[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anesthesia-general\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anesthesia-general":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,47,79,110,133,166,189,218,236,270,301,330,356,389,422,452,477],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100650611","ed90-of-tegileridine-for-suppressing-hemodynamic-response-to-tracheal-intubation-a-biased-coin-up-and-down-trial-100650611",false,"NCT07749131","ED90 of Tegileridine for Suppressing Hemodynamic Response to Tracheal Intubation: A Biased Coin Up-and-Down Trial","Determination of the 90% Effective Dose (ED90) of Tegileridine Fumarate for Inhibiting Hemodynamic Stress Response Induced by Tracheal Intubation During General Anesthesia: A Biased Coin Up-and-Down Sequential Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Aged ≥18 ears old\n* Scheduled for elective surgery requiring general anesthesia with tracheal intubation\n\nExclusion Criteria:\n\n* Resting Systolic Blood Pressure ≥ 160 mmHg, Diastolic Blood Pressure ≥ 110 mmHg, or heart rate ≥ 110 beats\u002Fmin on admission to operation room\n* Continuous opioid medication use for more than 2 weeks within 6 months before the procedure\n* Known hypersensitivity or allergic reaction to tegileridine, propofol or any excipients of the two drugs\n* Diagnosed psychiatric disorders or inability to communicate and cooperate with study assessment\n* Anticipated difficult airway","ALL","18 Years","90 Years",{"count":20,"type":21},108,"ESTIMATED","INTERVENTIONAL",[24],"NA","General anesthesia tracheal intubation causes sympathetic activation and hemodynamic stress response, which increases perioperative cardiovascular risk, especially in elderly subjects. Tegileridine fumarate is a novel μ-opioid receptor G protein-biased agonist. However, the optimal dose of tegileridine to suppress intubation-induced hemodynamic fluctuations during anesthesia induction remains unclear.\n\nThis is an open-label, single-center, age-stratified biased coin up-and-down sequential trial. Subjects undergoing elective surgery requiring tracheal intubation will be divided into young adult group (18-64 years) and elderly group (≥65 years). The primary objective is to determine the ED90 of intravenous tegileridine for inhibiting hemodynamic response to tracheal intubation using centered isotonic regression. Secondary outcomes include investigational-drug adverse events, serial hemodynamic parameters. This study will provide evidence for rational dosing of tegileridine in clinical anesthesia induction.",[27,28,29],"Tracheal Intubation","Anesthesia, General","Hemodynamics",[31,32,33],"Tegileridine","Hemodynamic Stress Response","ED90","NOT_YET_RECRUITING","2026-08-19",{"date":37,"type":38},"2026-08-21","ACTUAL",{"date":40,"type":21},"2026-09-01",{"date":42,"type":21},"2026-10-05",{"name":44,"class":45},"Shiyou Wei","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100643067","easix-score-and-post-induction-hypotension-in-frail-patients-undergoing-non-cardiac-surgery-100643067","NCT07642765","EASIX Score and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery","Evaluation of the Relationship Between Endothelial Activation and Stress Index (EASIX) and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery: A Prospective Observational Cohort Study","PIXEL","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective non-cardiac surgery under general anesthesia\n* Clinical Frailty Scale (CFS) score of 4 or above\n* Available routine preoperative laboratory values (LDH, creatinine, platelet count) within 24 hours before surgery\n\nExclusion Criteria:\n\n* Cardiac surgery\n* Emergency surgery\n* Preoperative vasopressor infusion\n* Severe hematological disease\n* Missing laboratory data required for EASIX calculation",{"count":56,"type":21},160,"OBSERVATIONAL","Post-induction hypotension (PIH) is a common and clinically significant hemodynamic complication following general anesthesia induction. Frail patients are particularly vulnerable due to impaired vascular reactivity and endothelial dysfunction. The Endothelial Activation and Stress Index (EASIX), calculated from routine laboratory parameters (LDH, creatinine, and platelet count), may serve as a preoperative biomarker to identify patients at risk for PIH.\n\nThis prospective observational cohort study aims to evaluate the association between preoperative EASIX score and the occurrence of post-induction hypotension in frail patients undergoing elective non-cardiac surgery under general anesthesia. A total of 160 patients with a Clinical Frailty Scale (CFS) score of 4 or above will be enrolled. Mean arterial pressure will be measured every 2 minutes for the first 15 minutes after induction. PIH is defined as MAP below 65 mmHg and\u002For a decrease of 20% or more from baseline.",[60,61,28],"Hypotension on Induction","Frailty",[63,64,65,61,66,67,68],"Post-induction hypotension","EASIX","Endothelial Activation and Stress Index","Perioperative hemodynamics","Non-cardiac surgery","Clinical Frailty Scale","RECRUITING","2026-08-03",{"date":72,"type":38},"2026-08-04",{"date":74,"type":38},"2026-07-01",{"date":76,"type":21},"2027-03-01",{"name":78,"class":45},"Konya City Hospital",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":46},"100636387","internal-jugular-vein-collapsibility-index-for-predicting-post-induction-hypotension-100636387","NCT07565025","Internal Jugular Vein Collapsibility Index for Predicting Post-Induction Hypotension","The Value of Internal Jugular Vein Collapsibility Index in Predicting Hypotension Following General Anesthesia Induction in Patients Undergoing Elective Laparoscopic Cholecystectomy","IJV-CI","Inclusion Criteria:\n\n* Patients aged 18-65 years.\n* Patients with ASA (American Society of Anesthesiologists) physical status I, II, or III.\n* Patients scheduled to receive general anesthesia.\n* Patients scheduled for elective laparoscopic cholecystectomy.\n\nExclusion Criteria:\n\n* Patients with obesity (Body Mass Index \\> 35 kg\u002Fm²).\n* Patients with Atrial Fibrillation or other serious cardiac arrhythmias.\n* Patients with a history of neck surgery or any pathology preventing Internal Jugular Vein (IJV) measurement.\n* Patients with advanced heart failure (Ejection Fraction \\\u003C 40%).\n* Patients with severe valvular heart disease.\n* Patients with peripheral vascular disease.\n* Patients undergoing emergency surgery.\n* Patients who are unwilling to participate in the study.","65 Years",{"count":89,"type":21},42,"This study aims to investigate whether the Internal Jugular Vein Collapsibility Index (IJV-CI), measured via ultrasonography, can predict hypotension (low blood pressure) that occurs after the induction of general anesthesia. Researchers will measure the diameter of the internal jugular vein in patients before surgery and compare these measurements with the blood pressure changes during the first minutes of anesthesia. The goal is to determine if IJV-CI can be used as a reliable, non-invasive tool to identify patients at higher risk of developing anesthesia-induced hypotension.",[92,28,93],"Hypotension","Cholecystectomy, Laparoscopic",[95,96,85,97,98,99,100,101],"Internal Jugular Vein","Collapsibility Index","Ultrasonography","Post-induction Hypotension","Anesthesia Induction","Laparoscopic Cholecystectomy","Fluid Responsiveness","2026-07-31",{"date":70,"type":38},{"date":105,"type":21},"2026-08-15",{"date":107,"type":21},"2027-02",{"name":109,"class":45},"University of Gaziantep",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":132},"100647888","the-impact-of-multimodal-brain-monitoring-on-postoperative-outcomes-in-elderly-patients-undergoing-major-abdominal-surgery-100647888","NCT07713355","The Impact of Multimodal Brain Monitoring on Postoperative Outcomes in Elderly Patients Undergoing Major Abdominal Surgery","Impact of Multimodal Brain Monitoring Under General Anesthesia on Postoperative Outcomes in Elderly Patients Undergoing Major Abdominal Surgery: A Multicenter, Prospective, Single-blind, Randomized Controlled Study","Inclusion Criteria:\n\nAged ≥65 years, regardless of gender; Scheduled for elective abdominal surgery with general anesthesia duration (from anesthesia induction to surgery completion) ≥ 2 hours; American Society of Anesthesiologists (ASA) physical status classification of I-III; Body mass index (BMI) of 18.5-29.9 kg\u002Fm²; Postoperative hospital stay expected to exceed 72 hours; Compliant with ethical standards, with voluntary signed informed consent.\n\nExclusion Criteria:\n\nSevere cardiovascular diseases, including:\n\nHistory of myocardial infarction within the past 6 months; Bradycardia (resting heart rate \\\u003C50 beats\u002Fmin); Uncontrolled hypertension (sitting systolic blood pressure ≥160 mmHg and\u002For diastolic blood pressure ≥100 mmHg during screening); Sitting systolic blood pressure ≤90 mmHg during screening; History of severe valvular heart disease; Uncontrolled severe respiratory infections: e.g., severe pneumonia, acute bronchitis.\n\nAbnormal liver function: Aspartate Aminotransferase (AST) and\u002For Alanine Aminotransferase (ALT) ≥2.5×Upper Limit of Normal (ULN), Total Bilirubin (TBIL) ≥1.5×Upper Limit of Normal (ULN); Abnormal renal function: urea or blood urea nitrogen (BUN) ≥1.5×Upper Limit of Normal (ULN), serum creatinine \\>Upper Limit of Normal (ULN); Admission hemoglobin A1c (HbA1c) ≥6.5% or ≥2 fasting blood glucose measurements ≥180 mg\u002Fdl (10 mmol\u002FL) and\u002For random blood glucose ≥200 mg\u002FdL (≈11.1 mmol\u002FL); Preoperative anemia (Hemoglobin \\[Hb\\] ≤90 g\u002FL), thrombocytopenia (Platelet \\[PLT\\] ≤80×10⁹\u002FL), hypoproteinemia (Albumin \\[Alb\\] ≤30 g\u002FL); History of drug abuse and\u002For alcoholism within the past 2 years (alcoholism defined as daily average alcohol consumption \\>2 units, where 1 unit = 360 mL beer or 45 mL 40% ethanol liquor or 150 mL wine); Neurological diseases (e.g., stroke within 6 months, Alzheimer's disease, Parkinson's disease, mental disease, myasthenia gravis) or psychiatric disorders (e.g., schizophrenia, mania, bipolar disorder, delirium), history of long-term use of neuropsychiatric medications, or cognitive impairment; Allergy or contraindication to study medications; Patients refusing or unable to cooperate with the study; Scheduled for pancreatic surgery; Other conditions deemed inappropriate for participation by the investigator.",{"count":118,"type":21},368,[24],"The purpose of this clinical trial is to investigate the effect of multimodal brain monitoring under general anesthesia on postoperative outcomes in elderly patients undergoing abdominal surgery.The research hypothesis is that multimodal brain monitoring under general anesthesia can reduce the incidence of postoperative composite complications and improve postoperative outcomes in elderly patients undergoing major abdominal surgery.\n\nEligible patients will be randomly assigned in a 1:1 ratio to the Multimodal Brain Monitoring under General Anesthesia Group (MBMGA group) and the Bispectral Index Monitoring under General Anesthesia Group (BIS group). The primary outcome is the postoperative composite complication rate . Secondary outcomes include intraoperative hyperglycemia, adverse events during anesthesia induction and maintanance, changes in blood pressure and heart rate, intraoperative hypotension, the dosage of perioperative anesthetics and vasoactive drugs, changes in serum cortisol, cardiac troponin I, blood creatinine (Cr) level, extubation time and awake time, the rate of transferring to ICU or AICU, The time to first use analgesia pump and the cumulative dose of postoperative oxycodone, systemic complications, hospitalization time, first exhaust time , first oral intake time, rate of second surgery and mortality within 30 days postoperatively.\n\nParticipants will:\n\n1. Undergo routine preoperative fasting for 6-8 hours;\n2. Prior to anesthesia induction, cooperate with the establishment of intravenous access, arterial catheterization, monitoring of physiological parameters, blood sample collection, and receive fluid preloading;\n3. During surgery, for patients in the MBMGA group , propofol and remifentanyl will be adjusted according to multimodal brain monitoring indices (WLi and PTi), while for patients in the BIS group, only propofol will be adjusted based on bispectral index and remifentanyl will be adjusted according to anesthesiologists' experience; simultaneously, vital signs, including respiration, body temperature, fluid therapy, blood pressure, and heart rate regulation, will be monitored and managed.\n4. After surgery, endotracheal tubes will be removed once extubation criteria are met, and patients will be transferred to the PACU, where they will receive routine monitoring and will be discharged from the PACU upon meeting corresponding scoring criteria;\n5. Participates in follow-ups on the day of surgery and for 1-30 days postoperatively, during which investigators will record the primary outcome and secondary outcomes.",[28,122],"Major Abdominal Surgeries","2026-07-15",{"date":125,"type":38},"2026-07-20",{"date":127,"type":21},"2026-08-01",{"date":129,"type":21},"2028-12-30",{"name":131,"class":45},"Xuanwu Hospital, Beijing",4,{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":140,"sex":16,"minAge":141,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":145,"briefSummary":146,"conditions":147,"keywords":153,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":46},"100590022","sugammadex-induced-clenching-during-neuromuscular-blockade-reversal-100590022","NCT06962007","Sugammadex-Induced Clenching During Neuromuscular Blockade Reversal","A Prospective, Randomized, Double-Blind Study of the Incidence, Severity, and Risk Factors of Clenching Induced by Sugammadex During Neuromuscular Blockade Reversal","Inclusion Criteria:\n\n* Eligible participants are adults aged 19-70 years, American Society of Anesthesiologists (ASA) physical status I-II, undergoing elective surgery under general anesthesia with rocuronium.\n\nExclusion Criteria:\n\n* Exclusion criteria include neuromuscular disorders, renal impairment (creatinine clearance \\\u003C 30 mL\u002Fmin), history of clenching or dental disease, allergy to study drugs, or emergency surgery.",true,"19 Years","70 Years",{"count":144,"type":21},240,[24],"Study Objective:\n\nThis study aims to evaluate the incidence, severity, and risk factors of sugammadex-induced mouth clenching during neuromuscular blockade (NMB) reversal in adult surgical patients.\n\nStudy Design:\n\nThis prospective, randomized, double-blind, controlled clinical trial enrolls adult patients (ASA physical status I-II, aged 19-70 years) undergoing elective surgery under general anesthesia with rocuronium. Patients will be randomized into four groups to receive either sugammadex at doses of 1 mg\u002Fkg, 2 mg\u002Fkg, or 4 mg\u002Fkg, or a combination of pyridostigmine and glycopyrrolate.\n\nPrimary Outcome:\n\nThe primary outcome is the incidence of clenching within 10 minutes after NMB reversal, assessed by clinical observation, masseter EMG, and airway pressure changes, using a novel five-grade severity scale.\n\nSecondary Outcomes:\n\nSecondary outcomes include the severity of clenching, time to TOF ratio ≥0.9, BIS values at clenching onset, complications, and identification of risk factors such as dose, sex, BIS, age, BMI, and rocuronium dose.\n\nSignificance:\n\nThis study seeks to improve perioperative safety by identifying modifiable risk factors and informing dose adjustments or alternative reversal strategies to prevent sugammadex-induced clenching, particularly in high-risk populations.",[148,149,28,150,151,152],"Neuromuscular Blockade Reversal Agent","Perioperative Complications","Sugammadex","Monitoring, Intraoperative","Masseter Muscle Spasm",[154,155,156],"sugammadex","mouth clenching","neuromuscular blockade reversal","2026-07-02",{"date":159,"type":38},"2026-07-07",{"date":161,"type":38},"2025-07-01",{"date":163,"type":21},"2026-10-14",{"name":165,"class":45},"Wonkwang University Hospital",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":173,"targetDuration":4,"studyType":22,"phases":175,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":46},"100638867","comparison-of-two-general-anesthesia-maintenance-strategies-on-intraoperative-visibility-during-arthroscopic-rotator-cuff-surgery-a-randomized-trial-100638867","NCT07628244","Comparison of Two General Anesthesia Maintenance Strategies on Intraoperative Visibility During Arthroscopic Rotator Cuff Surgery: A Randomized Trial","CLEAR-SHOULDER","Inclusion Criteria:\n\n1. Patient aged 18 or over\n2. Patient scheduled for elective rotator cuff repair arthroscopy (RCRA), performed in the \"beach-chair\" position under general anesthesia combined with an interscalene block (with or without standard associated procedures such as acromioplasty and\u002For tenotomy\u002Ftenodesis of the long biceps). Procedures for instability (Bankart\u002FLatarjet), fractures, capsulitis, simple lavage, or any arthroscopy not focused on rotator cuff repair (RCR) are not eligible.\n3. Patient with an ASA score of I to IV\n4. Patient affiliated to a social security scheme,\n5. Patient having given written consent following written and oral information.\n\nExclusion Criteria:\n\n1. Patients with a contraindication to any of the study agents, including known hypersensitivity or allergy to any of these agents or to any of their excipients.\n2. Patients with known coagulopathy (abnormal PT\u002FINR; platelets \\\u003C 100,000\u002FL) or\n3. Patients with active preoperative hemarthrosis or local infection.\n4. Non-elective (emergency) surgery or a procedure whose initial objective is not rotator cuff repair arthroscopy (RCRA). Note: Intraoperative conversion to open surgery is not an exclusion criterion; it will be considered an intraoperative event and managed in the analysis according to the intention-to-treat (ITT) principle, with a sensitivity analysis procedure described in the statistical plan.\n5. Uncooperative patient, inability to consent\n6. Pregnant women\n7. Patient protected by law under guardianship or curatorship, or unable to participate in a clinical study under article L. 1121-16 of the French Public Health Code.",{"count":174,"type":21},110,[24],"Shoulder arthroscopy is one of the most common orthopedic procedures, and the quality of the surgeon's view inside the joint is critical to its safety and success. Unlike limb surgery, no tourniquet can be applied to the shoulder, so surgical visibility depends almost entirely on how much bleeding occurs within the joint - which is itself influenced by the anesthetic drugs used to keep the patient asleep.\n\nTwo standard techniques exist for maintaining general anesthesia: inhaled anesthesia (sevoflurane) and total intravenous anesthesia (TIVA, using propofol). Evidence from other types of keyhole surgery (nasal, ear) suggests that propofol may produce better surgical visibility, possibly because sevoflurane causes slightly greater dilation of the smallest blood vessels in tissue, leading to more bleeding into the joint. However, in shoulder arthroscopy specifically, the data are scarce and contradictory.\n\nCLEAR-SHOULDER is a randomized, single-blind trial designed to determine whether propofol-based intravenous anesthesia provides superior intraoperative visibility compared to sevoflurane-based inhaled anesthesia during arthroscopic rotator cuff repair. Surgical visibility will be assessed from blinded video recordings of each procedure using the validated modified Fromme-Boezaart score. An exploratory artificial intelligence analysis of the arthroscopic videos will also be conducted.\n\nSecondary outcomes include operating time, irrigation fluid consumption, hemodynamic stability, vasopressor requirements, surgeon satisfaction, postoperative recovery, and environmental impact of each anesthetic strategy.",[178,28,179],"Rotator Cuff Injuries","Arthroscopy","2026-06-19",{"date":182,"type":38},"2026-06-24",{"date":184,"type":38},"2026-06-18",{"date":186,"type":21},"2028-03-18",{"name":188,"class":45},"Centre Hospitalier Universitaire de Nice",{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":195,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":22,"phases":200,"briefSummary":201,"conditions":202,"keywords":206,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":212,"startDateStruct":213,"completionDateStruct":214,"leadSponsor":216,"locationsCount":46},"100644228","quality-of-recovery-15-after-opioid-free-versus-opioid-based-general-anesthesia-in-major-urological-surgery-100644228","NCT07665463","Quality of Recovery-15 After Opioid-free Versus Opioid-based General Anesthesia in Major Urological Surgery","Uality of Recovery-15 After Opioid-free Versus Opioid-based General Anesthesia in Patients Undergoing Elective Major Urological Surgery: A Randomized Controlled Trial","QoR-OFA-URO","Inclusion Criteria:\n\n* Adults aged 18 to 75 years.\n* Scheduled for elective major urological surgery under general anesthesia, including laparoscopic or robotic nephrectomy, laparoscopic or robotic prostatectomy, or laparoscopic or robotic cystectomy.\n* Ability to operate a patient-controlled analgesia pump postoperatively.\n* Ability to understand and use the Numeric Rating Scale for pain assessment.\n* Ability to understand and complete the Quality of Recovery-15 questionnaire.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate.\n* Inability to operate the patient-controlled analgesia pump.\n* Inability to understand the Numeric Rating Scale for pain assessment.\n* Inability to understand or complete the Quality of Recovery-15 questionnaire.\n* Known hypersensitivity to any of the study drugs, including anesthetics, ketamine, dexmedetomidine, lidocaine, ropivacaine, oxycodone, metamizole, paracetamol, or ibuprofen.\n* Second- or third-degree atrioventricular block.\n* Symptomatic bradycardia.\n* Chronic opioid use.\n* Contraindication to the planned regional anesthesia technique, including coagulopathy, therapeutic anticoagulation, or infection at the puncture site.","75 Years",{"count":199,"type":21},200,[24],"This randomized controlled trial evaluates postoperative quality of recovery assessed with the Quality of Recovery-15 questionnaire in adult patients undergoing elective major urological surgery under opioid-free versus opioid-based general anesthesia.\n\nOpioid-free anesthesia is a multimodal anesthetic technique that avoids intraoperative opioids by combining non-opioid analgesic and sympatholytic agents such as dexmedetomidine, ketamine, lidocaine, non-steroidal anti-inflammatory drugs, and regional analgesia. Opioid-based general anesthesia in this trial includes intraoperative remifentanil infusion.\n\nParticipants will undergo elective urological surgery, including laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, or robotic cystectomy.\n\nThe primary objective is to compare patient-reported quality of recovery between the opioid-free anesthesia group and the remifentanil-based anesthesia group using the Quality of Recovery-15 questionnaire. QoR-15 will be assessed before surgery and on postoperative day 7.\n\nSecondary objectives include total postoperative oxycodone dose administered via patient-controlled analgesia during the first 24 hours after surgery, postoperative pain intensity measured using the Numeric Rating Scale at 1, 2, 6, 12, and 24 hours after surgery, incidence of postoperative nausea and vomiting, change in serum creatinine from baseline to postoperative day 1, change in white blood cell count from baseline to postoperative day 1, and the ratio of demanded to delivered PCA boluses.\n\nPre-specified subgroup analyses will compare outcomes according to surgical procedure type: laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, and robotic cystectomy. Subgroup-by-treatment interaction tests will be performed.\n\nPlanned enrollment is approximately 600 patients, with 300 patients per treatment arm. The primary patient-reported recovery endpoint will be assessed on postoperative day 7, while analgesic, pain, and early postoperative safety outcomes will be assessed during the first 24 hours after surgery.",[203,28,204,205],"Postoperative Recovery","Analgesics, Opioid","Urologic Surgical Procedure",[207,208,209,210,211],"Quality of Recovery-15","QoR-15","Opioid-free anesthesia","Remifentanil","Urological surgery",{"date":182,"type":38},{"date":74,"type":21},{"date":215,"type":21},"2027-12-31",{"name":217,"class":45},"Jagiellonian University",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":197,"enrollmentInfo":224,"targetDuration":4,"studyType":22,"phases":226,"briefSummary":227,"conditions":228,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":230,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":46},"100545310","opioid-free-anesthesia-as-an-alternative-to-general-anesthesia-in-abdominal-surgery-100545310","NCT06380244","Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery","Inclusion Criteria:\n\n* Adults aged 18-75 years scheduled for elective urological surgery under general anesthesia: laparoscopic or robotic nephrectomy, laparoscopic or robotic prostatectomy, or laparoscopic or robotic cystectomy.\n* Ability to operate a patient-controlled analgesia (PCA) pump postoperatively.\n* Ability to understand and use the Numeric Rating Scale (NRS) for pain assessment.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Patient's refusal to participate.\n* Inability to operate the PCA pump.\n* Inability to understand the NRS pain scale.\n* Known hypersensitivity to any of the study drugs (anesthetics, ketamine, dexmedetomidine, ropivacaine, oxycodone, metamizole, paracetamol, ibuprofen).\n* Second- or third-degree atrioventricular block, or symptomatic bradycardia.\n* Chronic opioid use.\n* Contraindication to the planned regional anesthesia technique (e.g. coagulopathy or therapeutic anticoagulation, infection at the puncture site).",{"count":225,"type":21},600,[24],"Opioid-free anesthesia (OFA) is a multimodal technique that eliminates intraoperative opioids by combining dexmedetomidine, ketamine, lidocaine, NSAIDs, and regional analgesia. Growing evidence suggests OFA reduces postoperative opioid consumption, opioid-related adverse effects, and may have favorable oncological implications in cancer surgery.\n\nThis randomized controlled trial compares OFA with opioid-based anesthesia (remifentanil) in patients undergoing elective urological surgery: laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, and robotic cystectomy.\n\nThe PRIMARY OBJECTIVE is to compare the total postoperative oxycodone dose (mg) administered via patient-controlled analgesia (PCA) during the first 24 hours after surgery between the OFA and remifentanil groups.\n\nSECONDARY OBJECTIVES include: postoperative pain intensity (NRS) at 1, 2, 6, 12, and 24 hours; incidence of postoperative nausea and vomiting (PONV); change in serum creatinine from baseline to postoperative day 1; change in white blood cell (WBC) count from baseline to postoperative day 1; and the ratio of demanded to delivered PCA boluses.\n\nPRE-SPECIFIED SUBGROUP ANALYSES will compare outcomes by surgical procedure type: laparoscopic nephrectomy, robotic nephrectomy, laparoscopic prostatectomy, robotic prostatectomy, laparoscopic cystectomy, and robotic cystectomy. Subgroup-by-treatment interaction tests will be performed and reported as forest plots.\n\nPlanned enrollment: approximately 600 patients (300 per arm). Follow-up: 24 hours postoperatively.",[204,229,28],"Anesthesia, Endotracheal",{"date":182,"type":38},{"date":232,"type":38},"2024-03-10",{"date":234,"type":21},"2026-12-31",{"name":217,"class":45},{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":140,"sex":16,"minAge":243,"maxAge":244,"enrollmentInfo":245,"targetDuration":247,"studyType":57,"phases":4,"briefSummary":248,"conditions":249,"keywords":254,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":46},"100633151","comparison-of-two-airway-devices-i-gel-and-air-q-in-children-aged-1-10-years-during-general-anesthesia-100633151","NCT07522957","Comparison of Two Airway Devices (I-Gel and Air-Q) in Children Aged 1-10 Years During General Anesthesia","Effect of I-gel and Air-Q SP LMAs on Oropharyngeal Leak Pressure and Gastric Insufflation in Children: An Ultrasonography-Guided Randomized Study","Inclusion Criteria:\n\n* Children aged 1-10 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective (non-emergency) surgery under general anesthesia\n* Planned use of a supraglottic airway device for airway management\n* Written informed consent obtained from a parent or legal guardian\n\nExclusion Criteria:\n\n* History of conditions associated with increased risk of aspiration (e.g., gastroesophageal reflux)\n* Known or predicted difficult airway (e.g., Mallampati score ≥ 3)\n* Congenital or acquired abnormalities of the face, neck, or upper airway\n* Active upper respiratory tract infection\n* Presence of significant pulmonary disease (e.g., asthma, bronchopulmonary dysplasia, cystic fibrosis)\n* Body mass index above the 95th percentile for age (morbid obesity)\n* Emergency surgery\n* Previous complications related to supraglottic airway device use\n* Failure of device placement or need to switch to an alternative airway management technique\n* Refusal of participation by parent or legal guardian","1 Year","10 Years",{"count":246,"type":21},60,"1 Day","This study aims to compare two commonly used airway devices (I-gel and Air-Q) in children aged 1-10 years undergoing general anesthesia for surgery. These devices help doctors keep the airway open and support breathing during the operation. The study will evaluate how well each device works, how easy they are to place, and whether they cause air to enter the stomach. Ultrasound will be used to safely check the position of the device and detect any air in the stomach. The results of this study may help improve the safety and effectiveness of airway management in children during anesthesia.",[250,97,251,252,253],"Anesthesia General","Laryngeal Mask Airways","Airway Management","Child",[255,256,257,97,258,259],"Airway management","Laryngeal mask airway","Pediatric patients","Gastric insufflation","Supraglottic airway devices","2026-04-21",{"date":262,"type":38},"2026-04-23",{"date":264,"type":21},"2026-04",{"date":266,"type":21},"2026-05",{"name":268,"class":269},"Ankara Etlik City Hospital","OTHER_GOV",{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":276,"eligibilityCriteria":277,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":278,"targetDuration":247,"studyType":57,"phases":4,"briefSummary":280,"conditions":281,"keywords":286,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":46},"100623438","machine-learning-assisted-management-of-intraoperative-hypotension-for-personalized-treatment-100623438","NCT07396636","Machine Learning-Assisted Management of Intraoperative Hypotension for Personalized Treatment","Machine Learning-Assisted Intraoperative Hypotension Management: Developing Personalized Treatment Recommendations","HYPOGUARD","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Patients scheduled for elective surgical procedures\n* Procedures performed under general anesthesia\n* Availability of continuous invasive arterial blood pressure monitoring during the intraoperative period\n* Planned surgical duration of at least 2 hours\n* Ability to provide written informed consent for participation in the study\n\nExclusion Criteria:\n\n* Emergency surgery\n* Diagnosis of sepsis, septic shock, or advanced cardiogenic shock\n* Cardiac rhythm disturbances that prevent reliable hemodynamic measurements (e.g., atrial fibrillation)\n* Severe left ventricular dysfunction or advanced heart failure (ejection fraction \\\u003C30%)\n* Inability to maintain intraoperative arterial cannulation due to technical or clinical reasons\n* Inability to provide informed consent (e.g., cognitive impairment or refusal to participate)",{"count":279,"type":21},50,"Intraoperative hypotension, defined as a drop in blood pressure during surgery, is a frequent event in patients undergoing general anesthesia. Even brief episodes of low blood pressure may reduce blood flow to vital organs such as the brain, heart, and kidneys, and have been associated with an increased risk of postoperative complications, prolonged recovery, and worse clinical outcomes. Despite its clinical importance, the management of intraoperative hypotension is often based on general guidelines and individual clinician experience rather than patient-specific physiological mechanisms.\n\nLow blood pressure during surgery can occur for different underlying reasons, including reduced circulating blood volume, excessive vasodilation caused by anesthetic agents, impaired heart contractility, or abnormalities in heart rate. In routine practice, these mechanisms are not always clearly distinguished, and similar treatment strategies may be applied to patients with different physiological causes of hypotension. As a result, the response to treatment can vary widely between patients.\n\nThis prospective observational study aims to improve the understanding of intraoperative hypotension by collecting detailed hemodynamic data during surgery and analyzing these data using machine learning methods. The study is designed to observe current clinical practice without altering or interfering with routine patient care. All decisions regarding anesthesia management and treatment of hypotension will be made by the attending anesthesiologists according to standard clinical practice. The research team will not provide treatment recommendations during surgery.\n\nAdult patients undergoing elective surgery under general anesthesia with continuous invasive arterial blood pressure monitoring will be included. During the intraoperative period, blood pressure, heart rate, cardiac output, stroke volume, systemic vascular resistance, and other advanced hemodynamic parameters will be continuously recorded at regular intervals. When hypotension occurs, the onset, duration, and severity of the episode will be documented, along with the treatment applied, such as fluid administration, vasopressor agents, or inotropic medications. The time required for blood pressure to recover to an acceptable level will also be recorded.\n\nThe collected data will be analyzed using machine learning techniques to identify distinct subtypes of intraoperative hypotension based on physiological patterns. These subtypes may reflect different underlying mechanisms, such as hypovolemia, vasodilation, myocardial depression, or heart rate-related causes. In addition, the study will evaluate how different treatment strategies perform across these hypotension subtypes and how quickly hemodynamic stability is restored.\n\nPatient-related factors such as age, sex, body mass index, physical status classification, and comorbid conditions will also be examined to determine their relationship with the occurrence, severity, and treatment response of hypotension episodes. By combining patient characteristics, physiological data, and treatment responses, the study aims to generate data-driven insights into personalized hypotension management.\n\nThe ultimate goal of this research is to support the development of individualized treatment recommendations for intraoperative hypotension based on objective physiological data rather than a one-size-fits-all approach. The findings of this study are expected to provide a strong scientific foundation for future clinical decision-support systems that can assist anesthesiologists in selecting the most appropriate treatment strategy for each patient. By improving the precision of blood pressure management during surgery, this approach has the potential to enhance patient safety and perioperative outcomes while maintaining standard clinical workflows.",[282,283,284,285,28],"Intraoperative Hypotension","Perioperative Care","Hemodynamic Monitoring","Blood Pressure",[287,288,289,290,291],"Intraoperative hypotension","Machine learning","Personalized treatment","Clinical decision support","Hemodynamic instability","2026-04-06",{"date":294,"type":38},"2026-04-09",{"date":296,"type":38},"2026-03-03",{"date":298,"type":21},"2026-09-30",{"name":300,"class":269},"Nevsehir Public Hospital",{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":22,"phases":311,"briefSummary":312,"conditions":313,"keywords":316,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":46},"100609228","eeg-and-pain-monitor-data-under-anesthesia-to-study-pharmacodynamic-effects-of-opioids-and-sedatives-100609228","NCT07211828","EEG and Pain Monitor Data Under Anesthesia to Study Pharmacodynamic Effects of Opioids and Sedatives","Pharmacodynamic Effects of Propofol and Alfentanil on EEG During Endoscopic Retrograde Cholangiopancreatography (ERCP)","SED-ERCP","Inclusion Criteria:\n\n* Patients who under go ERCP who require general anesthesia\n\nExclusion Criteria:\n\n* ASA\\> or = 4 , vulnerable groups such as prisoners, patients with physical or mental disabilities and HIV carriers",{"count":310,"type":21},20,[24],"Recording and analyzing electroencephalogram (EEG) and continuous pain monitor data under anesthesia in order to investigating the pharmacodynamic effects of opioids and sedatives.",[314,315,28],"Sedation and Analgesia","Cholangiopancreatography, Endoscopic Retrograde",[317,318,319,320],"sedation","phramacodynamics","opioid","ERCP","2026-03-24",{"date":323,"type":38},"2026-03-27",{"date":325,"type":38},"2025-10-10",{"date":327,"type":21},"2028-06-16",{"name":329,"class":45},"Chi Kwan Fung",{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":337,"targetDuration":4,"studyType":22,"phases":339,"briefSummary":341,"conditions":342,"keywords":344,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":350,"completionDateStruct":352,"leadSponsor":354,"locationsCount":46},"100628449","phase-4-effect-of-oxygen-administration-in-the-non-dependent-lung-on-postoperative-complications-after-lung-surgery-100628449","NCT07461779","Effect of Oxygen Administration in the Non-dependent Lung on Postoperative Complications After Lung Surgery","Impact of Continuous Oxygen Flow With or Without Airway Pressure in the Non-dependent Lung During One-lung Ventilation on Postoperative Complications in Lung Resection Surgery: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients of both genders undergoing lung resection surgery in the Thoracic Surgery Department at Hospital General Universitario Gregorio Marañón\n* Lung isolation using a double-lumen tube (DLT)\n* Scheduled surgery\n* Patients able and willing to give written informed consent\n* Patients over 18 years old and legally competent\n\nExclusion Criteria:\n\n* Patients with evidence of pulmonary bullae\n* Pregnancy or breastfeeding\n* Blood transfusion within 10 days prior to surgery\n* Treatment with immunosuppressants or corticosteroids within 3 months prior to surgery\n* Patient refusal to participate\n* Prior contralateral thoracic surgery\n* Robotic surgery\n* Pneumonectomy\n* Enrollment in another clinical trial",{"count":338,"type":21},177,[340],"PHASE4","The purpose of this study is to analyze the effectiveness of apneic oxygenation and CPAP applied to the non-dependent lung during pulmonary resection surgery in reducing inflammatory response, ischemia-reperfusion injury, and postoperative complications. We will conduct a randomized, controlled, and blinded study in 177 patients with three arms:\n\n* Control Group: Oxygen therapy according to standard clinical practice\n* Apneic oxygenation group: A probe will be introduced through the lumen of the double-lumen tube (DLT) to administer a continuous source of oxygen without any mechanism that generates airway pressure.\n* CPAP Group: Continuous positive airway pressure with 3-5 L\u002Fmin oxygen flow and 2 cm H2O pressure delivered via a Mapleson system.\n\nInflammatory mediators in blood and in both lungs will be measured intraoperatively and 24 hours after surgery. Patients will be followed from hospital admission until discharge and again 30 days after surgery to evaluate the postoperative course, particularly the occurrence of complications according to the revised Clavien-Dindo classification for thoracic surgery, as well as other relevant clinical outcomes.",[343,250],"Lung Resection Surgery",[345,346],"Postoperative complications","Thoracic surgery","2026-03-06",{"date":349,"type":38},"2026-03-10",{"date":351,"type":38},"2025-01-27",{"date":353,"type":21},"2027-03-30",{"name":355,"class":45},"Francisco Andres de la Gala",{"id":357,"slug":358,"hasResults":11,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":362,"eligibilityCriteria":363,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":364,"targetDuration":4,"studyType":22,"phases":365,"briefSummary":367,"conditions":368,"keywords":373,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":381,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":387,"locationsCount":46},"100443207","phase-2-co2-modulation-in-endovascular-thrombectomy-for-acute-ischemic-stroke-100443207","NCT05051397","CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke","Evaluation of the Effect of Moderate and Controlled Hypercapnia on Ischemic Penumbra Vascular Collaterality During General Anesthesia for Anterior Circulation Acute Ischemic Stroke Mechanical Thrombectomy","COMET-AIS","Inclusion Criteria:\n\n• Large vessel occlusion anterior circulation stroke (terminal carotid artery and\u002For middle cerebral artery M1-M2 segment) eligible to mechanical thrombectomy under general anesthesia\n\nExclusion Criteria :\n\n* Active smoker\n* Chronic respiratory failure with ambulatory oxygen supplementation\n* Obesity with BMI\\>40Kg\u002F m2\n* Intubation before the procedure\n* Heart failure with intolerance to decubitus\n* Severe renal failure\n* Suspected elevated intracranial pressure\n* Pregnant or breastfeeding women",{"count":279,"type":21},[366],"PHASE2","Acute ischemic stroke due to large vessel occlusion is responsible of cerebral blood flow impairment with a progressive and extensive ischemic process. Cerebral collateral circulation may preserve an ischemic penumbra that could recover providing timely reperfusion of the occluded vessel. Mechanical thrombectomy is the standard of care for anterior circulation large vessel reperfusion. Strategy to promote cerebral blood flow in collateral circulation before reperfusion is scarce and rely mainly on blood pressure maintenance. Carbon dioxide is a potent cerebral vasodilator that could enhance collateral circulation blood flow and cerebral protection before reperfusion. General anesthesia with endotracheal mechanical ventilation could be used for thrombectomy and give the opportunity to modulate and control carbon dioxide tension in the blood. This study will test the effect of moderate hypercapnia on penumbral collateral circulation before reperfusion during mechanical thrombectomy for anterior circulation acute ischemic stroke under general anesthesia.",[369,370,28,371,372],"Ischemic Stroke, Acute","Thrombectomy","Cerebrovascular Circulation","Carbon Dioxide",[374,375,376,377,378,379],"mechanical thrombectomy","large vessel occlusion stroke","carbon dioxide tension","cerebral blood flow","general anesthesia","cerebral collateral circulation","2025-09-30",{"date":382,"type":38},"2025-10-06",{"date":384,"type":38},"2022-07-20",{"date":386,"type":21},"2026-10-19",{"name":388,"class":45},"University Hospital, Clermont-Ferrand",{"id":390,"slug":391,"hasResults":11,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":4,"eligibilityCriteria":395,"healthyVolunteers":11,"sex":396,"minAge":17,"maxAge":4,"enrollmentInfo":397,"targetDuration":399,"studyType":57,"phases":4,"briefSummary":400,"conditions":401,"keywords":406,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":413,"lastUpdatePostDateStruct":414,"startDateStruct":416,"completionDateStruct":418,"leadSponsor":420,"locationsCount":46},"100594510","effect-of-anesthesia-techniques-on-quality-of-recovery-scores-in-holep-surgery-100594510","NCT07020390","Effect of Anesthesia Techniques on Quality of Recovery Scores in HOLEP Surgery","The Effect of Anesthesia Techniques on Quality of Recovery (QoR-40) Scores in Benign Prostatic Hyperplasia (Holmium Laser Enucleation of the Prostate - HoLEP) Surgery: A Cross-Sectional, Observational, Prospective Study","Inclusion Criteria:\n\n* Patients scheduled for HOLEP surgery due to benign prostatic hyperplasia.\n* Patients who consent to participate in the study.\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Presence of cognitive impairment\n* Use of psychoactive medications\n* Failure of the intraoperative anesthesia technique and necessity to change the anesthesia method\n* Requirement for reoperation or admission to the intensive care unit\n* Voluntary withdrawal from the study","MALE",{"count":398,"type":21},450,"2 Days","The aim of this observational study is to evaluate the effects of different anesthesia techniques on the quality of recovery (QoR) and patient satisfaction in male patients, typically older adults with benign prostatic hyperplasia, undergoing Holmium Laser Enucleation of the Prostate (HoLEP).\n\nParticipants will undergo HoLEP surgery under one of three anesthesia techniques-general, spinal, or combined spinal-epidural anesthesia-and will complete the QoR-40 questionnaire both before and after the surgery.",[402,403,28,404,405],"HoLEP","QoR-40","Anesthesia,Spinal","Anesthesia; Combine Spinal and Epidural",[402,407,408,409,410,411,412],"Quality of recovery (QoR-40)","Patient satisfaction","Spinal anesthesia","General anesthesia","Benign prostatic hyperplasia","spinal-epidural anesthesia","2025-07-31",{"date":415,"type":38},"2025-08-01",{"date":417,"type":38},"2025-06-20",{"date":419,"type":21},"2026-06-15",{"name":421,"class":45},"TC Erciyes University",{"id":423,"slug":424,"hasResults":11,"nctId":425,"briefTitle":426,"officialTitle":427,"acronym":4,"eligibilityCriteria":428,"healthyVolunteers":11,"sex":16,"minAge":429,"maxAge":430,"enrollmentInfo":431,"targetDuration":4,"studyType":22,"phases":433,"briefSummary":434,"conditions":435,"keywords":440,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":448,"leadSponsor":450,"locationsCount":46},"100591612","anesthesia-modality-and-oncologic-outcomes-in-high-risk-nmibc-a-randomized-trial-100591612","NCT06982690","Anesthesia Modality and Oncologic Outcomes in High-Risk NMIBC: A Randomized Trial","Impact of Anesthesia Modality on Recurrence and Progression in High-Risk Non-Muscle Invasive Bladder Cancer: A Randomized Controlled Trial Comparing Spinal Versus General Anesthesia","Inclusion Criteria:\n\n* Age ≥40 years for male subjects or postmenopausal female subjects\n* ECOG performance status 0-2\n* Patients with suspected or newly diagnosed UBUC\n* ASA I or II\n* Patients with any other adequately treated Stage I or II cancer except UC, from which the subject has been disease free for 5 years\n* Adequate renal function, defined as a serum creatinine (Cre) concentration ≤ the institutional ULN\n* Adequate hepatic function, defined as total bilirubin ≤ the institutional ULN and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ the institutional upper limit of normal (ULN)\n\nExclusion Criteria:\n\n* Patients with prior or concurrent UC involving the renal pelvis, ureter or urethra\n* Patients with clinical evidence of MIBC or mUC\n* Immunocompromised or immunosuppressed patients\n* Patients with chronic use of anti-inflammatory agents or beta-blockers\n* Patients with difficult airways or other significant cardiovascular comorbidities (severe aortic stenosis, significant pulmonary disease, CHF) who are intolerant to GA\n* Patients with elevated intracranial pressure (ICP), primarily due to intracranial mass and trauma or infection at the site of SA\n* Patients with a serious uncontrolled medical disorder (e.g., trauma, fracture) or active infection that would impair their ability to receive spinal or GA\n* Patients with known allergies to propofol, fentanyl, sevoflurane, or bupivacaine\n* Subjects with a known history or family history of malignant hyperthermia\n* Subjects with bleeding diathesis","20 Years","80 Years",{"count":432,"type":21},370,[24],"To demonstrate the superior efficacy of spinal anesthesia (SA) versus general anesthesia (GA) according to the delay of time to recurrence in high-risk NMIBC patients up to Week 104 after TURBT.",[436,437,438,439,28,404],"NMIBC","TURBT","Bladder (Urothelial, Transitional Cell) Cancer","Bladder Cancer Recurrence",[441,378,442,443,437],"bladder cancer","spinal anesthesia","recurrence","2025-05-13",{"date":446,"type":38},"2025-05-21",{"date":415,"type":21},{"date":449,"type":21},"2029-11-30",{"name":451,"class":45},"National Taiwan University Hospital",{"id":453,"slug":454,"hasResults":11,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":460,"enrollmentInfo":461,"targetDuration":4,"studyType":22,"phases":463,"briefSummary":464,"conditions":465,"keywords":466,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":468,"lastUpdatePostDateStruct":469,"startDateStruct":471,"completionDateStruct":473,"leadSponsor":475,"locationsCount":46},"100568743","observation-on-administration-of-propofol-at-different-titration-endpoints-100568743","NCT06685198","Observation on Administration of Propofol at Different Titration Endpoints","The Impact of Different Titration Endpoints of Propofol on Hemodynamics and Stress During the Induction Phase of General Anesthesia","OAPDTE","Inclusion Criteria:\n\n1. Age 18-60 years.\n2. Elective surgery with planned endotracheal intubation under general anesthesia.\n3. ASA classification of I or II,with heart function classified as 1 or 2.\n4. Body Mass Index (BMI) 18-30 kg\u002Fm².\n\nExclusion Criteria:\n\n1. Severe cardiac, pulmonary, hepatic, or renal diseases (heart function classification greater than 3 \u002F respiratory failure \u002F liver failure \u002F renal failure).\n2. Malignant arrhythmias: atrial flutter, atrial fibrillation, atrioventricular block, frequent ventricular premature beats, multifocal ventricular premature beats, ventricular premature beats R on T, ventricular flutter, and ventricular fibrillation.\n3. Expected difficulty with intubation, hypoalbuminemia, hypertension, or diabetes mellitus.\n4. Patients with a high risk of aspiration due to a full stomach, gastrointestinal obstruction, or pregnancy.\n5. Patients with schizophrenia, epilepsy, Parkinson's disease, intellectual disabilities, etc.\n6. Alcohol abusers or those who have been using sedatives or analgesics long-term.\n7. Allergic to propofol or its emulsion.\n8. Currently participating in a clinical trial that conflicts with this study.","60 Years",{"count":462,"type":21},258,[24],"Propofol has a rapid onset and short duration of action, making it widely used for induction of general anesthesia. However, its prominent drawback is circulatory depression. Our research team previously proposed an individualized dosing method for the titration of propofol. We then compared the effects of different titration rates of propofol on hemodynamics and stress during general anesthesia induction. It was found that the incidence of hypotension during the induction period was lower in the 0.5 mg\u002Fkg\u002Fmin group, with lower stress levels and faster postoperative recovery. However, this group still had a 25.3% incidence of hypotension. Therefore, we plan to further study the differences in hemodynamics, depth of anesthesia, stress response, and postoperative recovery in three groups of patients induced with a constant infusion rate of propofol at 0.5 mg\u002Fkg\u002Fmin titrated to an OAA\u002FS score of 1, an OAA\u002FS score of 2, and BIS ≤ 60, combined with remifentanil 2 μg\u002Fkg. This study aims to explore the appropriate propofol titration endpoint during general anesthesia induction to maintain stable perioperative haemodynamics and achieve rapid postoperative recovery.",[28,29],[467],"titration of propofol","2024-12-01",{"date":470,"type":38},"2024-12-04",{"date":472,"type":21},"2025-02-20",{"date":474,"type":21},"2025-08-20",{"name":476,"class":45},"SanQing Jin",{"id":478,"slug":479,"hasResults":11,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":4,"eligibilityCriteria":483,"healthyVolunteers":140,"sex":16,"minAge":87,"maxAge":4,"enrollmentInfo":484,"targetDuration":4,"studyType":22,"phases":486,"briefSummary":487,"conditions":488,"keywords":492,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":46},"100542468","the-effects-of-general-versus-spinal-anesthesia-on-postoperative-myocardial-injury-100542468","NCT06343259","The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury","Comparison of The Effects of General Anesthesia and Spinal Anesthesia on The Development of Postoperative Myocardial Injury in Elderly Patients Undergoing Hip Surgery","Inclusion Criteria:\n\n* who will undergo hip surgery\n* ASAII-III\n* Over the age of 65\n\nExclusion Criteria:\n\n* Patients diagnosed with sepsis, pulmonary embolism, decompensated heart failure, chronic kidney failure.\n* Patients who underwent cardioversion in the last 6 months or experienced myocardial infarction.\n* Patients with a surgical history in the last month.\n* Patients who required intubation in the intensive care unit.\n* Patients with a baseline Hs-Troponin T value exceeding 20 ng\u002FL.\n* Patients with a postoperative peak Hs-Troponin T value higher than baseline.",{"count":485,"type":21},100,[24],"In this prospective, randomized, single-blind study, we aim to compare the effects of general anesthesia and spinal anesthesia on postoperative myocardial injury in elderly patients undergoing hip surgery. Cardiovascular events are a leading cause of mortality and morbidity following non-cardiac surgery, with myocardial injury after non-cardiac surgery (MINS) being a significant concern. MINS, characterized by asymptomatic elevation of troponin levels without accompanying ECG findings, is closely associated with postoperative mortality. With the increasing prevalence of comorbidities in the elderly population and the rising frequency of non-cardiac surgeries in this demographic, understanding the effects of different anesthesia types on postoperative myocardial injury is crucial.",[489,490,28,491],"Myocardial Injury After Non-cardiac Surgery","Hypotension During Surgery","Anesthesia, Spinal",[493,28,491,494,495,496],"MINS","Hip Fractures","Myocardial Infarction","Troponin T","2024-07-22",{"date":499,"type":38},"2024-07-23",{"date":501,"type":38},"2024-04-05",{"date":503,"type":21},"2024-08-18",{"name":505,"class":45},"Sisli Hamidiye Etfal Training and Research Hospital"]