[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"amnesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:amnesia":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100607641","how-do-patients-with-amnesia-acquire-new-knowledge-100607641",false,"NCT07191197","How do Patients With Amnesia Acquire New Knowledge?","New Semantic Learning in Patients With Selective Brain Lesions in Temporal Regions: a Behavioural and MRI Study","ASSAM","Inclusion Criteria:\n\n* Patients aged between 18 and 70 years\n* Living in France since less than 20 years, being able to understand the French language, and have basic cultural knowledge as evaluated in classical clinical consultation\n* Written agreement to participate in the study\n* Intellectual capacities compatible with the cognitive tasks and signing of consent\n* Affiliation to the French social security system\n* For patients: bilateral brain lesion of the medial temporal lobe or the extended hippocampal system\n\nExclusion Criteria:\n\n* Subjects under the age of 18 or over 70\n* Contraindications for MRI (examples: wearers of a pacemaker or cardiac defibrillator, implanted equipment activated by an electrical, magnetic or mechanical system, wearers of haemostatic clips for intracerebral aneurysms or carotid arteries, wearers of orthopedic implants, claustrophobic)\n* Refusal to be informed of an anomaly detected during the MRI",true,"ALL","18 Years","70 Years",{"count":22,"type":23},150,"ESTIMATED","INTERVENTIONAL",[26],"NA","THE STUDY AIMS to constitute the largest group of patients with major memory impairment resulting from various etiology and specific lesions of the medial temporal lobe (MTL) and use a combined psychometric and neuroimaging approach to study the factors allowing these patients to successfully learn new semantic information.",[29,30],"Amnesia","Memory Disorder",[32,33,34,35],"Learning","Semantic memory","Hippocampus","Temporal pole","RECRUITING","2026-05-07",{"date":39,"type":40},"2026-05-08","ACTUAL",{"date":42,"type":40},"2026-04-08",{"date":44,"type":23},"2030-01-31",{"name":46,"class":47},"University Hospital, Toulouse","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":24,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":76},"100392395","oct-angiography-and-adaptive-optics-in-patients-with-memory-impairment-100392395","NCT04389437","OCT-Angiography and Adaptive Optics in Patients With Memory Impairment","OCTAVO","Inclusion Criteria:\n\n* Patient presenting in memory consultation for memory complaint or person accompanying a patient in memory consultation for memory complaint\n\nExclusion Criteria:\n\n* pregnant or lactating women\n* history of known non-degenerative neurological pathology (tumor, stroke territorial, in particular multiple sclerosis)\n* history of retinal pathology\n* ametropia greater in absolute value than 3 diopters on the sphere, or\u002Fand 1.5 diopters on the cylinder.\n* history of taking ethambutol for more than 2 months\n* history of takingsynthetic antimalarial for more than 2 years\n* Mini Mental State Score (MMS) and \u002F or Montreal Cognitive Assessment (MoCA) \\\u003C10 for patients and 26 for accompanying persons\n* MRI contraindication (for patients only)",{"count":56,"type":23},450,[26],"Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases.\n\nThese retinal anomalies objectified by OCT-A (Optical coherence tomography angiography) and adaptive optics (AO) appear different depending on the pathologies and could therefore serve as markers in vivo of the pathophysiological processes underlying NCD.\n\nNo study to date has studied the retina and its vessels in NCD using adaptive optics. In this pilot study, we are proposing a combination of two new ophthalmological imaging techniques (OCT-A and AO), which allow rapid in vivo analysis in a completely non-invasive way of the morphology of small vessels as well as architecture of the retina to better specify the retinal anomalies associated with NCD. We will compare the parameters in OCT-A and AO between patients with NCD and controls without NCD (with memory complaint or without) and will seek to determine if there are different profiles according to the causes of NCD.",[29,60,61,62],"Alzheimer Disease","Lewy Body Disease","Parkinsons Disease With Dementia",[64,65],"OCT-A","adaptative optics","2025-09-26",{"date":68,"type":40},"2025-09-29",{"date":70,"type":40},"2020-06-26",{"date":72,"type":23},"2026-06",{"name":74,"class":75},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",1]