstruation for the same period).\n* Women with hypothalamic amenorrhea.\n* Female smokers.\n* Women with metabolic syndrome.\n* For women using hormonal contraceptives, women who use adhesive, injectable, intrauterine devices, implants, vaginal rings, as well as progesterone-only CH methods.\n* Does not meet the inclusion criteria.","FEMALE","30 Years",{"count":133,"type":20},40,"The menstrual cycle is an important biological rhythm, whereby large cyclic fluctuations in endogenous sex hormones, such as estrogen and progesterone, are observed, which can affect performance. Evidence shows that endogenous and exogenous changes in hormone concentrations during the menstrual cycle exert many effects on the nervous and endocrine systems, in addition to the connective tissue, with consequences for the movement system. Pre-clinical studies (i.e., in animal models) show an estrogen association with the structural and mechanical properties of tendons and ligaments. Several elegant studies performed with female participants have tried to establish the mechanism underlying the effect of estrogen on collagen synthesis and its effects on exercise and functionality. Their findings suggest that the tendon properties may be affected when exposed to varying concentrations of estrogen. The largest tendon in humans, the Achilles tendon, has a direct role in functional capacity, activities of daily living, and locomotion. Studies show that the triceps surae's structural and mechanical properties may change throughout the menstrual cycle, and that these changes are related to endogenous and exogenous fluctuations in estrogen and progesterone. Musculotendinous stiffness, which is dependent on the collagen content, has been seen to vary considerably over the course of the menstrual cycle. In addition, it has been reported that females who have been taking the contraceptive pill for at least a year demonstrate lower levels of tendon strain compared to non-pill taking females, indicating a possible influence of hormonal state on tendon mechanical properties. However, the different experimental designs, the varied approaches to the evaluations and the lack of studies with high methodological quality limit our understanding of the effects of the different phases of the menstrual cycle on the triceps surae's neuromechanical properties. The aim of this observational study will be to investigate whether the morphological, mechanical (active and passive), material, and functional properties of the plantar flexor muscles and of the Achilles tendon, as well as functional parameters, change during voluntary contractions throughout the phases of the menstrual cycle in eumenorrheic women and in users of hormonal contraception. Understanding the acute effects of these properties in eumenorrheic women and users of hormonal contraception is essential so that we can adequately plan interventions and prescriptions of physical exercise and rehabilitation aimed for women.",[136,27],"Menstrual Cycle",[138,139,140,141,142],"mechanical properties","material properties","morphological properites","estrogen","progesterone","RECRUITING","2024-06-07",{"date":146,"type":39},"2024-06-10",{"date":148,"type":39},"2023-11-10",{"date":150,"type":20},"2024-12-31",{"name":152,"class":75},"Marco Aurélio Vaz, PhD"]