[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anosognosia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anosognosia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,77,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100649329","study-of-repetitive-behaviors-in-alzheimers-disease-100649329",false,"NCT07732842","Study of Repetitive Behaviors in Alzheimer's Disease","ECRA","Inclusion Criteria:\n\nI- RB+ (n=42) and RB- (n=30) groups :\n\n1. MMSE \\> 20\n2. 1 reliable family caregiver identified per patient\n3. Patients under legal protection (guardianship\u002Fcuratorship) or not\n4. Selection:\n\n4.a. AD patients with an SRI score \\> 0 will constitute the RB+ subgroup. 4.b. Only the first 30 patients included will undergo V2, V3, and V4. The first 30 AD patients included with an SRI score = 0 will constitute the RB- subgroup.\n\nII- Control group: healthy subjects (n=30)\n\n1. Healthy subjects\n2. MMSE ≥ 26\u002F30\n3. Men and women matched to AD patients in terms of age and sociocultural level.\n4. Healthy subjects will be included by the CMRR in Limoges\n\nIII- Control group: Patient with anterograde amnesia (AA) (n=1):\n\n1. The patient with anterograde amnesia is a patient who participated in the ANISAAFORNIX study (another study submitted by the investigator) and is included in this study due to rich RB symptomatology. He is a 54-year-old man with lesions of the fornix following complications from neurosurgery, which led to severe anterograde amnesia. This patient does not have AD.\n2. This patient is under legal protection (guardianship).\n3. Patient monitored and included at the CMRR in Limoges.\n\nExclusion Criteria: I- RB+ and RB- groups and healthy subjects:\n\n1. Isolated participants (without an identified caregiver) (RB+ and RB- groups)\n2. Participants must not have a history of alcohol or other substance dependence in the past 12 months.\n3. Participants must not have any other neurological condition (with the exception of patients with AA anterograde amnesia). Any history of moderate to severe head trauma, stroke, or developmental disorders is a criterion for exclusion.",true,"ALL","18 Years",{"count":20,"type":21},103,"ESTIMATED","OBSERVATIONAL","Alzheimer's disease (AD) is characterized by anterograde amnesia, the inability to memorize and remember events occurring after the cerebral lesion. Among the most frequently reported psycho-behavioural symptoms are repetitive behaviours (RB), defined as actions or statements repeated in an inappropriate and non-functional way.\n\nThe most commonly used tool to assess repetitive behaviours is the Stereotypy Rating Inventory (SRI). It is a questionnaire that evaluates five types of stereotypical behaviour: eating, wandering, speech, movements, and daily routines. The frequency and severity of the behaviours are reported, and a total score can be calculated.\n\nThere is no consensus on the types of repetitive behaviours observed specifically in AD, their frequency, or their cognitive correlates, nor is there a hypothesis explaining why this symptomatology does not occur in all AD patients. Furthermore, certain parameters, such as anosognosia (lack of awareness of the disorders), have not been linked to RB in the literature. We propose to evaluate patients with anterograde amnesia in terms of cognition and behaviour-specifically, the presence or absence of both RB and anosognosia-to examine possible links between cognitive performance, anosognosia, and RB.\n\nMoreover, there is no theoretical framework explaining the emergence of RB in amnesia. We suggest that CRs are linked to the lack of memory updating in the cognitive system. Since episodic memory no longer provides mnemonic feedback, previously encountered stimuli may trigger repeated behaviour.\n\nTo test this hypothesis, we decided to conduct a multicenter, cross-sectional, case-control study. Patients with AD, with or without RB, as well as healthy subjects, were repeatedly presented with sentence starters to complete freely, with the aim of studying the similarity of responses across sessions for each participant. We also included a patient with pure anterograde amnesia from a previously submitted case study protocol, who exhibited pronounced RB symptomatology following neurosurgery (non-AD patient), to examine the phenomenon in a non-Alzheimer's context.",[25,26,27],"Alzheimer Disease","Anterograde Amnesia","Anosognosia",[29],"Repetitive behavior","RECRUITING","2026-07-23",{"date":33,"type":34},"2026-07-29","ACTUAL",{"date":36,"type":34},"2021-06-24",{"date":38,"type":21},"2027-02-24",{"name":40,"class":41},"Centre Hospitalier Esquirol","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":5},"100477671","supporting-patients-by-family-education-in-psychotic-illness-a-prospective-cohort-study-100477671","NCT05500001","Supporting Patients by Family Education in Psychotic Illness: A Prospective Cohort Study","Inclusion Criteria:\n\n* Young adult service user is aged 17-27 at time of recruitment\n* Young adult service user has had an admission or discharge from an Alberta Health Services or Covenant Health psychiatric unit for psychosis in the Edmonton Zone within previous 12-months\n\nExclusion Criteria:\n\n* Not proficient in English\n* Young adult service user has NOT had an admission or discharge from an Alberta Health Services or Covenant Health psychiatric unit for psychosis in the Edmonton Zone within previous 12-months","17 Years","27 Years",{"count":52,"type":21},113,"INTERVENTIONAL",[55],"NA","Background: A lack of education, resources, and support for family carers of young adults with psychotic illnesses leaves them ill-equipped to support their loved one. Although family support groups exist, few groups offer evidence-based, skills-focused, psychoeducation taught by certified professionals and provided on a public-health level. By equipping families with skills and knowledge, public healthcare harnesses a powerful ally to maintain community stabilization.\n\nAims: The primary study goal is to implement a psychoeducation intervention for family carers supporting young adults with psychosis to reduce family burden and foster community stabilization of service users.\n\nMethods: A longitudinal pre-post design will be used to assess the long-term effectiveness of the psychoeducation intervention for family carers supporting a young adult with psychosis on service utilization and functional indexes. Nine expert-reviewed, and family peer-informed psychoeducation modules are administered in 2-hour sessions over 9 weeks to family carers.\n\nConclusion: Presenting the novel approach of an expert-reviewed, peer-informed psychoeducation intervention for family carers, with a focus on knowledge and skill development, the researchers contribute to literature and best practice in patient and family-centered care.",[58,59,27,60],"Psychotic Disorders","Family Members","Paranoia",[62,63,64,65,66,67],"Young Adult","Psychosis","Family Psychoeducation","Family Burden","Acceptance and Commitment Therapy","LEAP","2025-11-14",{"date":70,"type":34},"2025-11-18",{"date":72,"type":34},"2022-09-01",{"date":74,"type":21},"2026-09-01",{"name":76,"class":41},"University of Alberta",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":53,"phases":89,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100427401","improving-awareness-for-spatial-neglect-with-tdcs-100427401","NCT04845529","Improving Awareness for Spatial Neglect With tDCS","Improving Awareness in Right-brain-damaged Patients With Unilateral Spatial Neglect Using Transcranial Direct Current Stimulation (tDCS)","ANOSO","Inclusion Criteria:\n\n* First stroke affecting the right-hemisphere\n* Presence of USN, as assessed by a standard neuropsychological evaluation\n* Structural images of the brain lesion available (magnetic resonance or tomographic scans)\n* Criteria for electrical brain stimulation\n* Good (or corrected) visual acuity\n* High proficiency in French\n* Right-handed\n\nExclusion Criteria:\n\n* Presence of general cognitive deficits and\u002For suspicious of possible cognitive deficits\n* Presence of difficulty in task's comprehension\n* Impossibility to sustain a research session of at least 45minutes (e.g., attentional lability)\n* Precedent additional neurological disorder and\u002For current or precedent psychiatric disease\n* Presence of one or more exclusion criteria for the electrical brain stimulation 18, as following:\n\nPresence (or suspected presence) of metal in the brain or skull or body (except titanium) (e.g. splinters, fragments, clips, etc.) Presence of cochlear implants, implanted neuro-stimulator (e.g., DBS, epidural\u002Fsubdural, VNS), cardiac pacemaker, medication infusion device, spinal or ventricular derivations Presence of epilepsy (participant and\u002For the close family) and\u002For precedent epileptic seizures (participant) Presence of a fainting spell or syncope, due to neurological diseases (not consider syncope during blood sampling or after being in a warm environment or after emotionally stressful events) Presence of a severe (i.e., followed by loss of consciousness) head trauma Presence of hearing problems or ringing in your ears (e.g. tinnitus) Current treatment under psychoactive (e.g. antidepressants, tranquilizers) or antiepileptic medications Chronic headache For women: you are pregnant or there is any chance that you might be.","20 Years","85 Years",{"count":88,"type":21},12,[55],"Brain-damaged patients can show severe neurological and cognitive deficits, and yet often remain strikingly unaware of these symptoms: this condition is called anosognosia. The aim of this study is to improve awareness in right-brain-damaged patients with Unilateral Spatial Neglect (USN) following stroke using transcranial direct current stimulation (tDCS). tDCS is a neuromodulatory technique that delivers low-intensity current to the brain facilitating (anodal tDCS) or inhibiting (cathodal tDCS) spontaneous neuronal activity. tDCS does not induce activity in resting neuronal networks, but modulates spontaneous neuronal activity: consequently, the amount and direction of effects critically depend on the previous state of the neural structures.\n\nWe will test USN patients showing anosognosia for neglect symptoms. Different brain areas will be stimulated, to target explicit and implicit components of anosognosia, including parietal and frontal brain regions.",[92,27,93],"Stroke","Neglect, Hemispatial",[95,96,97],"Brain modulation","Recovery","Implicit and explicit anosognosia","NOT_YET_RECRUITING","2025-05-23",{"date":101,"type":34},"2025-05-30",{"date":103,"type":21},"2026-12",{"date":105,"type":21},"2027-01",{"name":107,"class":41},"University of Geneva, Switzerland",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":4},"100588398","development-of-a-novel-screening-tool-for-anosognosia-after-stroke-100588398","NCT06940882","Development of a Novel Screening Tool for Anosognosia After Stroke.","Development and Exploration of the Acceptability and Feasibility of a Novel Screening Tool for Anosognosia After Stroke, Designed for Routine Use in Hospital Settings.","Inclusion Criteria:\n\n* Patients aged 18 years or above who are admitted to the stroke rehabilitation unit with a clinical diagnosis of stroke.\n* Multi-disciplinary staff working on the stroke rehabilitation unit.\n\nExclusion Criteria:\n\n* Patients with a clinical diagnosis other than stroke.",{"count":116,"type":21},90,"Anosognosia, a neurological inability to acknowledge or comprehend one's own (dis)abilities, is a multi-faceted phenomenon which has consistently gained traction in research fields spanning psychology, neurology, and cognition since its conceptual introduction in 1914. Though anosognosia is not limited to following only neurological disease or injury, the majority of research has focused on the prevalence and mechanisms of anosognosia after stroke. Despite this, there is no clear consensus among the literature, and thus in clinical practice, as to how anosognosia after stroke should be assessed. This is startling given the plethora of studies which highlight anosognosia as a barrier to rehabilitation, a risk to safe discharge, and a predictor of poorer psychological and functional outcomes for both patients and their carers. Currently, there exists a vast number of assessment methods for anosognosia after stroke, which vary from performance- and observation-based tasks to self-report and discrepancy-based interviews; clinicians working in stroke make arbitrary choices as to which of these methods to use on a case-by-case basis, risking missed cases and subsequently noncomprehensive care. This research aims to develop a new screening tool for anosognosia that can be routinely implemented with post-stroke patients in hospital settings, to inform care, rehabilitation, and discharge. The study will explore the acceptability and feasibility of the new screening tool among multi-disciplinary staff working on a stroke rehabilitation unit, and provide grounds for future studies to assess the screen's psychometric properties and ability to inform novel interventions for anosognosia. Findings will have great implications for stroke survivors, their carers, and healthcare professionals alike.",[27,92],[27,92,120],"Assessment","2025-04-23",{"date":123,"type":34},"2025-04-27",{"date":125,"type":21},"2025-10",{"date":127,"type":21},"2026-06",{"name":129,"class":41},"University of Exeter"]