[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-variceal-bleeding\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-variceal-bleeding":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100623323","phase-3-albumin-in-acute-variceal-bleeding-100623323",false,"NCT07395141","Albumin in Acute Variceal Bleeding","Albumin in Acute Variceal Bleeding: A Randomized Controlled Trial: ALB-AVB Trial","ALB-AVB","Inclusion Criteria:\n\n* All adult patients with acute variceal bleeding and cirrhosis presenting to Medical Gastroenterology department at KGMU, Lucknow, U.P. India.\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years and \\> 70 years\n2. Patients with portal vein thrombosis\n3. Hepatocellular carcinoma\n4. Non-cirrhotic portal fibrosis\n5. Extrahepatic portal vein thrombosis\n6. Patients who received albumin in the last one month\n7. Patients who require fresh frozen plasma\n8. Patients with heart failure\n9. Patients with chronic kidney disease\n10. Volume overload state","ALL","18 Years","70 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","The objective of this randomized control clinical trial is to learn the role of albumin in patients with acute variceal bleed. The trial will include all adult patients with acute variceal bleeding and cirrhosis presenting to Medical Gastroenterology department at KGMU, Lucknow, U.P. India, will include patients with age between 18-70 years and all gender.\n\nThe primary endpoint will be re-bleeding during hospitalization and at 6 weeks. Participants will be randomized in two groups, the intervention group will receive albumin for 3 days along with standard treatment and comparison group will receive on standard treatment.",[28,29],"Acute Variceal Bleeding","Cirrhosis",[31,32,33,34],"albumin","acute variceal bleed","cirrhosis","Albumin in acute variceal bleeding","NOT_YET_RECRUITING","2026-02-03",{"date":38,"type":39},"2026-02-09","ACTUAL",{"date":41,"type":22},"2026-03-01",{"date":43,"type":22},"2026-05-31",{"name":45,"class":46},"King George's Medical University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":47},"100518504","timing-of-endoscopy-in-cirrhotic-patients-with-acute-variceal-bleeding-100518504","NCT06031402","Timing of Endoscopy in Cirrhotic Patients with Acute Variceal Bleeding","Inclusion Criteria:\n\n1. patients with AUGIB which is highly suspected to be caused by gastroesophageal variceal rupture;\n2. patients with a diagnosis of liver cirrhosis based on imaging and pathology;\n3. patients and\u002For their relatives who sign informed consents;\n4. patients' age ≥18 years.\n\nExclusion Criteria:\n\n1. patients who have undergone endoscopy at other hospitals before admissions;\n2. patients' hemodynamics are unstable after resuscitation;\n3. patients with severe cardiovascular or cerebrovascular diseases or renal injury;\n4. patients who have taken anticoagulants or antiplatelet drugs within 2 weeks before admissions, or are diagnosed with severe hematological diseases;\n5. patients with human immunodeficiency virus or other acquired or congenital immune deficiency diseases;\n6. patients with mental illness;\n7. pregnancy.",{"count":55,"type":22},368,[57],"NA","Endoscopy is important for the diagnosis and treatment of acute upper gastrointestinal bleeding (AUGIB), especially acute variceal bleeding (AVB), in patients with liver cirrhosis. However, the optimal timing of endoscopy remains controversial, primarily because the currently available evidence is of poor quality, and the definition of early endoscopy is also very heterogeneous among studies. Herein, a multicenter randomized controlled trial (RCT) is performed to explore the impact of timing of endoscopy on the outcomes of cirrhotic patients with AVB.",[60,28],"Acute Upper Gastrointestinal Bleeding",[62,63,64,65,66,67],"liver cirrhosis","variceal bleeding","gastrointestinal bleeding","endoscopy","survival","randomized controlled trial","RECRUITING","2025-02-25",{"date":71,"type":39},"2025-02-27",{"date":73,"type":39},"2024-09-04",{"date":75,"type":22},"2026-12",{"name":77,"class":46},"General Hospital of Shenyang Military Region"]