[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aldosterone-synthase\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aldosterone-synthase":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100650640","decode-the-environment-variation-of-targeted-aldosterone-inducer-and-silencer-100650640",false,"NCT07748975","Decode the Environment Variation of Targeted Aldosterone Inducer and siLencer","DETAIL","Inclusion Criteria:\n\n* Human birth in all sex chromosomes; evidence of systemic arterial hypertension, both treated and untreated.\n* Evidence of living with owned systemic\u002Farterial hypertension by one of the following;\n* Quantitative: Blood pressure number higher than the normal range by each protocol in mmHg unit in any arm of study.\n* Qualitative: Clarify whether both retrospective, observational, or intervention study of blood pressure, and clearly clarify the number of hypertension participants in the article.\n\nExclusion Criteria:\n\n* Under 18 years old\n* Specimens of studies not from humans or human specimens but not from an actual living hypertension patient, such as cell culture, in vitro synthesis from laboratory synthesis\n* No evidence of hypertension in the main study\n* Study of imaging confirms adrenal tumor in all types of histopathology results.","ALL","18 Years","100 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","Clinical outcome to identify and analyze the epigenetic, phenotypic, protein variation, metabolites of CYP450 Family 11 Subfamily B, both 1 and 2, human-associated aldosterone protein release, and signaling inhibitory pathways post-aldosterone-mineralocorticoid interaction.\n\nWe will include clinical studies (RCTs, cohort, case-control\u002Fseries\u002Freport) from fresh human specimens. We will exclude animal studies, studies generated from cell culture, and aldosterone synthesis.\n\nTo systematically review and synthesize the literature on the main 2 questions Question 1: Which environment induces CYP11B1 or CYP11B2 activation causing hyperaldosteronemia in hypertension patients? Question 2: Which intracellular signal silences aldosterone-MR activity? For Individual Participant Data Meta-analysis, data will be extracted from final analysis articles from the framework of the data selection process only; the effect measurement and multi-variable model meta-analysis will be performed.\n\nPrimary Objective1: to identify CYP450 Family 11 Subfamily B and Aldosterone in hypertension patients following; By structure ● Evidence confirms Epigenetic profile of CYP450 Family 11 Subfamily B, Aldosterone, Signal in hypertension patients, both random and treated from any DNA sequencing method Protein synthesis evidence of aldosterone protein induces hypertension from Western blot or LC-MS By function Metabolomic profile: the substrate or product refers to aldosterone interaction causing end-organ cell line dysfunction or impaired structure.\n\nInhibitory signaling profiling of hypertension patients compared to non-hypertension patients, which negatively feedback to CYP450 Family 11 Subfamily B or Aldosterone\n\nSecondary Objective 2:\n\nSub-group analysis effect measurement following;\n\n* Proposed mechanisms, biological markers, or pathways that contribute to failure to regulate aldosteronemia\n* Treatment-related permanent normotensive post-hyperaldosteronemia. Primary Objective 2: Identify possible intracellular signal inhibit aldosterone action\n* Analyze possible mechanisms of signal that are silent aldosterone-MR activity\n* Differentiation of free aldosterone and attached aldosterone\n\nSecondary Objective 2:\n\n● Sensitivity and specificity of outcomes of hypertension patients who underwent estimate substrate associated aldosterone circulation Plasma CYP450 Family 11 Subfamily B Urine CYP450 Family 11 Subfamily B Plasma Aldosterone (active form) Plasma Aldosterone (metabolite form) Urine Aldosterone",[27,28,29,30,31,32],"Hypertension","Aldosteronemia","CYP11B1","CYP11B2","Aldosterone Synthase","Beta-catenin","NOT_YET_RECRUITING","2026-07-31",{"date":36,"type":37},"2026-08-06","ACTUAL",{"date":39,"type":21},"2026-08-10",{"date":41,"type":21},"2028-02-05",{"name":43,"class":44},"DejthidaNathaphong","OTHER"]