[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aicardi-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aicardi-syndrome":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":25,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100080584","brain-development-research-program-100080584",false,"NCT00305305","Brain Development Research Program","Disorders of Cerebral Development: A Phenotypic and Genetic Analysis","Inclusion Criteria:\n\n* Clinical diagnosis of agenesis or dysgenesis of the corpus callosum, polymicrogyria, or Dandy-Walker malformation\n* Should be confirmed by an MRI (Magnetic Resonance Imaging) of the brain\n\nExclusion Criteria:\n\n* Fully formed but hypoplastic corpus callosum","ALL",{"count":18,"type":19},2000,"ESTIMATED","OBSERVATIONAL","Dr. Elliott Sherr and his collaborators at University of California, San Francisco (UCSF) are studying the genetic causes of disorders of cognition and epilepsy, in particular disorders of brain development that affect the corpus callosum, such as Aicardi syndrome, as well as two additional brain malformations, polymicrogyria and Dandy-Walker malformation. The goal of the investigators' research is to use a better understanding of the underlying genetic causes as a foundation to develop better treatments for these groups of patients.",[23,24],"Brain Disorders","Aicardi Syndrome",[26,27,28,29,30,31,32,33,34,35,36],"Agenesis Corpus Callosum","Polymicrogyria","Dandy-Walker","Brain Malformation","Autism","Epilepsy","Mental Retardation","MRI","Agenesis of the Corpus Callosum (complete or partial)","Confirmed by a brain MRI.","Aicardi Syndrome.","RECRUITING","2026-08-13",{"date":40,"type":41},"2026-08-17","ACTUAL",{"date":43,"type":41},"2003-08",{"date":45,"type":19},"2027-01",{"name":47,"class":48},"University of California, San Francisco","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":49},"100110076","study-of-selected-x-linked-disorders-aicardi-syndrome-100110076","NCT00697411","Study of Selected X-Linked Disorders: Aicardi Syndrome","Pathogenesis of Selected X-Linked Dominant Disorders and New Strategies to Identify the Gene Mutated in Aicardi Syndrome","Inclusion Criteria:\n\n* Features suggestive of Aicardi syndrome (not all features must be present)\n\n  * Agenesis of the corpus callosum\n  * Chorioretinal lacunae\n  * Seizures (infantile spasms)\n\nExclusion Criteria:\n\n* none",{"count":58,"type":19},500,"Based on our current understanding of Aicardi syndrome, the condition is hypothesized to occur due to a genetic change on the X-chromosome. The research team is investigating Aicardi syndrome to identify the specific gene location associated with the disorder. The investigators are collecting blood and skin biopsy samples from patients and their parents. A permanent cell line is prepared and DNA from the blood and skin samples and cell lines is isolated and then used for genetic testing. The current research includes microarray analysis which which is used to look for duplications or deletions of genetic material, mutation analysis of candidate genes by sequencing, genome-wide sequencing, review of medical records to identify trends suggesting possible candidate genes of interest, and X chromosome inactivation studies.",[24,23],[62,63,64],"Aicardi syndrome","Neurodevelopmental disorders","X-linked disorders","2026-04-29",{"date":67,"type":41},"2026-05-05",{"date":69,"type":41},"2002-10",{"date":71,"type":19},"2030-01",{"name":73,"class":48},"Baylor College of Medicine"]