[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"antenatal-depression\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:antenatal-depression":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,82,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100642741","stronger-together-antenatal-depressive-symptoms---prevalence-and-digital-treatment-100642741",false,"NCT07639164","Stronger Together: Antenatal Depressive Symptoms - Prevalence and Digital Treatment","Inclusion Criteria:\n\n* fluent in written and spoken Finnish or Swedish\n* access to computer or mobile phone with internet\n* between 12 and 22 weeks pregnant\n* screening and baseline score on the EPDS ≥10 points\n\nExclusion Criteria:\n\n* lifetime history of psychotic disorder (e.g. schizophrenia, schizoaffective disorder, bipolar disorder, psychotic depression)\n* active suicidal ideation\n* severe substance abuse or dependence\n* participates in another intervention study aiming at treating the symptoms of antenatal depression","FEMALE","18 Years","55 Years",{"count":19,"type":20},1000,"ESTIMATED","INTERVENTIONAL",[23],"NA","The main objective of the current research project is to evaluate the usability, satisfaction of the antenatal iCBT program including telephone coaching for antenatal and postnatal depressive symptoms and collect nationally representative data on population-based screening of antenatal depressive and anxiety symptoms. The overarching hypothesis is that iCBT, with easy access and affordability, is user friendly and well accepted. In addition to examining the treatment response by questionnaires, we will study the infant development comprehensively as well as potential physiological changes associated with antenatal depression or its treatment.",[26,27],"Depression \u002F Major Depressive Disorder","Antenatal Depression",[29,30,31],"Digital intervention","Cognitive Behaviour Therapy","Antenatal depression","NOT_YET_RECRUITING","2026-06-05",{"date":35,"type":36},"2026-06-10","ACTUAL",{"date":38,"type":20},"2026-08-01",{"date":40,"type":20},"2030-12-30",{"name":42,"class":43},"University of Turku","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":15,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":81},"100551147","integration-of-stepped-care-for-perinatal-mood-and-anxiety-disorders-among-women-attending-mch-clinics-100551147","NCT06456307","Integration of Stepped Care for Perinatal Mood and Anxiety Disorders Among Women Attending MCH Clinics","IPMH","Inclusion Criteria:\n\n* Pregnant and ≥28 weeks gestation\n* Attending ANC care at the facility\n* ≥14 years old\n* Screen positive for PMAD symptoms (PHQ-2≥3 and\u002For GAD-2≥3)\n* Willing to return to the MCH and PMTCT clinic for study visits\n\nExclusion Criteria:\n\n* Less than 28 weeks gestation\n* Any woman at high risk of self-harm based on a study self-harm assessment protocol,\n* Has cognitive impairments or psychotic symptoms",true,"14 Years",{"count":55,"type":20},2970,[23],"Perinatal mood and anxiety disorders (PMAD), defined as depression and anxiety during pregnancy or up to 1 year postpartum, account for substantial morbidity and mortality among birthing people globally especially in low- and middle-income countries. Several evidence-based interventions are recommended for identification and management of PMAD by non-specialist providers in resource-limited settings. This cluster-randomized trial seeks to evaluate the effect of a stepped-care intervention for screening and treatment of PMAD among perinatal women, on clinical and implementation outcomes.",[59,27,60],"Depression, Anxiety","Postnatal Depression",[62,63,64,65,66,67,68,69],"perinatal mood and anxiety disorders","telepsychiatry","Problem management plus","Integrated Perinatal Mental Health","Pregnancy","Postpartum","Depression","Anxiety","RECRUITING","2025-12-03",{"date":73,"type":36},"2025-12-10",{"date":75,"type":36},"2025-02-17",{"date":77,"type":20},"2028-03",{"name":79,"class":80},"Kenyatta National Hospital","OTHER_GOV",2,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":52,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100560568","happymums-mobile-application-study-100560568","NCT06578845","HappyMums Mobile Application Study","HappyMums - Can Data Collected by a Mobile App be Used to Help Learn More About Mental Health Symptoms in Pregnant Women and Birthing People at Risk of Depression in Pregnancy?","HappyMums","Inclusion Criteria:\n\n* Pregnant people, aged 18 or older and up to 28 weeks' gestation.\n* Satisfactory understanding of English\u002Fnational language of host country, in order to give fully informed consent.\n* Either suffering with depressive symptoms currently, or who have at least one risk factor for antenatal depression.\n* Owning a smartphone capable of downloading and running HappyMums application\n\nExclusion Criteria:\n\n* Inability to give informed consent.",{"count":19,"type":20},"OBSERVATIONAL","The goal of this study is to investigate whether pregnant people at risk of, or currently suffering from antenatal depression, find it acceptable to use the 'HappyMums' mobile application during their pregnancy. This app will collect data relevant to their mental health passively and through active engagement from the user. After the study is complete, these data will be put together to determine if such data types could be used in future to help predict and identify antenatal depression, and aid better treatment decisions.",[66,27],"2025-12-02",{"date":96,"type":36},"2025-12-09",{"date":98,"type":36},"2025-02-18",{"date":100,"type":20},"2026-10-31",{"name":102,"class":43},"King's College London",7,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":21,"phases":113,"briefSummary":114,"conditions":115,"keywords":116,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":44},"100480219","internet-cbt-for-antenatal-depression-100480219","NCT05533138","Internet CBT for Antenatal Depression","Guided-internet Cognitive Behavioral Therapy for Antenatal Depression - Treatment Effects, Assessment Modalities and Extra Support.","Inclusion Criteria:\n\n* Mild to moderate major depression\n* Pregnant at treatment start\n* Regular contact with maternity mental health clinic\n* \\> 18 years old\n* Being able to start the treatment earliest in gestational week 8 and latest in gestational week 30\n* Stable medication for depression and\u002For other psychiatric conditions for at least 3 weeks.\n* Being able to participate in the treatment during the treatment time and having access to and being able to use the internet and mobile phone during the treatment time\n* Being able to understand the Swedish language orally and in writing\n\nExclusion Criteria:\n\n* Montgomery-Åsberg Depression Rating Scale-Self report version (MADRS-S) score below 15 (symptoms of depression to low) or above 35 (severe depression)\n* High risk of self harm or suicide (based on semi-structured clinical suicide risk assessment)\n* Psychiatric comorbidity, disability, somatic disorder, or pregnancy complications that prevent treatment participation or that can be negatively affected or compose a risk for the fetus by treatment participation\n* Ongoing psychological treatment with similar content",{"count":112,"type":20},415,[23],"Pregnant women in pregnancy week 8-29 screening positive for antenatal depression will be randomized to either choose or to be allotted by chance to different forms of diagnostic assessment; i.e. telephone, video or face-to-face assessment.\n\nThose diagnosed with mild to moderate major depression will then be randomized to treatment with therapist-guided Internet-delivered Cognitive Behavioral Therapy (ICBT) adapted for women suffering from antenatal depression or to the same treatment with addition of up to three contacts with extra support by a midwife or experienced perinatal mental health nurse.\n\nThe primary aim is to assess whether extrasupport in addition to internet-guided pregnancy adapted ICBT decreases depressive symptoms more than internet-guided pregnancy adapted ICBT only. Secondary aims include effects of extrasupport and assessment mode on treatment satisfaction, fidelity and credibility.",[27],[117,118,119,120],"Cognitive behavior therapy","Internet treatment","Self-help treatment","Perinatal support","2024-06-24",{"date":123,"type":36},"2024-06-25",{"date":125,"type":36},"2021-02-25",{"date":127,"type":20},"2027-12-31",{"name":129,"class":43},"Karolinska Institutet"]