[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anisometropic-amblyopia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anisometropic-amblyopia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100650865","combining-noninvasive-brain-stimulation-and-augmented-reality-based-dichoptic-therapy-for-treating-amblyopic-adults-100650865",false,"NCT07752433","Combining Noninvasive Brain Stimulation and Augmented Reality-based Dichoptic Therapy for Treating Amblyopic Adults","NiBS4Vision","Inclusion Criteria:\n\n* Age between 18 and 35 years.\n* Diagnosis of anisometropic amblyopia.\n* Unilateral amblyopia with an interocular difference of at least 2 lines in best-corrected visual acuity, with visual acuity worse than 20\u002F32 in the worse-seeing eye.\n\nExclusion Criteria:\n\n* Any type of amblyopia other than anisometropic amblyopia.\n* Bilateral amblyopia.\n* Ophthalmological or neuro-ophthalmological disease other than amblyopia.\n* Neurological disease.\n* Chronic pharmacological treatment.\n* Presence of an implanted medical device.\n* Any ocular surgery or treatment within the previous year.\n* Significant ocular media opacities.\n* Previous treatment with transcranial direct current stimulation or another non-invasive brain stimulation technique.\n* Pregnancy or planning to become pregnant during the study period.\n* Inability to provide informed consent.\n* History of head trauma, seizures, or frequent headaches.\n* Electrical or electronic implants, such as a cardiac pacemaker.\n* Metallic objects or implants in the head, except dental implants.","ALL","18 Years","40 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn whether adding noninvasive brain stimulation to augmented reality-based vision therapy can improve vision in adults aged 18 to 40 years with unilateral anisometropic amblyopia, commonly called \"lazy eye.\" Anisometropic amblyopia develops during childhood when the two eyes have different focusing powers and the brain relies more on one eye than the other.\n\nThe main questions this study aims to answer are:\n\n* Does active high-definition transcranial direct current stimulation (HD-tDCS) improve best-corrected visual acuity in the amblyopic eye and depth perception more than sham stimulation?\n* Does the combined treatment improve contrast sensitivity, suppression between the eyes, and measures of retinal and visual brain function?\n\nAll participants will receive the same augmented reality-based dichoptic therapy. This therapy presents different visual information to each eye and lowers the contrast seen by the stronger eye. This gives the weaker, amblyopic eye a visual advantage and encourages both eyes to work together while participants carry out normal daily activities.\n\nDuring the first 2 weeks, participants will also receive either active HD-tDCS or sham stimulation immediately before the augmented reality therapy. Active HD-tDCS delivers a weak electrical current through small electrodes placed on the scalp. Sham stimulation uses the same equipment and procedures, but the current is applied only briefly at the beginning. Comparing the two groups will help researchers determine whether active brain stimulation provides additional benefits beyond those of augmented reality therapy alone.\n\nParticipants will:\n\n* Complete 40-minute augmented reality therapy sessions four times per week for 10 weeks.\n* Receive eight 20-minute sessions of active or sham HD-tDCS during the first 2 weeks, immediately before the augmented reality therapy.\n* Attend assessment visits before treatment, after 2 weeks, and after 10 weeks. These visits will include vision tests, retinal imaging, tests of retinal function, and brain imaging.",[27,28],"Amblyopia","Anisometropic Amblyopia",[30,28,31,32,33,34,35,36,37,38],"Adult Amblyopia","Dichoptic Therapy","Augmented Reality","Transcranial Direct Current Stimulation","High-Definition Transcranial Direct Current Stimulation","Noninvasive brain stimulation","Visual rehabilitation","Binocular vision","Neuroplasticity","RECRUITING","2026-08-03",{"date":42,"type":43},"2026-08-07","ACTUAL",{"date":45,"type":43},"2025-05-01",{"date":47,"type":21},"2028-04-30",{"name":49,"class":50},"Polytechnic Institute of Porto","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":4},"100636304","3d-movie-viewing-vs-occlusion-for-treating-amblyopia-in-children-100636304","NCT07563946","3D Movie Viewing vs Occlusion for Treating Amblyopia in Children","Efficacy of 3D Movie Viewing Versus Occlusion on Stereopsis and Visual Function in Children With Amblyopia: A Randomized Controlled Trial","VISTA3D","Inclusion Criteria:\n\nChildren aged 4 to 14 years Diagnosis of unilateral amblyopia (anisometropic, strabismic, or mixed) Interocular visual acuity difference ≥ 0.2 logMAR (equivalent to ≥ 2 Snellen lines) Ability to understand and follow age-appropriate instructions Written informed consent from parents or legal guardians Child assent obtained when applicable\n\nExclusion Criteria:\n\nPrevious treatment for amblyopia Ocular surgery within the last 6 months Strabismus with deviation greater than 10 prism diopters Presence of other ocular pathologies affecting vision (e.g., cataract, nystagmus, ptosis, corneal opacity, retinal disease, optic neuropathy) Neurological or cognitive impairment preventing compliance with study procedures Prior intensive exposure to 3D movies or virtual reality\u002F3D video games that could act as a confounding factor Refusal of the child or family to participate","4 Years","14 Years",{"count":63,"type":21},56,[24],"Amblyopia is a common childhood visual disorder that affects vision in one eye and can also impair depth perception (stereopsis). Standard treatment typically involves occlusion therapy (patching the stronger eye), which improves visual acuity but often does not fully restore binocular vision.\n\nThis study aims to evaluate whether watching 3D movies, combined with occlusion therapy, improves visual outcomes more than occlusion therapy alone in children with amblyopia. The immersive nature of 3D content may stimulate binocular vision and enhance treatment effectiveness.\n\nIn this randomized controlled trial, children aged 4 to 14 years with amblyopia will be assigned to one of two groups: one group will receive standard occlusion therapy, while the other will receive occlusion combined with weekly 3D movie sessions. After an initial phase, all participants will have access to 3D viewing sessions.\n\nThe study will assess improvements in depth perception, visual acuity, and eye alignment over time. The goal is to determine whether this combined approach provides additional benefits and could be used as a complementary therapy for amblyopia.",[28,67],"Strabismic Amblyopia",[27,69,70,71,72,73,74],"Stereopsis","3D Movie Viewing","Occlusion Therapy","Strabismus","Anisometropia","Binocular Treatment","NOT_YET_RECRUITING","2026-04-26",{"date":78,"type":43},"2026-05-04",{"date":80,"type":21},"2026-05-01",{"date":82,"type":21},"2027-06-01",{"name":84,"class":50},"Universitat Politècnica de Catalunya"]