[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-rheumatic-fever\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-rheumatic-fever":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100656827","phase-3-act4rhd-is-an-open-label-randomised-adaptive-platform-trial-to-evaluate-novel-and-repurposed-clinical-interventions-for-patients-with-acute-rheumatic-fever-and-carditis-act4rhd-seeks-to-determine-whether-these-interventions-reduce-rhd-severity-at-6-months-100656827",false,"NCT07830108","ACT4RHD is an Open-label, Randomised, Adaptive Platform Trial to Evaluate Novel and Repurposed Clinical Interventions for Patients With Acute Rheumatic Fever and Carditis. ACT4RHD Seeks to Determine Whether These Interventions Reduce RHD Severity at 6 Months.","ACT4RHD: Adaptive Collaborative Trial for Rheumatic Heart Disease","ACT4RHD","Inclusion Criteria:\n\n1. Aged ≥4 and ≤25 years old\n2. Currently admitted to hospital, or hospital like setting, with the primary diagnosis of Definite or Possible Acute Rheumatic Fever (diagnosed according to the 2015 Jones Criteria)\n3. Echocardiographic confirmed valvulitis during the current admission\n4. If previous participation in the randomised ACT4RHD platform, then meets pre-specified criteria for re-enrolment\n5. Patient expected to be able to complete protocol-required follow up assessments to 6 months post-enrolment\n\nExclusion Criteria:\n\n1. Presentation to current hospital was more than 10 days prior to randomisation\n2. Cardiac surgery (or anticipated interhospital transfer for cardiac surgery) or death is anticipated within 72 hours from screening\n3. Patient has had cardiac intervention (surgery or percutaneous) for RHD within the last 6 months\n4. Previous cardiac intervention \u002Fsurgery for RHD more than 6months ago, but patient has not had at least 2 post-intervention echocardiograms, including at least 1 echocardiogram more than 6months after the intervention.\n\nEach domain will have additional eligibility criteria. Refer to the appliable Domain Specific Appendix (DSA).","ALL","4 Years","25 Years",{"count":21,"type":22},600,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","The ACT4RHD trial is a multicentre, pragmatic, multi-arm, open-label adaptive platform trial addressing multiple therapeutic questions in patients with ARF and carditis. ACT4RHD aims to improve health outcomes for children and young people affected by ARF by finding treatments to reduce heart damage. The trial's Bayesian adaptive design enables multiple promising treatments to be tested at the same time. The trial will adapt by stopping treatments that are not effective sooner than traditional trials, adding new treatments as they become available, and answering research questions as soon as enough evidence has been collected. This flexibility allows researchers to identify the most effective treatments more quickly than traditional clinical trials.",[28,29,30,31],"Rheumatic Fever","Rheumatic Heart Disease in Children","Acute Rheumatic Fever","Rheumatic Heart Disease",[33],"Adaptive platform","NOT_YET_RECRUITING","2026-10-05",{"date":37,"type":38},"2026-10-07","ACTUAL",{"date":40,"type":22},"2026-12",{"date":42,"type":22},"2036-12",{"name":44,"class":45},"Starship Child Health, Te Toka Tumai Auckland","OTHER_GOV",3]