[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adequate-vitamin-c-status\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adequate-vitamin-c-status":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100604560","anti-inflammatory-activities-of-vitamin-c-supplementation-on-the-gut-barrier-function-in-adults-with-obesity-100604560",false,"NCT07151105","Anti-inflammatory Activities of Vitamin C Supplementation on the Gut Barrier Function in Adults With Obesity","Inclusion Criteria:\n\n* English speaking\n* Men and women between 18-50 years of age\n* BMI 30-40 kg\u002Fm²\n* Resting blood pressure \\\u003C140\u002F90 mm Hg\n* No use of multivitamin\u002Fvitamin C supplement within past 1-month\n* Non-vegetarian\u002Fnon-vegan\n* Willingness to follow a diet low in fruits and vegetables for two, 2-week periods\n\nExclusion Criteria:\n\n* Current smoker or vaper, including tobacco, cannabis, or nicotine products\n* Alcohol consumption \\>2 drinks\u002Fday\n* Use of antibiotics within past 1-month\n* Use of probiotic supplements within past 1-month\n* Use of anti-inflammatory drugs within past 1-month\n* Individuals with unmanaged or poorly controlled diabetes, dyslipidemia, hypertension\n* Known history of bleeding disorders, hemochromatosis, or kidney stones\n* For Women: Pregnancy, lactation, or change in birth control within the past 3-months\n* Use of certain medications that may interact with vitamin C, including blood thinners, some antiviral drugs (e.g., indinavir), and certain antipsychotic medications (e.g., fluphenazine).","ALL","18 Years","50 Years",{"count":19,"type":20},34,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study is testing whether taking vitamin C every day can help improve gut health and reduce inflammation in adults with obesity. Poor gut health-sometimes called \"leaky gut\"-can allow harmful substances from bacteria to enter the bloodstream, which may lead to inflammation and increase the risk of heart disease and liver problems.\n\nParticipants will complete two study periods, each lasting two weeks, with a two-week break in between. In one period, they will take vitamin C; in the other, a placebo. During each period, researchers will collect blood, urine, and stool samples, ask participants to track their diet and activity, and perform a test to measure gut permeability.\n\nThere are minimal risks, such as discomfort from blood draws or temporary stomach upset from a sugar drink. While participants may not directly benefit, their involvement will help researchers learn whether vitamin C is a safe and effective way to improve gut health in people with obesity.",[26,27],"Adequate Vitamin C Status","Inadequate Vitamin C Status","RECRUITING","2026-08-29",{"date":31,"type":32},"2026-09-01","ACTUAL",{"date":34,"type":32},"2025-10-01",{"date":36,"type":20},"2028-12-30",{"name":38,"class":39},"Ohio State University","OTHER"]