[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anorectal-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anorectal-diseases":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,83,115],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100642940","phase-1-research-on-the-efficacy-and-mechanism-of-shouhui-tongbian-capsules-in-treating-postoperative-constipation-of-benign-anal-and-rectal-diseases-based-on-gut-microbiota-analysis-100642940",false,"NCT07648394","Research on the Efficacy and Mechanism of Shouhui Tongbian Capsules in Treating Postoperative Constipation of Benign Anal and Rectal Diseases Based on Gut Microbiota Analysis","Inclusion Criteria:\n\nSurgical indication for a benign anorectal disease, including hemorrhoids or anal fistula Diagnosis of postoperative constipation after benign anorectal surgery Postoperative constipation symptoms such as difficulty defecating, reduced bowel movement frequency, hard or lumpy stools, incomplete evacuation, anorectal obstruction, or abdominal distension Ability to tolerate the planned anorectal surgical procedure without related contraindications Consciousness and ability to cooperate with treatment, follow-up, and questionnaire assessments Written informed consent provided by the participant or legally authorized representative Age 18 to 75 years, inclusive\n\nExclusion Criteria:\n\nSevere systemic disease, including serious psychiatric or immune disorders Severe infection Malignant tumor Severe organic disease of a major organ, including the heart, liver, or kidneys Pregnancy Breastfeeding Postpartum period Coagulation dysfunction Other anorectal disease that may affect outcome assessment Known allergy to either study treatment or any treatment component Any other condition considered by the investigators to make participation unsuitable","ALL","18 Years","75 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE1","PHASE2","The goal of this clinical trial is to evaluate whether Shouhui Tongbian Capsule can improve postoperative constipation in adults aged 18 to 75 years after surgery for benign anorectal diseases, including hemorrhoids and anal fistula. The clinical trial will also evaluate the safety of Shouhui Tongbian Capsule and explore associations between treatment effects and changes in gut microbiota, metabolic profiles, and inflammatory indicators.\n\nThe main questions are:\n\nDoes Shouhui Tongbian Capsule improve constipation symptoms after benign anorectal surgery? Does Shouhui Tongbian Capsule reduce postoperative and defecation-related pain? Does Shouhui Tongbian Capsule improve quality of life and anorectal function? What adverse events occur during treatment? Are clinical improvements associated with changes in gut microbiota, metabolic profiles, or inflammatory indicators?\n\nResearchers will compare Shouhui Tongbian Capsule with lactulose to evaluate differences in efficacy and safety for postoperative constipation.\n\nParticipants will:\n\nReceive either Shouhui Tongbian Capsule three times daily or lactulose once daily for 14 days Complete assessments of constipation symptoms, pain, quality of life, and anorectal function Provide stool and blood samples before treatment and on Day 14 Attend assessments during treatment and approximately 1 month after surgery Report adverse events and other medical problems during participation",[27,28,29,30],"Intestinal Flora","Anorectal Diseases","Surgery","Constipation","NOT_YET_RECRUITING","2026-07-21",{"date":34,"type":35},"2026-07-22","ACTUAL",{"date":37,"type":20},"2026-08-01",{"date":39,"type":20},"2027-06-30",{"name":41,"class":42},"China-Japan Friendship Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":52,"targetDuration":54,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":43},"100643888","glp-1-receptor-agonists-and-early-proctologic-effects-in-morbid-obesity-100643888","NCT07668765","GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity","Early Proctologic Effects of GLP-1 Receptor Agonist Therapy in Morbidly Obese Patients: A Prospective Cohort Study With Baseline and 3-Month Proctologic Assessment","GLP-PROCT","Inclusion Criteria:\n\n* Age ≥18 years\n* Morbid obesity (BMI ≥40 kg\u002Fm² or BMI ≥35 kg\u002Fm² with obesity-related comorbidities)\n* Newly prescribed GLP-1 receptor agonist therapy\n* Ability and willingness to provide written informed consent\n* Ability to attend 3-month follow-up visit\n\nExclusion Criteria:\n\n* Inflammatory bowel disease\n* Perianal Crohn's disease\n* History of anorectal malignancy\n* Previous pelvic radiotherapy\n* Anorectal surgery within the previous 3 months\n* Pregnancy\n* Neurogenic bowel dysfunction\n* Inability to comply with follow-up visits\n* Discontinuation of GLP-1 receptor agonist therapy before follow-up assessment\n* Active anorectal infection or abscess",{"count":53,"type":20},100,"3 Months","OBSERVATIONAL","Prospective observational cohort study evaluating the early proctologic effects of GLP-1 receptor agonist therapy in morbidly obese patients. Participants will undergo baseline and 3-month anorectal symptom assessment and proctologic examination to evaluate newly developed proctologic diseases and changes in pre-existing symptoms.",[58,28,59,30,60],"Morbid Obesity","Drug-Related Side Effects and Adverse Reactions","Diarrhea",[62,63,64,65,66,67,68,69,70,71,72,73],"GLP-1 receptor agonist","obesity","anorectal symptoms","hemorrhoids","anal fissure","constipation","semaglutide","tirzepatide","proctologic examination","bowel habits","anorectal disease","proctology","2026-06-23",{"date":76,"type":35},"2026-06-25",{"date":78,"type":20},"2026-08",{"date":80,"type":20},"2027-05",{"name":82,"class":42},"Gazi University",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":91,"targetDuration":92,"studyType":55,"phases":4,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":43},"100624064","hemorrhoid-suture-mucopexy-combined-with-laser-hemorrhoidoplasty-100624064","NCT07404774","Hemorrhoid Suture Mucopexy Combined With Laser Hemorrhoidoplasty","Prospective Evaluation of Hemorrhoid Suture Mucopexy (SM) Combined With Laser Hemorrhoidoplasty (LHP) for Symptomatic Hemorrhoidal Disease: A Cohort Study","HeMuLa","Inclusion Criteria:\n\n* Adults (\\>18 years).\n* Symptomatic Hemorrhoidal Disease (Goligher Grades II, III, IV).\n* Patients with or without recurrent disease after prior procedures (e.g., RBL, infrared coagulation, Milligan-Morgan, etc).\n\nExclusion Criteria:\n\n* Acutely thrombosed hemorrhoids.\n* Concomitant anal fistula or abscess requiring separate surgical management.\n* IBD (Crohn's\u002FUlcerative Colitis) with active rectal involvement.\n* Previous Stapled Haemorrhoidopexy (SH\u002FLongo).",{"count":53,"type":20},"12 Months","This prospective cohort study evaluates whether combining \"suture mucopexy\" (a simple stitch-based lift of prolapsed tissue) with Laser Hemorrhoidoplasty (LHP) can effectively relieve pain, bleeding and prolapse in adults with moderate-to-severe hemorrhoids (Grades II-IV). Participants will undergo the combined, non-Doppler-guided procedure and be followed for one year. The primary question is how long patients need post-operative pain medication and if they first experience complete symptom relief; secondary questions examine quality-of-life, safety (bleeding, urinary retention, stenosis) and the rate of hemorrhoid recurrence\u002Fre-operation.",[95,96,97,28],"Haemorrhoid","Haemorrhoidal Bleeding","Anorectal Surgeries",[99,100,101,102,103,104],"haemorrhoid","laser","mucopexy","suture mucopexy","LHP","haemorrhoidoplasty","RECRUITING","2026-02-08",{"date":108,"type":35},"2026-02-11",{"date":110,"type":35},"2026-01-01",{"date":112,"type":20},"2029-01",{"name":114,"class":42},"National and Kapodistrian University of Athens",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":15,"minAge":122,"maxAge":16,"enrollmentInfo":123,"targetDuration":4,"studyType":21,"phases":125,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":133,"leadSponsor":135,"locationsCount":4},"100598761","physiotherapy-applications-in-children-with-bladder-and-bowel-symptoms-after-anorectal-malformation-surgery-100598761","NCT07075692","Physiotherapy Applications in Children With Bladder and Bowel Symptoms After Anorectal Malformation Surgery","Effects of Physiotherapy Applications in Children With Bladder and Bowel Symptoms After Anorectal Malformation Surgery","Inclusion Criteria:\n\n* Children aged 5-18 years with bladder bowel symptoms after anorectal malformation surgery\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Presence of a congenital and\u002For chronic disease\n* Having a history of any additional neurological, orthopedic or psychiatric disease that will affect the evaluation parameters\n* Mental retardation\n* Having received physiotherapy within the last 1 year","5 Years",{"count":124,"type":20},20,[126],"NA","The aim of our study was to investigate the effects of physiotherapy applications in children with bladder and bowel symptoms after anorectal malformation surgery.",[28],"2025-07-11",{"date":131,"type":35},"2025-07-20",{"date":131,"type":20},{"date":134,"type":20},"2025-12-20",{"name":136,"class":42},"Ankara Yildirim Beyazıt University"]