[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"countryName\":\"Egypt\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":606},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,2860,0,25,[9,47,72,99,121,143,170,192,213,234,252,274,296,316,346,370,392,413,435,455,480,512,541,565,587],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":7},"100579387","an-international-multicenter-study-on-transcatheter-device-closure-of-perimembranous-ventricular-septal-defects-100579387",false,"NCT06823635","An International Multicenter Study on Transcatheter Device Closure of Perimembranous Ventricular Septal Defects","PERI-CLOSE","Inclusion Criteria:\n\n1. Patients with perimembranous ventricular septal defects (PmVSD) diagnosed by 2D transthoracic echocardiography according to established classification systems, who provided informed consent and underwent transcatheter closure using any commercially available occluder devices (whether specifically designed for this indication or used off-label), with follow-up according to local hospital protocols.\n2. Defect size between 3 mm and \\\u003C20 mm on the left ventricular side, as measured by 2D echocardiography.\n3. Age ≥1 month and body weight ≥5 kg.\n4. Left-to-right ventricular shunt.\n\nExclusion Criteria:\n\n1. Patients or legal guardians refusing the use of personal data for research purposes.\n2. Failure to attend any follow-up visit post-discharge.","ALL","1 Month",{"count":20,"type":21},2000,"ESTIMATED","OBSERVATIONAL","The international multicenter registry aims to gather real-world data on patient outcomes and assess the procedural success and performance of various device occluders used in the transcatheter treatment of pediatric and adult patients with perimembranous ventricular septal defects (PmVSD).",[25],"Perimembranous Ventricular Septal Defect",[27,28,29,30,31,32,33,34],"Cardiovascular Abnormalities","Congenital Heart Disease","Device Closure","Heart Defects, Congenital","Heart Septal Defects","Heart Septal Defects, Ventricular","Transcatheter Interventions","Ventricular Septal Defects","RECRUITING","2026-08-24",{"date":38,"type":39},"2026-08-25","ACTUAL",{"date":41,"type":39},"2025-01-01",{"date":43,"type":21},"2027-06-30",{"name":45,"class":46},"Fondation Hôpital Saint-Joseph","OTHER",{"id":48,"slug":49,"hasResults":12,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100653396","risk-factors-etiology-and-predictable-outcomes-with-risk-stratification-scores-in-acute-heart-failure-patients-100653396","NCT07785531","Risk Factors, Etiology and Predictable Outcomes With Risk Stratification Scores in Acute Heart Failure Patients","Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Heart Failure Patients Presenting to Assiut University Heart Hospital.","Inclusion Criteria:\n\n* Age more than 18yrs\n* Clinical diagnosis of acute heart failure according to current ESC guideline criteria.\n\nExclusion Criteria:\n\n* Age below than 18\n* Refusal to participate.","18 Years",{"count":56,"type":21},350,"Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Acute Heart Failure Patients Presenting to Assiut University Heart Hospital.",[59],"Acute Heart Failure (AHF)",[61],"Risk stratification scores","NOT_YET_RECRUITING","2026-08-23",{"date":38,"type":39},{"date":66,"type":21},"2026-08",{"date":68,"type":21},"2028-09",{"name":70,"class":46},"Assiut University",1,{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":12,"sex":17,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":92,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":71},"100621076","effect-of-core-stabilization-exercises-on-patients-with-cervical-radiculopathy-100621076","NCT07365917","Effect of Core Stabilization Exercises on Patients With Cervical Radiculopathy","Effect of Lumbar Core Stabilization Exercises on Craniovertebral Angle and Functional Outcome in Patients With Cervical Radiculopathy","Inclusion Criteria:\n\n1. Patients with Posterolateral cervical disc proplapse at level of C5-C6 and C6-C7 levels\n2. Neck Disability Index (NDI) score exceeding 20%.\n3. Neck pain of mild to moderate intensity (VAS ≥ 3).\n4. Their symptoms lasting for a duration exceeding six weeks\n5. Three out of four elements are positive in the following tests: spurling test, distraction test, upper limb tension test, shoulder abduction test.\n6. Body mass index should not exceed 30 kg\u002Fm².\n7. Patients complaining from neck pain and unilateral radicular pain, parathesia, motor manifestations or hyporeflexia\n8. Their age will range from 35 to 50 years.\n9. Their craniovertebral angle is less than 49 degrees.\n10. Their mean of cervical joint position error is larger than 4.5 degrees.\n\nExclusion Criteria:\n\n1. Cervical mylopathy or spinal tumors\n2. History of cervical spine surgeries\n3. Cervical fractures\n4. Vertebrobasilar insufficiency (VBI)\n5. Bone Infection","35 Years","50 Years",{"count":82,"type":21},40,"INTERVENTIONAL",[85],"NA","The goal of this clinical trial is to evaluate the effect of core stabilization exercise on functional outcome and craniovertebral angle which is the angle of forward head , in adults with cervical radiculopathy. The main questions it aims to answer are:\n\n* Is there a significant effect of core stabilization exercises (CSEs) on craniovertebral angle (CVA) in patients with cervical radiculopathy?\n* Is there a significant effect of core stabilization exercises (CSEs) on functional outcome in patients with cervical radiculopathy? Researchers will compare effect of adding core stabilization exercises to conventional physical therapy program (TENS, hot pack, US, manual therapy and strengthening exercises) Vs conventional physical therapy program alone to see if there is a beneficial effect of adding core stabilization exercises to physical therapy program Participants in study group will perform core stabilization exercises in addition to conventional PT program while participants in control group will receive conventional PT program",[88],"Cervical Radiculopathy",[90,91],"Core stabilization exercises","craniovertebral angle",{"date":38,"type":39},{"date":94,"type":39},"2026-02-01",{"date":96,"type":21},"2026-09-03",{"name":98,"class":46},"Cairo University",{"id":100,"slug":101,"hasResults":12,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":106,"sex":17,"minAge":107,"maxAge":54,"enrollmentInfo":108,"targetDuration":110,"studyType":22,"phases":4,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":71},"100653359","clinical-utility-of-urinary-n-acetyl--d-glucosaminidase-nag-kidney-injury-molecule-1-kim-1-and-diffusion-weighted-renal-mri-for-the-early-detection-of-sickle-cell-nephropathy-in-children-100653359","NCT07785752","Clinical Utility of Urinary N-Acetyl-β-D-Glucosaminidase (NAG), Kidney Injury Molecule-1 (KIM-1), and Diffusion-Weighted Renal MRI for the Early Detection of Sickle Cell Nephropathy in Children","sickle nephro","Inclusion Criteria:\n\n* • Children and adolescents aged less than 18 years.\n\n  * Confirmed diagnosis of sickle cell disease by hemoglobin electrophoresis and\u002For high-performance liquid chromatography (HPLC).\n  * Clinically stable patients at the time of enrollment, with no acute vaso-occlusive crisis or acute illness.\n\nExclusion Criteria:\n\n* • Age ≥18 years.\n\n  * Acute sickle cell crisis at least 3 week prior to sample collection\n  * Acute infection or fever.\n  * Known chronic kidney disease due to causes other than sickle cell disease.\n  * Congenital renal anomalies.\n  * Diabetes mellitus.\n  * Hypertension.\n  * Current use of nephrotoxic medications.",true,"4 Years",{"count":109,"type":21},90,"1 Year","To evaluate the diagnostic performance of urinary N-acetyl-β-D-glucosaminidase (NAG) and kidney injury molecule-1 (KIM-1) Biomarkers for detection of early onset of Sickle Cell Nephropathy in children under HU therapy",[113],"Sickle Cell Nephropathy","2026-08-22",{"date":38,"type":39},{"date":117,"type":21},"2026-10-01",{"date":119,"type":21},"2027-12-01",{"name":70,"class":46},{"id":122,"slug":123,"hasResults":12,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":12,"sex":128,"minAge":54,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":71},"100653391","male-sexual-function-and-sexual-quality-of-life-in-polygamous-versus-monogamous-marriages-100653391","NCT07783958","Male Sexual Function and Sexual Quality of Life in Polygamous Versus Monogamous Marriages","Sexual Function and Sexual Quality of Life Among Egyptian Men in Polygamous and Monogamous Marriages: A Web-Based Comparative Cross-Sectional Survey","Inclusion Criteria:\n\n* Egyptian males aged 18 years or older.\n* Currently married at the time of questionnaire completion.\n* Currently in either a monogamous marriage, defined as marriage to one wife, or a polygamous marriage, defined as marriage to two or more wives.\n* Able to read and understand Arabic.\n* Willing to complete the anonymous online questionnaire.\n* Able to provide electronic informed consent before accessing the questionnaire\n\nExclusion Criteria:\n\n* Unmarried, divorced, or widowed individuals.\n* Individuals who do not provide electronic informed consent.\n* Incomplete questionnaire responses that do not contain the primary outcome measure.\n* Duplicate or clearly invalid questionnaire responses.\n* Self-reported major psychiatric illness or neurological disease that substantially affects sexual function.\n* Participants receiving active treatment that substantially affects sexual function, unless the treatment can be documented and appropriately considered in the statistical analysis.\n* Individuals unable to read or understand Arabic.","MALE",{"count":130,"type":21},1820,"This web-based comparative cross-sectional survey will assess sexual function, sexual quality of life, psychological status, and marital satisfaction among Egyptian men in monogamous and polygamous marriages. Eligible participants will be married Egyptian men aged 18 years or older who provide electronic informed consent and complete an anonymous Arabic-language questionnaire. The primary outcome will be sexual function measured using the Sexual Health Inventory for Men (SHIM\u002FIIEF-5). Secondary outcomes will include Sexual Quality of Life-Male (SQOL-M), Depression Anxiety Stress Scales-21 (DASS-21), marital satisfaction, and sociodemographic and clinical predictors of impaired sexual function. Data will be analyzed using descriptive, comparative, correlation, and multivariable regression methods.",[133,134],"Erectile Dysfunction","Sexual Dysfunction","2026-08-21",{"date":38,"type":39},{"date":138,"type":39},"2026-08-20",{"date":140,"type":21},"2027-08",{"name":142,"class":46},"Al-Azhar University",{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":83,"phases":153,"briefSummary":154,"conditions":155,"keywords":159,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":165,"startDateStruct":166,"completionDateStruct":167,"leadSponsor":169,"locationsCount":71},"100653313","comparison-of-hyperosmolar-agent-in-reduction-of-increased-intracranial-pressure-in-patients-with-traumatic-brain-injury-using-ultrasonography-100653313","NCT07786324","Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Ultrasonography","Comparison of 3% Hypertonic Saline Versus 20% Mannitol in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Optic Nerve Sheath Diameter Measurements''","MHTS-ONSD","Inclusion Criteria:\n\n* • Age ≥18 years.\n\n  * Acute severe traumatic brain injury (TBI) (GCS 3-8) confirmed by CT brain.\n  * Elevated ONSD suggestive of raised ICP (ONSD cutoff value ≥5.6 mm ).(14)\n  * Initiation of hyperosmolar therapy within 24 hours of injury.\n\nExclusion Criteria:\n\n* • Penetrating head injury.\n\n  * Hypotension.\n  * Previous ocular trauma or orbital surgery.\n  * Glaucoma or optic nerve pathology.\n  * Bilateral ocular injuries preventing ultrasound assessment.\n  * Pregnancy.\n  * Chronic renal failure requiring dialysis.\n  * Initial serum sodium \\>150mmol\u002FL or Patients reaching a sodium level \\>160mmol\u002FL during hypertonic administration.\n  * Previous hyperosmolar therapy before enrollment.\n  * Refusal of consent by legal surrogate.",{"count":152,"type":21},100,[85],"The aim of this study to compare the efficacy of hypertonic saline and mannitol in reducing intracranial pressure, as assessed by serial optic nerve sheath diameter (ONSD) ultrasound measurements, in patients with traumatic brain injury.",[156,157,158],"TBI (Traumatic Brain Injury)","ICP (Intracranial Pressure) Increase","Optic Nerve Sheath Diameter Measurement",[160,161,162,163,164],"mannitol","hypertonic saline","ICP","ONSD","TBI",{"date":38,"type":39},{"date":117,"type":21},{"date":168,"type":21},"2029-09-30",{"name":70,"class":46},{"id":171,"slug":172,"hasResults":12,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":106,"sex":177,"minAge":54,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":185,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":71},"100653288","internal-jugular-vein-collapsibility-index-for-volume-status-assessment-in-preeclampsia-in-correlation-with-normotensive-parturients--a-prospective-observational-cohort-study-100653288","NCT07786246","Internal Jugular Vein Collapsibility Index for Volume Status Assessment in Preeclampsia in Correlation With Normotensive Parturients : a Prospective Observational Cohort Study","Internal Jugular Vein Collapsibility Index for Volume Status Assessment in Preeclampsia in Correlation With Normotensive Parturients: a Prospective Observational Cohort Study","Inclusion Criteria:\n\n1. Singleton parturients from 18 to 40 years old.\n2. Either normotensive or preeclamptic parturients scheduled for elective cesarean section under neuro-axial block matched for gestational age 28-40 weeks will be included:\n3. Normotensive group: uncomplicated normotensive pregnancy with systolic blood pressure below 140 mmHg and diastolic blood pressure below 90mmHg without proteinuria.\n4. Preeclamptic Group: new onset preeclamptic pregnant female with gestational hypertension after 20 weeks of pregnancy diagnosed based on ISSHP Guidelines: systolic blood pressure ≥140 mmHg and\u002For a diastolic blood pressure ≥90 mmHg, accompanied by one or more of the following:\n\n   * Proteinuria (≥300 mg in a 24-hour urine sample)\n   * Alb\u002FCr ratio ≥30 mg\u002Fmmol,\n   * Organ dysfunction (renal insufficiency (creatinine level\\>1.1mg%), liver involvement (liver enzyme levels ≥3 times normal), neurological complications (Headache and blurring of vision) and hematological involvement (thrombocytopenia\\\u003C100.000)).\n\nExclusion Criteria:\n\n1. Parturients with pre-existing cardiac \\& vascular disease affecting blood volume and vascular compliance: (Valvular or congenital heart disease, arrhythmia, previous history of venous thromboembolism, chronic kidney disease, gestational diabetes).\n2. multiple gestations\n3. known thyroid disorders or chronic hypertension\n4. patients with BMI \\>40 and patients requiring emergency delivery.","FEMALE","40 Years",{"count":180,"type":21},80,"This study aims to assess and analyze volume status in preeclamptic patients and compare these parameters with those of normotensive pregnant ones based on the change in internal jugular vein ultrasound-based indices.",[183,184],"Pre-Eclampsia","Preeclampsia",{"date":38,"type":39},{"date":187,"type":39},"2025-10-01",{"date":189,"type":21},"2026-09",{"name":191,"class":46},"Tanta University",{"id":193,"slug":194,"hasResults":12,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":106,"sex":17,"minAge":199,"maxAge":200,"enrollmentInfo":201,"targetDuration":4,"studyType":83,"phases":202,"briefSummary":203,"conditions":204,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":206,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":71},"100653266","effect-of-sensory-integration-on-gross-and-balance-on-children-with-down-syndrome-100653266","NCT07785011","Effect of Sensory Integration on Gross and Balance on Children With Down Syndrome","Effect of Sensory Integration on Gross Motor Function and Balance in Children With Down Syndrome","Inclusion Criteria:\n\n* All children diagnosed as Down syndrome, according to genetic lab reports.\n* Their age ranges from 3to 5 years.\n* Both genders will be included.\n* They are able to stand alone.\n* They are able to follow instructions. Their IQ ranges from 65 to 80, according to Stanford Binet Intelligence Scale).\n* They had been referred by sensory integration problems (low registration and seeking behavior).\n\nExclusion Criteria:\n\nPatients will be excluded from the study if they have any of the following:\n\n* Persistent heart disease.\n* Severe cognitive impairments.\n* Recent surgical interference in the lower limbs.\n* Obese children (BMI \\> 95).\n* Patients with hip subluxation.","3 Years","5 Years",{"count":82,"type":21},[85],"To investigate the effect of sensory integration on gross motor function in children with Down syndrome.\n\nTo investigate the effect of sensory integration on balance in children with Down syndrome.",[205],"Down Syndrome",{"date":38,"type":39},{"date":208,"type":39},"2025-09-15",{"date":210,"type":21},"2026-10-15",{"name":212,"class":46},"Raheel Sanad",{"id":214,"slug":215,"hasResults":12,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":106,"sex":17,"minAge":220,"maxAge":178,"enrollmentInfo":221,"targetDuration":4,"studyType":83,"phases":223,"briefSummary":224,"conditions":225,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":227,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":71},"100653253","effect-of-neosealer-flo-and-ah-plus-resin-sealer-on-postoperative-pain-and-healing-of-periapical-lesions-100653253","NCT07785973","Effect of NeoSEALER FLO and AH Plus Resin Sealer on Postoperative Pain and Healing of Periapical Lesions","Effect of NeoSEALER FLO and AH Plus Resin Sealer on Postoperative Pain and Healing of Periapical Lesions: A Randomized Clinical Study","Inclusion Criteria:\n\n* Patients with mature permanent teeth.\n* Patients with apical periodontitis.\n* Maxillary anterior teeth only will be involved.\n* Patients should be free from any systemic disease that may affect normal healing and predictable outcome.\n* Patients who will agree to the consent and will commit to follow-up period.\n* The selected teeth should have periapical lesion score ≤3\n\nExclusion Criteria:\n\n* Patients with immature canals.\n* Patients with swelling.\n* Pregnant females.\n* Patients who could\u002Fwould not participate in a 1-year follow-up.\n* Geriatric patients.\n* Patients with old age.\n* Teeth with periodontal involvement.\n* Teeth with vertical root fractures.\n* Non-restorable teeth.\n* cases with previously initiated endodontic treatment.","20 Years",{"count":222,"type":21},30,[85],"Tissue repair is an essential process that reestablishes tissue integrity and regular function. Nevertheless, different therapeutic factors and clinical conditions may interfere in this process of periapical healing.The success of root canal treatment is affected by the correct choice of clinical protocol.\n\nThese factors are dependent on the sanitization process (instrumentation, irrigating solution, irrigating strategies, and intracanal dressing) the apical limit of the root canal preparation and obturation, and the quality of the sealer. The challenges affecting the healing process of endodontically treated teeth include control of the inflammation of pulp or infectious processes and simultaneous neutralization of unpredictable provocations to the periapical tissue.",[226],"Post Operative Pain",{"date":38,"type":39},{"date":229,"type":39},"2026-08-01",{"date":231,"type":21},"2027-08-10",{"name":233,"class":46},"Minia University",{"id":235,"slug":236,"hasResults":12,"nctId":237,"briefTitle":238,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":12,"sex":177,"minAge":80,"maxAge":240,"enrollmentInfo":241,"targetDuration":4,"studyType":83,"phases":242,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":246,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":71},"100653218","effect-of-capacitive-resistive-energy-transfer-therapy-on-postmenopausal-women-with-frozen-shoulder-100653218","NCT07785583","Effect of Capacitive Resistive Energy Transfer Therapy on Postmenopausal Women With Frozen Shoulder","Inclusion Criteria:\n\n* Sedentary, ambulatory, non-smoking women.\n* Postmenopausal women with at least one-year amenorrhea.\n* Having natural menopause at least one year prior to participating in the study.\n* No history of bilateral surgical removal of the ovaries and\u002For the uterus.\n* Women with age of 50-60 years.\n* Their body mass index (BMI) will be ≤ 30 kg\u002Fm2.\n* The parity number will be 2-4 times.\n* Diagnosed with unilateral frozen shoulder (adhesive capsulitis) - Stage II (frozen stage).\n* Patients with moderate to severe shoulder pain (Pain score ≥ 4 on the visual analogue scale).\n\nExclusion Criteria:\n\n* Diabetes.\n* Osteoporosis.\n* Previous shoulder surgeries.\n* History of tumor.\n* Bilateral frozen shoulder.\n* Upper extremity fractures or cervical radiculopathy.\n* Impaired sensation or heart pacemaker.\n* Any autoimmune disease.","60 Years",{"count":82,"type":21},[85],"The purpose of this study is to determine the effect of capacitive resistive energy transfer therapy on postmenopausal women with frozen shoulder.",[245],"Frozen Shoulder",{"date":38,"type":39},{"date":248,"type":21},"2026-09-01",{"date":250,"type":21},"2027-03-15",{"name":98,"class":46},{"id":253,"slug":254,"hasResults":12,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":12,"sex":17,"minAge":259,"maxAge":260,"enrollmentInfo":261,"targetDuration":4,"studyType":83,"phases":263,"briefSummary":264,"conditions":265,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":268,"startDateStruct":269,"completionDateStruct":270,"leadSponsor":272,"locationsCount":71},"100653216","effect-of-mechanically-loaded-neuro-dynamics-in-subjects-with-thoracic-outlet-syndrome-100653216","NCT07785427","Effect of Mechanically Loaded Neuro-dynamics in Subjects With Thoracic Outlet Syndrome","Effect of Mechanically Loaded Neuro-dynamics on Physiological Findings and Functional Outcomes in Subjects With Thoracic Outlet Syndrome","Inclusion Criteria:\n\n1. Subjects from both genders diagnosed with Thoracic Outlet Syndrome will be recruited through direct referrals from their neurosurgeon.\n2. Subjects age between 30.8±7.4 years\n3. Subjects body mass index = 19.5±2.8\n4. Control group includes health volunteer subjects with negative root test results under supervision of neurosurgeon.\n\nExclusion Criteria:\n\nThe exclusion criteria are:\n\n1. head injury, stroke.\n2. epilepsy episodes.\n3. mental disorders.\n4. cardiovascular disease.\n5. having a pacemaker or cochlear implant.\n6. pregnancy, oncological episodes, inflammatory disease, myelopathy, degenerative changes in the cervical spine (after verification on computed tomography or magnetic resonance imaging scans).\n7. peripheral neuropathies from the level of the arm and COVID-19-related symptoms","24 Years","37 Years",{"count":262,"type":21},36,[85],"the study was done to: To assess the effect of Mechanically Loaded Neuro-dynamics on pain reduction in subjects with thoracic outlet syndrome.\n\nTo assess the effect of Mechanically Loaded Neuro-dynamics on shoulder range of motion in subjects with thoracic outlet syndrome.\n\nTo assess the effect of Mechanically Loaded Neuro-dynamics on clinical provocative tests in subjects with thoracic outlet syndrome.\n\nTo assess the effect of Mechanically Loaded Neuro-dynamics on neurophysiological findings in subjects with thoracic outlet syndrome.\n\nTo assess the effect of Mechanically Loaded Neuro-dynamics on quality of life and psychological status in subjects with thoracic outlet syndrome.",[266,267],"Thoracic Outlet Syndrome","Mechanically Loaded Neuro-dynamics",{"date":38,"type":39},{"date":248,"type":21},{"date":271,"type":21},"2026-12-01",{"name":273,"class":46},"Kafrelsheikh University",{"id":275,"slug":276,"hasResults":12,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":280,"eligibilityCriteria":281,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":178,"enrollmentInfo":282,"targetDuration":4,"studyType":83,"phases":284,"briefSummary":285,"conditions":286,"keywords":288,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":291,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":295,"locationsCount":71},"100652988","comparison-of-transversus-abdominis-plane-and-erector-spinae-plane-blocks-for-pain-control-after-renal-laparoscopy-100652988","NCT07781930","Comparison of Transversus Abdominis Plane and Erector Spinae Plane Blocks for Pain Control After Renal Laparoscopy","Comparison of Ultrasound-guided Transversus Abdominis Plane Block (TAP) and Erector Spinae Plane Block (ESPB) for Postoperative Analgesia in Adult Laparoscopic Renal Surgeries: A Randomized Controlled Trial.","TAP-ESPB","Inclusion criteria:\n\n* Age from 18 to 40 years old.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I, II.\n* Scheduled for laparoscopic renal surgeries under general anesthesia\n\nExclusion criteria:\n\n* Parent's refusal.\n* Coagulation disorders.\n* History of allergy to local anesthetics.\n* Infection or redness at the injection site.\n* History of renal and\u002For hepatic insufficiency.\n* Preexisting cardiac dysfunction.",{"count":283,"type":21},60,[85],"The goal of this study is to compare the analgesic efficacy of ultrasound-guided transversus abdominis plane (TAP) block versus erector spinae plane block (ESPB) in adult patients undergoing laparoscopic renal surgeries. Forty adults (18-60 years, ASA I-II) will be randomly assigned to receive either TAP or ESPB after induction of general anesthesia. Postoperative pain will be assessed using the Visual Analogue Scale (VAS) and total fentanyl consumption over 24 hours. Secondary outcomes include time to first analgesic request, hemodynamic parameters, patient satisfaction, and incidence of complications. The study will be conducted at Cairo University Hospitals following ethical approval, with all patients providing written informed consent.",[287],"Postoperative Pain, Acute",[289,290],"TAP Block","ESP Block",{"date":36,"type":39},{"date":293,"type":39},"2026-01-05",{"date":66,"type":21},{"name":98,"class":46},{"id":297,"slug":298,"hasResults":12,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":12,"sex":17,"minAge":303,"maxAge":304,"enrollmentInfo":305,"targetDuration":4,"studyType":83,"phases":307,"briefSummary":308,"conditions":309,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":311,"startDateStruct":312,"completionDateStruct":313,"leadSponsor":315,"locationsCount":71},"100652577","bedtime-device-restriction-and-desmopressin-in-pmne-100652577","NCT07776977","Bedtime Device Restriction and Desmopressin in PMNE.","Effect of Bedtime Digital-Device Restriction on the Therapeutic Response to Desmopressin in Children With Primary Monosymptomatic Nocturnal Enuresis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 6-14 years.\n* Diagnosis of PMNE (≥2 wet nights\u002Fweek for ≥6 months, no daytime symptoms, no prior sustained dryness \\>6 months).\n* Willingness to take oral desmopressin nightly for 8 weeks.\n* Parent\u002Fguardian able to monitor and report screen time and wet nights.\n* Written informed consent from parent\u002Fguardian and assent from child (if age-appropriate).\n\nExclusion Criteria:\n\n* Secondary enuresis or non-monosymptomatic enuresis (daytime incontinence, urgency, frequency).\n* Known organic causes (e.g., diabetes mellitus, urinary tract anomalies, neurological disorders).\n* Current use of other enuresis treatments (alarms, anticholinergics, imipramine) within 4 weeks prior to enrollment.\n* Severe sleep disorders (e.g., obstructive sleep apnea) or psychiatric conditions affecting compliance.\n* Inability to comply with study procedures or follow-up.","6 Years","14 Years",{"count":306,"type":21},140,[85],"This randomized controlled trial will evaluate whether restricting bedtime digital-device use improves the response to desmopressin in children with primary monosymptomatic nocturnal enuresis. Participants will receive desmopressin for 8 weeks and will be assigned to either bedtime device restriction or usual screen habits.",[310],"Primary Monosymptomatic Nocturnal Enuresis",{"date":36,"type":39},{"date":138,"type":39},{"date":314,"type":21},"2027-07",{"name":142,"class":46},{"id":317,"slug":318,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":323,"targetDuration":4,"studyType":83,"phases":324,"briefSummary":325,"conditions":326,"keywords":329,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":340,"startDateStruct":341,"completionDateStruct":342,"leadSponsor":344,"locationsCount":71},"100647722","prophylactic-anticoagulation-for-central-venous-line-insertion-in-critically-ill-children-100647722","NCT07710482","Prophylactic Anticoagulation for Central Venous Line Insertion in Critically Ill Children","Prophylactic Anticoagulation Versus Standard Care at Central Venous Line Insertion in Critically Ill Children: A Randomized Controlled Study","Inclusion Criteria:\n\n* All Children requiring a newly placed central venous line (peripherally inserted central catheter \\[PICC\\], or non-tunneled central venous catheter) for clinical care.\n\nExclusion Criteria:\n\n* Known major congenital bleeding diathesis or platelet count \\\u003C50,000\u002FµL at time of insertion.\n* Already on therapeutic anticoagulation for another indication.\n* Known heparin allergy or history of heparin-induced thrombocytopenia.\n* Use of dialysis catheters (study focuses on standard CVCs\u002FPICCs).",{"count":82,"type":21},[85],"This will be a Prospective, randomized, open- label, parallel-group, center trial, which will include 80 of Children which will be admitted at Pediatric Intensive Care Unit (PICU) of Menoufia university Hospital from August 2026 to Mars 2027.\n\nAim of the study will be:\n\n1. Compare the incidence of clinically significant catheter-related complications (catheter occlusion requiring intervention or catheter-related thrombosis) within 14 days after CVL insertion between children receiving prophylactic anticoagulation and those receiving standard care.\n2. Compare time-to- first catheter occlusion.\n3. Compare rate of catheter-related bloodstream infection (CLABSI) within 30 days.\n4. Compare number of catheter manipulations and unplanned catheter removals.\n5. Compare major and minor bleeding events.\n6. Assess catheter dwell time and need for thrombolysis or therapeutic anticoagulation.",[327,328],"Prophylactic","Anticoagulation",[327,328,330,331,332,333,334,335,336,337,338,339],"Central","venous","line","Insertion","critically","ill","childern","Randomized","Controlled","Study",{"date":36,"type":39},{"date":229,"type":21},{"date":343,"type":21},"2027-08-31",{"name":345,"class":46},"Menoufia University",{"id":347,"slug":348,"hasResults":12,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":352,"eligibilityCriteria":353,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":354,"targetDuration":4,"studyType":83,"phases":356,"briefSummary":357,"conditions":358,"keywords":360,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":365,"startDateStruct":366,"completionDateStruct":367,"leadSponsor":369,"locationsCount":71},"100647345","plasma-exchange-in-pediatric-autoimmune-encephalitis-100647345","NCT07707739","Plasma Exchange in Pediatric Autoimmune Encephalitis","Daily Versus Alternate-Day Plasma Exchange in Pediatric Autoimmune Encephalitis: A Randomized Controlled Trial","PE\u002FAIE","Inclusion Criteria:\n\n* Childern diagnosed as autoimmune encephalitis according to Cellucci et al., 2020; acute\u002Fsubacute onset (\\\u003C3 months) of encephalopathy with at least one of: new focal CNS findings, seizures, CSF pleocytosis, MRI suggestive of encephalitis, and supportive antibody testing when available.\n* Autoimmune encephalitis cases indicated clinically for PLEX as determined by the treating team (e.g., severe disease, refractory to steroids\u002FIVIG or as part of first-line combination therapy).\n\nExclusion Criteria:\n\n* Hemodynamic instability not amenable to plasma exchange.\n* Severe coagulopathy uncorrectable prior to PLEX (INR \\>2 despite correction, platelets \\\u003C50,000\u002FµL unless corrected).\n* Contraindications to central venous access placement.\n* Enrollment in another interventional trial that would interfere with the outcomes.",{"count":355,"type":21},22,[85],"The aim of the study will be to compare the efficacy of daily plasma exchange (PLEX) versus alternate-day PLEX in achieving a favorable functional outcome in children with autoimmune encephalitis.\n\nThe study population will be divided into two groups, the first group will perform PLEX on consecutive days and the second one will perform it every other day. Then, A Favorable functional outcome measure defined as modified Rankin Scale (mRS) score ≤ 2. The mRS will be assessed by a blinded assessor at the end of the sessions to determine which method has superior efficacy in treatment of autoimmune encephalitis.",[359],"Autoimmune Encephalitis (AE)",[361,362,363,364],"Plasma Exchange","Autoimmune Encephalitis","Pediatric","Randomized Controlled Trial",{"date":36,"type":39},{"date":229,"type":21},{"date":368,"type":21},"2027-03-31",{"name":345,"class":46},{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":376,"eligibilityCriteria":377,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":378,"targetDuration":4,"studyType":83,"phases":379,"briefSummary":380,"conditions":381,"keywords":383,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":388,"startDateStruct":389,"completionDateStruct":390,"leadSponsor":391,"locationsCount":71},"100647238","plasma-exchange-in-children-with-severe-sepsis-and-septic-shock-100647238","NCT07706413","Plasma Exchange in Children With Severe Sepsis and Septic Shock","Therapeutic Plasma Exchange in Children With Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial","PE\u002FSepsis","Inclusion Criteria:\n\n1. From one month to 18 years.\n2. With an established diagnosis of severe sepsis or septic shock according to international pediatric sepsis definitions.\n\nExclusion Criteria:\n\n1. Known congenital bleeding disorders and severe uncontrolled hemorrhage.\n2. End-stage chronic illness with expected survival \\\u003C 3 months.\n3. Previous plasma exchange during the same admission.\n4. Contraindications to central venous catheterization.",{"count":355,"type":21},[85],"The aim of the study will be to to evaluate whether therapeutic plasma exchange (TPE) reduces mortality in critically ill children with severe sepsis or septic shock compared to the standard care of sepsis alone.\n\nThe study population will be divided into two groups, the first group will receive standard sepsis management plus therapeutic plasma exchange and the second one will receive the standard sepsis management alone . Then we will assess the effect of TPE on : Severity of organ dysfunction (pSOFA score) , duration of vasopressor support , length of PICU stay, time to hemodynamic stabilization , and on inflammatory and coagulation biomarkers",[382],"Severe Sepsis",[384,385,386,336,387],"Plasma exchange","severe sepsis","septic shock","Randomized controlled trial",{"date":36,"type":39},{"date":229,"type":21},{"date":368,"type":21},{"name":345,"class":46},{"id":393,"slug":394,"hasResults":12,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":4,"eligibilityCriteria":398,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":399,"targetDuration":4,"studyType":83,"phases":401,"briefSummary":402,"conditions":403,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":407,"startDateStruct":408,"completionDateStruct":410,"leadSponsor":412,"locationsCount":71},"100495984","ureteral-stenting-after-retrograde-intrarenal-surgery-for-renal-stones-100495984","NCT05738304","Ureteral Stenting After Retrograde Intrarenal Surgery for Renal Stones","One-Day External Ureteral Catheter Versus Double-J Internal Ureteral Stent After Retrograde Intrarenal Surgery for Renal Stones: A Prospective, Randomized Trial","Inclusion Criteria:\n\n• Adult patients of either gender in whom RIRS was the primary modality.\n\nExclusion Criteria:\n\n* Pregnant women\n* Active urinary tract infection\n* solitary kidney\n* Concomitant pathology that need intervention in the same setting\n* Patients with surgical incidents that indicate double-J stenting (Residual sizable fragments, ureteral false passage, ureteral mucosal laceration, ureteral perforation, and calyceal rupture).",{"count":400,"type":21},250,[85],"Several studies evaluated the benefit of a short-term external ureteral catheter (UC) compared to double-J (DJ) ureteral stent after flexible ureteroscopy (URS); the results were controversial. These studies had combined analyses of ureteral and renal stones with a high risk of selection bias. Studies comparing external UC and DJ stent after flexible URS for isolated renal stones are lacking.\n\nIn the present study, the investigators will compare the outcomes of using a one-day external UC versus a DJ internal ureteral stent for ureteral drainage after retrograde flexible URS (retrograde intrarenal surgery \"RIRS\") for renal stones. The investigators aim to identify the best ureteral drainage method after RIRS regarding stone clearance, complications, and stent-related symptoms.",[404,405,406],"Kidney Stone","Retrograde Intrarenal Surgery","Ureteral Stent",{"date":36,"type":39},{"date":409,"type":39},"2021-01-12",{"date":411,"type":21},"2027-01-01",{"name":142,"class":46},{"id":414,"slug":415,"hasResults":12,"nctId":416,"briefTitle":417,"officialTitle":417,"acronym":4,"eligibilityCriteria":418,"healthyVolunteers":12,"sex":17,"minAge":419,"maxAge":80,"enrollmentInfo":420,"targetDuration":4,"studyType":83,"phases":422,"briefSummary":423,"conditions":424,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":430,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":434,"locationsCount":71},"100653404","effectiveness-of-biofeedback-assisted-pelvic-floor-muscle-training-on-sexual-function-and-quality-of-life-in-patient-after-hysterectomy-100653404","NCT07784465","Effectiveness of Biofeedback-Assisted Pelvic Floor Muscle Training on Sexual Function and Quality of Life in Patient After Hysterectomy","Inclusion Criteria:\n\n* Women aged 45-50 years.\n* Body Mass Index (BMI) within the range of 18.5 to 29.9 kg\u002Fm².\n* History of total or subtotal hysterectomy for benign conditions within the past 6 months.\n* Abdominal hysterectomy.\n* Women have menstrual cycle.\n* Presenting with at least one symptom of pelvic floor dysfunction (e.g., stress urinary incontinence and genital prolapse).\n* Willing to participate and provide informed consent.\n\nExclusion Criteria:\n\n* Hysterectomy performed for malignant conditions.\n* Prior pelvic floor rehabilitation.\n* Neurological disorders affecting muscle control.\n* Pelvic infection or current urinary tract infection (UTI).\n* Inability to follow instructions or adhere to the program.","45 Years",{"count":421,"type":21},70,[85],"The purpose of this study is to determine the effectiveness of biofeedback-assisted pelvic floor muscle training in improving pelvic floor muscle strength, decreasing urinary incontinence symptoms, reducing genital prolaps and enhancing the quality of life in women after hysterectomy.",[425,426,427,428,429],"Effectiveness","Biofeedback-Assisted Pelvic Floor Muscle Training","Sexual Function","Quality of Life","Hysterectomy",{"date":38,"type":39},{"date":432,"type":39},"2026-01-01",{"date":117,"type":21},{"name":273,"class":46},{"id":436,"slug":437,"hasResults":12,"nctId":438,"briefTitle":439,"officialTitle":439,"acronym":4,"eligibilityCriteria":440,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":441,"targetDuration":4,"studyType":83,"phases":442,"briefSummary":443,"conditions":444,"keywords":446,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":448,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":71},"100653220","true-muscle-transplantation-surgery-versus-augmented-semi-hang-back-recession-in-large-angle-exotropia-evaluation-of-efficacy-and-lateral-gaze-incomitance-100653220","NCT07784842","True Muscle Transplantation Surgery Versus Augmented Semi Hang Back Recession in Large Angle Exotropia: Evaluation of Efficacy and Lateral Gaze Incomitance","Inclusion Criteria:\n\n1. Patients with large angle exotropia more than 50 prism diopters.\n2. No previous squint surgery.\n\nExclusion Criteria:\n\n1. Patients with severe ocular surface diseases as ocular cicatricial pemphigoid and severe dry eye.\n2. Severe systemic illness that prevents general anesthesia",{"count":82,"type":21},[85],"This a randomized clinical trial comparing True muscle transplantation surgery versus Augmented Semi hang back recession for treatment of large angle exotropia",[445],"Large Angle Exotropia",[447],"exotropia,strabismus,muscle transplantation,augmented recession",{"date":38,"type":39},{"date":450,"type":39},"2026-03-01",{"date":452,"type":21},"2027-01",{"name":454,"class":46},"Hassnaa Mohamed Abdelhameed Ahmed",{"id":456,"slug":457,"hasResults":12,"nctId":458,"briefTitle":459,"officialTitle":460,"acronym":4,"eligibilityCriteria":461,"healthyVolunteers":12,"sex":128,"minAge":462,"maxAge":463,"enrollmentInfo":464,"targetDuration":4,"studyType":83,"phases":465,"briefSummary":466,"conditions":467,"keywords":468,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":474,"startDateStruct":475,"completionDateStruct":476,"leadSponsor":478,"locationsCount":71},"100653182","platelet-rich-plasma-alone-versus-prp-plus-low-intensity-shock-wave-therapy-for-erectile-dysfunction-100653182","NCT07783347","Platelet-Rich Plasma Alone Versus PRP Plus Low-Intensity Shock Wave Therapy for Erectile Dysfunction","Effect of Platelet-Rich Plasma Injection Alone Versus Combined Platelet-Rich Plasma and Low-Intensity Extracorporeal Shock Wave Therapy for the Treatment of Erectile Dysfunction","Inclusion Criteria:\n\n* Male participants aged 30-65 years.\n* Diagnosis of erectile dysfunction for at least 3 months.\n* Mild to moderate erectile dysfunction, defined by an International Index of Erectile Function-5 (IIEF-5) score of 8-21.\n* In a stable heterosexual relationship for at least 6 months.\n* Sexually active, with at least one sexual attempt per week.\n\nExclusion Criteria:\n\n* Severe erectile dysfunction, defined as IIEF-5 score \\\u003C8.\n* Primary psychogenic erectile dysfunction based on clinical history with or without psychosexual assessment.\n* Anatomical penile abnormalities, including Peyronie's disease.\n* History of radical pelvic surgery or pelvic radiotherapy.\n* Uncontrolled diabetes mellitus, defined as HbA1c \\>9%.\n* Uncontrolled hypertension, defined as blood pressure \\>160\u002F100 mmHg.\n* Recent myocardial infarction or stroke within the previous 6 months.\n* Unstable angina.\n* New York Heart Association class III-IV heart failure.\n* Severe hepatic impairment.\n* Severe renal impairment.\n* Hypogonadism, defined as total testosterone \\\u003C300 ng\u002FdL.\n* Hyperprolactinemia.\n* Untreated thyroid disease.\n* Current use of nitrates or nitric oxide donors.\n* Current use of alpha-blockers, unless the participant is on a stable low dose.\n* Current use of other phosphodiesterase type 5 inhibitors.","30 Years","65 Years",{"count":180,"type":21},[85],"Erectile dysfunction is a common condition that may result from vascular, neurological, hormonal, psychological, or medication-related factors. Platelet-rich plasma (PRP) and low-intensity extracorporeal shock wave therapy (Li-ESWT) are regenerative treatment approaches that may improve erectile function through mechanisms involving angiogenesis, tissue repair, and improvement of penile vascular function.\n\nThis randomized prospective study will compare the efficacy and safety of PRP injection alone with combined PRP injection and Li-ESWT in men with erectile dysfunction. A total of 80 participants will be randomly assigned to two groups. One group will receive PRP injections alone, while the other group will receive PRP injections combined with Li-ESWT. Participants will be followed after treatment to assess changes in erectile function, erection hardness, penile blood flow, patient satisfaction, and treatment-related adverse events.\n\nThe study hypothesis is that adding Li-ESWT to PRP therapy will result in greater improvement in erectile function than PRP therapy alone.",[133],[469,470,471,472,473],"Platelet-Rich Plasma","Erectile Function","Low-Intensity Extracorporeal Shock Wave Therapy","Penile Hemodynamics","Regenerative Therapy",{"date":36,"type":39},{"date":248,"type":21},{"date":477,"type":21},"2027-03-01",{"name":479,"class":46},"Benha University",{"id":481,"slug":482,"hasResults":12,"nctId":483,"briefTitle":484,"officialTitle":485,"acronym":4,"eligibilityCriteria":486,"healthyVolunteers":12,"sex":17,"minAge":487,"maxAge":488,"enrollmentInfo":489,"targetDuration":4,"studyType":83,"phases":490,"briefSummary":491,"conditions":492,"keywords":499,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":506,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":510,"locationsCount":71},"100653064","elastic-nailing-with-kirschner-wires-versus-plate-fixation-for-distal-tibial-fractures-in-adolescents-100653064","NCT07783529","Elastic Nailing With Kirschner Wires Versus Plate Fixation for Distal Tibial Fractures in Adolescents","Elastic Stable Intramedullary Nailing Supplemented by Kirschner Wires Versus Plate Fixation in the Treatment of Distal Tibial Metaphyseal-diaphyseal Junction Fractures in Adolescents","Inclusion Criteria:\n\n* Age 10-16 years. Patients diagnosed with distal tibial metaphyseal-diaphyseal junction (DTDMJ) fractures.\n\nClosed fractures or Gustilo-Anderson type I open fractures. Acute fractures presenting within two weeks of injury. Displaced or unstable fractures requiring surgical fixation. Open or partially open physis, as assessed on preoperative radiographs.\n\nExclusion Criteria:\n\n* Patients younger than 10 years or older than 16 years. Fractures involving the distal tibial physis (Salter-Harris fractures). Intra-articular distal tibial fractures. Gustilo-Anderson type II and III open fractures. Pathological fractures. Fractures associated with metabolic bone disease or congenital skeletal disorders.\n\nPolytrauma patients requiring alternative treatment priorities. Previous fracture, deformity, or surgical intervention involving the affected tibia.\n\nNeurovascular injury requiring repair.","10 Years","16 Years",{"count":283,"type":21},[85],"This prospective randomized controlled trial will compare two surgical methods for treating distal tibial metaphyseal-diaphyseal junction fractures in adolescents aged 10 to 16 years. Participants will be randomly assigned in a 1:1 ratio to receive either elastic stable intramedullary nailing supplemented by Kirschner wires or plate fixation. The study will compare fracture healing, radiological alignment, time to full weight-bearing, functional outcomes, and treatment-related complications. Participants will be followed at 2 weeks, 6 weeks, 3 months, and 6 months after surgery.",[493,494,495,496,497,498],"Distal Tibial Fracture","Tibial Fracture","Fracture Fixation, Intramedullary","Fracture Fixation, Internal","Bone Plates","Adolescents",[500,501,502,503,504,505],"Distal tibial fracture","Metaphyseal-diaphyseal junction","Adolescent fractures","Elastic stable intramedullary nailing","Kirschner wires","Plate fixation",{"date":36,"type":39},{"date":508,"type":39},"2026-07-01",{"date":43,"type":21},{"name":511,"class":46},"Sohag University",{"id":513,"slug":514,"hasResults":12,"nctId":515,"briefTitle":516,"officialTitle":517,"acronym":4,"eligibilityCriteria":518,"healthyVolunteers":12,"sex":17,"minAge":79,"maxAge":519,"enrollmentInfo":520,"targetDuration":4,"studyType":83,"phases":522,"briefSummary":523,"conditions":524,"keywords":528,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":534,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":539,"locationsCount":71},"100652831","passive-fit-of-implant-supported-frameworks-digital-vs-conventional-impressions-100652831","NCT07778199","Passive Fit of Implant-Supported Frameworks: Digital vs Conventional Impressions","Passive Fit Evaluation of Full-Arch Implant-supported Frameworks Using Digital and Conventional Impression Techniques: Crossover Study","Inclusion Criteria:\n\n* Completely edentulous patients requiring full-arch implant-supported fixed prosthesis\n* Age 35-70 years\n* Adequate mandibular bone to place at least four implants without major grafting\n* Ability to undergo digital scanning and radiographic evaluation\n* Signed informed consent\n\nExclusion Criteria:\n\n* Systemic conditions affecting healing (uncontrolled diabetes, immunosuppression)\n* History of head\u002Fneck radiotherapy or bisphosphonate therapy\n* Active oral infection or severe bruxism\n* Strong gag reflex preventing accurate scanning\n* Poor compliance or unwillingness to attend follow-up visits","70 Years",{"count":521,"type":21},8,[85],"This randomized crossover clinical trial compares the passivity of fit of complete-arch mandibular implant-supported frameworks fabricated using three impression techniques: a non-calibrated splinted digital scan body system (IO-Connect), a Reverse Scan Body (RSB) digital impression technique, and a conventional splinted open-tray impression technique. Eight completely edentulous patients each receiving four mandibular implants will be included. Passivity of fit will be evaluated clinically using the Sheffield one-screw test and radiographically using intraoral periapical radiographs obtained with the parallel technique.",[525,526,527],"Dental Implants","Edentulous Jaw","Passive Fit",[529,530,531,532,533],"Passive fit","Implant-supported framework","Digital impression","Full-arch implant prosthesis","Crossover study",{"date":135,"type":39},{"date":536,"type":39},"2026-01-25",{"date":538,"type":21},"2027-01-25",{"name":540,"class":46},"Mansoura University",{"id":542,"slug":543,"hasResults":12,"nctId":544,"briefTitle":545,"officialTitle":546,"acronym":4,"eligibilityCriteria":547,"healthyVolunteers":12,"sex":17,"minAge":548,"maxAge":240,"enrollmentInfo":549,"targetDuration":4,"studyType":83,"phases":551,"briefSummary":552,"conditions":553,"keywords":555,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":561,"startDateStruct":562,"completionDateStruct":563,"leadSponsor":564,"locationsCount":71},"100652184","hyaluronic-acid-and-polynucleotides-with-connective-tissue-graft-and-coronally-advanced-flap-for-rt-ii-gingival-recession-100652184","NCT07771244","Hyaluronic Acid and Polynucleotides With Connective Tissue Graft and Coronally Advanced Flap for RT II Gingival Recession","Assessment of Injectable Hyaluronic Acid Combined With Polynucleotides With Coronally Advanced Flap and Connective Tissue Graft in Treatment of RT II Gingival Recession Defects for Covering Gingival Recession","Inclusion Criteria:\n\n* Patients with RT II gingival recession.\n* Age range: 15-60 years.\n* Systemically healthy patients with no contraindications to surgery.\n* Patients who have not had previous periodontal surgery in the area of treatment.\n\nExclusion Criteria:\n\n* Periodontitis.\n* Active systemic disease affecting wound healing.\n* Pregnancy or breastfeeding.\n* Improperly aligned teeth or teeth with cervical restorations or crowns.\n* Non-carious cervical lesions","15 Years",{"count":550,"type":21},12,[85],"This case series will evaluate the effectiveness of injectable hyaluronic acid combined with polynucleotides as an adjunct to coronally advanced flap and connective tissue graft in patients with RT II gingival recession. Twelve patients will be included and followed for 6 months. Clinical outcomes will include percentage of root coverage, clinical attachment level gain, gingival thickness, probing depth, width of keratinized tissue, post-operative pain, and patient aesthetic satisfaction.",[554],"RT II Gingival Recession",[556,554,557,558,559,560],"Gingival Recession","Hyaluronic Acid","Polynucleotides","Coronally Advanced Flap","Connective Tissue Graft",{"date":135,"type":39},{"date":248,"type":21},{"date":477,"type":21},{"name":98,"class":46},{"id":566,"slug":567,"hasResults":12,"nctId":568,"briefTitle":569,"officialTitle":570,"acronym":4,"eligibilityCriteria":571,"healthyVolunteers":12,"sex":17,"minAge":572,"maxAge":573,"enrollmentInfo":574,"targetDuration":4,"studyType":83,"phases":575,"briefSummary":576,"conditions":577,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":579,"startDateStruct":580,"completionDateStruct":582,"leadSponsor":584,"locationsCount":71},"100640862","analgesia-for-perineal-surgeries-in-high-risk-pediatric-patients-100640862","NCT07602894","Analgesia for Perineal Surgeries in High-risk Pediatric Patients","Efficacy of Ultrasound-guided Sacral Multifidus Plane Block as Perioperative Analgesia for Anal and Penile Surgeries in High-risk Pediatric Patients","Inclusion Criteria:\n\n* Parents or caregivers' acceptance.\n* High-risk pediatric patients (the American Society of Anesthesiologists physical status class III-IV)\n* Body mass index equal to 5%: 85% of the same age and sex.\n\nExclusion Criteria:\n\n* Child with a contraindication to the regional block, such as infection at the site of injection, or coagulopathy.\n* Pre-existing neurological disorders.","12 Months","12 Years",{"count":283,"type":21},[85],"Perioperative pain management in pediatric patients, especially for anorectal and penile surgeries, presents significant challenges for anesthetists. Complications associated with systemic analgesia, such as respiratory issues, cardiovascular problems, and neurological effects, can be avoided by using regional anesthesia. This study aims to evaluate the effectiveness of Ultrasound-Guided Sacral Multifidus Plane Block as a method for perioperative analgesia in high-risk pediatric patients undergoing anorectal and penile surgeries, to reduce the risks associated with systemic analgesia.",[578],"Analgesia",{"date":36,"type":39},{"date":581,"type":39},"2026-07-20",{"date":583,"type":21},"2027-12",{"name":585,"class":586},"Zagazig University","OTHER_GOV",{"id":588,"slug":589,"hasResults":12,"nctId":590,"briefTitle":591,"officialTitle":592,"acronym":4,"eligibilityCriteria":593,"healthyVolunteers":12,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":594,"targetDuration":4,"studyType":83,"phases":596,"briefSummary":598,"conditions":599,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":602,"startDateStruct":603,"completionDateStruct":604,"leadSponsor":605,"locationsCount":71},"100638169","phase-2-bariatric-endoscopic-antral-myotomy-combined-with-fundal-gastric-mucosal-ablation-100638169","NCT07612527","Bariatric Endoscopic Antral Myotomy Combined With Fundal Gastric Mucosal Ablation","Bariatric Endoscopic Antral Myotomy Combined With Fundal Gastric Mucosal Ablation for The Management of Obesity","Inclusion Criteria:\n\nBody mass index (BMI) of ≥ 30 kg\u002Fm2 up to 40 kg\u002Fm2. BMI of 27.0 to 29.9 kg\u002Fm2 will be included on the condition of the presence of at least 1 obesity-related comorbidity (Indications based according to the American and European societies for bariatric endoscopy guidelines)\n\nExclusion Criteria:\n\n* Subjects with any previous surgeries to the stomach\n* Any previous bariatric procedures\n* Any current medications for the management of obesity (must be stopped at least 3 months before recruitment)\n* Evidence of severe gastritis, gastric peptic ulcer, or gastric cancer\n* Coagulopathy\n* Pregnancy",{"count":595,"type":21},10,[597],"PHASE2","The gastric fundus regulates appetite through orexigenic ghrelin-mediated and anorexigenic visceroceptive pathways. Accordingly, endoscopic gastric fundal mucosal ablation (GFMA) may benefit patients with obesity. Ablation not only affects these mechanisms, but similar to what happens after mucosal ablation for other indications (e.g. ESD for tumor removal), it is expected to cause shrinking of the fundus and reduce gastric volume.\n\nAnother potential target to achieve weight loss is gastric emptying. This is a critical step in digestion that has been found to be more rapid after prolonged exposure to a high-fat diet in both animal and human studies, with rapid emptying also being more common in young people with obesity in some studies. The bariatric endoscopic antral myotomy (BEAM) procedure has been shown to consistently delay gastric emptying without triggering symptoms of gastroparesis and to produce substantial weight loss.\n\nBoth GFMA and BEAM procedures have the advantages of being minimally invasive, performed completely endoscopic and less costly than surgical alternatives or other known endoscopic techniques like intragastric balloon or endoscopic sleeve gastroplasty.",[600,601],"Obesity & Overweight","Bariatric Endoscopy",{"date":135,"type":39},{"date":138,"type":39},{"date":583,"type":21},{"name":98,"class":46},""]