[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"airway-complication-of-anaesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:airway-complication-of-anaesthesia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100650869","comparison-of-acute-airwayrespiratory-complications-and-intervention-requirements-in-extubations-performed-during-on-hours-versus-off-hours-a-prospective-observational-cohort-study-100650869",false,"NCT07752173","Comparison of Acute Airway\u002FRespiratory Complications and Intervention Requirements in Extubations Performed During On-Hours Versus Off-Hours","Comparison of Acute Airway\u002FRespiratory Complications and Intervention Requirements in Extubations Performed During On-Hours Versus Off-Hours: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n\\- Age ≥ 18 years\n\nUndergoing elective or emergency surgery under general anaesthesia with endotracheal intubation\n\nPlanned tracheal extubation in the operating theatre or post-anaesthesia care unit (PACU)\n\nProvision of written informed consent (or deferred consent for emergency cases, in accordance with national regulations)\n\nExclusion Criteria:\n\n* Patients undergoing surgery under regional anaesthesia or sedation without endotracheal intubation\n\nPatients with a tracheostomy in situ\n\nPatients who remain intubated and are transferred to the intensive care unit (ICU) postoperatively\n\nPatients undergoing cardiothoracic surgery involving cardiopulmonary bypass\n\nEmergency airway management performed outside the operating theatre (e.g., ICU, emergency department)\n\nPatients with known or suspected difficult airway requiring awake fibreoptic intubation\n\nPatients who refuse to provide informed consent or withdraw consent during the study\n\nPregnant patients","ALL","18 Years",{"count":19,"type":20},2640,"ESTIMATED","1 Day","OBSERVATIONAL","Perioperative airway\u002Frespiratory complications are a major driver of morbidity and mortality. While UK audits NAP4 and NAP7 extensively examined major critical events (e.g., cardiac arrest), prospective standardized data on acute, more frequent extubation-phase complications-such as desaturation, laryngospasm, obstruction, bronchospasm, and aspiration-remain scarce. Off-hours procedures carry additional risks related to increased workload, reduced senior supervision, and clinician fatigue, though current evidence is inconclusive and requires further human-factors research using validated tools like the Karolinska Sleepiness Scale (KSS). This prospective cohort study at Kocaeli City Hospital aims to compare the incidence of acute airway\u002Frespiratory complications and intervention requirements during extubation and the first 30 minutes post-extubation between on-hours (08:00-16:00) and off-hours (\\>16:00). Notably, this will be the first prospective observational study to specifically test NAP7's off-hours risk findings at the extubation stage, with the goal of strengthening patient safety and guiding institutional quality improvement.",[25,26,27],"Extubation Failures","Extubation","Airway Complication of Anaesthesia",[26,29,30,31,32],"Airway complications","Off-hours","General anaesthesia","Prospective cohort study","RECRUITING","2026-08-15",{"date":36,"type":37},"2026-08-18","ACTUAL",{"date":39,"type":20},"2026-08-03",{"date":41,"type":20},"2027-05-15",{"name":43,"class":44},"Kocaeli City Hospital","OTHER_GOV",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":55,"conditions":56,"keywords":62,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100640762","effect-of-high-flow-nasal-oxygen-on-laryngoscopic-view-100640762","NCT07575776","Effect of High-Flow Nasal Oxygen on Laryngoscopic View","Effect of Different Flows Using High-Flow Nasal Oxygen (HFNO) on Laryngoscopic View Quality During Videolaryngoscopy","Inclusion Criteria:\n\n* Age ≥18 years\n* Scheduled for endotracheal intubation under general anesthesia\n* Use of videolaryngoscopy\n\nExclusion Criteria:\n\n* Anticipated difficult airway\n* Emergency intubation\n* Contraindications to HFNO\n* Inability to obtain adequate video recording",{"count":54,"type":20},150,"This prospective, multicenter observational study aims to evaluate the effect of different flow rates of high-flow nasal oxygen (HFNO) on the quality of the laryngoscopic view during videolaryngoscopy in adult patients undergoing general anesthesia. Each patient will serve as their own control, with repeated measurements obtained at three different HFNO flow settings (0, 40, and 60 L\u002Fmin). The study will assess objective and subjective parameters of glottic visualization using standardized scoring systems.",[57,58,59,27,60,61],"High Flow Nasal Canula","Laryngoscopy","Airway Anesthesia","Difficult Airway","Difficult \u002F Failed Intubation",[63,64,65,66,67],"high flow nasal canula","thrive","difficult airway","airway management","anaesthesia","NOT_YET_RECRUITING","2026-05-04",{"date":71,"type":37},"2026-05-08",{"date":73,"type":20},"2026-09-01",{"date":75,"type":20},"2027-12-01",{"name":77,"class":78},"Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.","OTHER",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":98,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":4},"100617980","comparison-of-the-effects-of-total-intravenous-anaesthesia-with-target-controlled-infusion-tci-and-inhalation-anaesthesia-on-airway-complications-during-extubation-and-in-the-early-postoperative-period-in-thyroidectomy-surgery-100617980","NCT07325669","Comparison of the Effects of Total Intravenous Anaesthesia With Target-Controlled Infusion (TCI) and Inhalation Anaesthesia on Airway Complications During Extubation and in the Early Postoperative Period in Thyroidectomy Surgery","Inclusion Criteria:\n\n* Aged 18 years or older,\n* Classified as ASA I-II,\n* Undergoing elective primary total or subtotal thyroidectomy surgery,\n* Patients undergoing intraoperative neuromonitoring will be included in the study.\n\nExclusion Criteria:\n\n* • History of difficult intubation,\n\n  * History of neuromuscular disease,\n  * Current vocal cord paralysis,\n  * Previous neck surgery\n  * Patients with a body mass index above 35 kg\u002Fm² were defined as morbidly obese.",true,{"count":87,"type":20},100,"INTERVENTIONAL",[90],"NA","Thyroid surgery is one of the most complex operations in the head and neck region due to its close relationship with anatomical structures and the high risk of recurrent laryngeal nerve injury. The proximity of the surgical field to the trachea and larynx increases the likelihood of postoperative airway complications. Common complications include hypoparathyroidism (HP), recurrent laryngeal nerve (RLN) injury, injury to the external branch of the superior laryngeal nerve (EBLN), postoperative bleeding, thoracic canal injury, laryngeal oedema, tracheospasm, tracheal injury, and oesophageal injury. Serious complications such as dyspnoea, asphyxia, or thyroid crisis can lead to patient death.\n\nSevere hypertension or coughing during awakening and extubation may cause bleeding from the surgical site, along with possible haematoma formation. In this context, safe extubation, maintenance of postoperative airway patency, and prevention of early complications are critical components of anaesthesia management in thyroid surgery.\n\nCurrently used anaesthesia techniques can directly affect the quality of the recovery process, the sensitivity of airway reflexes, and the reliability of nerve monitoring techniques. Total intravenous anaesthesia (TIVA) regimens, particularly when administered via target-controlled infusion (TCI) systems, allow for more precise control of anaesthetic depth and provide a more predictable, stable transition during the extubation period. In target-controlled intravenous anaesthesia, bolus and infusion of the anaesthetic agent are administered to achieve the desired target concentration based on the pharmacokinetic models of the drug according to the patient's age, gender, height, and weight. Various studies have indicated that the combination of propofol and remifentanil causes fewer complications such as agitation, coughing, and laryngospasm during the recovery period; in contrast, volatile agents such as sevoflurane may trigger undesirable effects such as increased secretion in the respiratory tract and laryngeal sensitivity more frequently.\n\nFurthermore, intraoperative neuromonitoring (IONM) applications are increasingly being used to prevent recurrent laryngeal nerve injuries. However, the accuracy and signal quality of this technology are directly affected by the impact of the anaesthetic regimen on nerve-muscle transmission. The literature has shown that inhalation anaesthetics may weaken IONM responses by suppressing synaptic transmission, whereas TIVA provides more reliable and stable signal transmission. A study comparing propofol and inhalation anaesthesia in patients with papillary thyroid carcinoma showed that propofol-based total intravenous anaesthesia was associated with fewer postoperative recurrences.\n\nIn a study comparing TCI-TIVA and sevoflurane inhalation anaesthesia in laparoscopic cholecystectomy surgery, TCI was reported to be associated with less postoperative nausea and vomiting and haemodynamic instability. In a study involving 50 patients undergoing lumbar disc surgery who received general anaesthesia with sevoflurane-fentanyl and propofol-remifentanil, less coughing and haemodynamic instability during awakening were observed in the TIVA group.\n\nThe hypothesis of this study is that TIVA administered using the TCI method will result in fewer airway complications after extubation and higher intraoperative neuromonitoring signal quality compared to inhalation anaesthesia. The study will comparatively evaluate the advantages and disadvantages of two different anaesthesia techniques in terms of both postoperative airway safety and haemodynamics, as well as intraoperative nerve monitoring.",[93,27,94,95,96,97],"Throid Surgery","Coughing Responses at Tracheal Extubation","Laryngospasm on Emergence","Target Controlled Infusion of Propofol","Sevoflurane Anaesthesia",[99,100,101],"airway complication of anesthesia","tiroid surgery","propofol anesthesia","2025-12-24",{"date":104,"type":37},"2026-01-08",{"date":106,"type":20},"2026-01-01",{"date":108,"type":20},"2027-03-01",{"name":110,"class":78},"dilara gocmen"]