[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cerebral-artery-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cerebral-artery-stroke":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,57],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100593973","transcranial-doppler-evaluation-after-endovascular-thrombectomy-for-acute-ischemic-stroke-precise-tcd-100593973",false,"NCT07013396","Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)","A Prospective Evaluation of Clinical Outcomes in Acute Ischemic Stroke After Endovascular Treatment Using Transcranial Doppler (PRECISE-TCD)","Inclusion Criteria:\n\n* Anterior circulation large vessel occlusion, including ACA, MCA, or ICA stroke, treated with endovascular thrombectomy, including tandem occlusions\n* Age ≥ 18 years\n* Ability to detect an adequate acoustic window via TCD.\n\nExclusion Criteria:\n\n* Inadequate acoustic windows defined as lack of bilateral MCA signal at standard depths.\n* Pregnancy\n* Incarceration","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","Endovascular thrombectomy (EVT) improves outcomes in acute ischemic stroke caused by large vessel occlusion. Despite successful recanalization, early neurological deterioration (END) remains frequent and is associated with poor outcomes. Transcranial Doppler (TCD) provides noninvasive, real-time assessment of cerebral blood flow velocities and may identify hemodynamic patterns associated with deterioration after EVT. PRECISE-TCD is a prospective, single-center observational study enrolling 180-300 patients undergoing EVT for anterior circulation large vessel occlusion at a tertiary academic medical center. Serial TCD examinations are performed immediately after EVT, daily for 72 hours, and as close as possible to early neurological deterioration events or clinically indicated head CT within 72 hours. The primary outcome is the association between TCD-derived hemodynamic parameters and END within 72 hours. Secondary outcomes include NIHSS at 24 hours and discharge, discharge disposition, and modified Rankin Scale at 90 days.",[24,25,26,27,28],"Anterior Cerebral Artery Syndrome","Anterior Cerebral Artery Stroke","Acute Ischemic Stroke","Cardioembolic Stroke","Vasogenic Cerebral Edema",[30,31,32,33,34,35,36,37,38,39,40,41,42,43],"systolic blood pressure","Transcranial Doppler","Large Vessel Occlusion","mean flow velocity","early neurological deterioration","cerebral hemodynamics","endovascular thrombectomy","cerebral autoregulation","blood pressure management","collateral circulation","pulsatility index","peak systolic velocity","end-diastolic velocity","Modified Rankin Scale","NOT_YET_RECRUITING","2026-07-13",{"date":47,"type":48},"2026-07-16","ACTUAL",{"date":50,"type":20},"2026-08",{"date":52,"type":20},"2029-08",{"name":54,"class":55},"Virginia Commonwealth University","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":67,"briefSummary":70,"conditions":71,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":56},"100627536","phase-2-safety-and-efficacy-of-baricitinib-after-endovascular-treatment-in-acute-anterior-circulation-large-vessel-occlusion-a-multicenter-randomized-controlled-clinical-trial-100627536","NCT07449910","Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial","Safety and Efficacy of Baricitinib Combined With Acute Large Vessel Occlusion Recanalization : A Multicenter, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Age is 18 years old or above.\n2. Diagnosed as anterior circulation large vessel occlusion stroke by CTA, MRA or DSA.\n3. Randomized within 24h after the onset.\n4. The NIHSS score is above 5 and the ASPECT score is above 3 points while receiving imaging examination;\n5. The mTICI score after endovascular treatment (EVT) is above 2b.\n6. informed consent.\n\nExclusion Criteria:\n\n1. Intracranial hemorrhage confirmed by CT or MRI.\n2. mRS score\\>2 for patients \\\u003C80 years, or mRS score\\>1 for those ≥80 years before onset.\n3. Pregnant or lactating women.\n4. Allergic to contrast agents.\n5. Allergic to baricitinib or having contraindications for using baricitinib.\n6. Participating in other clinical studies.\n7. Systolic blood pressure \\>185 mmHg or diastolic blood pressure \\>110 mmHg, and unable to be controlled by oral antihypertensive drugs.\n8. Genetic or acquired bleeding diathesis, lack of anticoagulant factors or having taken oral anticoagulants and INR \\>1.7.\n9. Hemoglobin value \\\u003C8g\u002FL.\n10. Recent history of using other JAK inhibitors or potent immunosuppressants, including but not limited to the combined use with potent immunosuppressive drugs such as azathioprine, tacrolimus, tofacitinib and fedratinib, etc. Tortuous arteries make the thrombectomy device unable to reach the target blood vessel.\n11. Previous history of diagnosed viral hepatitis and tuberculosis.",{"count":65,"type":20},750,"INTERVENTIONAL",[68,69],"PHASE2","PHASE3","The primary purpose of this study is to evaluate the efficacy and safety of Baricitinib combined with endovascular therapy in patients with acute anterior circulation large vessel occlusion, to address futile recanalization with priority, and to elucidating the mechanism of JAK\u002FSTAT pathway inhibition on neuroprotection and inflammatory regulation.",[72,25,73],"Acute Ichemic Stroke","Baricitinib","2026-02-27",{"date":76,"type":48},"2026-03-04",{"date":78,"type":20},"2026-03-17",{"date":80,"type":20},"2028-01-31",{"name":82,"class":55},"The First Affiliated Hospital of University of Science and Technology of China"]