[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anesthesia":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,198,0,25,[9,44,76,104,132,159,184,211,234,256,285,318,347,376,407,435,458,479,508,541,561,578,595,622,658],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100609979","phase-4-oral-methadone-in-cardiac-surgery-100609979",false,"NCT07221617","Oral Methadone in Cardiac Surgery","Oral Methadone In Cardiac Surgery","OMICS","Inclusion Criteria:\n\n• Undergoing elective cardiac surgery\n\nExclusion Criteria:\n\n* Chronic pain requiring opioid medications as an outpatient\n* Opioid use disorder on medication assistance treatment\n* Prolonged QTc \\>500ms\n* Chronic kidney disease with eGFR \\\u003C 30mL\u002Fmin\n* Documented cirrhosis\n* Intolerance to methadone\n* Admitted inpatient in an intensive care unit (ICU) immediately prior to surgery\n* Pregnancy at the time of surgery\n* Subsequent surgeries after index surgery","ALL","18 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.",[28,29,30],"Pain, Postoperative","Anesthesia","Cardiac Surgery","RECRUITING","2026-08-20",{"date":34,"type":35},"2026-08-21","ACTUAL",{"date":37,"type":35},"2026-01-13",{"date":39,"type":22},"2026-08-31",{"name":41,"class":42},"Mayo Clinic","OTHER",1,{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":60,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100652273","simulation-based-training-in-the-anaesthesia-residency-curriculum-100652273","NCT07771569","Simulation-based Training in the Anaesthesia Residency Curriculum","Inclusion Criteria:\n\n* WFSA representatives.\n\nExclusion Criteria:\n\n* not WFSA representatives.",{"count":51,"type":22},150,"OBSERVATIONAL","This study aims to describe the current implementation and structure of simulation-based education and training in anaesthesiology and intensive care residency programmes across countries affiliated with the World Federation of Societies of Anesthesiologists.",[55,56,57,29,58,59],"Education","Training","Simulation Based Medical Education","Intensive Care Medicine","Critical Care",[61,62,63,64,65],"simulation","education","anaesthesia","intensive care","survey","NOT_YET_RECRUITING","2026-08-15",{"date":69,"type":35},"2026-08-18",{"date":71,"type":22},"2026-10-01",{"date":73,"type":22},"2027-06-30",{"name":75,"class":42},"Brno University Hospital",{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":97,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":43},"100628710","phase-2-intrathecal-bupivacaine-with-or-without-dexmetomidine-for-cesserian-delivery-100628710","NCT07465185","Intrathecal Bupivacaine With or Without Dexmetomidine for Cesserian Delivery","Intrathecal Bupivacaine With or Without Dexmetomidine for Cesserian Delivery ;Arandomized Non - Inferiority Study","Inclusion Criteria:\n\n* (1) Full-term pregnant women undergoing elective cesarean section under spinal anesthesia. (2) Age: 20 \\~ 35 years. (3) ASA physical status II \\~ III\n\nExclusion Criteria:\n\n1. Multiple pregnancies.\n2. Cardiovascular disease(e.g., pre-eclampsia and hypertension).\n3. Serious hepatic dysfunction (Child-Pugh class C).\n4. serious renal dysfunction (undergoing dialysis before surgery).\n5. History of alcohol or opioid addiction.\n6. Contraindication to spinal anesthesia.\n7. Refusing to sign informed consent.","FEMALE","20 Years","35 Years",{"count":87,"type":22},300,[89],"PHASE2","Cesarean section (CS) is one of the most frequently performed surgical procedures globally, with an increasing demand for safe and effective anesthesia techniques. Regional anesthesia, particularly intrathecal anesthesia, has become the method of choice for elective cesarean deliveries.The most commonly used local anesthetic for intrathecal anesthesia is bupivacaine.Recent studies have focused on adjunctive agents to enhance the efficacy of local anesthetics.",[29],[93,94,95,96],"bupivacaine","dexmetomedine","spinal anesthesia","cessarian delivery",{"date":69,"type":35},{"date":99,"type":35},"2026-03-15",{"date":101,"type":22},"2026-09-01",{"name":103,"class":42},"Benha University",{"id":105,"slug":106,"hasResults":12,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":131},"100538848","open-lung-protective-extubation-following-general-anesthesia-100538848","NCT06296173","Open Lung Protective Extubation Following General Anesthesia","Open Lung Protective Extubation Following General Anesthesia: the OLEXT-3 Trial","OLEXT-3","Inclusion Criteria:\n\n* Adult patients (18 years of age or over)\n* Elective intra-abdominal surgery under general anesthesia.\n* Moderate or high risk of postoperative pulmonary complication according to the ARISCAT score (score of 26 or more)\n* Planned postoperative hospitalization\n\nExclusion Criteria:\n\n* Expected or known difficult intubation according to the treating anesthesiologist\n* Postoperative mechanical ventilation (planned or unplanned)\n* General anesthesia performed outside the main operating room",{"count":113,"type":22},270,[115],"NA","Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development. Protective \"open lung\" mechanical ventilation aims to minimize the occurrence of atelectasis during the perioperative period. Randomized controlled studies have been performed comparing various \"open lung\" ventilation protocols, but these studies report varying and conflicting effects. The interpretation of these studies is complicated by the absence of imagery supporting the pulmonary impact associated with the use of different ventilation strategies. Imaging studies suggest that the gain in pulmonary gas content in \"open lung\" ventilation regimens disappears within minutes after the extubation. Thus, the potential benefits of open-lung ventilation appear to be lost if, at the time of extubation, no measures are used to keep the lungs well aerated. Recent expert recommendations on good mechanical ventilation practices in the operating room conclude that there is actually no quality study on extubation.\n\nExtubation is a very common practice for anesthesiologists as part of their daily clinical practice. It is therefore imperative to generate evidence on good clinical practice during anesthetic emergence in order to potentially identify an effective extubation strategy to reduce postoperative pulmonary complications.",[118,29,119,120,121],"Intra-abdominal Surgery","Lung Injury","Ventilator-Induced Lung Injury","Atelectasis","2026-08-14",{"date":124,"type":35},"2026-08-17",{"date":126,"type":35},"2024-10-08",{"date":128,"type":22},"2027-04-01",{"name":130,"class":42},"Centre hospitalier de l'Université de Montréal (CHUM)",5,{"id":133,"slug":134,"hasResults":12,"nctId":135,"briefTitle":136,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":141,"conditions":142,"keywords":145,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":43},"100637996","perioperative-predictive-value-of-physical-activity-on-short--and-long-term-morbidity-and-mortality-100637996","NCT07603622","Perioperative Predictive Value of Physical Activity on Short- and Long-term Morbidity and Mortality","PeriopPrePA","Inclusion Criteria:\n\n* Elective non-cardiac surgery patients (equal to or over 18 years) at the two study sites, Karolinska University Hospital Solna and Karolinska University Hospital Huddinge\n\nExclusion Criteria:\n\n* Patients under the age of 18, transplant, day surgery, acute surgery, anesthesia monitoring, brachy therapy and gamma knife interventions. In case of multiple surgeries, only the first will be included.",{"count":140,"type":22},50000,"Over 300 million surgeries are performed globally every year. Complications after surgery - infections, cardiovascular conditions, postoperative pulmonary complications and renal impairment - affect survival and quality of life.\n\nAge and co-morbidity are unmodifiable factors, contributing to increased risk of these perioperative complications. However, a modifiable risk factor is physical activity. This study aims to test if self reported physical activity has added predicted value, beyond established risk factors, for predicting perioperative morbidity and mortality.",[29,143,144],"Surgery","Surgery Complications",[146,147,148,149],"Perioperative medicine","Outcome","Mortality","Morbidity","2026-08-09",{"date":152,"type":35},"2026-08-12",{"date":154,"type":35},"2026-05-01",{"date":156,"type":22},"2026-11-30",{"name":158,"class":42},"Karolinska Institutet",{"id":160,"slug":161,"hasResults":12,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":168,"conditions":169,"keywords":170,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":43},"100512621","a-study-of-changes-in-heart-function-and-blood-flow-in-people-receiving-anesthesia-100512621","NCT05954832","A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia","Changes in Loading Conditions on Induction of General Anesthesia: Mechanisms of Post-Induction Hypotension (PIH)","Inclusion Criteria:\n\n* Adult patients ≥ 18 years of age requiring general anesthesia for surgery\n* Intubation required for anesthetic management \u002F surgery\n* Anticipated prep time before incision of 20 minutes\n* Baseline MAP \\>70mmHg\n\nExclusion Criteria:\n\n* History of coronary artery disease\n* History of cardiac disease (e.g., HTN, arrythmias, valvular and structural abnormalities)\n* History of peripheral artery occlusive disease\n* Beta-blocker use\n* Anti-hypertensive medication use\n* Patients with epidural, spinal, paravertebral, serratus blocks preoperatively\n* Patients requiring rapid sequence induction (where intubation occurs concurrently with induction)\n* Emergency surgery",{"count":167,"type":22},250,"The purpose of this study is to understand changes in heart function (how the heart pumps blood) and blood flow in people who receive general anesthesia during surgery. The researchers are particularly interested in the heart function and blood flow changes in people who experience low blood pressure (hypotension) after receiving anesthesia.",[29],[171,172,173,174],"Changes in Heart Function","Changes in Blood Flow","Echocardiography","23-079","2026-08-05",{"date":177,"type":35},"2026-08-10",{"date":179,"type":35},"2023-07-13",{"date":181,"type":22},"2027-07",{"name":183,"class":42},"Memorial Sloan Kettering Cancer Center",{"id":185,"slug":186,"hasResults":12,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":191,"sex":18,"minAge":192,"maxAge":193,"enrollmentInfo":194,"targetDuration":4,"studyType":23,"phases":196,"briefSummary":198,"conditions":199,"keywords":200,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":43},"100486865","phase-1-oral-dexmedetomidine-in-pediatric-mri-100486865","NCT05619627","Oral Dexmedetomidine in Pediatric MRI","Utility of Oral Dexmedetomidine as the Sole Sedative Agent in Pediatric Population Undergoing MRI","Inclusion Criteria:\n\n1. Participants 3-6 years old, male and female, all races and ethnicities\n2. Requiring a clinically indicated MRI with general anesthesia\n\nExclusion Criteria:\n\n1. Refusal to take oral dexmedetomidine\n2. Known allergy to dexmedetomidine\n3. Inability to take dexmedetomidine at least 90 minutes prior to start of the MRI\n4. Medical contraindications to administration of dexmedetomidine including:\n\n   1. Unstable cardiac status including life threatening arrhythmias, abnormal cardiac anatomy, significant cardiac dysfunction\n   2. Current use of digoxin\n   3. Moya Moya disease\n   4. New onset stroke\n5. American Society of Anesthesiologists (ASA) physical status classification \\> II\n6. Contraindications to administering sedation including:\n\n   1. Active and uncontrolled gastroesophageal reflux\n   2. Active and uncontrolled vomiting\n   3. Current or recent history of apnea\n   4. Active respiratory disease including pneumonia, bronchitis, respiratory syncytial virus infection, asthma exacerbation\n   5. Craniofacial anomalies\n7. Inability to have MRI scans\n8. Non-English speaking volunteers",true,"3 Years","6 Years",{"count":195,"type":22},18,[197],"PHASE1","The objective of this preliminary study is to assess the utility of oral dexmedetomidine as the sole sedative agent in pediatric population undergoing MRI.",[29],[201],"Oral dexmedetomidine","2026-08-03",{"date":204,"type":35},"2026-08-04",{"date":206,"type":22},"2026-11-01",{"date":208,"type":22},"2028-03",{"name":210,"class":42},"Soroush Merchant",{"id":212,"slug":213,"hasResults":12,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":12,"sex":18,"minAge":219,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":223,"conditions":224,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":226,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":233},"100318590","anesthetics-and-analgesics-in-children-100318590","NCT03427736","Anesthetics and Analgesics in Children","Pharmacokinetics of Anesthetics and Analgesics in Children and Adolescent","ANA01","Inclusion Criteria:\n\n1. 0 to \\\u003C18 years of age at time of enrollment (must see applicable appendix for details as not all appendices enroll across the entire age range)\n2. Parent and\u002For participant (if applicable) is able to understand the consent process and provides informed consent and HIPAA Authorization (if applicable)\n3. Participant provides assent as required by the institutional review board (IRB) or research ethics board (REB)\n4. Receiving one or more drugs of interest (DOI) per local standard of care\n5. Meeting DOI-specific inclusion criteria (See Appendices)\n\nExclusion Criteria:\n\n1. Known pregnancy\n2. Extracorporeal life support (i.e., ECMO, dialysis, ventricular assist device)\n3. Any condition which would make the participant, in the opinion of the investigator, unsuitable for the study","0 Years","17 Years",{"count":222,"type":22},551,"The purpose of this study is to characterize the pharmacokinetic (PK) and safety profile of anesthetics and analgesics in children and adolescents.",[29,225],"Pain",{"date":175,"type":35},{"date":228,"type":35},"2018-12-13",{"date":230,"type":22},"2027-09-09",{"name":232,"class":42},"Chi Dang Hornik",13,{"id":235,"slug":236,"hasResults":12,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":191,"sex":18,"minAge":241,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":245,"conditions":246,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":4},"100650433","pain-and-anxiety-during-vital-pulp-therapy-using-different-local-anesthesia-techniques-in-children-100650433","NCT07748390","Pain and Anxiety During Vital Pulp Therapy Using Different Local Anesthesia Techniques in Children","Evaluation of the Effects of Different Local Anesthesia Techniques on Dental Anxiety and Pain During Vital Pulp Therapy","Inclusion Criteria:\n\n* Children aged 8-10 years.\n* Children and parents\u002Flegal guardians who agree to participate in the study and provide informed consent.\n* Patients requiring vital pulp therapy of a permanent mandibular first molar.\n* Patients classified as Frankl Behavior Rating Scale score 3 or 4. Systemically healthy children (ASA I).\n* Children with adequate cognitive and communication abilities to understand the study procedures and pain\u002Fanxiety assessment scales.\n* Permanent mandibular first molars without clinical or radiographic signs of abscess, fistula, or periapical pathology.\n\nExclusion Criteria:\n\n* Children with systemic diseases or medical conditions affecting dental treatment.\n* Children classified as Frankl Behavior Rating Scale score 1 or 2.\n* Patients with known allergy or hypersensitivity to local anesthetic agents (e.g., lidocaine, articaine).\n* Teeth with acute dental infection signs, including abscess, cellulitis, or extensive infection.\n* Teeth showing clinical or radiographic evidence of periapical pathology.\n* Children unable to understand or complete pain and anxiety assessment scales due to cognitive, visual, hearing, or communication limitations.\n* Patients who do not comply with the study procedures or withdraw consent.","8 Years","10 Years",{"count":244,"type":22},120,"This prospective observational study aims to evaluate the effects of different local anesthesia techniques on dental anxiety and pain in children undergoing vital pulp therapy of permanent mandibular first molars. Conventional inferior alveolar nerve block and two computer-controlled local anesthetic delivery (CCLAD) systems used in routine clinical practice will be compared. The choice of anesthesia technique will be based on the clinician's routine decision-making, and no additional intervention or modification of standard treatment will be performed for research purposes. Dental anxiety, pain, physiological parameters, and postoperative complications will be assessed using validated clinical scales and routine clinical measurements. The findings may help improve pain and anxiety management during pediatric dental treatment while supporting evidence-based selection of local anesthesia techniques.",[247,29],"Pediatric","2026-07-31",{"date":175,"type":35},{"date":251,"type":22},"2026-08-01",{"date":253,"type":22},"2026-12-30",{"name":255,"class":42},"Recep Tayyip Erdogan University Training and Research Hospital",{"id":257,"slug":258,"hasResults":12,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":263,"enrollmentInfo":264,"targetDuration":4,"studyType":23,"phases":266,"briefSummary":267,"conditions":268,"keywords":270,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":43},"100642256","phase-4-oliceridine-vs-sufentanil-for-cough-during-anesthesia-induction-100642256","NCT07660380","Oliceridine vs Sufentanil for Cough During Anesthesia Induction","Oliceridine vs Sufentanil for Cough During General Anesthesia Induction: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18 to 99 years.\n* American Society of Anesthesiologists (ASA) physical status classification I, II, or III.\n* Body mass index (BMI) between 18.5 and 28.0 kg\u002Fm².\n* Scheduled for elective surgery under general anaesthesia.\n* Able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Preoperative upper respiratory tract infection symptoms (e.g., cough, expectoration, or fever) or a history of bronchial asthma or other conditions associated with increased airway reactivity.\n* Severe cardiovascular disease (e.g., uncontrolled hypertension, recent myocardial infarction, or serious arrhythmia) or hepatic or renal dysfunction.\n* Long-term opioid use, defined as continuous opioid use for more than 2 weeks within the 3 months prior to surgery.\n* Known hypersensitivity to any study drug or anaesthetic agent used in this protocol.\n* Anticipated difficult airway requiring awake intubation.\n* Pregnancy or breastfeeding.","99 Years",{"count":265,"type":22},62,[25],"Sufentanil is the most widely used opioid analgesic for general anaesthesia induction; however, rapid intravenous bolus injection frequently triggers sufentanil-induced cough (SIC). In high-risk patients, SIC can cause abrupt elevation of intracranial and intraocular pressure and severe haemodynamic instability, posing a meaningful safety risk during the induction period.\n\nOliceridine, the first G protein-biased μ-opioid receptor agonist approved by the Food and Drug Administration in 2020, provides analgesia through μ-receptor activation while substantially reducing β-arrestin-2 recruitment. This biased signalling profile is hypothesised to raise the excitation threshold of airway C-fibres and thereby reduce the incidence of cough.\n\nThis prospective, single-centre, randomised, double-blind, parallel-group controlled trial directly compares oliceridine with sufentanil for general anaesthesia induction with respect to cough incidence, cough severity, haemodynamic responses, and perioperative safety, with the aim of providing evidence-based guidance for opioid selection during induction.",[269,29],"Cough",[271,272,273,274,275],"Oliceridine","Sufentanil","Sufentanil-induced cough","G protein-biased agonist","Anesthesia induction","2026-07-18",{"date":278,"type":35},"2026-07-21",{"date":280,"type":35},"2026-06-27",{"date":282,"type":22},"2026-07-28",{"name":284,"class":42},"Shiyou Wei",{"id":286,"slug":287,"hasResults":12,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":293,"enrollmentInfo":294,"targetDuration":4,"studyType":23,"phases":296,"briefSummary":297,"conditions":298,"keywords":301,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":4},"100648050","phase-4-ciprofol-and-remimazolam-for-intraoperative-neurophysiological-monitoring-during-spine-surgery-100648050","NCT07718152","Ciprofol and Remimazolam for Intraoperative Neurophysiological Monitoring During Spine Surgery","Effects of Alternating Ciprofol and Remimazolam on Intraoperative Motor and Somatosensory Evoked Potentials During Spine Surgery: A Randomized Crossover Trial","CIRIONM","Inclusion Criteria:\n\n1. Age 18 to 75 years.\n2. Scheduled to undergo elective spine surgery.\n3. Planned intraoperative monitoring with MEP and SEP\u002FSSEP.\n4. Expected surgical duration sufficient to complete two study drug periods and intraoperative monitoring windows, preferably at least 3.5 to 4 hours.\n5. American Society of Anesthesiologists physical status I to III.\n6. Able to provide written informed consent, or consent provided by a legally authorized representative where applicable.\n\nExclusion Criteria:\n\n1. Known allergy or contraindication to ciprofol, remimazolam, benzodiazepines, propofol-related formulations, opioids, or relevant excipients.\n2. Severe preoperative motor or sensory deficit preventing interpretable target MEP or SEP baseline recordings.\n3. Implanted cardiac pacemaker, skull defect, or other condition considered unsuitable for transcranial electrical stimulation.\n4. Severe neuromuscular disease, poorly controlled epilepsy, severe cognitive impairment, or inability to complete postoperative neurological assessment.\n5. Severe hepatic or renal dysfunction, severe hemodynamic instability, shock, or requirement for high-dose vasoactive medications before enrollment.\n6. Long-term benzodiazepine, sedative-hypnotic, antiepileptic drug use, or drug\u002Falcohol dependence that may substantially alter anesthetic response.\n7. Expected need for continuous deep neuromuscular blockade during surgery, preventing valid MEP monitoring.\n8. Any other condition judged by the investigators to make participation unsuitable or unsafe.","75 Years",{"count":295,"type":22},60,[25],"Intraoperative neurophysiological monitoring, including motor evoked potentials and somatosensory evoked potentials, is commonly used during spine surgery to help detect impending neurological injury. The quality of these signals can be affected by anesthetic agents. Ciprofol and remimazolam are newer intravenous hypnotic agents that may be suitable for total intravenous anesthesia during procedures requiring neurophysiological monitoring, but direct within-patient comparisons between the two agents are lacking. This single-center, prospective, randomized, two-sequence crossover trial will compare the effects of ciprofol and remimazolam, administered with remifentanil, on intraoperative MEP and SEP signal quality during spine surgery. Eligible participants will be randomized to receive either ciprofol followed by remimazolam or remimazolam followed by ciprofol during predefined stable intraoperative monitoring windows. The primary outcome is the within-participant difference in lower-extremity MEP peak-to-peak amplitude between the ciprofol and remimazolam periods. Secondary outcomes include SEP amplitude and latency, MEP latency, warning-threshold events, hemodynamic variables, rescue medication requirements, recovery characteristics, and postoperative neurological status.",[299,300,29],"Intraoperative Neurophysiological Monitoring","Spine Surgery",[302,303,304,305,306,307,308,309],"Ciprofol","Remimazolam","Motor evoked potential","Somatosensory evoked potential","Intraoperative neurophysiological monitoring","Spine surgery","Total intravenous anesthesia","Crossover trial","2026-07-17",{"date":278,"type":35},{"date":313,"type":22},"2026-08",{"date":315,"type":22},"2027-01",{"name":317,"class":42},"Affiliated 2 Hospital of Nantong University",{"id":319,"slug":320,"hasResults":12,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":324,"eligibilityCriteria":325,"healthyVolunteers":12,"sex":18,"minAge":326,"maxAge":19,"enrollmentInfo":327,"targetDuration":4,"studyType":23,"phases":329,"briefSummary":331,"conditions":332,"keywords":333,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":43},"100491626","phase-3-effect-of-sedative-and-anxiolytic-premedication-on-children-experience-after-general-anesthesia-100491626","NCT05681572","Effect of Sedative and Anxiolytic Premedication on Children Experience After General Anesthesia","\" Effect of Sedative and Anxiolytic Premedication on Children Experience After General Anesthesia \" The pediaPREM Study.","pediaPREM","Inclusion Criteria:\n\n* Subject over 7 and under 18 years of age\n* Subjects who are scheduled for surgery\n* Subject who will be under general anesthesia\n* Subject able to complete a self-questionnaire in French\n\nExclusion Criteria:\n\n* Subject who has already participated in the pediaPREM study\n* Subject with a treated anxiety disorder\n* Subject with cognitive disorders\n* Subject suffering from chronic pain (outside the operated area)\n* Subject with ADD (Attention Deficit Disorder) with or without hyperactivity, with or without treatment\n* Subject suffering from mental retardation\n* Subjects receiving psychotropic treatment\n* Subject whose intervention could reduce the ability to complete a self-questionnaire (neurosurgery etc.)\n* Subject with a contra-indication to midazolam and its excipients\n* Subject with a contra-indication to dexmedetomidine and its excipients\n* Subjects who need to receive intravenous alpha agonist in perioperative\n* Subjects requiring emergency intervention\n* Subjects requiring preoperative hypnosis\n* Subject who needs general anesthesia for diagnostic purposes (biopsy, etc...)\n* Subject having had a surgical intervention in the month preceding the inclusion.\n* Subject who will have an iterative surgical intervention within 15 days (removal of material, burns etc...)\n* Subjects who are scheduled for surgery as part of oncology management\n* Pregnant or breastfeeding woman\n* Subject whose two parents have not signed a written informed consent\n* Subjects who are not affiliated with or benefiting from a social security plan","7 Years",{"count":328,"type":22},1000,[330],"PHASE3","Children undergoing general anesthesia for surgery commonly need sedative and anxiolytic premedication but little clinical evidence supports is benefit for children older than 7 years old.\n\nThe aim of this prospective randomized clinical trial is to assess the impact of pharmacologic premedication on perioperative children experience.",[29],[334,335,336,337,338],"children premedication","anesthesia","children perioperative experience","anxiety","sedation","2026-07-16",{"date":310,"type":35},{"date":342,"type":35},"2023-04-18",{"date":344,"type":22},"2027-10-18",{"name":346,"class":42},"University Hospital, Montpellier",{"id":348,"slug":349,"hasResults":12,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":4,"eligibilityCriteria":353,"healthyVolunteers":12,"sex":83,"minAge":19,"maxAge":354,"enrollmentInfo":355,"targetDuration":4,"studyType":23,"phases":357,"briefSummary":358,"conditions":359,"keywords":362,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":368,"lastUpdatePostDateStruct":369,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":43},"100647558","lateral-ql-block-vs-intrathecal-morphine-for-cesarean-section-100647558","NCT07712783","Lateral QL Block vs Intrathecal Morphine for Cesarean Section","Comparison of the Analgesic Efficacy of Lateral Quadratus Lumborum Block and Intrathecal Morphine for Postoperative Pain Management Following Cesarean Delivery Under Spinal Anesthesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Women aged between 18 and 45 years.\n* Singleton term pregnancy (≥37 weeks of gestation).\n* American Society of Anesthesiologists (ASA) physical status II.\n* Scheduled to undergo elective cesarean delivery via a Pfannenstiel incision.\n* Planned to receive spinal anesthesia for cesarean delivery.\n* Provision of written informed consent following a comprehensive explanation of the study.\n* Sufficient cognitive capacity to understand and complete the study assessment instruments, including the Numeric Rating Scale (NRS) and the ObsQoR-11T.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to any of the study medications, including morphine, bupivacaine, or fentanyl.\n* Coagulopathy (international normalized ratio \\[INR\\] \\>1.5 or platelet count \\\u003C100,000\u002Fmm³).\n* Current treatment with anticoagulant or antiplatelet agents (e.g., heparin, low-molecular-weight heparin, or aspirin \\>100 mg\u002Fday).\n* Infection, hematoma, or skin lesion at the planned block insertion site.\n* Diagnosis of preeclampsia, eclampsia, or HELLP syndrome.\n* Placenta previa, placenta accreta spectrum, or placental abruption.\n* Gestational diabetes mellitus or chronic hypertension.\n* Emergency cesarean delivery indicated because of fetal distress.\n* Conversion to general anesthesia during cesarean delivery.\n* History of chronic pain syndrome (e.g., fibromyalgia, lumbar disc herniation, or neuropathic pain).\n* Regular use of opioids or psychotropic medications within the preceding 3 months.\n* Diagnosis of epilepsy, severe anxiety disorder, or major depressive disorder.\n* Obesity (body mass index \\>35 kg\u002Fm²).\n* Severe systemic disease, including New York Heart Association (NYHA) class III or IV heart failure, hepatic or renal failure, advanced respiratory disease, or obstructive sleep apnea.\n* Advanced pulmonary disease requiring continuous positive airway pressure (CPAP) therapy.\n* Inadequate spinal anesthesia or the requirement for supplemental intraoperative analgesia.\n* Surgical duration exceeding 120 minutes.\n* Excessive intraoperative blood loss (≥1,000 mL) or the need for blood transfusion.","45 Years",{"count":356,"type":22},56,[115],"Effective postoperative analgesia after cesarean delivery is essential for maternal recovery, early mobilization, breastfeeding, and maternal-infant bonding. Although intrathecal morphine (ITM) is considered the gold standard for post-cesarean analgesia, its use is associated with opioid-related adverse effects. Ultrasound-guided lateral quadratus lumborum block (QLB-I) has emerged as a promising alternative. This randomized, double-blind, non-inferiority trial aims to compare the postoperative analgesic efficacy of lateral QLB-I with ITM. Secondary outcomes include postoperative opioid consumption, pain scores, opioid-related adverse effects, quality of recovery (ObsQoR-11T), and maternal satisfaction.",[29,360,361],"Postoperative Pain","Regional Anesthesia",[363,364,365,366,367],"cesarean delivery","postoperative opioid consumption","postoperative pain","lateral quadratus lumborum block","intrathecal morphine","2026-07-14",{"date":310,"type":35},{"date":371,"type":22},"2026-07-15",{"date":373,"type":22},"2026-12-01",{"name":375,"class":42},"Ondokuz Mayıs University",{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":382,"eligibilityCriteria":383,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":384,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":386,"conditions":387,"keywords":390,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":402,"completionDateStruct":403,"leadSponsor":405,"locationsCount":4},"100646078","large-language-models-versus-anesthesiologists-for-asa-physical-status-classification-100646078","NCT07696221","Large Language Models Versus Anesthesiologists for ASA Physical Status Classification","Comparison of Clinical Assessment and Large Language Models in Preoperative Risk Classification: A Retrospective Analysis of ChatGPT, DeepSeek, Gemini, and Claude in ASA Physical Status Classification","ASA-LLM","Inclusion Criteria:\n\n* Age 18 years or older\n* Planned elective surgery\n* Completed preoperative anesthesia evaluation\n\nExclusion Criteria:\n\n* Emergency surgical procedures\n* ASA VI (brain death)\n* Incomplete clinical records",{"count":385,"type":22},350,"The American Society of Anesthesiologists Physical Status (ASA-PS) classification is a cornerstone of preoperative risk assessment, yet interrater variability among clinicians is well documented. Large language models (LLMs) have recently demonstrated expert-level performance in several clinical classification tasks, including ASA-PS assignment.\n\nThis retrospective observational study evaluates whether four widely used LLMs - ChatGPT, DeepSeek, Gemini, and Claude - can accurately and consistently assign ASA-PS classes from structured, fully anonymized clinical vignettes derived from real preoperative anesthesia evaluations, using a consensus of senior anesthesiologists as the reference standard.\n\nNo patient data will be transmitted to third-party platforms. Clinical information will be converted by the investigators into de-identified structured vignettes containing only age range, sex, body mass index range, presence or absence of systemic diseases, functional capacity, and the major\u002Fminor nature of the planned surgery, in full compliance with national data protection legislation (KVKK).",[29,388,389],"Preoperative Risk Prediction","Preoperative Risk Assessment",[391,392,393,394,395,396,397,398],"asa physical status","large language models","artificial intelligence","chatgpt","gemini","deepseek","Claude","risk classification","2026-07-06",{"date":401,"type":35},"2026-07-10",{"date":278,"type":22},{"date":404,"type":22},"2026-10-21",{"name":406,"class":42},"Marmara University Pendik Training and Research Hospital",{"id":408,"slug":409,"hasResults":12,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":413,"eligibilityCriteria":414,"healthyVolunteers":191,"sex":18,"minAge":19,"maxAge":293,"enrollmentInfo":415,"targetDuration":4,"studyType":23,"phases":417,"briefSummary":418,"conditions":419,"keywords":422,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":427,"lastUpdatePostDateStruct":428,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":43},"100615344","effectiveness-of-retrolaminar-block-in-lumbar-spine-fusion-with-multimodal-analgesia-100615344","NCT07291388","Effectiveness of Retrolaminar Block in Lumbar Spine Fusion With Multimodal Analgesia","Effectiveness of Retrolaminar Block in Reducing Postoperative Opioid Consumption in Patients Undergoing Lumbar Spine Fusion With Multimodal Analgesia","RBLUF","Inclusion Criteria:\n\n* Adults aged 18-75 years, scheduled for lumbar spine fusion surgery by a trauma team\n* American Society of Anesthesiologists (ASA) Classification I-III\n* Willing and able to provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* History of chronic use of strong or weak opioids for more than 3 months.\n* Diagnosis of chronic pain and treatment by a pain management team.\n* ASA score greater than or equal to 4.\n* Patients with prior lumbar spine surgery. Spinal instrumentation at the surgical site.\n* Estimated creatinine clearance less than 60 ml\u002Fmin.\n* Coagulation disorder or abnormal coagulation tests.\n* Infection at the surgical site.\n* Weight less than 50 kg.\n* Altered mental status that prevents reliable evaluation.\n* Allergy to local anesthetics or analgesic drugs used in the study.\n* Patients with contraindications to peripheral nerve blocks.\n* Lumbar spine fixation due to oncologic disease or acute trauma.\n* Use of intraoperative neuromonitoring and TIVA.",{"count":416,"type":22},44,[115],"This randomized, blinded, controlled clinical trial aims to evaluate the effectiveness of ultrasound-guided retrolaminar block in reducing postoperative opioid consumption in patients undergoing lumbar spine fusion surgery under multimodal analgesia.\n\nThe participants will:\n\n* Be randomly assigned in a 1:1 ratio to receive either a retrolaminar block with 0.25% bupivacaine plus epinephrine or a sham block (normal saline) prior to surgical incision.\n* Receive standardized multimodal analgesia.\n* Have follow-up by the Acute Pain Unit during the first 3 days, to assess opioid consumption (morphine) in 24 hours, pain intensity measured by Numeric Rating Scale, quality of recovery assessed by the QoR-15 questionnaire, intraoperative blood loss, and postoperative complications.",[420,29,421],"Acute Pain","Lumbar Spine Disease",[423,424,425,426],"acute pain","retrolaminar block","regional anesthesia","lumbar arthrodesis","2026-07-01",{"date":399,"type":35},{"date":430,"type":35},"2026-06-30",{"date":432,"type":22},"2027-03",{"name":434,"class":42},"Pontificia Universidad Catolica de Chile",{"id":436,"slug":437,"hasResults":12,"nctId":438,"briefTitle":439,"officialTitle":439,"acronym":440,"eligibilityCriteria":441,"healthyVolunteers":191,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":442,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":444,"conditions":445,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":43},"100642858","clinical-performance-and-multitasking-in-anesthesia--a-simulation-based-study-100642858","NCT07615582","Clinical Performance and Multitasking in Anesthesia : a Simulation-based Study","FOCUS","Inclusion Criteria:\n\n* Anesthesiology and intensive care resident or attending physician\n* Written informed consent\n\nExclusion Criteria:\n\n* None",{"count":443,"type":22},35,"Cognitive failure under multitasking conditions has been demonstrated in various settings, including healthcare. However, in anesthesiology, the impact of multitasking on clinical performance has not yet been fully characterized.\n\nThe objective of our study is to evaluate the impact of multitasking on anesthesiologists' clinical performance in a simulated setting.",[446,447,448,57,449,29],"Multitasking Behavior and Multitasking Ability","Clinical Performance","Simulation Training","Clinical Reasoning",{"date":451,"type":35},"2026-07-02",{"date":453,"type":35},"2026-06-09",{"date":455,"type":22},"2026-12",{"name":457,"class":42},"University Hospital, Grenoble",{"id":459,"slug":460,"hasResults":12,"nctId":461,"briefTitle":462,"officialTitle":463,"acronym":4,"eligibilityCriteria":464,"healthyVolunteers":191,"sex":83,"minAge":19,"maxAge":4,"enrollmentInfo":465,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":467,"conditions":468,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":43},"100646960","upper-vs-lower-extremity-bp-in-spinal-cesarean-using-clearsight-100646960","NCT07685730","Upper vs Lower Extremity BP in Spinal Cesarean Using ClearSight","Comparative Analysis of the Predictive Performance of Noninvasive Beat-by-Beat Blood Pressure and Flow Measurements at the Lower Extremity Versus the Upper Extremity for Neonatal Outcomes Under Spinal Anesthesia for Elective Cesarean Delivery","Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Singleton pregnancy\n* Gestational age ≥ 37 weeks\n* Women undergoing CD under SAB or Combined Spinal-Epidural (CSE) electively.\n* Ability to consent in English and in Spanish language\n\nExclusion Criteria:\n\n* CD under or converted to general anesthesia\n* CD under epidural anesthesia or converted to epidural anesthesia\n* Diabetes Mellitus (DM)\u002FGestational Diabetes Mellitus (GDM)\n* Evidence of unstable cardiac disease other than HDP (including chronic hypertension, gestational hypertension, preeclampsia-eclampsia, and chronic hypertension with superimposed preeclampsia) judged by the investigator to have any impact on BP will make the subject unsuitable for participation in the study\n* Documented fetal anomaly\u002F congenital malformations and genetic syndromes\n* Intrauterine growth retardation\n* Unable to consent in English\u002FSpanish.\n* Prisoners",{"count":466,"type":22},327,"This is a single-center, prospective observational study in patients undergoing cesarean delivery under spinal or combined spinal-epidural anesthesia. It compares whether continuous noninvasive hemodynamic measurements from the lower extremity (toe) better predict neonatal outcomes than upper extremity (arm\u002Ffinger) measurements during spinal-induced hypotension.\n\nParticipants receive standard spinal anesthesia and routine blood pressure management, with additional monitoring using the ClearSight™ system at both upper and lower extremities from before spinal anesthesia through delivery.\n\nThe primary outcome is a composite of neonatal outcomes (APGAR scores, need for respiratory support, cord gases, and NICU admission). Secondary outcomes include maternal side effects and comfort.\n\nOverall, the study evaluates whether lower-extremity hemodynamic monitoring improves detection of clinically relevant hypotension and prediction of neonatal outcomes compared to traditional arm measurements.",[29,469,470],"Pregnancy Related","Blockades Neuromuscular","2026-06-29",{"date":399,"type":35},{"date":474,"type":35},"2025-02-06",{"date":476,"type":22},"2029-08-06",{"name":478,"class":42},"Ohio State University",{"id":480,"slug":481,"hasResults":12,"nctId":482,"briefTitle":483,"officialTitle":484,"acronym":485,"eligibilityCriteria":486,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":487,"targetDuration":4,"studyType":23,"phases":489,"briefSummary":490,"conditions":491,"keywords":494,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":501,"startDateStruct":502,"completionDateStruct":504,"leadSponsor":506,"locationsCount":43},"100635864","multimodal-anesthesia-in-robotic-laparoscopic-nephrectomy-100635864","NCT07558226","Multimodal Anesthesia in Robotic Laparoscopic Nephrectomy","Efficacy of Multimodal Anesthesia in Robotic Laparoscopic Nephrectomy: Impact on Recovery and Early Hospital Discharge.","MANTRA","Inclusion Criteria:\n\n* Patients ≥18 years.\n* Indication for elective oncological robotic partial or radical nephrectomy.\n* ASA classification I-III.\n* Candidates for short-stay surgery according to institutional protocol.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Chronic opioid use. Defined as continuous opioid use during the 3 months prior to surgery\n* Uncontrolled chronic pain. Defined as chronic pain not adequately controlled with usual treatment during the 3 months prior to surgery.\n* Contraindications to NSAIDs, regional anesthesia, or drugs of the multimodal protocol.\n* Advanced renal failure (GFR \\\u003C30 ml\u002Fmin) at the preanesthetic visit.",{"count":488,"type":22},80,[115],"It is a prospective, randomized, controlled and superiority clinical trial, with the objective of comparing the effectiveness of multimodal anesthesia versus conventional anesthesia in patients undergoing oncological robotic nephrectomy within a short-stay surgery program (SSA). The effect of no specific drug will be evaluated, but rather the anesthetic approach ologies of surgical patients. The clinical trial will be carried out in a third-level university hospital, between the first half of 2026 and the second half of 2027 and, after approval by the corresponding Clinical Research Ethics Committee.",[29,492,493],"Anesthesia and Procedure Related Time Intervals","Nephrectomy \u002F Methods",[495,496,497,29,498,499,500],"laparoscopic nephrectomy robotic","multimodal anesthesia","early hospital discharge","Multimodal","Nephrectomy","Robotic",{"date":427,"type":35},{"date":503,"type":35},"2026-05-02",{"date":505,"type":22},"2027-11-30",{"name":507,"class":42},"Fundacio Puigvert",{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":512,"acronym":513,"eligibilityCriteria":514,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":515,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":517,"conditions":518,"keywords":532,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":538,"leadSponsor":539,"locationsCount":43},"100642312","risk-factors-of-atrial-fibrillation-after-cardiac-surgery-100642312","NCT07625033","Risk Factors of Atrial Fibrillation After Cardiac Surgery","PFAS","Inclusion Criteria:\n\n* age \\>18\n* having undergone a scheduled cardiac surgery in the study center\n* having agreed to the reuse of their hospital care data\n\nExclusion Criteria:\n\n* Atrial fibrillation at the admission in hospital.",{"count":516,"type":22},918,"Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death. Preventing the occurrence of these arrhythmias is a major challenge. This study aims to investigate risk factors and protective factors regarding atrial fibrillation and other iatrogenic cardiac arrhythmias after cardiac surgery, particularly innovative anesthetic strategies such as stellar ganglion blockade which have been recently implemented in our center.",[30,519,520,521,522,523,524,525,526,527,528,529,29,530,531],"Peri Operative Medicine","Thoracic Surgery","Cardiopulmonary Bypass","Coronary Artery Bypass","Heart Valve Prosthesis Implantation","Aortic Valve Replacement","Perioperative Medicine","Preoperative Care","Intraoperative Care","Postoperative Care","Enhanced Recovery After Surgery","Cardiac Anesthesia","Intensive Care Unit",[533],"Stellar Ganglion Blockade, SGB, cardiac surgery","2026-06-23",{"date":536,"type":35},"2026-06-25",{"date":427,"type":22},{"date":427,"type":22},{"name":540,"class":42},"Centre Hospitalier Régional Metz-Thionville",{"id":542,"slug":543,"hasResults":12,"nctId":544,"briefTitle":545,"officialTitle":546,"acronym":4,"eligibilityCriteria":547,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":548,"targetDuration":4,"studyType":23,"phases":549,"briefSummary":550,"conditions":551,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":554,"lastUpdatePostDateStruct":555,"startDateStruct":557,"completionDateStruct":558,"leadSponsor":559,"locationsCount":4},"100642447","remifentanil-vs-nicardipine-for-controlled-hypotension-in-elective-nasal-surgery-100642447","NCT07660562","Remifentanil vs. Nicardipine for Controlled Hypotension in Elective Nasal Surgery","Comparison of Remifentanil and Nicardipine Infusions for Controlled Hypotension in Elective Nasal Surgery Where Bleeding Control is Critical: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\> 18 years\n* ASA physical status I-II\n* Scheduled for elective nasal surgery\n* No known serious cardiovascular, respiratory, renal, or hepatic disease\n* No known allergy to remifentanil or nicardipine\n* No chronic use of beta-blockers, calcium channel blockers, or antihypertensive agents\n* Not pregnant or breastfeeding\n* BMI ≤ 35 kg\u002Fm²\n* No emergency surgical indication\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* ASA III or above\n* Known serious cardiovascular, respiratory, renal, or hepatic disease\n* Known allergy to remifentanil or nicardipine\n* Chronic use of beta-blockers, calcium channel blockers, or antihypertensive agents\n* Pregnancy or breastfeeding\n* Morbid obesity (BMI \\> 35 kg\u002Fm²)\n* Emergency surgery\n* Refusal to participate",{"count":416,"type":22},[115],"This study compares remifentanil infusion versus nicardipine infusion for controlled hypotension during elective nasal surgery. Both agents are standard clinical methods. The study evaluates hemodynamic stability, surgical field quality (Fromme-Boezaart score), tissue perfusion, intraoperative blood loss, surgeon satisfaction, and perioperative adverse effects.",[552,29,553],"Nasal Surgery","Controlled Hypotension for Nasal Surgeries","2026-06-16",{"date":556,"type":35},"2026-06-22",{"date":536,"type":22},{"date":371,"type":22},{"name":560,"class":42},"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital",{"id":562,"slug":563,"hasResults":12,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":4,"eligibilityCriteria":567,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":568,"targetDuration":4,"studyType":23,"phases":569,"briefSummary":570,"conditions":571,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":554,"lastUpdatePostDateStruct":572,"startDateStruct":573,"completionDateStruct":575,"leadSponsor":576,"locationsCount":43},"100642251","cerebral-oximetry-guided-low-fio2-strategies-in-thoracic-surgery-100642251","NCT07659483","Cerebral Oximetry-Guided Low FiO2 Strategies in Thoracic Surgery.","Safety and Efficacy of Cerebral Oximetry-Guided Low FiO2 Strategies in Thoracic Surgery","Inclusion Criteria:\n\n* Patients aged 18 years or older. Scheduled for elective thoracic surgery requiring one-lung ventilation (OLV). American Society of Anesthesiologists (ASA) Physical Status classification I-III.\n\nExclusion Criteria:\n\n* History of cerebrovascular disease. Left ventricular ejection fraction Pulmonary hypertension. Interstitial lung disease.\n\nRenal failure. Neuromuscular disease. Pregnancy. Expected OLV duration less than 30 minutes (\\\u003C 30 min)",{"count":295,"type":22},[115],"Brief Summary (Kısa Özet)The purpose of this study is to evaluate the safety and efficacy of a cerebral oximetry-guided low fraction of inspired oxygen (FiO\\_2) ventilation strategy compared to a standard high FiO\\_2 strategy in patients undergoing elective thoracic surgery requiring one-lung ventilation (OLV).Oxygen toxicity and related postoperative pulmonary complications remain significant risks during thoracic anesthesia. While standard protocols often rely on high inspired oxygen concentrations to maintain peripheral oxygen saturation (SpO\\_2), this approach may induce hyperoxia. Conversely, lowering FiO\\_2 arbitrarily can increase the risk of hypoxemia or compromise tissue oxygenation. This prospective, parallel-group, 1:1 randomized, single-blind clinical trial aims to safely reduce intraoperative oxygen exposure by using regional cerebral oxygen saturation (rSO\\_2) monitoring as a physiological guide.A total of 60 participants aged 18 and older, classified as ASA I-III and scheduled for elective thoracic surgery, will be randomly assigned to one of two arms:Experimental Group (Guided Low FiO\\_2 Strategy): Ventilation will be initiated at a low FiO\\_2 of 0.5. The FiO\\_2 level will not be increased unless peripheral saturation (SpO\\_2) falls below 90% or cerebral oxygenation (rSO\\_2) drops below 80% of the patient's baseline value.Active Comparator Group (Standard Strategy): Patients will receive conventional anesthesia management, maintaining standard high FiO\\_2 levels to keep SpO\\_2 above 90% without cerebral oximetry guidance.The primary outcomes to be measured are the incidence of cerebral desaturation during the perioperative period and the incidence of postoperative delirium assessed via the 3D-CAM tool until hospital discharge. Secondary outcomes include intraoperative hemodynamic stability, arterial blood gas parameters (PaO\\_2, PaCO\\_2, pH, lactate), incidence of hypoxemia, total one-lung ventilation duration, postoperative cognitive dysfunction (POCD), and lengths of stay in both the intensive care unit (ICU) and the hospital.By utilizing real-time non-invasive cerebral oximetry, the study intends to demonstrate a safe ventilation protocol that minimizes oxygen toxicity without compromising cerebral oxygenation or clinical recovery outcomes.",[520,29],{"date":556,"type":35},{"date":574,"type":22},"2026-06-15",{"date":67,"type":22},{"name":577,"class":42},"Dicle University",{"id":579,"slug":580,"hasResults":12,"nctId":581,"briefTitle":582,"officialTitle":583,"acronym":4,"eligibilityCriteria":584,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":585,"targetDuration":4,"studyType":23,"phases":586,"briefSummary":587,"conditions":588,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":554,"lastUpdatePostDateStruct":590,"startDateStruct":591,"completionDateStruct":592,"leadSponsor":594,"locationsCount":43},"100642156","remifentanil-monotherapy-vs-remifentanil-nicardipine-for-controlled-hypotension-in-otolaryngological-surgery-100642156","NCT07659496","Remifentanil Monotherapy vs. Remifentanil-Nicardipine for Controlled Hypotension in Otolaryngological Surgery","The Effects of Remifentanil Monotherapy Versus Remifentanil-Nicardipine Combination on Advanced Hemodynamic Parameters for Controlled Hypotension During Otolaryngological Surgery","Inclusion Criteria:\n\n* Patients aged \\> 18 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled to undergo otolaryngological surgery under general anesthesia\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Aged \\\u003C 18 years\n* ASA physical status III or higher\n* Known severe cardiovascular (coronary artery disease, heart failure, uncontrolled hypertension), respiratory, renal, or hepatic disease\n* Known allergy to the study drugs (remifentanil, nicardipine)\n* Chronic use of beta-blockers, calcium channel blockers, or any other medication affecting blood pressure\n* Pregnancy or breastfeeding\n* Morbid obesity\n* Emergency surgery requirement\n* Refusal to participate in the study",{"count":295,"type":22},[115],"Controlled hypotension is a widely employed technique in otolaryngological (ear, nose, and throat) surgery, primarily aimed at improving surgical field visibility and minimizing intraoperative blood loss. By maintaining mean arterial pressure within a targeted range, this approach facilitates a clearer operative field, reduces the need for blood transfusion, and shortens operative time, thereby contributing to improved surgical outcomes.\n\nAmong the pharmacological agents used to achieve controlled hypotension, remifentanil - an ultra-short-acting synthetic opioid - has gained widespread acceptance due to its rapid onset, predictable offset, and favorable hemodynamic profile. Nicardipine, a second-generation dihydropyridine calcium channel blocker, is also utilized for its potent vasodilatory properties and titratable antihypertensive effect. When used in combination, these two agents may offer complementary mechanisms of action; however, their combined impact on advanced hemodynamic parameters remains insufficiently characterized in the otolaryngological surgical setting.\n\nThe primary aim of this study is to compare the effects of remifentanil monotherapy versus remifentanil-nicardipine combination therapy on advanced hemodynamic parameters, cardiac physiology, and tissue perfusion in patients undergoing controlled hypotension during otolaryngological surgery. Advanced hemodynamic monitoring - including parameters such as cardiac output, stroke volume, systemic vascular resistance, and oxygen delivery indices - will provide a more comprehensive physiological assessment beyond conventional blood pressure measurements.\n\nAs secondary objectives, this study will evaluate and compare both regimens with respect to surgical field quality, surgeon satisfaction, intraoperative hemodynamic stability, and perioperative adverse effects. It is anticipated that a thorough comparative analysis of these two approaches will contribute to evidence-based anesthetic decision-making and help optimize patient safety and surgical outcomes in otolaryngological procedures.",[589,29],"Otolaryngological Surgery",{"date":556,"type":35},{"date":430,"type":22},{"date":593,"type":22},"2026-08-30",{"name":577,"class":42},{"id":596,"slug":597,"hasResults":12,"nctId":598,"briefTitle":599,"officialTitle":600,"acronym":4,"eligibilityCriteria":601,"healthyVolunteers":12,"sex":602,"minAge":19,"maxAge":4,"enrollmentInfo":603,"targetDuration":4,"studyType":23,"phases":604,"briefSummary":605,"conditions":606,"keywords":609,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":574,"lastUpdatePostDateStruct":614,"startDateStruct":615,"completionDateStruct":617,"leadSponsor":619,"locationsCount":621},"100642494","spinal-versus-general-anesthesia-in-open-simple-prostatectomy-100642494","NCT07643415","Spinal Versus General Anesthesia in Open Simple Prostatectomy","Effect of Spinal Versus General Anesthesia on Postoperative Bleeding in Patients Undergoing Open Simple Prostatectomy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Male patients aged 18 years or older.\n* Diagnosis of benign prostatic hyperplasia (BPH).\n* Scheduled to undergo open simple prostatectomy.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Refusal or inability to provide informed consent.\n* Patients scheduled for radical prostatectomy due to prostate cancer.\n* Emergency surgery.\n* Known coagulation disorders or clinically significant thrombocytopenia.\n* Ongoing anticoagulant or antiplatelet therapy that cannot be discontinued according to institutional protocols.\n* Contraindication to spinal anesthesia.\n* Participation in another interventional clinical trial that may affect study outcomes.\n* Administration of tranexamic acid or any additional hemostatic agent during the perioperative period.","MALE",{"count":488,"type":22},[115],"Open simple prostatectomy is still performed for selected patients with benign prostatic hyperplasia, particularly in cases with large prostate volume. Postoperative bleeding, hematuria, clot retention, and transfusion requirement are clinically important complications after this procedure.\n\nThis prospective randomized controlled trial will compare the effects of spinal anesthesia and general anesthesia on postoperative bleeding in patients undergoing open simple prostatectomy. Participants will be randomized into two groups: spinal anesthesia or general anesthesia. Tranexamic acid or any additional hemostatic agent will not be used. Postoperative bleeding will be assessed using hemoglobin and hematocrit changes, transfusion requirement, hematuria, clot retention, need for bladder irrigation, and bleeding-related reintervention.\n\nThe study aims to determine whether spinal anesthesia is associated with reduced postoperative bleeding compared with general anesthesia in open simple prostatectomy.",[607,608,29],"Urologic Neoplasms","Benign Prostatic Hyperplasia",[610,611,612,613],"Open simple prostatectomy","Spinal anesthesia","general anesthesia","postoperative bleeding",{"date":554,"type":35},{"date":616,"type":35},"2026-04-29",{"date":618,"type":22},"2026-09-15",{"name":620,"class":42},"Hitit University",2,{"id":623,"slug":624,"hasResults":12,"nctId":625,"briefTitle":626,"officialTitle":627,"acronym":4,"eligibilityCriteria":628,"healthyVolunteers":12,"sex":18,"minAge":629,"maxAge":630,"enrollmentInfo":631,"targetDuration":4,"studyType":23,"phases":633,"briefSummary":634,"conditions":635,"keywords":642,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":650,"lastUpdatePostDateStruct":651,"startDateStruct":652,"completionDateStruct":654,"leadSponsor":656,"locationsCount":43},"100431190","phase-4-opioid-free-anesthesia-analgesia-strategy-and-surgical-stress-in-elective-open-abdominal-aortic-aneurysm-repair-100431190","NCT04894864","Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study","Inclusion Criteria:\n\n1. Patient Consent\n2. Age between 40 and 85 years old\n3. Patients undergoing Elective Open Abdominal Aortic Infrarenal Aneurysm Repair\n\nExclusion Criteria:\n\n1. Immunocompromised patients\n2. Patients with active infection\n3. Reoperation on the aorta\n4. Inflammatory bowel Disease\n5. Malignancy\n6. Chronic Inflammatory conditions (e.g. Rheymatoid arthritis, Psoriatic arthritis)\n7. Chronic corticosteroid or immunosuppressive drug use\n8. Intraoperative transfusion with \\>2 units of packed Red Blood Cells","40 Years","85 Years",{"count":632,"type":22},40,[25],"Open Abdominal Aortic Aneurysm (AAA) repair is a high-risk surgical procedure accompanied by intense endocrine and metabolic responses to surgical stress, with subsequent activation of the inflammatory cascade, cytokine and acute-phase protein release, and bone marrow activation. There is a proven correlation of surgical stress, which patients undergoing open AAA repair are subjected to, with patient outcome, morbidity\u002Fmortality, intensive care unit stay and overall length of stay. Modern general anesthetic techniques have been revised and rely on perioperative multimodal anesthetic and analgesic strategies for improved overall patient outcome. Based on this context of a multimodal anesthetic technique and having taken into consideration the international \"opioid-crisis\" epidemic, an Opioid Free Anesthesia-Analgesia (OFA-A) strategy started to emerge. It is based on the administration of a variety of anesthetic\u002Fanalgesic agents with different mechanisms of action, including immunomodulating and anti-inflammatory effects.\n\nOur basic hypothesis is that the implementation of a perioperative multimodal OFA-A strategy, involving the administration of pregabalin, ketamine, dexmedetomidine, lidocaine, dexamethasone, dexketoprofen, paracetamol and magnesium sulphate, will lead to attenuation of surgical stress response compared to a conventional Opioid-Based Anesthesia-Analgesia (OBA-A) strategy. Furthermore, the anticipated attenuation of the inflammatory response, is pressumed to be associated with equal or improved analgesia, compared to a perioperative OBA-A technique.",[636,360,29,637,638,639,640,641],"Elective Surgical Procedures","Opioid Use","Abdominal Aortic Aneurysm Without Rupture","Vascular Surgical Procedure","Interleukin 6","Immunomodulators",[643,644,645,646,647,648,649],"Opioid-free Anesthesia-Analgesia","Cytokines","Opioid-based Anesthesia-Analgesia","Haemodynamic Stability","Open Abdominal Aortic Aneurysm Repair","Immunomodulation","Inflammatory Markers","2026-06-13",{"date":554,"type":35},{"date":653,"type":35},"2020-10-08",{"date":655,"type":22},"2027-09-01",{"name":657,"class":42},"University of Crete",{"id":659,"slug":660,"hasResults":12,"nctId":661,"briefTitle":662,"officialTitle":663,"acronym":664,"eligibilityCriteria":665,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":666,"targetDuration":668,"studyType":52,"phases":4,"briefSummary":669,"conditions":670,"keywords":674,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":686,"lastUpdatePostDateStruct":687,"startDateStruct":689,"completionDateStruct":691,"leadSponsor":693,"locationsCount":43},"100641518","prospective-multicentre-observational-registry-of-peri-procedural-anaesthesia-sedation-and-related-medication-exposure-in-patients-with-brugada-syndrome-100641518","NCT07655102","Prospective Multicentre Observational Registry of Peri-procedural Anaesthesia, Sedation and Related Medication Exposure in Patients With Brugada Syndrome","BRUGADA-ANAESTHESIA Registry: Prospective Multicentre Observational Registry of Peri-procedural Anaesthesia, Sedation and Related Medication Exposure in Patients With Brugada Syndrome","PROSP_BRUGANAE","Patients should match all the inclusion criteria to be entered for data collection:\n\n* Documented type 1 Brugada ECG pattern (spontaneous, fever-related, or induced by sodium-channel blocker challenge\u002Fother recognised provocation test) with a diagnosis considered compatible with Brugada syndrome by the treating cardiology team.\n* Undergoing general anaesthesia, monitored sedation, loco-regional anaesthesia for any surgical, diagnostic, interventional, obstetric or other non-surgical procedure (including epidural analgesia for labour and sedation for endoscopy).\n\nPatients with one or more exclusion criteria will not be included for data collection and analysis:\n\n* No documented type 1 Brugada ECG pattern, uncertain diagnosis without sufficient supporting data.\n* Refusal to participate in the study.",{"count":667,"type":22},200,"30 Days","The goal of this observational study is to evaluate the perioperative risk of malignant ventricular arrhythmias in adult patients diagnosed with Brugada Syndrome undergoing anaesthetic procedures. Brugada Syndrome is a rare inherited cardiac condition associated with an increased risk of life-threatening arrhythmias, and perioperative management remains challenging due to limited high-quality evidence.\n\nThe main questions it aims to answer are:\n\n* What is the incidence of malignant ventricular arrhythmias during anaesthesia and up to 30 days after the procedure?\n* Are anaesthetic drugs traditionally considered \"non-recommended\" associated with an increased risk of perioperative arrhythmic events?\n\nResearchers will also explore the relative contribution of anaesthetic drugs versus perioperative physiological factors (e.g., haemodynamic changes, fever, bradycardia) in triggering arrhythmias.\n\nParticipants will:\n\n* Undergo anaesthetic procedures (general, locoregional, or sedation) as part of routine clinical care\n* Have clinical data collected prospectively from electronic medical records during the perioperative period\n* Be followed for 30 days after the procedure to assess outcomes, including arrhythmias, complications, ICU admission, and mortality\n\nThis is a multicentre, prospective observational registry, and no additional interventions or changes to standard clinical practice will be performed.",[671,672,29,673],"Brugada Syndrome (BrS)","Ventricular Arrhythmia","Sedation",[675,676,29,677,678,679,680,681,682,683,684,685],"Brugada Syndrome","Anaesthesia","Perioperative Care","Ventricular Arrhythmias","Cardiac Arrhythmias","Perioperative Risk","Anesthetic Drugs","Propofol","Sodium Channel Blockers","Observational Registry","Multicentre Study","2026-06-12",{"date":688,"type":35},"2026-06-17",{"date":690,"type":22},"2026-07-20",{"date":692,"type":22},"2028-12-20",{"name":694,"class":42},"Hospital Clinic of Barcelona"]