[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aging-and-exercise-impacts-on-glymphatic-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aging-and-exercise-impacts-on-glymphatic-function":13},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100652727","aging-and-exercise-impacts-on-glymphatic-function-100652727",false,"NCT07775196","Aging and Exercise Impacts on Glymphatic Function","Impact of Aging and Exercise on Glymphatic Function Using Multi-modal MRI","Inclusion Criteria:\n\n* age 25-75 years old\n* cognitively unimpaired (CU)\n* Mini-Mental State Examination (MMSE) score ≥27 at enrollment screening\n* matched gender\n* all racial\u002Fethnic groups\n\nExclusion Criteria:\n\n* pregnant women\n* history of stroke or other major cerebrovascular disease;\n* diagnosis of Alzheimer's disease (AD) or other types of dementia;\n* diagnosis of major neurologic and psychiatric disorders (e.g., Parkingson's disease, major depression);\n* history of prior head trauma, significant autoimmune disorders,\n* sleep apnea;\n* major systemic illness likely to affect the central nervous system, e.g., uncontrolled diabetes, severe cardiovascular disease, cancer, etc.;\n* prior or current alcoholism or drug abuse;\n* resistant hypertension (SBP ≥140 or DBP ≥ 90 mmHg despite 3 antihypertensive drugs at maximal doses);\n* orthostatic hypotension defined as the third standing systolic blood pressure (SBP) \\\u003C 100mmHg; any contraindications to having a MRI, e.g., claustrophobia, pacemaker or other medical device of metal;\n* any conditions judged by the investigators to be medically inappropriate, risky or likely to cause poor study compliance.",true,"ALL","25 Years","75 Years",{"count":21,"type":22},240,"ESTIMATED","INTERVENTIONAL",[25],"NA","This is a prospective, interventional, non-blinded, single center research project that will recruit cognitively unimpaired subjects in the 25-55 year old and 55-75 year old range. This study will use acute aerobic exercise as a natural intervention model to increase cardiac activity which may further drive the glymphatic function. There will be no randomization, and all enrolled subjects will participate in the exercise session.\n\nHypotheses: revealed by the multi-modal magnetic resonance imaging (MRI) approach, glymphatic dysfunction increases with age and is associated with preclinical Alzheimer's Disease (AD) pathology in cognitively unimpaired individuals. Using acute aerobic exercise as a human model, the enhancement of cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange caused by elevated cardiac activity and paravascular cerebrospinal fluid (pCSF) dynamics can be validated.",[13],[29,30,31,32],"Aging","Exercise","Glymphatic Function","Alzheimer's Disease","NOT_YET_RECRUITING","2026-08-17",{"date":36,"type":37},"2026-08-20","ACTUAL",{"date":39,"type":22},"2026-12",{"date":41,"type":22},"2029-12",{"name":43,"class":44},"University of Texas Southwestern Medical Center","OTHER"]