[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"countryName\":\"Jamaica\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":394},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,47,86,110,146,171,205,233,256,283,311,336,367],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":4,"leadSponsor":43,"locationsCount":46},"100184467","tissue-collection-for-studies-of-lymph-cancer-100184467",false,"NCT01676805","Tissue Collection for Studies of Lymph Cancer","Lymphoid Malignancies and Precursors: Tissue Acquisition Protocol","* LYMPHOID MALIGNANCIES\u002FDISEASES: The following criteria apply only to patients with a known lymphoid malignancy or precursor\n\ndisease, as described:\n\nINCLUSION CRITERIA:\n\n* Patients with a known lymphoid malignancy or precursor disease to a lymphoid malignancy, including multiple myeloma, B-cell and T-cell lymphomas: including but not limited to diffuse large B-cell lymphoma (DLBCL), Hodgkin s lymphoma (HL), multiple myeloma (MM), lymphomatoid granulomatosis (LYG) and adult T-cell leukemia\u002Flymphoma (ATL).\n* Confirmation of pathological diagnosis is required from the Laboratory of Pathology, NCI. Tumor tissue that has been previously collected and is available for study or that can be collected with minimal additional risk to the subject during sampling required for routine patient care or required testing on an NIH research protocol will be used for diagnosis.\n* Age \\>= 18 years of age\n* Ability of patient or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document NOTE: Patients enrolling with a LAR must be co-enrolled on another study.\n\nEXCLUSION CRITERIA:\n\n* Pregnant individuals will not be eligible.\n* Active symptomatic major organ disorder that would increase the risk of biopsy, including but not limited to ischemic heart disease, recent myocardial infarction, active congestive heart failure, and\u002For pulmonary dysfunction.\n* Active concomitant medical or psychological illnesses that may increase the risk to the subject or inability to obtain informed consent, at the discretion of the principal investigator.\n\nNON-LYMPHOID MALIGNANCIES\u002FDISEASES: The following criteria apply only to patients without a known lymphoid malignancy or precursor disease, as described:\n\nINCLUSION CRITERIA:\n\n-Patients without a known lymphoid malignancy or lymphoid precursor diagnosis who have a planned surgical procedure during which blood or normal lymph node(s)\u002Ftissue (i.e., those not with pre-determined likelihood of abnormality\u002F malignancy) may be obtained for research studies as part of this protocol.\n\nPatient is appropriate to undergo the surgical procedure planned, and consented for the same, as needed. NOTE: This study will not evaluate eligibility of the patient for surgery.\n\n* Age \\>= 18 years of age\n* Must be able and willing to sign informed consent\n\nEXCLUSION CRITERIA:\n\n* Pregnant individuals will not be eligible.\n* Other active malignancy. NOTE: Patients with a history of curatively treated basal or squamous cell carcinoma or stage 1 melanoma of the skin as well as any in situ carcinoma are eligible. Patients with a malignancy that has been treated with curative intent and who are without evidence of disease for \\>=2 years will also be eligible at the discretion of the investigator.\n* Active concomitant medical or psychological illnesses that may increase the risk to the subject or inability to obtain informed consent, at the discretion of the principal investigator.","ALL","18 Years",{"count":19,"type":20},1295,"ESTIMATED","OBSERVATIONAL","Background:\n\n\\- Lab studies help researchers better understand cancer biology. This information may lead to new methods for diagnosing or treating cancer. To develop these studies, researchers want to collect samples from people with cancer or precancer conditions of the lymph system. These conditions include multiple myeloma, different types of lymphoma, and adult leukemia\u002Flymphoma. The samples collected will include blood, urine, bone marrow, and tumor and skin tissue.\n\nObjectives:\n\n\\- To collect tissue samples to study different types of lymph cancer.\n\nEligibility:\n\n\\- Individuals at least 18 years of age who have a lymphoid cancer or precancer condition.\n\nDesign:\n\n* Participants will be screened with a physical exam and medical history.\n* Different samples will be collected for study. Blood samples will be collected at the initial testing. More blood samples will be collected at different treatment points. Other liquid samples include urine, bone marrow, and any abnormal fluid. Tumor tissue and skin tissue biopsies will also be collected for study.\n* Treatment will not be provided as part of this study.",[24,25,26,27,28],"Hodgkin Disease","Lymphoma, Non-Hodgkin","Multiple Myeloma","Lymphomatoid Granulomatosis","Leukemia-Lymphoma, Adult T-Cell",[30,31,32,33,34,35],"Developing Novel Treatment Approaches","Developing Therapeutic Agents","Analysis of Genetic and Genomic Biology","New Prognostic and Diagnostic Models","Analysis of Cellular and Molecular Biology","Natural History","RECRUITING","2026-08-21",{"date":39,"type":40},"2026-08-24","ACTUAL",{"date":42,"type":40},"2012-09-21",{"name":44,"class":45},"National Cancer Institute (NCI)","NIH",2,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":17,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":69,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":85},"100651615","gwan-enjoy-life-a-peer-supported-mental-health-mentoring-intervention-to-improve-engagement-in-care-among-sexual-minority-men-living-with-hiv-in-jamaica-100651615","NCT07762612","\"Gwan Enjoy Life:\" A Peer-Supported Mental Health Mentoring Intervention to Improve Engagement in Care Among Sexual Minority Men Living With HIV in Jamaica","\"Gwan Enjoy Life:\" Protocol for a Randomized Controlled Trial to Test a Peer-Supported Mental Health Intervention to Improve Engagement in Care for High-Priority Sexual Minority Men Living With HIV","GwanEnjoyLife","Inclusion Criteria:\n\n* Self-identified as a cisgender man who have sex with men\n* Age 18 and older,\n* Living in one of the 14 parishes\n* Able to offer informed consent\n* Living with HIV (currently engaged, marginally engaged, and not engaged in care)\n* Provide consent to clinic staff to review medical records.\n\nExclusion Criteria:\n\n* Self-reported participation in another HIV care engagement study\n* Unable to understand the consent process\n* Planning on relocating out of Jamaica over the next 12 months.",true,"MALE",{"count":58,"type":20},60,"INTERVENTIONAL",[61],"NA","Sexual minority men (SMM) in Jamaica face many challenges that affect their health and well-being. Although they make up a relatively small part of the population, they are much more likely to be living with HIV than the general public. Many also experience discrimination because of their sexual orientation, HIV-related stigma, violence, poverty, unstable housing, limited educational opportunities, and barriers created by laws and social attitudes. These experiences can have a serious impact on mental health, leading to problems such as depression, anxiety, trauma, and thoughts of suicide. Many people also face barriers to getting mental health care because of stigma or a lack of services that are welcoming and appropriate for their needs. These challenges can make it difficult for people living with HIV to stay connected to medical care and take their HIV medications consistently. Missing appointments or stopping treatment can make it harder to keep the virus under control and can lead to poorer health over time. While researchers know that stigma, discrimination, and violence affect health, we still do not fully understand how these experiences work together to influence HIV care among sexual minority men in Jamaica.\n\nTo help address these challenges, we developed the Gwan Enjoy Life program, a culturally relevant program designed specifically for sexual minority men living with HIV in Jamaica. The program combines practical coping skills, emotional support, and strategies for managing the effects of trauma and stress. It is led by trained peer mentors who are also living with HIV, allowing participants to learn from people who understand their experiences. The six-session program gives participants the option of meeting one-on-one with a peer mentor or participating in a small group, depending on what they find most comfortable. The program will be tested in partnership with Jamaica AIDS Support for Life (JASL), one of Jamaica's leading HIV service organizations. Sixty participants from JASL clinics in Kingston and St. Andrew, St. James, and St. Ann will take part in the intervention. Participants will be randomly assigned to either receive the Gwan Enjoy Life program or continue with their usual care, and they will be followed for one year. Researchers will examine whether the program improves mental health, strengthens social support, helps participants stay engaged in HIV care, and improves medication adherence.\n\nThe goal of the intervention is to determine whether the Gwan Enjoy Life intervention is a practical and effective program that can be expanded to reach more people across Jamaica. The findings will help researchers, healthcare providers, and policymakers better understand how stigma, violence, and mental health affect HIV care and will support the development of programs that improve the health and well-being of sexual minority men living with HIV.",[64,65,66,67,68],"Mental Health","HIV","Pyschological Distress","Suicidal Ideation","Engagement in HIV Care",[64,65,70,71,72,73],"Engagement in Care","Jamaica","Sexual Minority Men","Psychological Distress","NOT_YET_RECRUITING","2026-08-07",{"date":77,"type":40},"2026-08-13",{"date":79,"type":20},"2026-08-25",{"date":81,"type":20},"2027-08-30",{"name":83,"class":84},"University of California, San Francisco","OTHER",1,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":56,"minAge":93,"maxAge":4,"enrollmentInfo":94,"targetDuration":96,"studyType":21,"phases":4,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":109},"100297409","international-registry-for-men-with-advanced-prostate-cancer-ironman-100297409","NCT03151629","International Registry for Men With Advanced Prostate Cancer (IRONMAN)","IRONMAN","• Willing and able to provide written informed consent and privacy authorization for the release of personal health information.\n\nNOTE: Privacy authorization may be either included in the informed consent or obtained separately.\n\n* Males 21 years of age and above\n* Histological or cytological confirmed prostate adenocarcinoma from TRUS biopsy, radical prostatectomy or TURP Or Documented histopathology or cytopathology of prostate adenocarcinoma from a biopsy of a metastatic site Or Metastatic disease typical of prostate cancer (i.e., involving bone or pelvic lymph nodes or para-aortic lymph nodes) AND a serum concentration of PSA \\>20ng\u002FmL at the time of initial prostate cancer diagnosis\n* No previous diagnosis of a second, non-prostate malignancy that requires additional systemic therapy except cancer in situ of bladder and basal cell cancer of skin","21 Years",{"count":95,"type":20},5000,"5 Years","Our intent is to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced cancer, including men with mHSPC and M0\u002FM1 CRPC. The goal is to establish a population-based registry and recruit patients across academic and community practices from Australia, Barbados, Brazil, Canada, Ireland, Jamaica, Kenya, Nigeria, Norway, Spain, South Africa, Sweden, Switzerland, the United Kingdom (UK), and the United States (US). Target accrual number and number of participating sites are subject to change based on accrual, funding, and interest in participation by other international sites. This cohort study will facilitate a better understanding of the variation in care and treatment of advanced prostate cancer across countries and across academia and community based practices.\n\nDetailed data will be collected from patients at study enrollment and then during follow-up, for a minimum of five years. Patients will be followed prospectively for overall survival, clinically significant adverse events, comorbidities, changes in cancer treatments, and PROMs.\n\nPROMs questionnaires will be collected at enrollment and every three months thereafter.\n\nPhysician Questionnaires will be collected from all participating sites at patient enrollment, time of first change in treatment and\u002For one year follow-up, at each subsequent change of treatment, and discontinuation of treatment.\n\nAs such, this registry will help identify the treatment sequences or combinations that optimize overall survival and PROMs for men with mHSPC and M0\u002FM1 CRPC. By collecting blood at enrollment, time of first change in treatment and\u002For one year follow-up (plasma, cell free DNA, buffy coat \u002F RNA), this registry will further identify and validate molecular phenotypes of disease that predict response and resistance to specific therapeutics. Additionally, every effort will be made to collect blood specimen at each subsequent change in treatment due to progression of disease. When feasible, existing tumor tissue may be collected for correlation with described blood based studies. All samples will be used for future research. This cohort study will provide the research community with a unique biorepository to identify biomarkers of treatment response and resistance.",[99],"Prostate Cancer","2026-05-19",{"date":102,"type":40},"2026-05-22",{"date":104,"type":40},"2017-07-21",{"date":106,"type":20},"2032-01",{"name":108,"class":84},"Prostate Cancer Clinical Trials Consortium",121,{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":117,"minAge":17,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":59,"phases":120,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":145},"100633598","phase-2-gemcitabine-vs-paclitaxel-in-caribbean-women-of-african-ancestry-with-metastatic-triple-negative-breast-cancer-100633598","NCT07528768","Gemcitabine vs Paclitaxel in Caribbean Women of African Ancestry With Metastatic Triple-Negative Breast Cancer","Breaking Barriers in Breast Cancer Treatment for the Caribbean - Gemcitabine Versus Standard First-Line Chemotherapy in Caribbean Women of African Ancestry With Metastatic Triple-Negative Breast Cancer","Inclusion Criteria:\n\n1. Self-identified Caribbean Black women of Jamaican, Trinidadian, or Barbadian ancestry\n2. Age ≥18 years\n3. Histologically confirmed metastatic triple-negative breast cancer (recent biopsy required)\n4. ECOG (Eastern Cooperative Oncology Group) performance status 0-1\n5. No prior systemic therapy for metastatic disease\n6. Adequate organ function (detailed laboratory criteria specified)\n7. Written informed consent\n8. Willingness to provide biospecimens for research\n\nExclusion Criteria:\n\n1. Prior gemcitabine, anthracycline, or taxane treatment in any setting\n2. Active brain metastases requiring immediate treatment\n3. Pregnant or breastfeeding\n4. Concurrent participation in other interventional trials\n5. Medical conditions precluding safe chemotherapy administration\n6. Inability to provide informed consent","FEMALE",{"count":119,"type":20},750,[121],"PHASE2","The goal of this clinical trial is to learn if Gemcitabine, a chemotherapy drug that is usually used to treat breast cancer after other treatments have failed, is better at treating triple negative breast cancer in Black Caribbean women than Paclitaxel, one of the chemotherapy drugs that is usually used first. People will be invited to participate in the trial if they are Caribbean women of African ancestry, are 18 years or older, have had a biopsy that shows that they have triple negative breast cancer (TNBC), and are willing to take part.\n\nThe main questions the trial aims to answer are:\n\n1. Does Gemcitabine stop triple negative breast cancer from growing or spreading better than Paclitaxel?\n2. Are participants more likely to get better when taking Gemcitabine or Paclitaxel?\n3. What medical problems do participants have when taking Gemcitabine for breast cancer?\n4. Do Gemcitabine and Paclitaxel affect Black Caribbean women differently than women from other regions or ethnic groups?\n\nTo answer these questions, half of participants will be treated with Gemcitabine while half is treated with Paclitaxel. Both drugs are given by injection and have already been approved for breast cancer treatment. Participants will:\n\n* Take Gemcitabine for two weeks followed by a two-week break, or take Paclitaxel once a week for the same time period.\n* Have some of the cancer tissue that was tested from their biopsy taken for more testing.\n* Have a physical exam and a blood test done every 3 weeks.\n* Have images of their cancer taken using CT (Computed Tomography) or MRI (Magnetic Resonance Imaging) every 6 weeks.\n* Answer a brief questionnaire about how they are feeling every 8 weeks.\n* Be checked on every month after treatment is finished to make sure the cancer hasn't come back.",[124,125],"Triple Negative Breast Cancer","Metastatic Triple-negative Breast Cancer",[127,128,129,130,131,132,133,71,134,135],"Triple Negative Breast Neoplasms","Gemcitabine","Paclitaxel","Progression-Free Survival","Overall Survival","Quality of Life","Caribbean","Trinidad and Tobago","Barbados","2026-04-10",{"date":138,"type":40},"2026-04-14",{"date":140,"type":20},"2026-06-01",{"date":142,"type":20},"2034-06-01",{"name":144,"class":84},"AntiCancer Research Jamaica",3,{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":59,"phases":155,"briefSummary":156,"conditions":157,"keywords":160,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":85},"100631880","tourniquet-vs-no-tourniquet-technique-in-total-knee-arthroplasty-at-the-university-hospital-of-the-west-indies-100631880","NCT07506434","Tourniquet Vs. No-Tourniquet Technique in Total Knee Arthroplasty at the University Hospital of the West Indies","Is Routine Tourniquet Use Still Warranted? A Randomized Controlled Equivalence Trial Comparing Tourniquet Vs. No-Tourniquet Technique in Total Knee Arthroplasty at the University Hospital of the West Indies","Inclusion Criteria:\n\n* • Age ≥ 18 years.\n\n  * Clinical and radiographic diagnosis of knee osteoarthritis requiring primary unilateral Total Knee Arthroplasty.\n  * Medically fit for elective surgery (typically ASA I-III).\n  * Able to provide informed consent.\n\nExclusion Criteria:\n\n* • Revision TKA or bilateral simultaneous TKA.\n\n  * Preexisting coagulopathy or active anticoagulation that cannot be perioperatively managed per protocol.\n  * Known allergy or contraindication to tranexamic acid.\n  * Active infection or immunosuppression.\n  * Severe peripheral vascular disease in the operative limb.\n  * BMI \\> 45 kg\u002Fm²\n  * Inability to provide informed consent or comply with follow-up",{"count":154,"type":20},30,[61],"The goal of this clinical trial is to determine whether performing total knee replacement surgery (total knee arthroplasty, TKA) without a tourniquet is clinically equivalent to performing the procedure with a tourniquet in adults with symptomatic knee osteoarthritis.\n\nA tourniquet is commonly used during surgery to reduce bleeding and improve the surgeon's view. However, some studies suggest it may be associated with certain complications. It is currently unclear whether using a tourniquet meaningfully changes outcomes compared to not using one. This study aims to assess whether both approaches result in similar outcomes within a clinically acceptable range.\n\nThe main question this study aims to answer is:\n\nIs total blood loss during surgery equivalent between TKA performed with a tourniquet and TKA performed without a tourniquet, within a predefined margin of ±100 mL?\n\nAdditional questions include:\n\nAre surgical field quality, postoperative pain, functional recovery, and complication rates comparable between the two techniques?\n\nResearchers will compare:\n\nTKA performed with a pneumatic tourniquet TKA performed without a tourniquet\n\nto determine whether outcomes between the two approaches are equivalent rather than whether one is superior to the other.\n\nParticipants will:\n\nBe randomly assigned to one of the two surgical groups using a computer-generated process Undergo standard total knee replacement surgery and routine perioperative care Have blood loss assessed during and after surgery Be monitored for pain, recovery of function, wound healing, and complications during hospital stay and follow-up visits\n\nThis study is designed as a randomized controlled equivalence trial to determine whether both surgical approaches produce comparable outcomes within clinically acceptable limits, in a standardized local setting.",[158,159],"Knee Osteoarthritis (OA)","Total Knee Anthroplasty",[161],"tourniquet use","2026-03-27",{"date":164,"type":40},"2026-04-01",{"date":166,"type":20},"2026-06",{"date":168,"type":20},"2027-09",{"name":170,"class":84},"The University of The West Indies",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":59,"phases":181,"briefSummary":182,"conditions":183,"keywords":191,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":202,"leadSponsor":204,"locationsCount":85},"100607914","the-prevalence-of-neck-and-low-back-pain-in-fmstrc-staff-at-the-uwi-mona-100607914","NCT07194746","The Prevalence of Neck and Low Back Pain in FMSTRC Staff At the UWI Mona","The Prevalence of Neck and Low Back Pain With a Randomised Controlled Trial Comparing Spine-Specific and Non-Spine Specific Exercise Interventions in Staff of the Faculty of Medical Sciences Teaching & Research Complex at The University of the West Indies, Mona, Jamaica: A Two-Phase Study","Inclusion Criteria\n\n1. All full time academic\u002Foffice\u002Fsupplementary\u002Fancillary staff employed to the Faculty of Medical Science, Training and Research Complex, UWI, Mona.\n2. Individuals with a willingness to adhere to exercise program given in a handout.\n3. Individuals age 18-65\n4. Individuals with at least 1 year experience in their current position.\n\nExclusion Criteria\n\n1. Individuals with a history of having spine surgery\n2. Individuals previously diagnosed with a spine pathology\n3. Individuals currently receiving physiotherapy for a spine problem","65 Years",{"count":180,"type":20},200,[61],"The purpose of this study is to determine the prevalence of neck and low back pain among full-time staff at the Faculty of Medical Sciences Teaching and Research Complex (FMSTRC), The University of the West Indies, Mona. It also seeks to assess staff members' knowledge, attitudes, and practices regarding spine health and to evaluate the effectiveness of an eight-week standardised spine-specific exercise programme in reducing musculoskeletal discomfort among those experiencing neck and low back pain. The study will be conducted in two phases using a descriptive cross-sectional design followed by a prospective randomised controlled trial, in which participants reporting pain will be allocated to either a spine-specific exercise intervention group or a non-spine-specific exercise control group for comparative analysis of outcomes.",[184,185,186,187,188,189,190],"Neck Pain","Back Pain","Musculoskeletal Pain","Low Back Pain","Spine","Work Related Illnesses","Work Related Musculoskeletal Disorders",[192,193,194,195,196,197],"neck pain","back pain","Musculoskeletal pain","low back pain","spinal health","work related musculoskeletal disorders","2026-02-20",{"date":200,"type":40},"2026-02-24",{"date":164,"type":20},{"date":203,"type":20},"2027-03-31",{"name":170,"class":84},{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":55,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":59,"phases":214,"briefSummary":215,"conditions":216,"keywords":222,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":229,"startDateStruct":230,"completionDateStruct":231,"leadSponsor":232,"locationsCount":85},"100606549","neck-and-low-back-pain-in-physical-therapy-students-at-the-university-of-the-west-indies-mona-jamaica-100606549","NCT07177001","Neck and Low Back Pain in Physical Therapy Students at The University of the West Indies, Mona, Jamaica","The Prevalence of Neck and Low Back Pain With a Randomised Controlled Trial Comparing Spine-Specific and Non-Spine Specific Exercise Interventions in Physical Therapy Students at The University of the West Indies, Mona, Jamaica: A Two-Phase Study","Inclusion Criteria:\n\n1. All students enrolled in the Physical Therapy program at the University of the West Indies, Mona Campus, Jamaica during the period November 1, 2025 to October 31, 2026.\n2. Individuals who express a willingness to consent to the study.\n3. Individuals who express a willingness to adhere to the standardised exercise program for the stipulated period.\n\nExclusion Criteria:\n\n1. Individuals with a history of having spine surgery.\n2. Individuals who were previously diagnosed with spine pathology and currently receiving rehabilitation therapy.\n3. Individuals who express an unwillingness to participate in the study.",{"count":213,"type":20},120,[61],"The purpose of this study is to determine the prevalence of neck and low back pain among physical therapy students enrolled at The University of the West Indies, Mona. It also aims to assess students' knowledge, attitudes, and practices regarding spine health and to evaluate the effectiveness of an eight-week standardised spine-specific exercise programme in reducing musculoskeletal pain and improving functional status among those reporting symptoms. The study will be conducted in two phases, beginning with a descriptive cross-sectional assessment of prevalence, followed by a prospective randomised controlled trial in which students experiencing neck and\u002For low back pain will be allocated to either a spine-specific exercise intervention group or a non-spine-specific exercise control group for comparative analysis of outcomes.",[185,187,186,217,218,219,220,221,184],"Spine Health","Physical Therapy","Physiotherapist Students","Physiotherapy","Rehabilitation",[223,195,192,224,225,226,227,228],"lower back pain","musculoskeletal pain","spine health","physical therapy students","physiotherapy students","rehabilitation",{"date":200,"type":40},{"date":164,"type":20},{"date":203,"type":20},{"name":170,"class":84},{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":55,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":240,"targetDuration":4,"studyType":59,"phases":242,"briefSummary":243,"conditions":244,"keywords":249,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":252,"startDateStruct":253,"completionDateStruct":254,"leadSponsor":255,"locationsCount":85},"100605850","low-back-and-neck-pain-in-nursing-students-at-the-university-of-the-west-indies-100605850","NCT07167888","Low Back and Neck Pain in Nursing Students at The University of The West Indies","The Prevalence of Neck and Low Back Pain With a Randomised Controlled Trial Comparing Spine-Specific and Non-Spine Specific Exercise Interventions in Nursing Students at The University of the West Indies, Mona: A Two-Phase Study","Inclusion Criteria:\n\n1. All students enrolled in the student nursing program at the University of the West Indies, Mona Campus, Jamaica during the period October 4, 2025 to October 3, 2026.\n2. Individuals who express a willingness to consent to the study.\n3. Individuals who express a willingness to adhere to the standardised exercise program for the stipulated period.\n\nExclusion Criteria:\n\n1. Individuals with a history of having spine surgery.\n2. Individuals who were previously diagnosed with spine pathology and currently receiving rehabilitation therapy.\n3. Individuals who express an unwillingness to participate in the study.",{"count":241,"type":20},400,[61],"The purpose of this study is to identify the prevalence of neck and low back pain in nursing students enrolled at the University of the West Indies, Mona; to assess their knowledge, attitude and practice of good spine health and to determine the outcome of a standardised spine exercise program on nursing students experiencing neck and low back pain, using a prospective randomised control design.",[185,187,186,184,217,245,246,247,248],"Musculoskeletal Pain Disorder","Lower Back Pain","Nursing Students","Preclinical Education",[223,195,224,192,228,250,251,225],"university student","nursing students",{"date":200,"type":40},{"date":164,"type":20},{"date":203,"type":20},{"name":170,"class":84},{"id":257,"slug":258,"hasResults":11,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":262,"eligibilityCriteria":263,"healthyVolunteers":11,"sex":16,"minAge":264,"maxAge":4,"enrollmentInfo":265,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":267,"conditions":268,"keywords":270,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":145},"100601920","serial-assessment-of-fertility-experiences-100601920","NCT07116772","Serial Assessment of Fertility Experiences","A Prospective Longitudinal Study of Growth, Development, Fertility and Reproductive Outcomes Among Adolescents and Young Adults With Sickle Cell Anemia With Hydroxyurea","SAFE","Inclusion Criteria:\n\n* Patients with documented sickle cell anemia (SCA).\n* At least 8 years of age at the time of enrollment.\n* Enrolled on the EXTEND or SACRED study.\n* Provide informed consent.\n* Able to take part in all parts of the study, including treatments, check-ups, and follow-up visits.\n\nExclusion Criteria:\n\n* Currently taking part in another treatment study (not EXTEND or SACRED).\n* Has received other treatments for sickle cell disease in the past 6 months.","8 Years",{"count":266,"type":20},250,"The SAFE study is a long-term research project that watches people with sickle cell anemia (SCA) over time. The main goal is to see how a medicine called hydroxyurea affects their growth, puberty, and ability to have children. A second goal is to see how hydroxyurea affects pregnancy outcomes, by comparing people who take the medicine to those who don't.",[269],"Sickle Cell Anemia",[271,272,273],"Hydroxyurea","Fertility","Sickle Cell Disease","2026-02-03",{"date":276,"type":40},"2026-02-04",{"date":278,"type":40},"2023-07-10",{"date":280,"type":20},"2035-12-31",{"name":282,"class":84},"Children's Hospital Medical Center, Cincinnati",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":290,"enrollmentInfo":291,"targetDuration":4,"studyType":59,"phases":293,"briefSummary":295,"conditions":296,"keywords":299,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":85},"100495366","phase-1-a-study-of-the-clinical-efficacy-and-safety-of-20-cassia-alata-extract-against-tinea-versicolor-100495366","NCT05730244","A Study of the Clinical Efficacy and Safety of 20% Cassia Alata Extract Against Tinea Versicolor","A Single Arm No-treatment Self-controlled Trial Pilot Study Evaluating the Clinical Efficacy and Safety Profile of 20% Cassia Alata Cream Against Tinea Versicolor","Inclusion Criteria:\n\n* Patients aged 18-89 of either sex\n* Clinical features suggestive of tinea versicolor AND Microscopic confirmation using skin scraping stains with chlorazol black preparation AND\u002FOR Wood's lamp fluorescence\n* No treatment for versicolor in the preceding 4 weeks\n* No contraindications to the application of C.alata cream including\n* No history of allergy to C. alata\n* No history of preservative allergy\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>89 years\n* Pregnant females\n* History of hypersensitivity to C. alata or preservative\n* Treatment within 4 weeks prior to enrollment\n* Lesions which do not meet the diagnostic criteria of tinea versicolor","89 Years",{"count":292,"type":20},20,[294],"PHASE1","The goal of this clinical trial is to establish the efficacy of Cassia alata extract as a cream form in treating tinea versicolor (liver spots\u002Fshifting clouds). The main questions the study aims to answer are:• Does the use of this extract help resolve tinea versicolor better than no treatment? Does the use of this cream have significant side effects i.e, is it safe? Participants will be asked to treat a designated area while leaving additional areas untreated. 1-2 finger tip units of cream will be applied to the treatment site twice daily at least 8 hours apart. Participants will attend the trial clinic every 4 weeks for 12 weeks.",[297,298],"Tinea Versicolor","Pityriasis Versicolor",[300,301,302],"Tinea Versicolor,","Cassia alata extract","Pityriasis versicolor","2025-11-14",{"date":305,"type":40},"2025-11-19",{"date":307,"type":40},"2025-03-01",{"date":309,"type":20},"2026-12-30",{"name":170,"class":84},{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":55,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":318,"targetDuration":4,"studyType":59,"phases":320,"briefSummary":321,"conditions":322,"keywords":324,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":46},"100340036","neck-and-low-back-pain-in-medical-students-at-the-university-of-the-west-indies-mona-jamaica-100340036","NCT03707288","Neck and Low Back Pain in Medical Students at The University of the West Indies, Mona, Jamaica","The Prevalence of Neck and Low Back Pain in Medical Students at The University of the West Indies, Mona, Jamaica","Inclusion Criteria:\n\n1. All students enrolled in the medical program at the University of the West Indies, Mona Campus, Jamaica during the period October 1, 2018 to January 2, 2026.\n2. Individuals who express a willingness to consent to the study.\n3. Individuals who express a willingness to adhere to the standardised exercise program for the stipulated period.\n\nExclusion Criteria:\n\n1. Individuals with a history of having spine surgery.\n2. Individuals who were previously diagnosed with spine pathology and currently receiving rehabilitation therapy.\n3. Individuals who express an unwillingness to participate in the study.",{"count":319,"type":20},1000,[61],"The purpose of this study is to identify the prevalence of neck and low back pain in medical students enrolled at the University of the West Indies, Mona; to assess their knowledge, attitude and practice of good spine health and to determine the outcome of a standardised spine exercise program on medical students experiencing neck and low back pain, using a prospective randomised control design.",[185,187,184,323,246,217,186,245],"Neck Pain Musculoskeletal",[223,195,192,325,225,326,327,224],"neck and back pain","medical students","university students","2025-09-03",{"date":330,"type":40},"2025-09-10",{"date":332,"type":40},"2018-10-01",{"date":334,"type":20},"2026-12-02",{"name":170,"class":84},{"id":337,"slug":338,"hasResults":11,"nctId":339,"briefTitle":340,"officialTitle":340,"acronym":4,"eligibilityCriteria":341,"healthyVolunteers":11,"sex":16,"minAge":342,"maxAge":343,"enrollmentInfo":344,"targetDuration":4,"studyType":59,"phases":346,"briefSummary":347,"conditions":348,"keywords":350,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":366},"100436452","empowering-adolescents-to-lead-change-using-health-data-100436452","NCT04963426","Empowering Adolescents to Lead Change Using Health Data","Inclusion Criteria:\n\n* School going\n* Aged 13-17 years\n\nExclusion Criteria:\n\n* Not going to school\n* Outside the age range 13-17 years","13 Years","17 Years",{"count":345,"type":20},12612,[61],"This study is a cluster randomized trial carried out in schools of secondary cities of four low- and middle income countries. Baseline surveys in 30 randomly selected schools will assess the health behaviours of 13-17 year old students as well as school policies and practices. The intervention arm (15 schools) will use the baseline information to develop a package of actions in collaboration with students, teachers, and local authorities that will subsequently be implemented an monitored over two years. Follow-up surveys to evaluate the effectiveness of the implemented actions will be conducted after two years in all 30 previously selected schools.",[349],"Healthy",[351,352,353,354,355,356],"adolescent health","students","schools","risk factors","protective factors","school health services","2024-08-06",{"date":359,"type":40},"2024-08-07",{"date":361,"type":40},"2022-01-01",{"date":363,"type":20},"2027-01",{"name":365,"class":84},"World Health Organization",5,{"id":368,"slug":369,"hasResults":11,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":373,"eligibilityCriteria":374,"healthyVolunteers":11,"sex":16,"minAge":375,"maxAge":376,"enrollmentInfo":377,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":379,"conditions":380,"keywords":381,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":393,"locationsCount":85},"100496782","arterial-function-parameters-and-transcranial-doppler-velocity-in-paediatric-patients-with-sickle-cell-disease-100496782","NCT05748717","Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell Disease","The Relationship of Transcranial Doppler Velocity With Other Vascular Measurements in Children With Sickle Cell Anaemia","AFAT","Inclusion Criteria:\n\n1. Pediatric participants with sickle cell anaemia (HbSS, HbSβ0 thalassemia, HbSD, HbSOArab)\n2. Age: Between 4-16 years of age, at the time of enrolment\n3. Has had at least one complete TCD study whether or not on hydroxyurea treatment or in a clinical trial.\n4. Parent or guardian willing and able to provide informed consent and child gives assent\n5. Ability to comply with study-related evaluations.\n\nExclusion Criteria:\n\n* Participants who meet any of the following criteria are disqualified from enrollment in the study:\n\n  1. Patients in whom a TCD study cannot be completed\n  2. Patients who have had an Erythrocyte transfusion in the past two months\n  3. Patients who are acutely ill or have had an acute infection in the past two weeks","4 Years","16 Years",{"count":378,"type":20},34,"Structural and functional changes in arteries are increasingly being recognized as significant features of sickle cell disease. This study aims to determine whether there are differences in arterial function parameters between children with sickle cell disease with normal and abnormal transcranial Doppler velocity. After informed consent is obtained, participants will have vascular, Transcranial Doppler, haematological and biochemical parameters measured. Researchers will compare children with sickle cell disease who have normal Transcranial Doppler velocity and no history of stroke with children with those who have an abnormal Transcranial Doppler velocity with or without a history of stroke to see if there are significant differences in arterial function parameters.",[273],[382,383,384,385,386],"Sickle Cell disease","Transcranial Doppler Velocity","Arterial Stiffness","Augmentation Index","Arterial Function","2023-02-17",{"date":389,"type":40},"2023-03-01",{"date":391,"type":40},"2023-02-01",{"date":166,"type":20},{"name":170,"class":84},""]