[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-sinusitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-sinusitis":63},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,76,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100604576","efficacy-of-bee-venom-phonophoresis-in-treating-chronic-sinusitis-100604576",false,"NCT07151313","Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:","Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis: A Double-Blind Randomized Controlled Trial","BEE-SONIC","Inclusion Criteria:\n\n* Adults aged 18 to 65 years.\n* Clinical diagnosis of chronic sinusitis (symptoms ≥ 12 weeks) or acute sinusitis confirmed by an otolaryngologist.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to bee venom or bee products.\n* Skin conditions (e.g., eczema, dermatitis, open wounds) over the area of ultrasound application.\n* Severe comorbid medical conditions (e.g., uncontrolled asthma, autoimmune disease, malignancy).\n* Pregnancy or breastfeeding.\n* Use of systemic corticosteroids, antibiotics, or other medications that may significantly alter sinusitis symptoms within 4 weeks prior to enrollment.\n* Participation in another clinical trial within the past 30 days.","ALL","18 Years","65 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","This double-blind, randomized controlled trial (BEE-SONIC) aims to evaluate the efficacy of bee venom phonophoresis in the treatment of chronic sinusitis. Thirty adult patients (aged 18-65 years) with clinically diagnosed chronic or acute sinusitis will be randomized into two groups: the intervention group will receive bee venom phonophoresis using low-to-moderate intensity ultrasound, while the control group will receive standard care consisting of oral decongestants and saline nasal irrigation. Primary outcomes include improvement in symptom severity (SNOT-22, Visual Analog Scale) and quality of life (SF-33). Secondary outcomes include reduction in facial pain, nasal congestion, and patient satisfaction. Data will be collected at baseline, midpoint, and post-intervention, and analyzed using paired t-tests and ANOVA. The study has received ethics approval from Sinai University's Human Research Ethics Committee, and informed consent will be obtained from all participants.",[28,29,30],"Chronic Sinusitis","Acute Sinusitis","Rhinosinusitis",[32,33,34],"Sinusitis","Rhinosinusitis, Chronic","Rhinosinusitis, Acute","NOT_YET_RECRUITING","2026-08-01",{"date":38,"type":39},"2026-08-04","ACTUAL",{"date":41,"type":22},"2026-08-15",{"date":43,"type":22},"2027-12-25",{"name":45,"class":46},"Sinai University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100649360","phase-4-comparative-effectiveness-of-available-treatments-for-sinus-and-ear-infections-in-children-acute-sinusitis-100649360","NCT07732699","Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis)","MEASURE","Inclusion Criteria:\n\n* Age 2 years to \\\u003C12 years.\n* Clinical diagnosis of AS.\n\nExclusion Criteria:\n\n* Known allergy or other contraindication to oral amoxicillin or clavulanate\n* Prior use of systemic antibiotics in the last 7 days\n* History of renal impairment\n* History of hepatic impairment\n* Phenylketonuria or allergy to aspartame\n* History of craniofacial abnormalities\n* Concurrent bacterial infection requiring systemic antibiotic therapy (e.g., pneumonia, streptococcal pharyngitis)\n* Ill appearance, systemic toxicity, or immunodeficiency\n* Incomplete pneumococcal vaccination, defined as receipt of fewer than three doses of a pneumococcal conjugate vaccine\n* Parent or caregiver unable to complete study surveys in English or Spanish\n* Previous randomization into either MEASURE trial within the last 6 months\n* Periorbital redness and\u002For swelling, proptosis, or swelling of the forehead\n* Individuals who qualify for both the AS and AOM trials (to avoid dual enrollment) will be excluded from the AS trial.","2 Years","12 Years",{"count":58,"type":22},1100,[60],"PHASE4","This study is being conducted at multiple hospitals and clinics to better understand whether antibiotics truly help children feel better when they have a sinus infection (acute sinusitis). Children in the study are randomly assigned (like flipping a coin) to receive either amoxicillin, amoxicillin-clavulanate, or a placebo (a look-alike medicine with no active antibiotic). Neither families nor study staff know which treatment the child is receiving during the study. The main goal is to compare how severe children's symptoms are each day while on these treatments. Parents or caregivers will report symptoms daily using a simple electronic diary. The study will also examine whether factors such as the severity of the child's illness or signs of allergies affect how well antibiotics work. The results will help guide better treatment decisions for children with sinus infections.",[63,32],"ACUTE SINUSITIS",[65,32],"Pediatric Sinusitis","2026-07-23",{"date":68,"type":39},"2026-07-29",{"date":70,"type":22},"2026-10-01",{"date":72,"type":22},"2032-03-17",{"name":74,"class":46},"Nader Shaikh",5,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100521954","phase-4-nasal-steroids-irrigation-oral-antibiotics-and-subgroup-targeting-for-effective-management-of-acute-sinusitis-100521954","NCT06076304","Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis","NOSES","Inclusion Criteria:\n\n1. 18-75 years old; AND are experiencing either:\n2. \"persistent\" symptoms or signs compatible with ARS or sinus infection lasting for 1-21 days without any evidence of clinical improvement (Symptoms include facial pain or pressure, facial congestion or fullness, nasal obstruction, nasal discharge, no or reduced sense of smell, fever ≤39°C or 102°F, headache, bad smelling breath, fatigue, ear pain or pressure, and dental pain); OR\n3. onset with worsening symptoms or signs characterized by the new onset of fever, headache, or increase in nasal discharge following a typical viral upper respiratory infection (URI) that lasted 5-6 days and were initially improving (''double-sickening'').\n\nExclusion Criteria:\n\n* allergy or intolerance to penicillin\n* received systemic antibiotic therapy in the past 4 weeks\n* prior sinus surgery (cosmetic surgery, such as rhinoplasty, septal deviation, etc. are not exclusionary)\n* complications of sinusitis (facial edema (swelling), cellulitis), or orbital, meningeal or cerebral signs)\n* health care clinician determined IV (intravenous) antibiotics or hospital admission are required\n* pregnancy or breastfeeding\n* presence of a comorbidity or medication that may impair a patient's immune response as determined by a health care clinician\n* hospitalization in past 5 days\n* unable or unwilling to provide informed consent or comply with study protocol requirements\n* fever \\>39°C or 102°F today\n* taking intranasal corticosteroids (INCS) regularly in the past two weeks and unwilling to stop its use while in the study; OR\n* previously enrolled or participated in the feasibility phase or this stage of study","75 Years",{"count":85,"type":22},3720,[60],"Sinus infections (also called acute rhinosinusitis or ARS) affect about 15% of adults each year, and are one of the top reasons people receive antibiotics in outpatient settings. Since most sinus infections are caused by viruses, many patients who take antibiotics for this condition do not actually benefit. Even though this has decreased over recent years, 70% of people are still prescribed them after a visit for ARS. Our goal is to better understand which patients truly benefit from antibiotics and which other treatment options can help people with sinus infections.",[89,29],"Sinus Infection",[91,92,93,94,95],"sinusitis","antibiotics","intranasal corticosteroids","saline nasal irrigation","comparative effectiveness","RECRUITING","2026-02-27",{"date":99,"type":39},"2026-03-03",{"date":101,"type":39},"2023-11-21",{"date":103,"type":22},"2028-12",{"name":105,"class":46},"Daniel Merenstein",7,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":130,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":47},"100620566","impact-of-a-multimodal-intervention-on-antibiotic-prescribing-for-respiratory-infections-in-primary-care-100620566","NCT07359287","Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care","Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care: A Cluster-Randomized Trial","GRASP","Inclusion Criteria:\n\n\\- Patient seen in consultation for an upper or lower respiratory tract infection (Angina, Acute bronchiolitis, Acute bronchitis, COPD exacerbation (AECOPD), Laryngitis, Acute otitis media (AOM), Serous or congestive otitis, Viral respiratory infection (e.g., influenza), Community-acquired pneumonia (CAP), Rhinitis \u002F Nasopharyngitis, Acute sinusitis)\n\nExclusion Criteria:\n\n\\- Patient under legal protection",{"count":116,"type":22},4500,[25],"Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France are prescribed and where misuse remains common.\n\nWe are proposing a cluster-randomized controlled trial to evaluate the effectiveness of a bimodal intervention combining: (1) improved communication about the circulation of respiratory viruses, and (2) strengthened collaborative practices between general practitioners and pharmacists through a multidisciplinary protocol aimed at verifying that prescribed treatment durations comply with guidelines.\n\nThe study will include six primary care practices (24 physicians), with three practices in each study arm.\n\nThe aim of this project is to assess whether the bimodal intervention can reduce the duration of antibiotic treatments for upper and lower respiratory tract infections. The first component (a \"viral infection prescription\" tool) focuses on reducing unnecessary treatment initiation, while the second (pharmacist-led review) aims to shorten excessive prescription durations.",[120,121,122,123,124,125,126,127,128,129,29],"Angina","Acute Bronchiolitis","Acute Bronchitis","COPD Exacerbation (AECOPD)","Laryngitis","Acute Otitis Media (AOM)","Serous or Congestive Otitis","Viral Respiratory Infection (e.g., Influenza)","Community-Acquired Pneumonia (CAP)","Rhinitis \u002F Nasopharyngitis",[131,132],"Upper respiratory tract infection","Lower respiratory tract infection","2026-01-13",{"date":135,"type":39},"2026-01-22",{"date":137,"type":39},"2025-12-01",{"date":139,"type":22},"2026-09-01",{"name":141,"class":46},"University Hospital, Caen"]