[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"alveolar-bone-loss\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:alveolar-bone-loss":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,31,0,25,[9,44,68,95,129,164,187,217,250,278,303,334,358,384,405,436,469,497,524,544,568,596,617,646,675],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100652952","thbccgf-for-alveolar-bone-regeneration-a-real-world-study-100652952",false,"NCT07779421","THBC\u002FCGF for Alveolar Bone Regeneration: A Real-World Study","A Real-World Study on Temperature-Sensitive Hydroxybutyl Chitosan-Loaded Concentrated Growth Factor for Alveolar Bone Defect Repair","* Inclusion Criteria:\n* Preoperative CBCT imaging confirming mandibular third molars (M3s) with low to moderate impaction according to the Pell and Gregory classification, and not in the acute inflammatory stage.\n* Ipsilateral mandibular second molars (M2s) with retention value and no indication for extraction.\n* Patients able to provide written informed consent and willing to comply with the scheduled follow-up visits.\n* Age between 18 and 60 years (inclusive).\n* Exclusion Criteria:\n* Presence of systemic diseases or other contraindications to tooth extraction surgery.\n* Known or suspected current malignancy.\n* History of radiation therapy to the head and neck region.\n* History of chemotherapy within 5 years prior to surgery.\n* Smoking \\> 15 cigarettes per day.\n* Subjects with mental or neurological disorders, or otherwise unable to provide informed consent.","ALL","18 Years","60 Years",{"count":21,"type":22},136,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to combine real-world research with relevant bone repair materials and techniques to improve alveolar bone resorption in extraction sockets following impacted wisdom tooth removal, while achieving effective bone preservation or promoting bone regeneration. All eligible cases within specified parameters will be included in the clinical study scope. Based on real-world clinical data, we will proactively collect postoperative clinical examination findings and imaging data. Statistical analysis will be performed on clinical outcomes and follow-up data from patients undergoing mandibular impacted M3 extraction. The study aims to clarify the therapeutic efficacy of the thermosensitive hydroxyethylchitosan-loaded concentrated growth factor group in repairing mesial bone defects of M2s following M3 extraction.",[28,29,30],"Alveolar Bone Loss","Alveolar Ridge Resorption After Extraction","Tooth, Impacted","RECRUITING","2026-08-19",{"date":34,"type":35},"2026-08-21","ACTUAL",{"date":37,"type":35},"2024-08-01",{"date":39,"type":22},"2027-07-31",{"name":41,"class":42},"Stomatological Hospital Affiliated with Fujian Medical University","OTHER",1,{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":43},"100626260","alveolar-ridge-preservation-arp-in-the-posterior-maxilla-after-the-extraction-of-maxillary-molars-100626260","NCT07433322","Alveolar Ridge Preservation (ARP) in the Posterior Maxilla After the Extraction of Maxillary Molars","Alveolar Ridge Preservation (ARP) in the Posterior Maxilla: A Clinical and Economic Evaluation of ARP After the Extraction of Maxillary Molars","Inclusion Criteria:\n\n* Intact or \\\u003C5mm dehiscence buccally and palatally\n* Initial residual bone height (RBH) of at least 6 mm. 3-A minimum distance of 1 mm between root apices and sinus membrane.\n\nExclusion Criteria\n\n* Medically compromised\n* heavy smokers\n* young (\\\u003C18 yrs.) or those refusing treatment are excluded.",{"count":52,"type":22},40,[25],"Dental implants are a fixed replacement solution with reported long-term survival rates between 94-98% over 20-40 years. In order to ensure successful implant therapy, adequate bone and soft tissue as well as correct 3D positioning of the implant are required. Upon extraction of a tooth, socket width can decrease by up to 60% within six months post-extraction, with a 11-22% vertical reduction. Additionally, sinus pneumatization occurs post-extraction as the maxillary sinus expands into the empty socket due to disuse atrophy and intra-sinus air pressure, as explained by Wolff's law. This further reduces residual bone height (RBH), often resulting in posterior maxillary sites requiring supplemental procedures to prevent bone loss or to augment the bone height at the time of implant placement. However, if the bone height and width dimensions are sufficient before and after extraction - in that, even with the aforementioned loss in width and height percentages in the latter, a standard implant may still be placed in the surrounding bone, one can argue that grafting may not be necessarily done at the time of extraction. Rather, it can be tailored to the patients' needs; thus potentially reducing overall post-operative discomfort and pain.",[28],[57,58,59],"Dental Implant","Alveolar Ridge Preservation (ARP)","Maxilla",{"date":61,"type":35},"2026-08-20",{"date":63,"type":35},"2026-06-18",{"date":65,"type":22},"2028-04",{"name":67,"class":42},"Virginia Commonwealth University",{"id":69,"slug":70,"hasResults":12,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":17,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":79,"briefSummary":80,"conditions":81,"keywords":82,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":43},"100551229","demineralized-dentin-allograft-versus-demineralized-dentin-autograft-for-socket-preservation-100551229","NCT06457373","Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation","The Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation After Surgical Extraction of Impacted Mandibular Third Molar","Inclusion Criteria:\n\n1. Patients aged between 25 to 35 years old.\n2. Patients scored as (ASA I).\n3. No adverse habits such as smoking, tobacco chewing, alcohol.\n4. Patients having bilaterally impacted mandibular third molar with similar degree of difficulty according to (Kim JY, et al).\n5. The recipient alveolar sockets are free of any pre-existing periapical pathology, based on x-ray.\n6. Alveolar sockets with a depth of 5 mm or more, using periodontal probe for assessment.\n7. Patients sign a consent for all procedures.\n\nExclusion Criteria:\n\n* 1\\) Pregnant or lactating patients. 2) Relevant systemic diseases. 3) Patients with history of chemotherapy or radiotherapy.",true,"25 Years","35 Years",{"count":52,"type":22},[25],"This study is designed to evaluate and compare clinically and radiographically the effectiveness of Demineralized Dentin Allograft (DDA) versus Demineralized Dentin Autograft (Auto-DD) for preservation of alveolar ridge dimensions after surgical extraction of the impacted mandibular third molar.",[28],[83,84,85],"Socket preservation","Impacted mandibular third molar","Alveolar ridge Augmentation","2026-08-14",{"date":88,"type":35},"2026-08-18",{"date":90,"type":35},"2026-08-13",{"date":92,"type":22},"2027-08-30",{"name":94,"class":42},"Horus University",{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":23,"phases":104,"briefSummary":105,"conditions":106,"keywords":110,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":43},"100650514","ovate-pontic-versus-essix-provisional-after-tooth-extraction-and-alveolar-ridge-preservation-pontic-essix-100650514","NCT07748871","Ovate Pontic Versus Essix Provisional After Tooth Extraction and Alveolar Ridge Preservation (Pontic-Essix)","Socket Sealing With a Fixed Ovate Pontic Provisional Versus a Removable Provisional Following Tooth Extraction and Alveolar Ridge Preservation: A Randomized Controlled Trial","Pontic-Essix","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* ASA physical status I or II\n* Requiring a single non-molar tooth extraction (incisor, canine, or premolar) in the maxilla or mandible, with planned tooth replacement\n* Extraction site bounded by natural, periodontally stable adjacent teeth\n* Intact alveolar socket upon extraction, or no more than one bony wall (facial, palatal, or lingual) presenting a dehiscence extending less than 50% of the total bony wall height\n* Willingness and ability to comply with the follow-up protocol\n* Ability to give informed consent, as documented by signature\n\nExclusion Criteria:\n\n* Current smokers, or former smokers who quit less than 6 months before extraction\n* Uncontrolled diabetes mellitus (HbA1c \\> 7.0%)\n* Clinical attachment loss ≥ 2 mm at the extraction site\n* Active or recent chemotherapy, or history of head and neck radiotherapy\n* Current or previous bisphosphonate therapy within the past 10 years\n* Immunosuppressive medication\n* Active oral or systemic acute infection\n* Severe hematologic disorder, hepatic or renal failure, or any clinically relevant bleeding disorder or anticoagulant medication that cannot be safely managed for the planned surgical procedure\n* Pregnancy or lactation\n* Known allergy or hypersensitivity to any of the study materials, including bovine-derived bone substitute, porcine-derived collagen matrix, or collagen-containing biomaterials\n* Any other disease or medication that may compromise normal wound healing\n* Inability to follow the study procedures (e.g., insufficient language comprehension, cognitive impairment, psychological disorder, or dementia)\n* Known or suspected non-compliance\n* Participation in another clinical trial that may interfere with the present study",{"count":52,"type":22},[25],"This randomized controlled trial compares two provisional socket-sealing concepts following single non-molar tooth extraction and alveolar ridge preservation: a fixed, tooth-supported, 3D-printed ovate pontic provisional restoration providing active soft tissue support (test) versus a removable Essix-type provisional restoration without intentional soft tissue contact combined with a porcine collagen matrix seal (control). Both groups receive alveolar ridge preservation using a deproteinized bovine bone mineral with 10% collagen. The primary endpoint is interproximal soft tissue height at 5 months, adjusted for baseline, assessed by digital superimposition of intraoral surface scans. Up to 40 participants will be enrolled at the University of Bern School of Dental Medicine.",[107,108,28,109],"Tooth Loss \u002F Rehabilitation","Tooth Extraction","Alveolar Ridge Augmentation",[111,112,113,114,115,116,117,118],"alveolar ridge preservation","ovate pontic","socket sealing","provisional restoration","interproximal soft tissue","papilla","digital superimposition","randomized controlled trial","NOT_YET_RECRUITING","2026-07-31",{"date":122,"type":35},"2026-08-06",{"date":124,"type":22},"2026-10",{"date":126,"type":22},"2029-02",{"name":128,"class":42},"University of Bern",{"id":130,"slug":131,"hasResults":12,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":77,"enrollmentInfo":136,"targetDuration":4,"studyType":23,"phases":138,"briefSummary":139,"conditions":140,"keywords":143,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":163},"100648392","regenerative-gel-emdogain-for-healing-after-wisdom-tooth-extraction-100648392","NCT07718932","Regenerative Gel (Emdogain®) for Healing After Wisdom Tooth Extraction","The Role of Enamel Matrix Derivative in Reducing the Periodontal Defect Distal to the Mandibular Second Molar Following Surgical Extraction of the Third Molar","Inclusion Criteria:\n\n* Healthy adult patients aged 18 to 35 years old (ASA I or II).\n* Presence of an asymptomatic, partially or fully impacted mandibular third molar requiring surgical extraction.\n* The third molar impaction must be mesioangular or horizontal, with its crown in direct physical contact with the adjacent second molar, as assessed by a preoperative panoramic radiograph.\n* The adjacent mandibular second molar must be vital, fully erupted, and structurally sound (free of extensive dental caries or prosthetic crowns).\n* Patients must demonstrate an adequate level of overall oral hygiene and gingival health (e.g., Full-Mouth Plaque Index \\\u003C 20% and Full-Mouth Bleeding Score \\\u003C 20% following initial prophylaxis and oral hygiene instructions).\n* Willingness to comply with postoperative instructions and adhere to the scheduled follow-up visits.\n* Ability to understand the study procedures and voluntarily sign the informed consent form.\n\nExclusion Criteria\n\n* Presence of systemic diseases or conditions that could compromise wound healing or periodontal health (e.g., uncontrolled diabetes mellitus, autoimmune disorders).\n* Current or recent use of medications known to affect bone metabolism or wound healing (e.g., bisphosphonates, long-term systemic corticosteroids, immunosuppressants).\n* History of heavy smoking (e.g., \\>10 cigarettes per day) or use of smokeless tobacco products.\n* Pregnant or lactating females.\n* Diagnosis of periodontitis (Stage II, III, or IV) affecting the remaining dentition, excluding the localized defect associated with the impacted third molar.\n* Presence of active acute infection (e.g., purulent pericoronitis) or radiolucent pathologic lesions extending beyond the normal follicular space (e.g., dentigerous cysts) that would significantly alter the baseline bony defect morphology.\n* Known allergy or hypersensitivity to any of the medications utilized in the surgical or postoperative protocol (e.g., local anesthetics, prescribed antibiotics, or analgesics).\n* Previous orthodontic treatment utilizing bands on the mandibular second molars that could have affected the periodontal attachment.",{"count":137,"type":22},70,[25],"This study investigates whether the intraoperative application of a specialized regenerative gel (Emdogain®) can improve the periodontal health of the mandibular second molar by preventing or reducing the formation of tissue defects after the surgical removal of an adjacent impacted lower wisdom tooth.\n\nSurgical extraction of a lower wisdom tooth frequently leaves a deep pocket or a permanent hard and\u002For soft tissue defect on the back side of the neighboring second molar. This defect compromise the surrounding tissues and predispose the healthy second molar to future complications like root caries, dentin hypersensitivity, or localized gum disease. While most existing treatments address these defects after they have formed, this trial evaluates a site-specific preventive approach during the extraction process itself.\n\nThe study will involve 70 systemically healthy adults (ages 18-45) requiring surgical removal of a horizontally or mesially oriented impacted lower third molar. Participants will be randomized into two equal groups:\n\nThe Test Group: Will receive root conditioning with PrefGel and a single application of Emdogain® gel directly to the root surface and socket immediately after tooth removal.\n\nThe Control Group: Will undergo identical surgery but will follow a natural, spontaneous healing process without the application of any biomaterials.\n\nThe main objective is to measure changes in Clinical Attachment Level (CAL) at the distal aspects of the second molar using stable vertical anatomical reference points over a 6-month period. The trial will also monitor secondary healing parameters, including probing pocket depths, gum recession, radiographic bone level changes using standardized jigs, postoperative pain, swelling, and early tissue healing dynamics.",[28,141,142],"Periodontal Pocket","Impacted Tooth With Abnormal Positioning",[144,145,146,147,148,149,150,151,152,153],"Enamel Matrix Derivative","Emdogain","Third Molar Surgery","Periodontal Defect","Osseous Defect","Clinical Attachment Level","Probing Pocket Depth","Periodontal Regeneration","Mandibular Second Molar","Prophylactic Periodontal Treatment","2026-07-17",{"date":156,"type":35},"2026-07-22",{"date":158,"type":35},"2026-03-09",{"date":160,"type":22},"2027-10-30",{"name":162,"class":42},"Aristotle University Of Thessaloniki",2,{"id":165,"slug":166,"hasResults":12,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":75,"sex":17,"minAge":18,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":23,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":43},"100643845","khourys-bone-shell-technique-versus-titanium-reinforced-polytetrafluoroethylene-for-augmentation-of-horizontal-deficiency-in-posterior-mandible-histomorphometry-analysis-100643845","NCT07669792","Khoury's Bone Shell Technique Versus Titanium-Reinforced Polytetrafluoroethylene for Augmentation of Horizontal Deficiency in Posterior Mandible (Histomorphometry Analysis)","Khoury's Bone Shell Technique Versus Titanium-Reinforced Polytetrafluoroethylene for Augmentation of Horizontal Deficiency in Posterior Mandible (Histomorphometry Analysis): A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Have two or more missing teeth in the posterior mandibular segment.\n2. The patients age of 18 and above.\n3. The alveolar ridge in the edentulous site of the selected patients will have a buccolingual width of less than 4mm.\n4. Sufficient vertical bone height.\n5. Free of any local or systemic condition that may contraindicate ridge expansion procedure.\n\nExclusion Criteria:\n\n1. Patients taking any medication that may interfere with bone healing or bone biology.\n2. Patients with any systemic disease that may affect bone healing.\n3. Any patients with any previous bone grafting procedure at the site of interest.\n4. Smokers.\n5. Patient's that have been diagnosed with periodontal disease, as sufficient ridge height would be improbable.\n6. Patients with significant vitamin D deficiency.","65 Years",{"count":173,"type":22},16,[25],"The purpose of the study is the comparison of bone gained histologically from the Bone Shell Khoury's Technique in comparison with the usage of non-resorbable membrane polytetrafluoroethylene and discussing its eligibility for implant placement in restoring the atrophic posterior mandible.",[28,177],"Posterior Mandible","2026-07-15",{"date":180,"type":35},"2026-07-16",{"date":182,"type":35},"2025-06-20",{"date":184,"type":22},"2027-03",{"name":186,"class":42},"British University In Egypt",{"id":188,"slug":189,"hasResults":12,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":75,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":194,"targetDuration":4,"studyType":23,"phases":196,"briefSummary":197,"conditions":198,"keywords":200,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":43},"100645750","novel-synthetic-membrane-for-horizontal-bone-augmentation-a-case-series-100645750","NCT07701473","Novel Synthetic Membrane for Horizontal Bone Augmentation: A Case Series","Efficacy of a Novel Synthetic GBR Membrane (Inox Nanoksa G-Plus) for Horizontal Ridge Augmentation: A Case Series","Inclusion Criteria:\n\n* Partial edentulism in the maxilla or mandible requiring single or multiple implant-supported restorations.\n* Insufficient bone volume for standard implant placement, defined as:\n\n  * Horizontal defect: residual ridge width \\\u003C 5 mm at the intended implant site, OR\n  * Vertical defect: residual ridge height \\\u003C 8 mm above vital structures (mandibular canal, maxillary sinus, nasal floor).\n* Healthy oral mucosa with no signs of active infection or inflammation at the defect site.\n* Systemically healthy or with well-controlled medical conditions (American Society of Anesthesiologists - ASA class I or II).\n\nExclusion Criteria:\n\n* Untreated periodontitis or active peri-implant disease.\n* Current or previous treatment with intravenous bisphosphonates (or oral bisphosphonates for \\> 3 years).\n* Severe immunosuppression or chronic systemic corticosteroid therapy (\\> 10 mg\u002Fday prednisolone for \\> 3 months).\n* Active smoking (\\> 10 cigarettes per day). Smoking cessation for at least 2 weeks before surgery is required; heavy smokers may be excluded.\n* Pregnant or lactating women.",{"count":195,"type":22},12,[25],"The goal of this clinical study is to learn if the Inox Nanoksa G-Plus membrane works to rebuild bone in the upper or lower jaw (ridge augmentation) for adults who need dental implants but do not have enough bone width or height. It will also learn about the safety of this membrane and how patients feel after surgery.\n\n\\- The main questions it aims to answer are: How much pain, swelling, and bleeding do participants experience during the first week after the bone-building surgery? How much new bone width and height does the membrane help grow, as measured on a 3D X-ray (CBCT) taken 6 months after surgery? What medical problems or side effects (such as the membrane becoming visible through the gums, infection, or graft loss) do participants experience? This is a single-treatment study; all participants will receive the same surgery using the Inox Nanoksa G-Plus membrane together with a bone graft material.\n\nParticipants will:\n\nHave surgery to place the membrane and bone graft under their gums to rebuild their jawbone.\n\nTake antibiotics and pain relievers, and use a special mouth rinse for about 2 weeks after surgery.\n\nRate their pain, swelling, and bleeding on simple scales on days 1, 3, and 7 after surgery.\n\nReturn for a checkup at 1 month and have a follow-up 3D X-ray at 6 months. Undergo a second surgery at 6 months to have dental implants placed and to evaluate the newly formed bone.",[199,28],"Alveolar Ridge Deficiency",[109,201,202,203,204,205,206,207,57],"Guided Bone Regeneration","Membranes, Artificial","Bone Transplantation","GBR Membrane","Synthetic Membrane","Inox Nanoksa G-Plus","Vertical Bone Defect","2026-07-13",{"date":210,"type":35},"2026-07-14",{"date":212,"type":22},"2026-09-01",{"date":214,"type":22},"2027-09-01",{"name":216,"class":42},"Cairo University",{"id":218,"slug":219,"hasResults":12,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":75,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":23,"phases":227,"briefSummary":229,"conditions":230,"keywords":233,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":43},"100643193","early-phase-1-assessment-of-the-impact-of-neocement-inject-p-beta-tricalcium-phosphate-on-bone-volume-in-alveolar-ridge-preservation-after-tooth-extraction-100643193","NCT07638319","Assessment of the Impact of Neocement Inject P® (Beta-Tricalcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction","Assessment of Safety and Performance of Neobone®: A Prospective Observational Study in the Field of Dentistry","BTCPARPBV","Inclusion Criteria:\n\n* 18 years or older\n* Acceptance of informed consent\n* Type 1 or 2 extraction sockets (Elian et al. 2007)\n\nExclusion Criteria:\n\n* Presence of active infection or severe inflammation in the intervention zone\n* Relevant medical history that contraindicates implant surgery\n* Patients with poor oral hygiene (full-mouth plaque score and full-mouth bleeding score \\>15%) and lack of motivation\n* Uncontrolled diabetes (reported levels of glycated haemoglobin exceeding 7%)\n* Uncontrolled and \u002For untreated periodontal disease\n* Heavy smokers (more than 10 cigarettes per day)\n* Immunosuppression",{"count":226,"type":22},30,[228],"EARLY_PHASE1","The goal of this randomized clinical trial is to assess whether β-TCP (Beta-Tricalcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction. The main question it aims to answer is whether using β-TCP for alveolar ridge preservation has a positive effect on bone volume compared with natural healing.\n\nThe main questions it aims to answer are:\n\nDoes β-TCP improve ridge preservation compared with natural healing?\n\nResearchers will compare β-TCP grafted sockets to natural healing sockets to see if β-TCP better preserves ridge volume.\n\nParticipants will:\n\nHave a tooth indicated for extraction.\n\nBe assigned to either β-TCP or natural healing.\n\nUndergo CBCT (Cone Beam Computed Tomography) and intra-oral scanning after extraction and after six months of healing to measure horizontal and vertical resorption and bone density.",[108,231,232,28],"Tooth Extraction Site Healing","Alveolar Bone Grafting",[234,235,236,237,83,238,239,240],"Beta-tricalcium phosphate","Alveolar ridge preservation","Bone volume","Implant site development","Ridge augmentation","Tooth extraction","Volumetric Changes","2026-06-09",{"date":243,"type":35},"2026-06-11",{"date":245,"type":35},"2025-12-01",{"date":247,"type":22},"2028-12",{"name":249,"class":42},"Egas Moniz - Cooperativa de Ensino Superior, CRL",{"id":251,"slug":252,"hasResults":12,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":4,"eligibilityCriteria":256,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":257,"enrollmentInfo":258,"targetDuration":4,"studyType":23,"phases":259,"briefSummary":260,"conditions":261,"keywords":263,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":43},"100640921","effect-of-collagen-membrane-on-ridge-preservation-100640921","NCT07580495","Effect of Collagen Membrane on Ridge Preservation","Effect of Collagen Membrane on Ridge Preservation for Delayed Implant Placement in Sites With Absent Buccal Bone Wall: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18-80\n* Indicated for extraction of a single-rooted maxillary tooth\n* ≥ 50% buccal bone dehiscence confirmed by CBCT reconstructions\n* Presence of both adjacent teeth\n* No interproximal bone loss\n* ASA I-II health status\n* Ability to comply with required procedures, including attending required number of clinic visits\n\nExclusion Criteria:\n\n* Patients diagnosed with periodontitis adjacent to the area to be treated\n* History of allergic reactions to local anesthetics or bone graft material (self-reported);\n* Current heavy smokers (≥ 10 cigarettes\u002Fday) or those who quit smoking recently (self-reported; last 6 months);\n* Diagnosis of diabetes mellitus, liver or kidney failure (self-reported);\n* Presence of active infectious diseases of any kind;\n* History of chemotherapy or radiation therapy to the head or neck within the past 5 years (self-reported);\n* Severe hematologic disorders (risk for hemorrhage)(self-reported);\n* Assumption of corticosteroids, IV bisphosphonates or immunosuppressive drugs;\n* Any history of alcohol or drug abuse (self-reported);\n* Pregnancy or plans to become pregnant within 4 months of study enrollment (self-reported);","80 Years",{"count":226,"type":22},[25],"This study will evaluate whether adding a resorbable collagen membrane to an anorganic bone-collagen composite (ABCC) graft improves ridge preservation after tooth extraction. Ridge preservation is a procedure used to maintain the shape and volume of the jawbone following tooth removal, which is important for future dental implant placement.\n\nParticipants will be randomly assigned to receive either ABCC alone or ABCC combined with a collagen membrane. Healing outcomes will be assessed after approximately 4 months using three-dimensional cone beam computed tomography (CBCT) scans.\n\nThe primary outcome is the change in horizontal ridge dimension (width). Secondary outcomes include vertical and contour changes in ridge dimensions, changes in soft tissue contour assessed with digital scans, postoperative healing and complications (such as wound dehiscence, swelling, or infection), and patient-reported outcomes, including pain and satisfaction. In a subset of participants, bone healing will also be evaluated using laboratory and imaging analyses of bone samples obtained at the time of implant placement. The study will additionally assess whether the treatment allows implant placement in the ideal position without the need for further bone grafting.",[262,108,28],"Dehiscence",[264,265,266,267,268],"Ridge preservation","Collagen membrane","Socket grafting","Buccal bone loss","Delayed implant placement","2026-06-02",{"date":271,"type":35},"2026-06-04",{"date":273,"type":35},"2026-05-26",{"date":275,"type":22},"2027-10-31",{"name":277,"class":42},"Debora Dias",{"id":279,"slug":280,"hasResults":12,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":284,"eligibilityCriteria":285,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":23,"phases":287,"briefSummary":288,"conditions":289,"keywords":290,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":43},"100630208","reduced-time-interval-for-implant-placement-after-extraction-socket-preservation-using-the-vega-plus-implants-100630208","NCT07484685","Reduced Time Interval for Implant Placement After Extraction Socket Preservation Using the Vega Plus Implants","Effect of Reducing the Time Interval for Implant Placement After Extraction Socket Preservation Using the Vega Plus Implant System (Klockner): A Randomized Controlled Clinical Trial","RIP-VEGA","Inclusion Criteria:\n\n* Age: ≥ 18 years.\n* Good general health.\n* Need of extraction of incisors, canines or premolars due to carious lesion, endodontic complication, root fracture or prosthetic reason.\n* Presence of three intact socket walls after tooth extraction with a defect of 50% or more of the buccal wall.\n* Need of single-tooth implant treatment, with presence of adjacent teeth and opposing occluding teeth (for measurement stent indexing).\n* Enough available bone assessed on CBCT to place implants with 3.6 mm diameter and 10 mm in length.\n* Periodontal health in intact or reduced periodontium.\n* Full-mouth plaque and bleeding scores \\\u003C 20%.\n* Able and willing to follow study procedures and instructions.\n\nExclusion Criteria:\n\n* \\\u003C 18 years.\n* Compromised health. Existence of any systemic condition such as uncontrolled diabetes mellitus, cancer, HIV, disorders that compromise wound healing, chronic high dose steroid therapy, intravenous and oral bisphosphonate therapy, bone metabolic diseases, history of irradiation of the head and neck area, or any other immunosuppressive therapy that would contraindicate oral surgical treatment.\n* Absence of any adjacent teeth or the opposing occluding teeth.\n* The hopeless tooth is a molar.",{"count":52,"type":22},[25],"This randomized controlled clinical trial aims to evaluate whether reducing the healing interval for implant placement after extraction socket preservation improves clinical and radiographic outcomes compared with the conventional waiting period. Participants requiring single-tooth extraction and implant therapy will be randomly assigned to implant placement either 4 months or 6 months after ridge preservation using the Vega Plus implant system (Klockner).\n\nClinical and radiographic assessments will be performed at baseline and during follow-up visits. The primary outcome will be the mean change in horizontal alveolar ridge width measured using cone-beam computed tomography (CBCT). Secondary outcomes will include vertical bone height changes measured on CBCT, implant stability measured using resonance frequency analysis (ISQ values), marginal bone level changes assessed on standardized periapical radiographs, and postoperative pain assessed using the Visual Analog Scale (VAS).\n\nThe results of this study may contribute to optimizing treatment timing and improving efficiency in implant dentistry while maintaining favorable clinical outcomes.",[28,108],[291,239,235,201,292,293],"Dental implant","Bone regeneration","Dental Implant Placement","2026-04-27",{"date":296,"type":35},"2026-05-01",{"date":298,"type":35},"2026-02-28",{"date":300,"type":22},"2027-02-27",{"name":302,"class":42},"Universidad Catolica Santiago de Guayaquil",{"id":304,"slug":305,"hasResults":12,"nctId":306,"briefTitle":307,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":23,"phases":310,"briefSummary":311,"conditions":312,"keywords":314,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":43},"100557075","the-application-of-a-biphasic-calcium-sulfate-graft-material-in-sinus-floor-elevation-100557075","NCT06533397","The Application of a Biphasic Calcium Sulfate Graft Material in Sinus Floor Elevation","Inclusion Criteria:\n\n* Patients over the age of 18 years,\n* Patients who need dental implant-borne prostheses,\n* Patients with insufficient bone height in the posterior maxilla due to sinus pneumatization.\n\nExclusion criteria:\n\n.• Patients who had major systemic diseases as classified by the American Society of Anesthesiologists (ASA grades III-IV),\n\n* psychiatric contraindications,\n* patients on medication interfering with bone metabolism, including steroid therapy and antiresorptive medication,\n* radiation to the head or neck region within the previous five years,\n* localized periapical disease, odontogenic and nonodontogenic cysts, and maxillary sinusitis,\n* evidence of uncontrolled periodontal disease,\n* Alcohol Use Disorder defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5),\n* recreational drug abuse,\n* heavy smoking (\\>10 cigarettes\u002Fday),\n* diseases of the oral mucosa, including blisters and ulcers, i.e.: red and white lesions, pigmented lesions, benign tumors of the oral cavity, and oral cancer. Leukoplakia, Erythroplakia, Precancerous lesions, Oral squamous cell carcinoma and malign tumors of the soft and hard tissues, Oral candidiasis, Oral lichen planus, Psoriasis, Pemphigus, and Pemphigoid.\n* pregnancy or nursing,\n* poor oral hygiene",{"count":52,"type":22},[25],"Pneumatization of the maxillary sinus may lead to insufficient bone volume for dental implant placement in the edentulous posterior maxilla. Sinus floor elevation (SFE) surgery with the lateral window technique is a safe and predictable surgical intervention to restore bone height in the maxillary premolar and molar areas. According to the literature, several bone graft materials may be successfully applied for SFE surgery. There is a lack of evidence regarding the application of biphasic calcium sulfate (BCS) for SFE. The healing period following staged SFE is 2-9 months.\n\nThe aim of this study is:\n\n* to evaluate the success of SFE surgery using BCS as graft material,\n* to compare the microarchitecture of the augmented bone depending on the healing period,\n* to evaluate the success of dental implants placed in the augmented bone and that of the prostheses delivered on the dental implants.",[28,313],"Edentulism Nos",[315,316,317,318,319,320,321,322,323,324],"bone graft material","biphasic calcium sulfate","sinus floor elevation","sinus lift","maxillary sinus augmentation","microcomputed tomography","cone beam computed tomography","histology","histomorphometry","dental implant","2026-04-21",{"date":327,"type":35},"2026-04-24",{"date":329,"type":35},"2024-08-24",{"date":331,"type":22},"2031-09",{"name":333,"class":42},"Semmelweis University",{"id":335,"slug":336,"hasResults":12,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":340,"eligibilityCriteria":341,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":342,"targetDuration":4,"studyType":23,"phases":344,"briefSummary":345,"conditions":346,"keywords":347,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":357,"locationsCount":43},"100633040","evaluation-of-guided-tissue-regeneration-with-autogenous-bone-chips-and-cgf-during-implant-placement-100633040","NCT07521514","Evaluation of Guided Tissue Regeneration With Autogenous Bone Chips and CGF During Implant Placement","Clinical and Radiographic Evaluation of Guided Tissue Regeneration Using Autogenous Bone Chips and Concentrated Growth Factors Membranes With Simultaneous Implant Placement. (Case Series)","CGF","inclusion criteria:\n\n* A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism,etcetera(Chrcanovic et al., 2014).\n\nexclusion criteria: A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera(Chrcanovic et al., 2014).",{"count":343,"type":22},8,[25],"CGF membranes will be prepared using a swing-lock centrifuge. A full-thickness mucoperiosteal flap will be elevated in a narrow alveolar ridge. Implants will be inserted. Autologous bone chips will be harvested via bone scraping and used for augmentation, CGF membranes will be placed over the grafted area. Suturing of the mucoperiosteal flap. Radiographic evaluation of the bone density and tissue thickness will be performed by CBCT preoperatively, immediate postoperative and after the procedure by 4 months. Clinical evaluation of the tissue thickness using periodontal probe preoperatively, immediate postoperatively and after the procedure by 4 months",[28,109,57],[340,348,349,324,350],"autogenous bone graft","gingival biotype","guided tissue regeneration","2026-04-08",{"date":353,"type":35},"2026-04-13",{"date":355,"type":22},"2026-04-16",{"date":124,"type":22},{"name":216,"class":42},{"id":359,"slug":360,"hasResults":12,"nctId":361,"briefTitle":362,"officialTitle":363,"acronym":340,"eligibilityCriteria":364,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":365,"targetDuration":4,"studyType":23,"phases":367,"briefSummary":368,"conditions":369,"keywords":374,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":378,"startDateStruct":379,"completionDateStruct":381,"leadSponsor":383,"locationsCount":43},"100632964","immediate-implant-placement-using-socket-shield-with-cgf-100632964","NCT07520526","Immediate Implant Placement Using Socket Shield With CGF","Clinical and Radiographic Evaluation of Concentrated Growth Factors With Simultaneous Immediate Implant Placement in Socket Shield Technique","Inclusion Criteria:\n\n* Age ≥18 years old. (Younis, W., \\& El-Rashidy, A. 2020).\n* Both male and female patients.\n* Maxillary, anterior and premolar segment.\n\nExclusion Criteria:\n\n* A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera.",{"count":366,"type":22},7,[25],"This prospective case series study aims to clinically and radiographically evaluate the effectiveness of the socket shield technique combined with concentrated growth factors (CGF) in immediate implant placement in the esthetic zone. Outcomes will include crestal bone level changes assessed by CBCT and implant stability measured using Osstell.",[370,371,372,373,28],"Socket Shield Technique","Concentrated Growth Factors","Immediate Dental Implant Placement","Alveolar Bone Preservation",[375,376,377],"Socket shield technique","immediate implants","concentrated growth factor",{"date":353,"type":35},{"date":380,"type":22},"2026-04-01",{"date":382,"type":22},"2026-12-30",{"name":216,"class":42},{"id":385,"slug":386,"hasResults":12,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":340,"eligibilityCriteria":390,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":391,"targetDuration":4,"studyType":23,"phases":392,"briefSummary":393,"conditions":394,"keywords":397,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":400,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":404,"locationsCount":43},"100632963","socket-shield-technique-with-cgf-and-xenograft-for-immediate-implants-100632963","NCT07520513","Socket Shield Technique With CGF and Xenograft for Immediate Implants","Clinical and Radiographic Evaluation of Bone Grafting Using Concentrated Growth Factors and Xenograft With Simultaneous Immediate Implant Placement in Socket Shield Technique","Inclusion criteria:\n\n* Age ≥18 years old. (Younis, W., \\& El-Rashidy, A. 2020).\n* Both male and female patients.\n* Maxillary, anterior and premolar segments.\n\nExclusion Criteria:\n\n* A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera.",{"count":366,"type":22},[25],"This prospective case series aims to evaluate the clinical and radiographic outcomes of immediate implant placement using the socket shield technique combined with concentrated growth factors (CGF) and xenograft in the esthetic zone. The study will assess crestal bone level changes and implant stability over a 6-month follow-up period.",[28,370,395,372,371,396,373],"Bone Resorption","Xenograft",[376,398,399,396],"socket shield technique","Concentrated growth factor",{"date":353,"type":35},{"date":402,"type":22},"2026-04-05",{"date":382,"type":22},{"name":216,"class":42},{"id":406,"slug":407,"hasResults":12,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":4,"eligibilityCriteria":411,"healthyVolunteers":75,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":412,"targetDuration":414,"studyType":415,"phases":4,"briefSummary":416,"conditions":417,"keywords":422,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":43},"100633395","impact-of-alveolar-ridge-preservation-on-the-potential-need-for-sinus-floor-elevation-a-10-year-retrospective-radiographical-study-100633395","NCT07526129","Impact of Alveolar Ridge Preservation on the Potential Need for Sinus Floor Elevation: A 10-year Retrospective Radiographical Study","Impact of Alveolar Ridge Preservation on the Potential Need for Sinus Floor Elevation in Posterior Maxillary Implant Sites: A 10-year Retrospective Radiographical Study","Inclusion Criteria:\n\n* • Patients aged ≥18 years.\n\n  * Patients who underwent alveolar ridge preservation after extraction of maxillary posterior teeth, as a test group.\n  * Patients who underwent extraction of maxillary posterior teeth with unassisted socket healing without alveolar ridge preservation as a control group.\n\nExclusion Criteria:\n\n* • The presence of a clinically symptomatic periapical radiolucency, acute abscesses, or chronic sinus tract, that may falsify the classification of posterior maxillary teeth on 2D radiographs.",{"count":413,"type":22},130,"12 Months","OBSERVATIONAL","This research aims to investigate the influence of alveolar ridge preservation, after extraction of maxillary posterior teeth, on the potential need of sinus floor augmentation procedures (that include lateral or crestal sinus augmentations). From peri-apical radiographs, maxillary posterior teeth will be divided into 4 groups according to the relationship of their apexes with the sinus. Then, the patients will be divided into 2 sub-groups: unassisted socket healing (only extraction) and ARP group (extraction + ARP) and their CBCT scans before implant placement will be collected. The CBCT scans should be at least 4 months post-extraction and ARP. Depending on the residual bone height, patients will be divided into 3 categories, according to the ABC classification:\n\n1. In need of lateral sinus floor augmentation\n2. In need of crestal sinus floor augmentation\n3. No need for sinus floor augmentation, therefore, implant placement.\n\nThese divisions will be conducted, according to:\n\n\\- The residual bone height (RBH) which is the height in mm from the alveolar ridge crest to the lowest point of the maxillary sinus floor.\n\nThe results of the proposed hypothesis are verified and interpreted after statistical analysis.",[28,418,419,420,421],"Sinus Floor Augmentation","Sinus Pneumatization","Alveolar Bone Atrophy","Alveolar Ridge Preservation",[423,424,425,426,427],"alveolar bone loss","alveolar process atrophy","extraction","tooth socket","sinus floor augmentation","2026-04-06",{"date":353,"type":35},{"date":431,"type":35},"2025-01-01",{"date":433,"type":22},"2026-05-30",{"name":435,"class":42},"Saint-Joseph University",{"id":437,"slug":438,"hasResults":12,"nctId":439,"briefTitle":440,"officialTitle":441,"acronym":442,"eligibilityCriteria":443,"healthyVolunteers":75,"sex":17,"minAge":444,"maxAge":445,"enrollmentInfo":446,"targetDuration":4,"studyType":23,"phases":447,"briefSummary":450,"conditions":451,"keywords":453,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":43},"100632003","phase-1-evaluation-of-stem-cell-exosomes-versus-platelet-rich-fibrin-in-tooth-extraction-socket-healing-100632003","NCT07508033","Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing","Evaluation of Mesenchymal Stem Cell-Derived Exosomes Versus Platelet-Rich Fibrin (PRF) in Post-Extraction Socket Healing: A Randomized Controlled Clinical Trial.","MSC-EXO vs PRF","Inclusion Criteria:\n\n* Patients aged between 20 and 45 years.\n* Patients requiring a single tooth extraction of a non-infected tooth in the aesthetic zone (incisors, canines) or premolar area.\n* Presence of adjacent teeth to the extraction site.\n* Adequate oral hygiene (Plaque Index \\\u003C 20%).\n* Patients willing and able to comply with the follow-up schedule and 3-month CBCT scan.\n* Signed informed consent provided by the participant.\n\nExclusion Criteria:\n\n* Patients with systemic diseases that contraindicate oral surgery or interfere with bone healing (e.g., uncontrolled diabetes, osteoporosis, hyperparathyroidism).\n* History of head and neck radiation therapy or bisphosphonate medication use.\n* Active infection or acute abscess at the extraction site.\n* Heavy smokers (more than 10 cigarettes per day).\n* Pregnant or lactating women.\n* Patients with poor oral hygiene or active periodontal disease in the rest of the mouth.\n* Use of any medications known to affect bone metabolism (e.g., long-term corticosteroids).","20 Years","45 Years",{"count":52,"type":22},[448,449],"PHASE1","PHASE2","This study evaluates two different treatments used to help the jawbone heal after a tooth is removed. When a tooth is extracted, the surrounding bone often shrinks, which can make it difficult to place dental implants later. Currently, doctors often use Platelet-Rich Fibrin (PRF), which is made from the patient's own blood, to help the area heal.\n\nThis research compares PRF to a newer treatment using \"exosomes\" derived from stem cells. Exosomes are tiny particles that carry signals to tell the body to repair tissue and grow new bone. The goal of this study is to see if these exosomes work better than PRF at keeping the bone strong and thick after an extraction. Researchers will use specialized X-rays (CBCT) to measure the bone three months after the procedure to see which treatment provided better results.",[28,108,452],"Bone Regeneration",[454,455,421,456,457,458,459],"MSC-derived Exosomes","Platelet-Rich Fibrin (PRF)","Socket Grafting","Cone-Beam Computed Tomography (CBCT)","Stem Cell Secretome","Bone Density","2026-03-27",{"date":462,"type":35},"2026-04-02",{"date":464,"type":35},"2026-01-15",{"date":466,"type":22},"2026-08-01",{"name":468,"class":42},"Al Salam University",{"id":470,"slug":471,"hasResults":12,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":475,"eligibilityCriteria":476,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":477,"targetDuration":4,"studyType":23,"phases":479,"briefSummary":480,"conditions":481,"keywords":483,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":43},"100628318","immediate-implant-placement-with-autogenous-maxillary-tuberosity-graft-in-the-esthetic-zone-100628318","NCT07460076","Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone","Clinical and Esthetic Outcomes of Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone: A Prospective Case Series","TUBERO-IMPLANT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Patients requiring single implant placement in the maxillary esthetic zone\n* Indication for immediate implant placement following tooth extraction\n* Presence of a buccal bone defect requiring augmentation with an autogenous maxillary tuberosity bone graft\n* Adequate oral hygiene and ability to maintain postoperative care\n* Willingness to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* Uncontrolled sHistory of radiotherapy in the head and neck region ystemic diseases\n* History of radiotherapy in the head and neck region\n* Active periodontal disease or untreated oral infection\n* Heavy smoking (more than 10 cigarettes per day)\n* Pregnancy or lactation\n* Severe parafunctional habits\n* Insufficient bone volume preventing implant placement with the planned protocol\n* Patients unable to attend follow-up visits",{"count":478,"type":22},15,[25],"Immediate implant placement in the esthetic zone is often associated with buccal bone deficiency, which may compromise esthetic outcomes and long-term implant stability. Autogenous bone graft harvested from the maxillary tuberosity provides corticocancellous bone with favorable biological properties and may help reconstruct the buccal bone plate during immediate implant placement.\n\nThis prospective case series aims to evaluate the clinical and esthetic outcomes of immediate implant placement combined with autogenous maxillary tuberosity graft in the esthetic zone. The primary outcomes include buccal bone thickness measured on cone-beam computed tomography (CBCT), facial soft tissue thickness measured clinically, and the pink esthetic score (PES) after implant restoration.",[28,482],"Esthetic Zone Implant Rehabilitation",[484,485,486,57,487],"Immediate Implant Placement","Maxillary Tuberosity Graft","Autogenous Bone Graft","Pink Esthetic Score","2026-03-04",{"date":490,"type":35},"2026-03-10",{"date":492,"type":35},"2026-01-01",{"date":494,"type":22},"2026-11",{"name":496,"class":42},"University of Medicine and Pharmacy at Ho Chi Minh City",{"id":498,"slug":499,"hasResults":12,"nctId":500,"briefTitle":501,"officialTitle":502,"acronym":4,"eligibilityCriteria":503,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":504,"targetDuration":4,"studyType":23,"phases":506,"briefSummary":507,"conditions":508,"keywords":510,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":516,"startDateStruct":518,"completionDateStruct":520,"leadSponsor":522,"locationsCount":43},"100627528","assessment-of-labial-plate-thickness-after-immediate-implant-placement-using-two-different-xenografts-in-the-esthetic-zone-100627528","NCT07449806","Assessment of Labial Plate Thickness After Immediate Implant Placement Using Two Different Xenografts in the Esthetic Zone","Assessment of Labial Plate Thickness After Immediate Implant Placement in Type II Extraction Sockets Using Two Different Xenografts in the Esthetic Zone: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients with one or more non-restorable teeth or remaining roots without signs of acute infection in the maxillary anterior region.\n* Type II extraction sockets.\n* Sufficient bone (\\>3 mm) apically and palatally to allow for proper implant positioning with sufficient primary stability (≥ 30 N cm).\n* Good compliance.\n\nExclusion Criteria:\n\n* Teeth with current acute periapical infection.\n* Medically compromised patients.\n* Heavy smokers (smoking of more than 10 cigarettes per day ).\n* Alcohol or drug abuse.\n* Patients undergoing chemotherapy and radiotherapy.\n* Poor oral hygiene.\n* Vulnerable groups (pregnant females and decision- impaired individual).",{"count":505,"type":22},26,[25],"This randomized clinical trial aims to evaluate labial bone plate changes following immediate implant placement in Type II extraction sockets using two different xenograft materials and de-epithelialized free gingival graft in the esthetic zone . Patients requiring extraction and immediate implant placement will be randomly allocated into two groups according to the xenograft material used for defect grafting. Clinical and radiographic outcomes will be assessed to determine dimensional bone changes and implant success",[28,509,484],"Tooth Extraction Status Nos",[511,512,513,514,515],"immediate implant placement","type II extraction socket","esthetic zone.","xenograft","randomized controlled clinical trial",{"date":517,"type":35},"2026-03-06",{"date":519,"type":35},"2025-09-05",{"date":521,"type":22},"2026-09-25",{"name":523,"class":42},"Basma Gamal Mohamed Ahmed",{"id":525,"slug":526,"hasResults":12,"nctId":527,"briefTitle":528,"officialTitle":528,"acronym":529,"eligibilityCriteria":530,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":531,"targetDuration":4,"studyType":23,"phases":532,"briefSummary":533,"conditions":534,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":536,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":542,"locationsCount":43},"100625179","comparison-of-customized-allogenic-versus-autogenous-bone-block-graft-for-alveolar-ridge-augmentation-100625179","NCT07419269","Comparison of Customized Allogenic Versus Autogenous Bone Block Graft for Alveolar Ridge Augmentation","IndiALLO","INCLUSION CRITERIA\n\n* 1-4 missing teeth that need to be replaced with dental implants\n* Bone ridge width insufficient for dental implant placement; \\\u003C5 mm of width as measured in a cone beam computed tomography at the ideal prosthetic position\n* Medically healthy with no known allergies to antibiotics\n* Non-smoker or light smoker (\\\u003C 10) or previous smoker who had quit for 5 years or more\n* Periodontal health, as confirmed by clinical examination (Full mouth bleeding score and full mouth plaque score \\\u003C 25%) and at least one neighboring natural tooth to the defect site(s)\n* Age of 18 or above\n\nEXCLUSION CRITERIA\n\n* All contraindications against implant treatment or augmentative procedures (e.g., advanced systemic diseases, corticosteroid medication, immunodeficiency, pregnancy, intention to become pregnant, breastfeeding, lack of safe contraception)\n* Treatments or diseases that may have an effect on bone turnover or the bone itself or non-mineralized tissue metabolism (e.g., bisphosphonates or local radiotherapy, skeletal immaturity)\n* Pathological fractures such as those observed in (but not limited to) Paget's disease or in metastatic bone diseases\n* Any active malignancy or patient undergoing treatment for a malignancy Study protocol: IndiALLO Version 4\u002F19.03.2025 Page 9 von 32\n* Contraindications to the class of drugs under study, e.g., known hypersensitivity or allergy to class of drugs or the investigational product\n* Persistent compartment syndrome or neurovascular residua of compartment syndrome",{"count":505,"type":22},[25],"The aim of this study is to determine whether jawbone augmentations using allogeneic and autogenous bone blocks lead to comparable three-dimensional clinical and radiological outcomes.\n\nIn addition, the study seeks to investigate whether there are differences regarding safety, biocompatibility, complications, and PROMs.\n\nFurthermore, it aims to clarify whether differences exist between the two groups with respect to implant condition (one year after implantation and during annual follow-ups for up to five years).",[28],"2026-02-16",{"date":537,"type":35},"2026-02-18",{"date":539,"type":35},"2025-04-01",{"date":541,"type":22},"2032-08-01",{"name":543,"class":42},"Medical University of Graz",{"id":545,"slug":546,"hasResults":12,"nctId":547,"briefTitle":548,"officialTitle":549,"acronym":4,"eligibilityCriteria":550,"healthyVolunteers":75,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":551,"targetDuration":4,"studyType":415,"phases":4,"briefSummary":553,"conditions":554,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":560,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":43},"100517411","ultrasound-for-socket-healing-evaluation-100517411","NCT06017193","Ultrasound for Socket Healing Evaluation","Ultrasonic Imaging of Bone Graft Healing in Extraction Sockets for Precise and Personalized Implant Therapy (HUM00226516)","Inclusion Criteria:\n\n* Patients at least 18 years of age and have at least a tooth that is considered hopeless, planned for an extraction and a bone grafting procedure for subsequent dental implant surgery.\n\nExclusion Criteria:\n\n* Patients not willing or not able to have an extraction, bone graft and subsequent implant surgery due to health, finance, or any other reasons.",{"count":552,"type":22},140,"The design is a single blinded, dual comparative study of ultrasound versus micro-CT\u002FLASCA in one study group. Up to a total of 140 subjects registered will be recruited. Subjects who are treatment planned for extraction of a hopeless tooth and socket augmentation with bone graft and are planned for a dental implant surgery. The socket will be evaluated before the extraction and multi-time points during healing until an implant is placed with various evaluation tools, including ultrasound.",[555,556,28,557,558],"Healing Wound","Alveolar; Wound","Image","Dent Disease","2025-10-30",{"date":561,"type":35},"2025-10-31",{"date":563,"type":35},"2024-07-25",{"date":565,"type":22},"2027-07-01",{"name":567,"class":42},"University of Michigan",{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":574,"eligibilityCriteria":575,"healthyVolunteers":12,"sex":17,"minAge":444,"maxAge":171,"enrollmentInfo":576,"targetDuration":4,"studyType":23,"phases":578,"briefSummary":579,"conditions":580,"keywords":583,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":588,"lastUpdatePostDateStruct":589,"startDateStruct":591,"completionDateStruct":593,"leadSponsor":594,"locationsCount":4},"100602617","efficacy-of-bioactive-glass-vs-xenograft-in-maxillary-sinus-augmentation-100602617","NCT07125846","Efficacy of Bioactive Glass vs. Xenograft in Maxillary Sinus Augmentation","Clinical, Radiographic and Histologic Assessment of the Efficacy of Bioactive Glass as a Novel Grafting Material in Maxillary Sinus Floor Augmentation: A Randomized Controlled Study","BIOXENO","Inclusion Criteria:\n\n* Patients requiring maxillary sinus floor augmentation for dental implant placement.\n* Residual alveolar bone height ≤ 4 mm in posterior maxilla (SA4 classification).\n* Age between 20 to 65 years.\n* Good general health and able to attend scheduled follow-up visits.\n* Signed written informed consent.\n\nExclusion Criteria:\n\n* Presence of systemic conditions that could affect bone healing (e.g., uncontrolled diabetes, osteoporosis).\n\nHistory of radiotherapy in the head and neck region.\n\n* Heavy smoking (more than 10 cigarettes\u002Fday).\n* Active sinus pathology or previous sinus surgery.\n* Pregnant or breastfeeding women.\n* Use of medications affecting bone metabolism (e.g., bisphosphonates or corticosteroids).\n* Poor oral hygiene or untreated periodontal disease.",{"count":577,"type":22},20,[25],"This randomized controlled study aims to evaluate the clinical, radiographic, and histologic efficacy of using bioactive glass bone graft (UNIGRAFT by Biomed Inc., USA) compared to a conventional xenograft in maxillary sinus augmentation procedures. A total of 20 patients classified as SA4 according to the Misch classification will be enrolled and randomly allocated into two groups. Outcomes will be assessed using Cone Beam Computed Tomography (CBCT) for vertical bone gain and, where applicable, histologic analysis. The study is conducted at the Faculty of Dentistry, Suez Canal University.",[28,581,582],"Maxillary Sinus Disease","Tooth Loss",[584,585,396,586,587,57],"Maxillary Sinus Augmentation","Bioactive Glass","Sinus Lift","Bone Grafting","2025-08-14",{"date":590,"type":35},"2025-08-15",{"date":592,"type":22},"2025-10-15",{"date":380,"type":22},{"name":595,"class":42},"Suez Canal University",{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":601,"acronym":602,"eligibilityCriteria":603,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":604,"targetDuration":4,"studyType":23,"phases":605,"briefSummary":606,"conditions":607,"keywords":4,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":608,"lastUpdatePostDateStruct":609,"startDateStruct":611,"completionDateStruct":613,"leadSponsor":615,"locationsCount":43},"100599086","alveolar-ridge-augmentation-using-minimally-invasive-subperiosteal-tunneling-with-xenogenic-bone-graft-and-prf-100599086","NCT07079917","Alveolar Ridge Augmentation Using Minimally Invasive Subperiosteal Tunneling With Xenogenic Bone Graft and PRF","Alveolar Ridge Augmentation Using Minimally Invasive Subperiosteal Tunneling With Xenogenic Bone Graft and Platelet-Rich Fibrin: Randomized Controlled Trial","MISTT","Inclusion Criteria:\n\n* Adults over 18 years old seeking an implant-supported restoration with deficient horizontal posterior maxillary alveolar ridge, at area of one or two missed teeth of less than 5 mm buccolingual width.\n* Minimum vertical height of 8 mm.\n* Gingival tissue of healthy adequate keratinization, more than 2mm.\n\nExclusion Criteria:\n\n* The presence of uncontrolled diabetes or any other systemic condition which may complicate the surgical procedure or interfere with bone healing\n* Radiotherapy to the head and neck region\n* Chemotherapy within the last 12 months\n* Uncontrolled periodontitis\n* Smoking\n* Bisphosphonate therapy\n* Pregnancy\n* Presence of periapical infection or lesion",{"count":173,"type":22},[25],"surgical horizontal augmentation for maxillary alveolar ridge using minimally invasive subperiosteal tunneling in comparison to conventional surgical technique",[28],"2025-07-14",{"date":610,"type":35},"2025-07-23",{"date":612,"type":22},"2025-08-01",{"date":614,"type":22},"2026-06-21",{"name":616,"class":42},"Fayoum University",{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":621,"acronym":4,"eligibilityCriteria":622,"healthyVolunteers":75,"sex":17,"minAge":77,"maxAge":4,"enrollmentInfo":623,"targetDuration":4,"studyType":23,"phases":624,"briefSummary":625,"conditions":626,"keywords":630,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":638,"lastUpdatePostDateStruct":639,"startDateStruct":641,"completionDateStruct":643,"leadSponsor":644,"locationsCount":43},"100439112","phase-1-autogenous-mesenchymal-stem-cell-culture-derived-signalling-molecules-as-enhancers-of-bone-formation-in-bone-grafting-100439112","NCT04998058","Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting","Inclusion Criteria:\n\n* patients \\>35 years-old.\n* presenting highly atrophic fully edentulous maxilla (residual bone height \\\u003C5 mm).\n* In need of bilateral sinus floor augmentation aiming full mouth implant-supported rehabilitation.\n* having teeth extraction at least 8 weeks prior to bone augmentation.\n\nExclusion Criteria:\n\n* smokers, illicit drug users and alcohol daily consumers.\n* patients with metabolic and\u002For systemic diseases leading to impaired healing (e.g. decompensated diabetes, leukocyte or coagulation disorders, immunosuppression).\n* history of radiotherapy in the head or neck region.\n* bisphosphonate-based therapy recipients.\n* intolerant to general\u002Flocal anesthesia.",{"count":577,"type":22},[448,449],"This study aims to evaluate bone formation in grafts in terms of its quality (density), quantity (volume) and maturation obtained with the application of a tissue-engineered bone grafting compound containing concentrated autogenous cell-culture medium (CM) and a synthetic bone substitute. The present study was designed as an experimental prospective split-mouth randomized controlled clinical trial. After protocol approval by the Research Ethics Committee, a total of 20 consecutive participants in need of maxillary reconstruction aiming implant-supported oral rehabilitation will be invited to join the study. To collect autogenous adipose tissue-derived mesenchymal stem cells (hASCs), an outpatient lipoplasty procedure at the abdominal area of each patient will be performed. To isolate and expand hASCs from the lipoaspirate, specific cell culture protocols will be followed, resulting in cultured viable cells and their conditioned medium (CM). Cells and CM will be then separated by a sequence of filters and centrifugation, and isolated CM will be frozen. ELISA will analyze the presence of chemokines and their concentration in CM before grafting. Following pre-op surgical planning, both maxillary sinuses of each patient will be grafted internally applying a lateral window to each sinus. The bony floor of the test maxillary sinus will be augmented with synthetic bone substitute (BoneCeramic™ 1-2 mm) mixed with 10 to 15 ml of CM (test). The control site will receive bone substitute with saline. Lateral windows in both sinuses will be then closed with a collagen membrane (Bio-Gide™). After 6 months, first-stage implant surgery will be performed placing 6 implants in each patient. Registration of implant stability by manual torque wrench will be performed. Also, bone biopsies from each drilled implant site will be collected for histology, histomorphometry and immunohistochemistry (RT-PCR). Tomographic evaluation of the bone formation will include cone beam computed tomographies (CBCTs) at pre-operative \\[Baseline\\], 90 \\[T1\\] and 180 \\[T2 = implant placement\\] days for bone 3D image analysis.",[627,628,28,420,629],"Bone Loss, Osteoclastic","Bone Loss, Alveolar","Grafting Bone",[631,632,633,634,635,636,637],"bone","bone formation","bone graft","tissue engineering","stem cell","exosome","cell-free therapy","2025-06-02",{"date":640,"type":35},"2025-06-05",{"date":642,"type":22},"2025-12-15",{"date":382,"type":22},{"name":645,"class":42},"Pontificia Universidade Católica do Rio Grande do Sul",{"id":647,"slug":648,"hasResults":12,"nctId":649,"briefTitle":650,"officialTitle":651,"acronym":652,"eligibilityCriteria":653,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":654,"enrollmentInfo":655,"targetDuration":4,"studyType":23,"phases":657,"briefSummary":658,"conditions":659,"keywords":662,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":666,"lastUpdatePostDateStruct":667,"startDateStruct":669,"completionDateStruct":671,"leadSponsor":673,"locationsCount":4},"100588070","rgd-with-minimally-invasive-non-surgical-technique-in-treatment-of-periodontal-intrabony-defect-100588070","NCT06936605","RGD With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect","The Use of Integrin Binding Domain Loaded Hydrogel (RGD) With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect (Randomized Clinical Trial Study)","MINST + RGD","Inclusion Criteria:\n\n* • All patients included will have moderate to advanced periodontitis.\n\n  * Patients included in this study will be free from any systemic diseases according to criteria of Modified Cornell Medical Index(10).\n  * Patients who had not undergone any type of regenerative periodontal therapy six months prior to the initial examination.\n\nExclusion Criteria:\n\n* • Patients with systemic diseases, smokers, pregnant (female).\n\n  * Patients received antibiotics or non-steroidal anti-inflammatory drugs six months before the beginning of the study.","55 Years",{"count":656,"type":22},45,[25],"Periodontal regeneration is a complex process that involves coordinated activities and interactions of many cell types, extracellular matrix, cytokines, and specific growth factors to restore tissue integrity. The most important challenge facing periodontal regeneration is cellular insufficiency. Periodontal defects usually have a limited regenerative capacity due to their bounded surface area which is supposed to provide the wound area with a limited number of viable cells and a limited amount of biologic mediators. Cell recruitment and adhesion into the defect area are essential for cells to survive and secrete collagen.\n\nApoptosis is initiated when failure in adhesion in many different cell types occurs. Some periodontal treatment options failed in the reconstruction of the defect due to failure in wound stabilization and subsequent cell adhesion. Many treatment options have been developed to enhance defect stability and cellular recruitment including the use of GTM and different biologics. However, the treatment outcomes vary considerably depending on the level of the defect cellularity and the degree of cell recruitment into the defect area. For maximum outcomes, enhanced stability, vascularity, and biologics-sustained delivery were suggested. The minimally invasive surgical technique (MIST) suggested by Cortellini et al. offers a suitable level of tissue preservation that could help in defect stability and cellular adhesion. It was suggested to promote flap stability, maintain space, and maintain a greater amount of blood supply at the alveolar crest and papillary levels.",[660,661,28],"Intrabony Defect","Periodontal Diseases",[663,664,665],"MINST","RGD","intrabony defect","2025-04-17",{"date":668,"type":35},"2025-04-20",{"date":670,"type":22},"2025-04-15",{"date":672,"type":22},"2025-10-20",{"name":674,"class":42},"Minia University",{"id":676,"slug":677,"hasResults":12,"nctId":678,"briefTitle":679,"officialTitle":680,"acronym":4,"eligibilityCriteria":681,"healthyVolunteers":75,"sex":17,"minAge":444,"maxAge":682,"enrollmentInfo":683,"targetDuration":4,"studyType":23,"phases":684,"briefSummary":685,"conditions":686,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":687,"lastUpdatePostDateStruct":688,"startDateStruct":690,"completionDateStruct":692,"leadSponsor":694,"locationsCount":43},"100540328","composite-plug-vs-d-ptfe-membrane-in-socket-preservation-100540328","NCT06315413","Composite Plug Vs D-PTFE Membrane in Socket Preservation","Evaluation of Socket Seal Using Flowable Composite Above Xenograft Compared to Dense Polytetrafluoroethylene (d-PTFE) Membrane in Ridge Preservation Procedures: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients having single non-adjacent hopeless maxillary tooth in the esthetic zone that are indicated for extraction.\n* Patients with healthy systemic condition.\n* Patients aged from 20 to 70 years old.\n* Good oral hygiene.\n* Accepts 4 months follow-up period (cooperative patients).\n\nExclusion Criteria:\n\n* Systemic diseases or medications that might affect bone metabolism, increase surgical risk or complicate post-operative healing.\n* Previous bone augmentation to implant site.\n* Untreated periodontal diseases.\n* Para-functional habits such as bruxism and clenching.\n* History of radiation therapy to the head and neck.\n* Heavy smokers (≥ 10 cigarettes per day).\n* Pregnant or lactating females.\n* Alcoholism or drug abuse.\n* Psychiatric problems.","70 Years",{"count":577,"type":22},[25],"The aim of the current study is to compare the effect socket sealing with flowable resin composite compared to dense polytetrafluoroethylene membrane after filling the extraction site with xenograft particles in terms of soft and hard tissue changes, procedural time, post operative pain, patients' satisfaction, and cost effectiveness.",[28],"2025-03-22",{"date":689,"type":35},"2025-03-26",{"date":691,"type":22},"2025-05",{"date":693,"type":22},"2025-10",{"name":216,"class":42}]