[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"countryName\":\"Bahrain\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":114},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100652274","early-phase-1-total-osteo-cartilage-replacement-for-the-treatment-of-osteoarthritis-of-knee-100652274",false,"NCT07769632","Total Osteo-Cartilage Replacement for the Treatment of Osteoarthritis of Knee","Inclusion Criteria:\n\n* Being between 45 and 70 years of age of either gender. (OAK is common in this Age group)\n* Diagnosed with OAK with Kellgren and Lawrence Grading III and IV.\n* No ligamentous laxity and varus or valgus deformity. (In standard TKR patients with ligamentous laxity Constrained Condylar Knee (CCK) with intramedullary stem is used).\n* Patients who wish to have an active lifestyle.\n* Agreeing to participate and signing informed consent voluntarily.\n\nExclusion Criteria:\n\n* Previous knee surgery within six months.\n* Uncontrolled Diabetes Mellitus\n* Chronic Kidney Disease. (Patients on hemodialysis)\n* Metabolic bone disease. (Severe osteoporosis with T Score of -\\\u003C3.5)\n* Patients who will not consent to follow-up.\n* Mental disorders and drug dependency (Patients who cannot understand the consent or the procedure of the TOCR).","ALL","45 Years","70 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","Young patients who require total knee arthroplasty with metallic and plastic implants will undergo femoral condyle cartilage and top of the tibia with meniscus replacement. With the proposed surgery patients will have increased range of movements so that they can sit on the ground to fulfill their social was of life, which is not possible with the standard of care total knee replacement.",[26],"Osteoarthritis (OA) of the Knee",[28,29,30,31,32],"Osteoarthritis","Kellgran and Lawrence","Knee joint","Total knee Replacement","Allogenic graft","NOT_YET_RECRUITING","2026-08-18",{"date":36,"type":37},"2026-08-19","ACTUAL",{"date":39,"type":20},"2026-11-01",{"date":41,"type":20},"2027-10-31",{"name":43,"class":44},"AlSalam Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":45},"100651605","supervised-exercise-during-neoadjuvant-chemotherapy-for-breast-cancer-100651605","NCT07764341","Supervised Exercise During Neoadjuvant Chemotherapy for Breast Cancer","Supervised Exercise During Neoadjuvant Chemotherapy for Breast Cancer: Protocol for a Randomized Feasibility Trial","Inclusion Criteria:\n\n1. Histologically confirmed invasive breast carcinoma, clinical stage I-III.\n2. Female, age ≥18 years.\n3. Planned to undergo standard neoadjuvant chemotherapy of ≥4 months duration with curative intent, followed by definitive surgery. This includes common regimens such as taxane- and anthracycline-based chemotherapy or TCHP (docetaxel, carboplatin, trastuzumab, pertuzumab) for HER2-positive disease.\n4. Availability of a baseline CT or PET\u002FCT scan (as part of routine diagnosis or staging) that includes axial images at the third lumbar vertebra (L3) level, performed prior to starting NACT.\n5. Anticipated post-NACT CT or PET\u002FCT scan (e.g. for re-staging) that includes the L3 level, to be performed after completion of NACT and before surgery per standard care practice.\n6. Eastern Cooperative Oncology Group (ECOG) performance status 0-2.\n7. Cleared by treating oncologist and physiotherapist as medically able to participate in a moderate-intensity exercise program (e.g. able to walk independently with or without an assistive device and perform basic resistance exercises).\n8. Able and willing to provide written informed consent.\n9. Able to understand study instructions and complete questionnaires.\n\nExclusion Criteria:\n\n1. Evidence of distant metastatic disease (stage IV) or treatment plan not aiming for curative intent.\n2. Unstable or severe cardiac, pulmonary, or other systemic comorbidities that would make moderate exercise unsafe, such as unstable angina or recent myocardial infarction, decompensated heart failure, uncontrolled severe arrhythmia, uncontrolled severe hypertension, or severe symptomatic lung disease.\n3. Major musculoskeletal or neurological conditions that would preclude safe participation in supervised exercise (e.g. unstable orthopedic injuries, severe neuropathy or neurologic deficit, or recent major surgery not yet recovered).\n4. Current second active malignancy (excluding second localized early breast cancer).\n5. Regular participation in ≥150 minutes per week of moderate-vigorous aerobic activity and ≥2 resistance training sessions per week in the 3 months before cancer diagnosis.\n6. Baseline imaging not available or not including L3, or patient unlikely to have a post-NACT scan including L3 (e.g. if they refuse imaging).\n7. CT images of insufficient quality (e.g. severe artifacts or truncated field of view at L3) that would prevent accurate muscle measurement.\n8. Pregnant or breastfeeding at the time of enrollment.\n9. Significant cognitive impairment, psychiatric disorder, or language barrier that would prevent informed consent or compliance with the protocol.\n10. Any other condition or circumstance that, in the opinion of the investigator, would make participation not in the patient's best interest or would compromise the scientific integrity of the study.","FEMALE","18 Years",{"count":56,"type":20},80,[58],"NA","The goal of this clinical trial is to learn whether supervised exercise is practical and safe for women receiving chemotherapy before surgery for breast cancer.\n\nThe main questions it aims to answer are:\n\n* Can participants attend and complete the supervised exercise program during chemotherapy?\n* Is the exercise program safe?\n* Does exercise help maintain muscle mass, strength, quality of life, and chemotherapy delivery?\n\nParticipants will be assigned to either:\n\n* supervised aerobic and strength exercise during chemotherapy, or\n* usual care without a study exercise program. Researchers will compare the two groups before and after chemotherapy.",[61,62],"Breast Cancer Early Stage Breast Cancer (Stage 1-3)","Breast Neoplasm Malignant Female",[64,65,66,67,68,69,70,71,72,73,74],"breast cancer","sarcopenia","neoadjuvant chemotherapy","exercise","resistance training","body composition","physical activity","quality of life","skeletal muscle","pathologic complete response","relative dose intensity","2026-08-11",{"date":77,"type":37},"2026-08-13",{"date":79,"type":20},"2026-09",{"date":81,"type":20},"2027-09",{"name":83,"class":44},"King Hamad University Hospital, Bahrain",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":15,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":99,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":113},"100521412","movement-behaviours-among-bahraini-diabetics-100521412","NCT06069258","Movement Behaviours Among Bahraini Diabetics","Movement Behaviours Among Bahraini Type 2 Diabetic Adults: a Cross-sectional Study","Inclusion Criteria:\n\n* Sex: Men and women are eligible.\n* Age: Individuals aged 20-75 years old are eligible.\n* Ethnicity: Bahraini adults of all ethnic groups are eligible for the study.\n* Type 2 diabetes and glycaemic control: Individuals with controlled type 2 diabetes (i.e. HbA1c \\\u003C9 on medication) based on the medical record of each patient's last visit to the health centre for routine follow-up will be eligible if within the last four months. Otherwise, these measurements will be ordered at the first visit to confirm eligibility.\n* Blood pressure: Individuals whose blood pressure is under moderate control will be eligible - specifically, treated or untreated resting systolic\u002Fdiastolic pressure \\\u003C 160\u002F100 mmHg.\n* Lipid control: Individuals with fasting triglyceride concentration \\\u003C 600 mg are eligible.\n\nExclusion Criteria:\n\n* HbA1c \\>9%\n* Type 1 diabetes\n* Taking insulin\n* Pregnancy\n* Non-ambulant or severely incapacitated with any medical condition(s) reducing ability to stand or mobilize.\n* Currently participating in a study to reduce sedentary behaviour or increase physical activity\n* Language. Inability to read and understand Arabic or English language.\n* Inability to give informed consent.","20 Years","75 Years",{"count":94,"type":20},340,"OBSERVATIONAL","This observational study aims to measure movement behaviours and explore factors influencing these among Bahraini patients with type 2 diabetes.\n\nThe main objectives are:\n\n(i) Measure free-living physical activity and sedentary behaviour with an accelerometer device (ii) Examine associations between movement behaviours and anthropometric and diabetes-related biochemical\u002Fclinical parameters (iii) Examine associations between movement behaviours and psychological and environmental determinants that influence movement behaviours (iv) Assess the feasibility and acceptability of the physical activity assessment tools as part of routine clinical practice with clinicians and diabetic patients\n\nParticipants will be invited to wear an accelerometer device for seven days.",[98],"Diabetes Mellitus, Type 2",[100,101,102],"Physical activity","Behaviour","mHealth","RECRUITING","2025-02-24",{"date":106,"type":37},"2025-02-26",{"date":108,"type":37},"2024-04-24",{"date":110,"type":20},"2025-12-31",{"name":112,"class":44},"Royal College of Surgeons in Ireland - Medical University of Bahrain",4,""]