[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"advanced-colorectal-laterally-spreading-tumours-lsts\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:advanced-colorectal-laterally-spreading-tumours-lsts":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100652744","development-and-validation-of-a-circulating-tumour-dna-marker-for-pre-neoplastic-colorectal-tumours-100652744",false,"NCT07776548","Development and Validation of a Circulating Tumour DNA Marker for Pre-neoplastic Colorectal Tumours.","ctDNA-LST","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Referred for resection of a large (≥ 10 mm) colorectal laterally spreading tumour (LST).\n* Lesion judged amenable to endoscopic resection by the treating endoscopist.\n* Able to provide written informed consent.\n\nExclusion Criteria:\n\n* Known concurrent or prior colorectal cancer, or another active malignancy that could contribute circulating tumour DNA.\n* Lesion \\\u003C 10 mm.\n* Inability to provide informed consent.","ALL","18 Years",{"count":19,"type":20},110,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this prospective interventional biomarker development and validation study is to determine whether circulating tumour DNA (ctDNA) can be detected in patients with large pre-neoplastic colorectal lesions undergoing endoscopic resection and whether ctDNA can be used to identify local recurrence after resection.\n\nThe main questions it aims to answer are:\n\n* Can advanced colorectal laterally spreading tumours (LSTs) shed detectable ctDNA into the bloodstream before endoscopic resection?\n* Can ctDNA measured at the first surveillance colonoscopy detect or predict local recurrence after endoscopic resection?\n\nParticipants will:\n\n* Provide a blood sample before their planned endoscopic resection procedure for ctDNA analysis.\n* Undergo standard endoscopic resection of their colorectal lesion.\n* Allow collection and molecular analysis of tissue samples obtained from the resected lesion.\n* Allow researchers to collect clinical, endoscopic, pathological, and molecular data from their medical records for research purposes.\n\nThe study does not alter the standard clinical management, resection technique, or surveillance schedule. The only study-specific procedures are blood sample collections performed during routine intravenous catheter placement for the participant's endoscopic procedures.",[26],"Advanced Colorectal Laterally Spreading Tumours (LSTs)","NOT_YET_RECRUITING","2026-08-17",{"date":30,"type":31},"2026-08-20","ACTUAL",{"date":33,"type":20},"2027-01-04",{"date":35,"type":20},"2029-01-03",{"name":37,"class":38},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER"]