[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cruciate-ligament-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cruciate-ligament-injuries":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,46,0,25,[9,41,74,102,130,157,182,209,232,257,290,313,340,368,396,421,454,474,499,524,551,570,596,617,645],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100484129","arthroscopic-anterior-cruciate-ligament-repair-versus-reconstruction-for-acute-anterior-cruciate-ligament-injury-100484129",false,"NCT05584020","Arthroscopic Anterior Cruciate Ligament Repair Versus Reconstruction for Acute Anterior Cruciate Ligament Injury","Arthroscopic Anterior Cruciate Ligament Repair Versus Reconstruction for Acute Anterior Cruciate Ligament Injury: a Multicenter Randomized Controlled Surgical Trial","Inclusion Criteria:\n\n1. Patients with anterior cruciate ligament tear clearly identified by imaging or intraoperative microscope, Sherman grade I, II; planned surgery within 3 weeks after injury\n2. Basic reading and writing skills, and barrier-free communication\n3. A smartphone, can use WeChat or be able to learn\n4. Patients give informed consent, and sign the informed consent form, and the process must meet the requirements of GCP\n\nExclusion Criteria:\n\n1. Combined with other knee joint injuries (posterior cruciate ligament injury, patellar dislocation, osteoarthritis, etc.)\n2. Suffering from systemic immune diseases;\n3. Existing other knee joint diseases or inflammatory diseases, including osteoarthritis, cervical spine disease, rheumatoid arthritis, fibromyalgia, polymyalgia rheumatica, etc.\n4. Patients who have received local hormone injection within 3 months;\n5. Those who have participated in clinical trials or are undergoing other clinical trials within 3 months before screening\n6. Those who have serious primary cardiovascular disease, lung disease, endocrine and metabolic disease or serious diseases that affect their survival, such as tumor or AIDS, the researchers believe that they are not suitable for selection\n7. Patients with severe liver disease, kidney disease, and hematological disease, such as renal function exceeding the upper limit of the normal value, and liver function exceeding 2 times the upper limit of the normal value;\n8. Suffering from viral hepatitis, infectious diseases, severe abnormal blood coagulation mechanism and other Diseases that the researchers consider inappropriate for surgery\n9. Women who are pregnant or breastfeeding, or who plan to become pregnant during the follow-up period, those who have a positive urine human chorionic gonadotropin test result before sampling; menstruating women should wait until the end of menstruation before surgery;\n10. Severe neurological and mental disorders Disease patients;\n11. Suspected or actual history of alcohol and drug abuse.","ALL","18 Years",{"count":20,"type":21},140,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background: Arthroscopic anterior cruciate ligament(ACL) reconstruction is so far the gold standard for the treatment of ACL ruptures, but this technique still suffers from problems of tendon-bone healing, bone tunnel enlargement, bone resorption, a low rate of return to motion,etc. In recent years, due to the innovation of medical materials and surgical techniques, anterior cruciate ligament repair technology has returned to the field of vision of clinical doctors. This technique has the advantages of preserving the natural ligaments and their proprioceptive sensation, avoiding the bone injury of the tunnel and the complications of the donor site. However, there is still a lack of high-quality clinical randomized controlled trails to provide evidence of the effect of arthroscopic ACL repair.\n\nHypothesis: Arthroscopic ACL repair is comparable to ACL reconstruction in patients with ACL tears (Sherman grades I and II).\n\nStudy Design: This study was a prospective, multicenter, randomized, double-blinded, parallel-controlled, non-inferiority trial design. A total of 330 patients with ACL tears were randomly divided into 2 groups, and were randomly assigned to the experimental group (arthroscopic anterior cruciate ligament repair) and the control group (arthroscopic anterior cruciate ligament reconstruction) according to 1:1. Follow-up knee function and other scores were performed at 3 months, 6 months, 1 year, and 2 years after surgery, and the total study time is expected to be 3 years.",[27],"Anterior Cruciate Ligament Injuries","RECRUITING","2026-07-22",{"date":31,"type":32},"2026-07-24","ACTUAL",{"date":34,"type":32},"2022-11-18",{"date":36,"type":21},"2029-12",{"name":38,"class":39},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",1,{"id":42,"slug":43,"hasResults":12,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":12,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":40},"100648430","graft-type-and-outcomes-after-acl-reconstruction-in-female-athletes-100648430","NCT07722104","Graft Type and Outcomes After ACL Reconstruction in Female Athletes","Influence of Graft Type on Functional and Neuromuscular Outcomes After Anterior Cruciate Ligament Reconstruction in Female Athletes: A Prospective Multicenter Cohort Study","LCA-WOMEN","Inclusion Criteria:\n\n* Female patients aged 16 to 35 years with skeletal maturity\n* Active athlete: minimum two training sessions per week during the six months prior to injury in pivoting sports\n* Confirmed complete ACL rupture by MRI and clinical examination\n* Primary ACL reconstruction (first ligament surgery on the index knee)\n* Time from injury to surgery no longer than 6 months\n* Signed informed consent\n\nExclusion Criteria:\n\n* Previous ligament surgery on either knee\n* Multiligament injury: simultaneous PCL, grade III MCL or LCL injury\n* Neuromuscular, rheumatological or systemic pathology interfering with rehabilitation or functional assessments\n* Pre-existing radiological osteoarthritis grade Kellgren-Lawrence ≥2 in the index knee\n* Inability to complete 24-month follow-up protocol\n* Pregnancy at inclusion or during follow-up period","FEMALE","16 Years","35 Years",{"count":53,"type":21},82,"OBSERVATIONAL","This prospective multicenter cohort study aims to compare clinical and functional outcomes between hamstring tendon and quadriceps tendon autografts in anterior cruciate ligament (ACL) reconstruction in female athletes. Participants will be followed for two years after surgery to evaluate graft failure rates, return to sport, knee stability, and patient-reported outcomes.",[27,57],"Knee Injuries",[59,60,61,62,63],"ACL reconstruction","hamstring tendon","quadriceps tendon","female athletes","autograft","NOT_YET_RECRUITING","2026-07-19",{"date":67,"type":32},"2026-07-23",{"date":69,"type":21},"2026-08-01",{"date":71,"type":21},"2028-12-01",{"name":73,"class":39},"Universidad Católica San Antonio de Murcia",{"id":75,"slug":76,"hasResults":12,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100645582","postoperative-analgesic-efficacy-of-acbipack-vs-ftbselective-tibialobturator-blocks-in-acl-reconstruction-100645582","NCT07702552","Postoperative Analgesic Efficacy of ACB+iPACK vs FTB+Selective Tibial+Obturator Blocks in ACL Reconstruction","Evaluation of Postoperative Analgesic Efficacy in Anterior Cruciate Ligament Reconstruction: Ultrasound-Guided Adductor Canal Block Combined With iPACK Block Versus Femoral Triangle Block Combined With Selective Tibial and Obturator Nerve Blocks at Da Nang Hospital","ACL-Analgesia","Inclusion Criteria:\n\n* Age 16 years and older\n* Patients undergoing elective arthroscopic anterior cruciate ligament (ACL) reconstruction\n* ASA physical status I-II\n* Indicated for spinal anesthesia\n* Provided informed consent\n\nExclusion Criteria:\n\n* Infection at the injection site\n* Spinal cord or lower limb nerve injury\n* Contraindications to regional anesthesia (Levobupivacaine)\n* Known allergy to Paracetamol or Diclofenac\n* Coagulopathy",{"count":83,"type":21},100,[24],"This prospective, comparative study aims to evaluate the postoperative analgesic efficacy of ultrasound-guided Adductor Canal Block (ACB) combined with iPACK block versus Femoral Triangle Block (FTB) combined with selective tibial nerve block and obturator nerve block in patients undergoing arthroscopic anterior cruciate ligament (ACL) reconstruction. The primary objective is to determine which regional anesthesia regimen provides superior pain relief at rest and during movement. The secondary objectives include assessing morphine consumption, motor blockade using the Bromage score, patient satisfaction, and potential adverse effects of these anesthesia techniques.",[27,87],"Postoperative Pain",[89,90,91,92],"Adductor Canal Block","iPACK Block","Femoral Triangle Block","Knee Arthroscopy","2026-07-08",{"date":95,"type":32},"2026-07-14",{"date":97,"type":21},"2026-07",{"date":99,"type":21},"2027-03",{"name":101,"class":39},"Da Nang Hospital",{"id":103,"slug":104,"hasResults":12,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":108,"targetDuration":4,"studyType":22,"phases":110,"briefSummary":111,"conditions":112,"keywords":118,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":40},"100504462","gait-rehabilitation-to-treat-fastoa-100504462","NCT05848622","Gait Rehabilitation to Treat FastOA","Inclusion Criteria:\n\n* Have completed all other formal physical therapy\n* Are between the ages of 16 and 35\n* Underwent an anterior cruciate ligament reconstruction (ACLR) between 6 and 60 months prior to enrollment\n* Demonstrate underloading during gait (vGRF- impact peak \\\u003C1.12 x BW)\n\nExclusion Criteria:\n\n* A multiple ligament surgery (i.e., PCL)\n* A lower extremity fracture (i.e., displaced tibial plateau fracture)\n* Knee osteoarthritis",{"count":109,"type":21},70,[24],"The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament reconstructed patients.",[27,113,114,115,57,116,117],"Post-traumatic Osteoarthritis","Knee Osteoarthritis","Osteo Arthritis Knee","Cartilage, Articular","Gait",[119,120],"Biofeedback","FastOA","2026-06-24",{"date":123,"type":32},"2026-06-25",{"date":125,"type":32},"2023-06-13",{"date":127,"type":21},"2027-06",{"name":129,"class":39},"University of North Carolina, Chapel Hill",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":143,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":40},"100643537","perturbation-training-vs-functional-activities-on-pain-rom-balance-and-function-post-acl-100643537","NCT07642752","Perturbation Training vs Functional Activities on Pain, ROM, Balance, and Function Post-ACL","Effects of Perturbation Training Versus Task-oriented Functional Activities on Pain, Range of Motion, Balance and Function in Post-anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Age range: 18-45 years\n\nMale participants only\n\nHistory of Anterior Cruciate Ligament Reconstruction (ACLR) of 3 to 12 months\n\nNo prior ACL surgery on the affected knee\n\nACL reconstruction with autograft of hamstrings tendon\n\nKnee flexion range of motion less than 120°\n\nExtension lag less than or equal to 10°\n\nPain during functional activities\n\nExclusion Criteria:\n\n* Any type of fracture\n\nConcurrent ligamentous injury or repairable meniscus\n\nOsteochondral defect\n\nAny systemic and\u002For neurological illness\n\nRheumatoid arthritis\n\nOsteomyelitis or any neurological disorders\n\nSpinal disorders\n\nInflammatory conditions such as ankylosing spondylitis","45 Years",{"count":139,"type":21},54,[24],"Anterior cruciate ligament (ACL) injuries are among the most common and functionally disabling knee injuries, particularly in physically active individuals. Despite advancements in surgical techniques, optimal post-operative rehabilitation remains critical for successful functional recovery, minimizing re-injury risk, and restoring pre-injury performance levels",[27],[144,145,146,147],"Knee","Disability","Range of motion","Balance","2026-06-08",{"date":150,"type":32},"2026-06-11",{"date":152,"type":21},"2026-06-20",{"date":154,"type":21},"2026-11-06",{"name":156,"class":39},"Riphah International University",{"id":158,"slug":159,"hasResults":12,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":12,"sex":17,"minAge":164,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":22,"phases":167,"briefSummary":168,"conditions":169,"keywords":171,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":40},"100474701","quadriceps-tendon-versus-bone-patellar-tendon-bone-autograft-acl-reconstruction-rct-100474701","NCT05461326","Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT","All Soft Tissue Quadriceps Tendon Autograft Versus Patellar Tendon Autograft in Anterior Cruciate Ligament Reconstruction: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Skeletally mature patients younger 65\n* ACL insufficiency\n* Scheduled to undergo autograft ACL reconstruction\n* Appropriate candidate for autograft harvest\n\nExclusion Criteria:\n\n* \\\u003C14 or 65\\>\n* Poor autograft candidate (poor tissue quality)\n* Multi ligamentous reconstruction (PCL, MCL, or PLC)\n* Pregnant or nursing\n* High likelihood of remaining non-compliant with physical therapy regimen\n* Desire to return to sport prior to 6 months\n* Inability to read and write English","14 Years","65 Years",{"count":83,"type":21},[24],"The choice of autograft for ACL reconstruction continues to be debated. To date, there has only be one completed randomized controlled trial with quad tendon to BTB and the tendon included a bone plug. There has been no study to date comparing an all soft tissue quad tendon to patellar tendon in a randomized controlled trial for ACL reconstruction.",[170,27],"Orthopedic Disorder",[61,172,63],"bone tendon bone","2026-06-07",{"date":175,"type":32},"2026-06-10",{"date":177,"type":32},"2023-09-26",{"date":179,"type":21},"2030-06-30",{"name":181,"class":39},"University of Alabama at Birmingham",{"id":183,"slug":184,"hasResults":12,"nctId":185,"briefTitle":186,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":12,"sex":17,"minAge":189,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":22,"phases":192,"briefSummary":193,"conditions":194,"keywords":195,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":40},"100376613","robotic-assistance-for-tunnel-positioning-in-anterior-cruciate-ligament-reconstruction-100376613","NCT04183803","Robotic Assistance for Tunnel Positioning in Anterior Cruciate Ligament Reconstruction","MIRRACL","Inclusion Criteria:\n\n* All patients treated at CHU Amiens-Picardie for ACL reconstruction by practitioner who has robot experience.\n* children and adults from 10 to 45 years old\n\nExclusion Criteria:\n\n* Patients managed by another ACL reconstruction technique\n* Patients under guardianship, curators deprived of liberty\n* Pregnant and nursing women.\n* Patient who refused to participate in the study and to sign informed consent","10 Years",{"count":191,"type":21},30,[24],"Accurate ideal graft tunnel positioning is essential for the successful application of anatomic anterior cruciate ligament (ACL) reconstruction. The accurate insertion of the tibial tunnel (TT) and femoral tunnel (FT) remain a challenge.\n\nA robotic assisted new strategy for drill TT and FT in ACL reconstruction will be performed and its efficacy and accuracy will be assess.\n\nThe investigators will prospectively include 30 patients with ACL rupture requiring surgical treatment. The reconstruction will be performed with hamstring tendon graft or patellar tendon graft. The femoral and tibial tunnels placement will be guided by the Rosa robot (Zimmer®).",[27],[196,197,198,199],"anterior cruciate ligament","reconstruction","robot","tunnel","2026-05-12",{"date":202,"type":32},"2026-05-13",{"date":204,"type":32},"2019-11-19",{"date":206,"type":21},"2027-09-30",{"name":208,"class":39},"Centre Hospitalier Universitaire, Amiens",{"id":210,"slug":211,"hasResults":12,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":217,"enrollmentInfo":218,"targetDuration":4,"studyType":22,"phases":220,"briefSummary":221,"conditions":222,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":40},"100530942","steps-towards-osteoarthritis-prevention-100530942","NCT06193343","Steps Towards Osteoarthritis Prevention","Steps Towards Osteoarthritis Prevention: A Pilot Study","STOP","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* For children, signed and dated informed assent by child and parental permission form by parent\u002Fguardian to participate in the study\n* Underwent an anterior cruciate ligament reconstruction (ACLR) between 6-60 months prior to enrollment\n* Stated willingness to comply with all study procedures and lifestyle considerations and availability for the duration of the study\n* Completed all other formal physical therapy and therapeutic exercise regimens, and will not be engaging in any other formal therapy for their ACLR during the study\n* Physician clearance for unrestricted activity\n* Owning a smartphone\n* Demonstrate \\\u003C 8,000 steps per day during the screening phase of aim 2 as assessed using the Actigraph Link monitor\n\nExclusion Criteria:\n\n* Underwent an ACLR revision surgery due to a previous anterior cruciate ligament (ACL) graft injury\n* A multiple ligament surgery was indicated with their ACL injury\n* A lower extremity fracture was suffered during the ACL injury\n* The participant has previously been diagnosed with any diseases that affect joints is present in either knee including knee osteoarthritis inflammatory arthritis\n* Pregnant or plans to become pregnant over next 4 months\n* Body mass index (BMI) ≥ 36 kg\u002Fm2\n* Unable to speak English\n* Cochlear implant\n* Metal in body (metal fragments, shrapnel, permanent make-up, body piercings that cannot be removed)\n* Claustrophobia\n* History of seizures\n* Pacemaker","40 Years",{"count":219,"type":21},56,[24],"Optimal knee joint loading, which refers to the forces acting on the knee caused by daily activities such as daily steps, plays an essential role in maintaining knee articular cartilage health and reducing the risk of osteoarthritis (OA). After anterior cruciate ligament reconstruction (ACLR), individuals take fewer daily steps as compared to uninjured controls resulting in insufficient knee joint loading to joint tissues, but it is unclear how changes in daily steps impact knee joint cartilage health in OA development. Therefore, the overall single arm, longitudinal pre-test post-test study objective is to determine the mechanistic links between knee joint loading as measured by daily steps and comprehensive magnetic resonance imaging (MRI) measures of knee joint cartilage health post-ACLR. The central hypothesis is that individuals post-ACLR who take low daily steps will demonstrate deconditioned, less resilient cartilage characterized by poor tibiofemoral cartilage composition and greater cartilage strain.",[27],"2026-04-23",{"date":225,"type":32},"2026-04-29",{"date":227,"type":32},"2024-09-23",{"date":229,"type":21},"2028-01-30",{"name":231,"class":39},"University of Georgia",{"id":233,"slug":234,"hasResults":12,"nctId":235,"briefTitle":236,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":238,"sex":17,"minAge":189,"maxAge":165,"enrollmentInfo":239,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":241,"conditions":242,"keywords":245,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":40},"100564937","baseline-acl-injury-risk-screening-and-normative-data-100564937","NCT06635668","Baseline ACL Injury Risk Screening and Normative Data","Inclusion Criteria:\n\n* Healthy athletes participating in formal, organized, competitive sports between the ages of 10 and 65 years old",true,{"count":240,"type":21},5000,"This is a prospective, observational cohort study aimed at establishing a database of normative biomechanics for healthy athletes and surveying these athletes for 12 months following baseline testing for the occurrence of new musculoskeletal injuries, with a particular emphasis on ACL injuries.",[243,27,244],"ACL Injury","Musculoskeletal Injury",[246,247],"Athletes","Biomechanics","2026-04-14",{"date":250,"type":32},"2026-04-17",{"date":252,"type":32},"2022-07-19",{"date":254,"type":21},"2033-07-01",{"name":256,"class":39},"Sanford Health",{"id":258,"slug":259,"hasResults":12,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":12,"sex":17,"minAge":265,"maxAge":266,"enrollmentInfo":267,"targetDuration":269,"studyType":54,"phases":4,"briefSummary":270,"conditions":271,"keywords":277,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":287,"leadSponsor":289,"locationsCount":40},"100631464","clinical-outcomes-of-arthroscopic-surgeries-for-shoulder-and-knee-sports-injuries-100631464","NCT07501013","Clinical Outcomes of Arthroscopic Surgeries for Shoulder and Knee Sports Injuries","Clinical Outcomes and Associated Factors Following Arthroscopic Surgeries for Shoulder and Knee Sports Injuries: A Prospective Cohort Study","SK-COHORT","Inclusion Criteria:\n\n* Age \\>= 8 years.\n* No gender restrictions.\n* Definitive diagnosis of shoulder or knee sports injuries or related joint conditions.\n* Scheduled to undergo elective, standard-of-care surgery at the study center (procedures include but are not limited to: arthroscopic meniscus repair\u002Fmeniscectomy, cartilage repair, cruciate ligament reconstruction, high tibial osteotomy \\[HTO\\], unicompartmental knee arthroplasty \\[UKA\\], arthroscopic rotator cuff repair, shoulder stabilization, and shoulder arthroplasty).\n* Clear consciousness, with the ability to read, understand, and communicate.\n* Willing and able to comply with postoperative follow-up requirements.\n* Voluntarily signed the written informed consent form.\n\nExclusion Criteria:\n\n* Patients requiring emergency surgery due to acute, severe trauma (e.g., open fractures, polytrauma).\n* Coexisting severe neurological or psychiatric diseases, or cognitive impairment that prevents understanding of the informed consent or cooperation with follow-up.\n* Patients in an involuntary state (e.g., under coercion).\n* Refusal to sign the informed consent form or refusal to participate in the study.\n* Currently participating in other interventional clinical trials that may confound or affect the clinical outcomes of this study.","8 Years","80 Years",{"count":268,"type":21},500,"2 Years","This observational study aims to evaluate the long-term recovery and clinical outcomes of patients undergoing minimally invasive (arthroscopic) surgeries for sports-related shoulder and knee injuries.\n\nSports injuries, such as ligament tears, meniscus damage, and rotator cuff tears, are common and can significantly impact a person's daily life and ability to return to sports. While surgery is an effective treatment, the recovery process and final outcomes can vary greatly from person to person.\n\nResearchers will follow patients who are already scheduled for routine shoulder or knee surgery at the study center. By collecting detailed information about the patient's initial injury, the specific surgical techniques used by the doctor, and the patient's recovery progress over two years, the study hopes to identify which factors lead to the best healing and functional outcomes.\n\nParticipants will be asked to complete standard questionnaires about their joint function and pain levels before their surgery, and again at 6 months, 1 year, and 2 years after surgery. The study is strictly observational; it will not change the standard medical care, surgical plan, or rehabilitation routine the patients receive.",[272,273,274,275,27,276],"Athletic Injuries (C26.857.500.124)","Rotator Cuff Injuries","Tibial Meniscus Injuries","Shoulder Dislocation or Subluxation","Posterior Cruciate Ligament Tear",[278,279,280,281,282],"Arthroscopy","Sports Medicine","Patient Reported Outcome Measures","Prospective Cohort","Clinical Outcomes","2026-04-07",{"date":285,"type":32},"2026-04-13",{"date":283,"type":32},{"date":288,"type":21},"2046-04-07",{"name":38,"class":39},{"id":291,"slug":292,"hasResults":12,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":217,"enrollmentInfo":297,"targetDuration":4,"studyType":22,"phases":299,"briefSummary":301,"conditions":302,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":40},"100555372","phase-4-intraosseous-morphine-administration-during-anterior-cruciate-ligament-reconstruction-100555372","NCT06511232","Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction","Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction: A Randomized Control Trial","Inclusion Criteria:\n\n* Patients of the IRB approved surgeon(s) undergoing ACL reconstruction with bone-to-bone (BTB) autograft\n* Patients aged between 18-40 years old at the time of surgery\n\nExclusion Criteria:\n\n* Patients undergoing ACL reconstruction with any other type of autograft or allograft other than BTB\n* Patients younger than 18 years old or older than 40 years old\n* Patients undergoing meniscal root repair or any other repair that changes their weight-bearing status\n* Patients with a history of substance abuse\n* Vulnerable populations\n* Patients on chronic pain medication within the last 6 months\n* BMI \\>\u002F= 35\n* Allergy to morphine\n* Unwilling to participate\n* Any additional reason the PI deems reasonable",{"count":298,"type":21},84,[300],"PHASE4","The purpose of this study is to determine if intraosseous (IO) morphine decreases pain and post-operative opioid use in patients undergoing anterior cruciate ligament (ACL) reconstruction.",[303,27,304],"Anterior Cruciate Ligament Tear","Anterior Cruciate Ligament Rupture",{"date":306,"type":32},"2026-04-09",{"date":308,"type":32},"2024-08-19",{"date":310,"type":21},"2029-07-31",{"name":312,"class":39},"The Methodist Hospital Research Institute",{"id":314,"slug":315,"hasResults":12,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":319,"eligibilityCriteria":320,"healthyVolunteers":12,"sex":17,"minAge":164,"maxAge":321,"enrollmentInfo":322,"targetDuration":4,"studyType":22,"phases":324,"briefSummary":325,"conditions":326,"keywords":327,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":40},"100588542","bracing-and-reconstruction-of-the-anterior-cruciate-ligament-for-efficacy-trial-100588542","NCT06942754","Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial","Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial (BRACE-trial)","BRACE","Inclusion Criteria:\n\n* patients with unilateral complete ACL injury\n* patients involved in sports and the desire to return to sports\n* patients undergoing quadriceps autograft ACL reconstruction\n* must be 14 to 39 years old\n\nExclusion Criteria:\n\n* multiligamentous knee injuries defined as two ligaments requiring surgical stabilization\n* concomitant suture tape augmentation, extra-articular tenodesis or anterolateral ligament reconstruction\n* concomitant femoral, tibial, or patellar fracture(s)\n* patients with significant osteoarthritis\n* concomitant ipsilateral knee dislocation or patellar dislocation\n* significant lower leg malalignment requiring correcting osteotomies\n* prior ACL surgery, including contralateral knee\n* pregnancy during injury or surgery\n* unable to provide consent\n* prolonged use of prednisolone or cytostatics\n* comorbidities (e.g., muscular, neurological, vascular) that influence rehabilitation","39 Years",{"count":323,"type":21},96,[24],"Several attempts have been made to reduce these failure rates and improve return to sports rates in high-risk populations, and one of these approaches has been postoperative bracing. A recent survey of the Anterior cruciate ligament (ACL) Study Group has shown that 53% of surgeons prefers functional bracing following ACL reconstruction. Currently, however, there is no clear consensus on whether functional bracing following ACL reconstruction leads to lower failure rates, improved stability or better patient-reported outcomes when compared to ACL reconstruction without bracing.",[27],[328,329,330],"Anterior Cruciate Ligament (ACL) reconstruction","postoperative bracing","functional bracing","2026-03-26",{"date":333,"type":32},"2026-04-01",{"date":335,"type":32},"2025-09-11",{"date":337,"type":21},"2028-12",{"name":339,"class":39},"Wake Forest University Health Sciences",{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":22,"phases":350,"briefSummary":351,"conditions":352,"keywords":354,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":40},"100477764","vibration-on-patellofemoral-joint-pain-after-aclr-100477764","NCT05501210","Vibration on Patellofemoral Joint Pain After ACLR","The Effect of Whole-Body Vibration on Patellofemoral Joint Pain After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n1. Age between 18 to 60\n2. Unilateral ACLR\n3. Persisting PFJ pain\n4. Isolated symptomatic site or pathology\n\nExclusion Criteria:\n\n1. Age \\> 60\n2. Bilateral ACLR\n3. Revision ACLR\n4. Any rheumatological diseases\n5. Previous contralateral knee injury\n6. Any knee osteoarthritis","60 Years",{"count":349,"type":21},50,[24],"Anterior cruciate ligament (ACL) injury is a prevailing problem among sports participants, especially in non-contact sports. Studies have reported that 70-84% of ACL injuries are non-contact in nature, and movements like changing in direction while running, cutting and pivoting on a planted foot have resulted in a majority of ACL injuries. Even after ACL reconstruction (ACLR) surgeries, study has reported a 30-50% prevalence of developing patellofemoral joint (PFJ) pain in 1-2 years post-operation. Whole body vibration (WBV) therapy has been gaining attention as an effective method of training in recent years. It has been proved to have a positive effect on improving muscle strength, muscle activities, muscle power and loading during drop jump. Though duration of WBV may differ according to the effect of interest, several studies have had positive results with a 8 week WBV therapy in increasing muscle strength, proprioception, and post-ACLR knee functions. Further investigation on the underlying mechanism and possible application are to be continued to explore more possibilities with the WBV therapy.",[27,304,303,353],"Patellofemoral Pain",[355,356,357,358],"ACLR","Patellofemoral joint","Whole Body vibration","Knee function","2026-03-17",{"date":361,"type":32},"2026-03-18",{"date":363,"type":32},"2022-03-01",{"date":365,"type":21},"2029-09-01",{"name":367,"class":39},"Chinese University of Hong Kong",{"id":369,"slug":370,"hasResults":12,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":12,"sex":17,"minAge":164,"maxAge":375,"enrollmentInfo":376,"targetDuration":4,"studyType":22,"phases":377,"briefSummary":379,"conditions":380,"keywords":382,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":40},"100470939","phase-3-prp-in-aclr-to-prevent-ptoa-100470939","NCT05412381","PRP in ACLR to Prevent PTOA","Platelet Rich Plasma (PRP) Treatment of the Anterior Cruciate Ligament Injured Knee to Decrease the Risk of Post-traumatic Osteoarthritis (PTOA): a Randomized Double-blind Controlled Trial","Inclusion Criteria:\n\n* Acute ACL injury within 6 weeks of presentation\n* Age 14-50\n* Male or female\n* Meniscus injury that can be treated with meniscectomy or repair (the lack of meniscus injury will not exclude patients)\n\nExclusion Criteria:\n\n* Prior ACL reconstruction\n* Prior cartilage repair procedure\n* Prior meniscus surgery within 12 months\n* Prior steroid, hyaluronic acid, or PRP injection within 6 months\n* Other ligament injury requiring repair\n* Any cartilage lesion requiring repair\n* Any cartilage lesion greater than grade 2 (partial thickness injury)\n* History of inflammatory arthritis or joint sepsis\n* Non English speakers","50 Years",{"count":219,"type":21},[378],"PHASE3","The purpose of our study is to examine the effect of platelet-rich-plasma (PRP) injection on the short-term resolution of post-injury inflammation (biomarkers) and improvement in joint function in patients with acute ACL injury. This RCT has been powered based on the questionnaire KOOS Jr. but it is considered a 'pilot study' in terms of the lab analysis proposed.",[27,113,381],"PRP",[383,384,385,386],"platelet-rich plasma","regenerative medicine","anterior cruciate ligament reconstruction","post-traumatic osteoarthritis","2026-02-11",{"date":389,"type":32},"2026-02-13",{"date":391,"type":32},"2022-06-27",{"date":393,"type":21},"2026-12-31",{"name":395,"class":39},"Hospital for Special Surgery, New York",{"id":397,"slug":398,"hasResults":12,"nctId":399,"briefTitle":400,"officialTitle":400,"acronym":4,"eligibilityCriteria":401,"healthyVolunteers":238,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":402,"targetDuration":4,"studyType":22,"phases":404,"briefSummary":406,"conditions":407,"keywords":408,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":415,"completionDateStruct":417,"leadSponsor":419,"locationsCount":40},"100360115","early-phase-1-biologic-therapy-to-prevent-osteoarthritis-after-acl-injury-100360115","NCT03968913","Biologic Therapy to Prevent Osteoarthritis After ACL Injury","Inclusion Criteria:\n\n* patients age 18 to 35 years with closed growth plates as visualized on plain radiographs who participate in cutting and pivoting activities.\n* we will enroll an equal number of men and women in each treatment group (16 total per group; 8 men, 8 women).\n* study participants must have an MRI-confirmed ACL injury within 2 weeks of presentation\n* must elect to undergo bone-patellar tendon-bone (BTB) autograft ACL reconstruction within 45 days of injury\n* no clinical or MRI evidence of posterior cruciate ligament injury\n* no more than grade 1 medial collateral ligament injury\n* no concurrent posterolateral corner injury to the ipsilateral knee\n\nExclusion Criteria:\n\n* injury occurring more than 2 weeks prior to enrollment\n* previous ipsilateral knee injury\n* multi-ligamentous knee injury\n* pre-existing or concurrent grade 3 or 4 chondral (cartilage) injuries\n* previous ipsilateral knee surgery (meniscus tear, ACL tear, chondral injury, etc.)\n* of note, concurrent acute meniscus injury is NOT an exclusion criteria\n* active infection\n* known allergy or adverse reaction to anakinra\n* intra-articular cortisone injection into either knee within 3 months of injury\n* prior exposure to IL-1Ra\n* participation in another clinical drug trial within the 4 weeks before injury\n* history of any coagulopathy or current anti-coagulation therapy\n* current malignancy\n* current inflammatory\u002Frheumatologic disease\n* current immune-compromised state\n* current renal failure",{"count":403,"type":21},32,[405],"EARLY_PHASE1","Anterior cruciate ligament (ACL) injuries are extremely common. On average, 50% of individuals suffering an ACL injury will develop radiographic osteoarthritis (OA) 10 to 20 years after injury. Unfortunately, ACL reconstruction does not prevent risk of future OA.\n\nInterleukin-1 (IL-1) levels in the human knee joint increase transiently after an ACL injury. In animal experiments, if interleukin-1 levels are increased in the joint, this alone causes arthritis to occur. Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of IL-1. However, in ACL injuries the balance of these two proteins is disturbed transiently after injury, with the effects of IL-1 dominating this balance. In a large animal model of ACL injury, injection of IL-1Ra into the knee joint after ACL injury significantly decreased the amount of arthritis that was later observed. Thus, the investigators hypothesize that early injection of IL-1 inhibitor (IL-1Ra) into the knee joint of patients suffering recent ACL injury will decrease the incidence of cartilage damage later in life.\n\nAfter appropriate IRB approval, a total of 32 active patients will be randomized into one of two treatment groups. Group 1 will receive removal of the knee joint fluid (aspiration of hemarthrosis) using a needle and syringe within 1 to 2 weeks of injury. Following aspiration of the knee joint, an injection of 5 milliliters (mls) of sterile saline (as a placebo control) will be administered. In addition, a second knee aspiration procedure and an injection of 5mls of sterile saline into the injured knee joint will be performed at 3 to 5 days after the initial injection. Group 2 will receive aspiration of the knee hemarthrosis as described in group 1 as well as intra-articular administration of 150mg (\\~5mls) of anakinra (rhIL-1Ra) within 1 to 2 weeks of ACL injury. In addition, a second knee aspiration and intra-articular administration of 150mg (\\~5mls) of anakinra (rhIL-1Ra) will be performed at 3 to 5 days after the initial injection. Thus, all patients in this randomized placebo-controlled trial will undergo two injection procedures prior to surgery.\n\nInvestigators will analyze subjects self-reported function and pain scores as well as urinary levels of cartilage breakdown products over time. Additionally, MRI studies will be used to compare MRI findings among patients in these 2 treatment groups. Urine samples will be obtain prior to surgery, at the time of surgery and at multiple time points after surgery (3, 6, 9, 12 and 24 months after surgery). Subjective outcome measure assessments (surveys) will be completed by participants prior to surgery and then again at 6, 9, 12 and 24 months post-operatively. MRI studies will be obtained at 1 year and 2 years following surgery. Additional, MRI studies at time points are optional and highly encouraged. These additional MRIs are at no cost to the patient.",[27],[409,410,411],"Osteoarthritis","ACL","Anakinra","2026-01-23",{"date":414,"type":32},"2026-01-26",{"date":416,"type":32},"2021-09-15",{"date":418,"type":21},"2027-01-30",{"name":420,"class":39},"University of California, Los Angeles",{"id":422,"slug":423,"hasResults":12,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":427,"eligibilityCriteria":428,"healthyVolunteers":238,"sex":17,"minAge":18,"maxAge":165,"enrollmentInfo":429,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":431,"conditions":432,"keywords":434,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":445,"lastUpdatePostDateStruct":446,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":451,"locationsCount":453},"100621130","magic-angle-direction-imaging-madi-acl-study-100621130","NCT07366619","Magic Angle Direction Imaging (MADI) ACL Study","Diagnostics of the Anterior Cruciate Ligament (ACL) Using Magic Angle Directional Imaging (MADI)","MADI","Inclusion Criteria:\n\n* adults aged 18 - 65 years\n* selected for ligament repair surgery\n* ability to give informed consent, either written or e-consent\n* no contraindications to MRI\n* BMI ≤ 28 or thigh circumference less than 47 cm at approximately 7.5cm above the joint line\n\nExclusion Criteria:\n\n* acutely unwell or frail patients in whom extension of scanning time may not be tolerated or may delay treatment\n* contraindications to MRI\n* participants who are too big to be able to fit in the prototype scanner\n* recent surgery to the affected joint\n* severe pain\n* pregnant and\u002For breastfeeding participants",{"count":430,"type":21},20,"This study will be conducted to see if a new Magnetic Resonance Imaging (MRI) scanner could give additional information or help view the body in a different way. The new scanner may be useful to diagnose conditions affecting tissues such as ligaments, tendons and cartilage more accurately, potentially improving the quality of care by the NHS. To develop such protocols and to test the clinical capabilities of the scanner, it is necessary to evaluate the scans of healthy volunteers before recruiting patient participants.\n\nConventional MRI scans are unable to detect the signal from tissues such as ligaments, tendons, cartilage and cortical bone, which contain highly aligned collagen fibres and the signal decays too quickly to be captured. These tissues appear black and are only seen because of the surrounding brighter tissues. If a bright region appears, it can be a sign of an injury or disease, but it can also appear due to the Magic Angle artefacts, when the collagen fibres are at a specific angle to the main magnetic field of the MR scanner. This anomaly can make assessment of these tissues difficult. Currently the diagnostic gold standard is arthroscopy, though it is mostly undertaken therapeutically.\n\nThe method harnesses this inherent tissue property to gain information about these collagen-rich tissues in joints. Using Magic Angle Direction Imaging (MADI) it is possible to obtain detailed information about the collagen fibre structures, and this is not available using conventional MRI. MADI could be important for planning surgery, developing new tissue implants, and monitoring outcome measures.\n\nIn both standard cylindrical scanner and the conventional open scanner, it is impossible to move the magnet, nor the patient, in the required manner. This motivated the development of a novel prototype MA scanner that can move around the patient.\n\nThe aim of this study is to evaluate the ability to routinely perform in-vivo Magic Angle-MRI of collagen structures in joints based on the magic angle principle, and to assess the ability to use qualitative and quantitative assessment of the Magic Angle-MR images to distinguish between the pathologies of the soft structures imaged.",[27,433],"Meniscus Tear",[435,436,437,438,439,410,440,441,442,443,444],"magic angle","musculoskeletal","low field","magnetic resonance imaging (MRI)","knee","degenerative meniscus","patellar tendon","magic angle directional imaging (MADI)","short T2","collagen fibre orientation","2026-01-16",{"date":414,"type":32},{"date":448,"type":32},"2025-01-29",{"date":450,"type":21},"2027-06-30",{"name":452,"class":39},"Imperial College London",2,{"id":455,"slug":456,"hasResults":12,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":4,"eligibilityCriteria":460,"healthyVolunteers":238,"sex":17,"minAge":461,"maxAge":217,"enrollmentInfo":462,"targetDuration":4,"studyType":22,"phases":463,"briefSummary":464,"conditions":465,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":466,"lastUpdatePostDateStruct":467,"startDateStruct":469,"completionDateStruct":470,"leadSponsor":472,"locationsCount":40},"100618551","investigation-of-the-effects-of-proprioceptive-exercises-after-anterior-cruciate-ligament-surgery-100618551","NCT07333092","Investigation of the Effects of Proprioceptive Exercises After Anterior Cruciate Ligament Surgery","Investigation of the Effects of Proprioceptive Exercises on Balance, Kinesiophobia, and Functionality After Anterior Cruciate Ligament Surgery: A Randomized Controlled Trial","Inclusion Criteria\n\n* Being between 20-40 years of age\n* Having undergone anterior cruciate ligament (ACL) surgery\n* Being in the 2nd week of rehabilitation after ACL surgery\n\nExclusion Criteria\n\n* Having a concomitant meniscus injury\n* Having a concomitant medial collateral ligament injury\n* Being in the 1st week of rehabilitation after ACL surgery","20 Years",{"count":349,"type":21},[24],"The aim of this study is to investigate the effects of proprioceptive exercises on balance, kinesiophobia, and functionality after anterior cruciate ligament surgery.",[27,304],"2026-01-15",{"date":468,"type":32},"2026-01-20",{"date":466,"type":32},{"date":471,"type":21},"2026-08-20",{"name":473,"class":39},"Uskudar University",{"id":475,"slug":476,"hasResults":12,"nctId":477,"briefTitle":478,"officialTitle":478,"acronym":4,"eligibilityCriteria":479,"healthyVolunteers":238,"sex":17,"minAge":18,"maxAge":137,"enrollmentInfo":480,"targetDuration":4,"studyType":22,"phases":482,"briefSummary":483,"conditions":484,"keywords":485,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":490,"lastUpdatePostDateStruct":491,"startDateStruct":493,"completionDateStruct":495,"leadSponsor":497,"locationsCount":40},"100616485","effect-of-visual-guided-balance-training-on-knee-motor-function-and-biomechanical-characteristics-after-acl-reconstruction-100616485","NCT07306221","Effect of Visual-Guided Balance Training on Knee Motor Function and Biomechanical Characteristics After ACL Reconstruction","Inclusion criteria for patients:\n\n1. Age between 18 and 45 years old;\n2. Body Mass Index (BMI) ranging from 18.5 kg\u002Fm² to less than 35 kg\u002Fm²;\n3. First unilateral ACL rupture and reconstruction surgery performed at this hospital;\n4. Autologous hamstring tendon transplantation;\n5. No or only minor injury to the meniscus, posterior cruciate ligament, medial collateral ligament or lateral collateral ligament;\n6. Voluntary participation in this study and signing of informed consent form.\n\nExclusion criteria for patients:\n\n1. Patients who underwent ACL reconstruction more than one year after the injury;\n2. Patients with severe injuries to the posterior cruciate ligament, medial collateral ligament or lateral collateral ligament (more than grade I; grade II is partial tear, thickening and tortuosity of the ligament, partial fiber interruption, and swelling of the surrounding soft tissues; grade III is complete rupture). ； Combined with severe meniscus tear;\n3. Has a history of previous knee surgery, such as meniscus repair, ligament reconstruction, joint replacement, joint cleaning, etc.;\n4. Has other knee joint diseases, such as: knee osteoarthritis, knee joint tumor, rheumatoid arthritis, tuberculosis, knee joint infection or inflammatory diseases, fracture, dislocation or other bone injuries, etc.;\n5. Severe heart, lung, brain diseases or liver and kidney dysfunction, and visual and cognitive impairments.\n\nInclusion criteria for the healthy control group\n\n1. Age 18-45 years old;\n2. Body Mass Index (BMI) ≥ 18.5 kg\u002Fm2 and \\\u003C 35 kg\u002Fm2;\n3. No surgical history, injury history, or chronic joint diseases of the lower extremities;\n4. No visual, cognitive impairments or neurological diseases;\n5. No trauma or diseases that cause abnormal gait. Exclusion criteria\n\n1\\. Poor compliance of the subject; 2. The subject withdraws the informed consent form; 3.The subject requests to terminate the study or is unable to complete all the trials for some reason; 4. The investigator believes that the subject's continued participation in the trial may cause significant adverse effects on their physical condition; 5. The ethics review committee decides to terminate the trial.",{"count":481,"type":21},45,[24],"This study aims to investigate the improvement effect of visual-guided balance training on the knee joint function and gait performance of patients after ACLR, and to clarify the advantages of this training program compared to conventional rehabilitation training; at the same time, by including healthy individuals as the control group, it quantifies the differences in knee joint function and gait performance between patients after ACLR and healthy individuals, to verify whether visual-guided balance training can more effectively narrow the functional gap between patients after ACLR and healthy individuals, and promote the recovery of patients' knee joint function and gait closer to the healthy level. Ultimately, it provides scientific theoretical basis and practical guidance for the optimization of the rehabilitation plan after ACLR, and helps patients achieve comprehensive and high-quality recovery.",[27],[486,487,488,355,489],"anterior cruciate ligament injuries","Visual-guided balance training","gait","reconstruction of anterior cruciate ligament","2026-01-12",{"date":492,"type":32},"2026-01-14",{"date":494,"type":32},"2025-11-22",{"date":496,"type":21},"2027-08-31",{"name":498,"class":39},"Peking University Third Hospital",{"id":500,"slug":501,"hasResults":12,"nctId":502,"briefTitle":503,"officialTitle":503,"acronym":4,"eligibilityCriteria":504,"healthyVolunteers":12,"sex":17,"minAge":505,"maxAge":18,"enrollmentInfo":506,"targetDuration":4,"studyType":22,"phases":508,"briefSummary":509,"conditions":510,"keywords":512,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":515,"lastUpdatePostDateStruct":516,"startDateStruct":518,"completionDateStruct":520,"leadSponsor":522,"locationsCount":40},"100497237","the-impact-of-blood-flow-restriction-training-in-adolescents-after-acl-reconstruction-a-randomized-controlled-trial-100497237","NCT05754632","The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Prior to surgery participated in \\>50 hours\u002Fyear of level I or II sports as defined by Noyes et al and planned to return to prior level.\n\nLevel I Sports (4-7 days\u002Fweek) Jumping, hard pivoting, cutting (basketball, volleyball,football, soccer, gymnastics, skiing. wrestling)\n\n* Level II sports (1-3 days\u002Fweek) Jumping, hard pivoting, cutting (basketball, volleyball,football, soccer, gymnastics, skiing. wrestling)\n* Completion of postoperative rehabilitation following standard protocols\n* Orthopedic surgical intervention and physical therapy completed at Connecticut Children's.\n\nExclusion Criteria:\n\n* An additional lower extremity injury at time of knee injury or previous surgical intervention on the knee (ipsilateral and contralateral)\n* Multiple ligament ruptures or trauma\n* Weight bearing restrictions for greater than 4 weeks after surgery due to concomitant pathology such as meniscal root\u002Fradial repair, chondral pathology, or multi-ligament pathology\n* Follow-up surgical procedures including, but not limited to, post-operative arthrofibrosis Inability to attend regular physical therapy sessions (≥80% of patient treatment sessions and all assessment visits\n* Contraindications to performing BFRT including known history of central or peripheral neurologic impairments, cardiac or metabolic condition or history of deep vein thrombosis (DVT).","12 Years",{"count":507,"type":21},40,[24],"While there are a number studies that have reported on the use of blood flow restriction training (BFRT) in the adult population, there is limited information about the use of BFRT in the adolescent population. This study aims to evaluate the use of BFRT in conjunction with traditional anterior ligament reconstruction (ACLR) rehabilitation in adolescents.\n\nThe purpose of this study is to compare the addition of a BFRT based exercise protocol to a standard ACL rehabilitation protocol in adolescents. Does the addition of BFRT-based exercise improve strength, hypertrophy, and patient reported outcomes after ACLR in the adolescent population?",[27,57,511],"Quadriceps Muscle Atrophy",[513,514],"physical therapy","rehabilitation","2026-01-05",{"date":517,"type":32},"2026-01-07",{"date":519,"type":32},"2023-06-08",{"date":521,"type":21},"2029-05-01",{"name":523,"class":39},"Connecticut Children's Medical Center",{"id":525,"slug":526,"hasResults":12,"nctId":527,"briefTitle":528,"officialTitle":529,"acronym":4,"eligibilityCriteria":530,"healthyVolunteers":12,"sex":17,"minAge":531,"maxAge":532,"enrollmentInfo":533,"targetDuration":4,"studyType":22,"phases":535,"briefSummary":536,"conditions":537,"keywords":538,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":541,"lastUpdatePostDateStruct":542,"startDateStruct":544,"completionDateStruct":546,"leadSponsor":548,"locationsCount":40},"100542361","dynamic-muscular-electrical-stimulation-following-anterior-cruciate-ligament-reconstruction-in-military-academy-cadets-100542361","NCT06341868","Dynamic Muscular Electrical Stimulation Following Anterior Cruciate Ligament Reconstruction in Military Academy Cadets","Dynamic Gait-Synchronous Neuromuscular Electrical Stimulation Following Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n1. United States Military Academy cadet between ages of 17-27 years\n2. Undergoing a Primary ACL Reconstruction, or Revision ACL Reconstruction\n\nExclusion Criteria:\n\n1. Concomitant or prior high tibial osteotomy (HTO)\n2. Concomitant or prior cartilage restoration procedure\n3. Concomitant ligamentous reconstruction (lateral collateral ligament; posterior cruciate ligament; medial collateral ligament)\n4. Contraindications to using the KneeStim device\n\n   \\- Use of pacemaker, defibrillators, or other implanted electronic devices, as this may cause electric shock, burns, electrical interference, or death Unstable angina or decompensated heart failure Epilepsy or history of seizure disorder Pregnancy or planning to become pregnant (Self reported) Critical ischemia of lower limbs Moderate to severe dementia Altered sensation at the knee such that the user cannot feel a pinprick Undiagnosed pain syndromes\n5. Any meniscus tear precluding weight bearing for 6 weeks.","17 Years","27 Years",{"count":534,"type":21},60,[24],"The goal of this clinical trial is to examine the effects of 12 weeks of post-operative use of a novel wearable electrical stimulation knee sleeve device (KneeStim) on post-operative biomechanical function (gait). Participants will be United States Military Academy cadets aged 17-27 years. The main questions it aims to answer are:\n\n* Examine the effects of KneeStim wear on cadets' post-operative gait\n* Examine changes in site-specific skeletal muscle mass\n* Examine the changes in patient-reported outcomes\n* Assess time to return to full duty\n* Compare Bioelectrical Impedance Analysis (BIA) measurements to Magnetic Resonance Imaging (MRI) measurements (total thigh volume)\n* Determine the concurrent criterion validity of the KneeStim device compared to gold- standard metrics (3D Motion Capture)\n\nParticipants will undergo body composition analysis, MRI, strength testing, standard of care rehabilitation, gait analysis, and complete surveys. Participants will wear the KneeStim during their standard of care rehabilitation visits for the first 5 weeks post-operative, and throughout daily tasks from 6-12 weeks.\n\nResearchers will compare a control group (standard of care + KneeStim controlled low intensity) to an experimental group (standard of care + KneeStim flexible intensity) to assess the aims previously mentioned..",[27],[439,539,117,540],"Anterior Cruciate Ligament","Neuromuscular electric stimulation","2025-12-30",{"date":543,"type":32},"2026-01-02",{"date":545,"type":32},"2024-09-19",{"date":547,"type":21},"2026-09",{"name":549,"class":550},"Keller Army Community Hospital","FED",{"id":552,"slug":553,"hasResults":12,"nctId":554,"briefTitle":555,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":238,"sex":17,"minAge":18,"maxAge":137,"enrollmentInfo":557,"targetDuration":4,"studyType":22,"phases":559,"briefSummary":560,"conditions":561,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":4},"100616655","the-effect-of-single-leg-20-degree-squats-combined-with-conventional-training-on-the-biomechanical-characteristics-of-gait-after-anterior-cruciate-ligament-reconstruction-surgery-100616655","NCT07308431","The Effect of Single-leg 20-degree Squats Combined With Conventional Training on the Biomechanical Characteristics of Gait After Anterior Cruciate Ligament Reconstruction Surgery","Inclusion Criteria:\n\n* Clinical diagnosis of unilateral Anterior Cruciate Ligament (ACL) rupture.\n* Aged between 18 and 45 years.\n* Scheduled for primary unilateral ACL reconstruction at our hospital.\n* Presence of quadriceps atrophy, defined as the bilateral difference in quadriceps strength is \\>10% of the contralateral unaffected limb.\n* The operated knee has no significant redness, swelling, pain, inflammation, or limitations in range of motion and has essentially restored basic joint mobility.\n* No or only minor (Grade I) injury to the posterior cruciate ligament, medial collateral ligament, or lateral collateral ligament.\n\nExclusion Criteria:\n\n* Severe injury (Grade II or III) to the posterior cruciate ligament, medial collateral ligament, or lateral collateral ligament in the affected knee.\n* Concomitant severe meniscal tear(s) in the affected knee.\n* History of significant prior trauma or surgery to the affected knee.\n* Presence of other knee joint diseases (e.g., osteoarthritis, tumors, rheumatoid arthritis, tuberculosis).\n* Poor subject compliance or anticipated inability to complete the entire study protocol.Subject withdrawal of informed consent.\n* Any reason the subject proposes to terminate the study or is unable to complete the trial.\n* In the investigator's judgment, continued participation would adversely affect the subject's physical condition.\n* Decision by the Ethics Review Committee to terminate the study.",{"count":558,"type":21},48,[24],"Anterior cruciate ligament (ACL) tears are one of the most common sports injuries, with an ACL injury rate as high as 20.9% in the general population . Currently, the primary treatment for ACL tears is arthroscopic reconstruction surgery to restore knee stability and function . Following ACL injury, abnormal gait biomechanical characteristics persist, even after ACL reconstruction surgery (ACLR) and evidence-based rehabilitation therapy. These abnormal gait biomechanical characteristics remain unresolved, with the lower limbs exhibiting insufficient loading and stiffness, which are associated with quadriceps muscle dysfunction. Interventions for quadriceps atrophy following ACLR should be initiated early to prevent worsening of early knee pain, swelling, and abnormal gait. Additionally, since ACL reconstruction results in different biomechanical characteristics at various stages and gait phases, it is important to adopt more targeted and precise rehabilitation measures to correct biomechanical abnormalities and improve gait function in patients.",[27],"2025-12-19",{"date":564,"type":32},"2025-12-29",{"date":566,"type":21},"2026-01-10",{"date":568,"type":21},"2026-04-10",{"name":498,"class":39},{"id":571,"slug":572,"hasResults":12,"nctId":573,"briefTitle":574,"officialTitle":575,"acronym":4,"eligibilityCriteria":576,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":577,"enrollmentInfo":578,"targetDuration":4,"studyType":22,"phases":579,"briefSummary":580,"conditions":581,"keywords":584,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":589,"lastUpdatePostDateStruct":590,"startDateStruct":592,"completionDateStruct":594,"leadSponsor":595,"locationsCount":453},"100540028","phase-4-concentrated-bone-marrow-aspirate-in-revision-acl-reconstruction-100540028","NCT06311513","Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction","Multi-Center Pilot Study to Evaluate Concentrated Bone Marrow Aspirate (cBMA) as a Treatment to Modify Post-Traumatic Osteoarthritis (PTOA) Following Revision Anterior Cruciate Ligament Reconstruction (ACLR)","Inclusion Criteria:\n\n* Males and Females\n* Age 18 to 55\n* Previous unilateral ACLR (Anterior Cruciate Ligament Reconstruction) within the last 5 years, and identified as having experienced failure of the primary ACLR\n* Scheduled to have a revision ACLR surgery, with any graft type (including patellar tendon, hamstring, quad or allograft)\n* Able to complete all study procedures and participate in a standardized physical therapy program\n\nExclusion Criteria:\n\n* History of inflammatory arthritis or joint sepsis\n* Prior or concurrent total or sub-total meniscectomy\n* Prior or present avascular necrosis of the index knee\n* Oral or intra-articular corticosteroid injection within 3 months\n* Hyaluronic acid or PRP (Platelet-Rich Plasma) injection within 6 months\n* Use of duloxetine, doxycycline, indomethacin, glucosamine and\u002For chondroitin (ongoing or within 2 months)\n* Any clinical or laboratory abnormality greater than grade 3 CTCAE, which in the view of the investigator, will compromise the participant's safety.\n* Planned arthroplasty in the index knee","55 Years",{"count":507,"type":21},[300],"The goal of this pilot randomized clinical trial is to look into the efficacy of concentrated bone marrow aspirate (cBMA) in improving post traumatic osteoarthritis (PTOA) symptoms in patients undergoing revision anterior cruciate ligament reconstruction surgery. The main questions it aims to answer are whether clinical outcomes, such as pain, are improved in patients who get cBMA with surgery, if there is a change in circulating markers of inflammation and what part of the cellular and molecular composition of cBMA may explain its effects.",[27,582,583,243],"Post-Traumatic Osteoarthritis of Knee","Bone Marrow Aspirate Concentrate",[585,586,587,588],"Regenerative Medicine","Orthobiologics","Concentrated Bone Marrow Aspirate","Revision ACLR","2025-11-19",{"date":591,"type":32},"2025-11-20",{"date":593,"type":32},"2024-01-22",{"date":337,"type":21},{"name":395,"class":39},{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":601,"acronym":4,"eligibilityCriteria":602,"healthyVolunteers":12,"sex":17,"minAge":164,"maxAge":51,"enrollmentInfo":603,"targetDuration":4,"studyType":22,"phases":604,"briefSummary":605,"conditions":606,"keywords":607,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":612,"completionDateStruct":614,"leadSponsor":616,"locationsCount":40},"100512186","graded-exposure-and-mindfulness-meditation-for-patients-post-acl-reconstruction-100512186","NCT05949177","Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction","The GEMM Trial: Graded Exposure and Mindfulness Meditation for Patients Post- ACL Reconstruction","Inclusion Criteria:\n\n* Ages 14-35 years\n* Have self-reported levels of fear on the Tampa Scale of Kinesiophobia-11 and the Photographic Series of Sports Activities for ACLR\n* Injured their knee playing or training for sports (recreational or organized)\n* Have a history of unilateral ACLR\n* 6 months to 10-years post-ACLR\n\nExclusion Criteria:\n\n* History of secondary ACL injury\n* Do not exhibit elevated injury-related fear\n* Concomitant surgeries at the time of ACL reconstruction",{"count":349,"type":21},[24],"To evaluate the effect of graded exposure and mindfulness meditation after ACLR, the investigators will determine the effect of graded exposure and mindfulness meditation to 1) decrease self-reported injury-related fear and reinjury anxiety, and 2) improve lower extremity reaction time when compared to a waitlist control group.",[27],[608],"Rehabilitation","2025-11-11",{"date":611,"type":32},"2025-11-13",{"date":613,"type":32},"2024-10-30",{"date":615,"type":21},"2026-07-31",{"name":129,"class":39},{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":622,"acronym":623,"eligibilityCriteria":624,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":625,"targetDuration":4,"studyType":22,"phases":626,"briefSummary":627,"conditions":628,"keywords":630,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":636,"lastUpdatePostDateStruct":637,"startDateStruct":639,"completionDateStruct":641,"leadSponsor":643,"locationsCount":40},"100542309","comparison-between-combined-allr-with-single-bundle-and-double-bundle-anterior-cruciate-ligament-reconstruction-100542309","NCT06341192","Comparison Between Combined ALLR With Single Bundle and Double Bundle Anterior Cruciate Ligament Reconstruction","Clinical Comparison and Motion Analysis of Sports Function Between Combined Anterolateral Ligament Reconstruction With Single Bundle and Double Bundle Anterior Cruciate Ligament Reconstruction","ALLR","Inclusion Criteria:\n\n* Patients plan to receive ACL surgery\n* at least 18 years old\n\nExclusion Criteria:\n\n* Presented history of the injured leg or congenital abnormality",{"count":507,"type":21},[24],"The goal of this clinical trial is to test and compare different surgical techniques in patients with anterior cruciate ligament (ACL) injuries. The main questions it aims to answer are:\n\n* What are the optimal criteria for selecting between single-bundle ACL reconstruction combined with anterolateral ligament (ALL) reconstruction versus double-bundle ACL reconstruction combined with ALL reconstruction?\n* How do these two surgical techniques compare in terms of post-operative knee stability, functional outcomes, and reducing re-tear rates?\n\nParticipants will:\n\n* Undergo pre-operative MRI imaging, ligament stability testing, and motion analysis evaluations\n* Be randomly assigned to either:\n\n  * Single-bundle ACL + ALL reconstruction\n  * Double-bundle ACL + ALL reconstruction\n* Receive the assigned surgical procedure\n* Participate in post-operative follow-ups, ligament stability testing, and motion analysis at 6 months and 1 year\n\nResearchers will compare the single-bundle ACL + ALL group and the double-bundle ACL + ALL group to see if one technique demonstrates superior knee stability, functional outcomes (e.g. return to sport ability), and lower ACL re-tear rates.",[27,629],"Anterior Cruciate Ligament Reconstruction",[196,631,632,633,634,635],"anterolateral ligament","single bundle","double bundle","optical motion capture","graft rupture","2025-09-24",{"date":638,"type":32},"2025-09-25",{"date":640,"type":32},"2024-06-26",{"date":642,"type":21},"2026-10-31",{"name":644,"class":39},"Chang Gung Memorial Hospital",{"id":646,"slug":647,"hasResults":12,"nctId":648,"briefTitle":649,"officialTitle":650,"acronym":651,"eligibilityCriteria":652,"healthyVolunteers":238,"sex":17,"minAge":50,"maxAge":217,"enrollmentInfo":653,"targetDuration":4,"studyType":22,"phases":655,"briefSummary":656,"conditions":657,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":658,"lastUpdatePostDateStruct":659,"startDateStruct":661,"completionDateStruct":663,"leadSponsor":665,"locationsCount":40},"100385164","sequar-semitendinosus-vs-quadriceps-in-anterior-cruciate-ligament-reconstruction-100385164","NCT04295148","SEQUAR SEmitendinosus vs QUadriceps in Anterior Cruciate Ligament Reconstruction","SEQUAR - SEmitendinosus vs QUadriceps in Anterior Cruciate Ligament Reconstruction - a Prospective Randomized Study","SEQUAR","Inclusion Criteria:\n\n* Pre-injury Tegner Activity Scale≥7\n* Intended return to sports to prior sport and Tegner Activity Scale Level\n* Time between injury and inclusion not more than 6 months\n* MR verified ACL rupture\n\nExclusion Criteria:\n\n* Previous knee injury with symptoms before ACL injury\n* Neurological disease, inflammatory disease, connective tissue disease or balance disorder\n* Previous lower limb fracture or surgery\n* Laxity in the medial collateral ligament (MCL) and lateral collateral ligament (LCL) \\> grade 1\n* PCL rupture or Multiligament knee injury (MLKI)\n* Radiographic sign of osteoarthritis (OA)\n* Previous knee surgery or ligament injury in contralateral knee\n* Beighton score ≥ 5",{"count":654,"type":21},200,[24],"Randomized control trial comparing two different Anterior Cruciate Ligament (ACL) grafts in Anterior Cruciate Ligament Reconstruction: the semitendinosus hamstrings graft and the quadriceps graft. Capio Artro Clinic (Stockholm) has vast experience in ACL surgery using both semitendinosus and quadriceps grafts.",[27,304,303],"2025-09-12",{"date":660,"type":32},"2025-09-18",{"date":662,"type":32},"2020-02-10",{"date":664,"type":21},"2035-05-31",{"name":666,"class":39},"Karolinska Institutet"]