[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-disc-displacement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-disc-displacement":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100598729","liquid-phase-concentrated-growth-factor-versus-conventional-arthrocentesis-in-temporomandibular-disc-displacement-100598729",false,"NCT07075276","Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Temporomandibular Disc Displacement","Injection of Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Management of Temporomandibular Disc Displacement: A Randomized Controlled Clinical Trial","LPCGF in TMDs","Inclusion Criteria:\n\n* 1\\. Adults aged 18-45 years. 2. Patients scored as (ASA I).9 3. Presence of complete or nearly complete set of natural dentition with Angle class I occlusion. 4. Diagnosed with unilateral involvement of disc displacement, according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC\u002FTMD).10 5. Symptoms include one or more of the following: pain, joint sounds, and limited mandibular movement (Maximum Mouth Opening\\\u003C 40mm) 6. No prior surgical intervention for TMD. 7. Patient's willingness to participate and follow the study protocol.\n\nExclusion Criteria:\n\n* 1\\. TMJ pathology related to mechanical deformities 2. Psychiatric problems or presence of systemic diseases that may affect healing (e.g., uncontrolled diabetes, autoimmune disorders, hematologic or neurologic disorders, inflammatory or connective tissue disorders as well as rheumatological or previous infectious diseases, head and neck cancer). 3. Patient unwilling or has contraindication to MRI 4. Previous injections or surgical interventions of the TMJ. 5. Concurrent use of anticoagulants or anti-inflammatory medications within the last 30 days. 6. Pregnant or breastfeeding women. 7. History of trauma or infection in the TMJ region. 8. Allergy to local anesthetics or other components used in the study. 9. Patients diagnosed with (Disc Displacement with reduction with no pain or limited mandibular movements).",true,"ALL","18 Years","45 Years",{"count":22,"type":23},32,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study aims to rigorously assess the effectiveness of LPCGF in the management of internal disc displacement in patients with TMD through a randomized clinical trial. By comparing LPCGF therapy with conventional arthrocentesis, this research looks to provide robust evidence on the efficacy, safety, and potential role of (LPCGF) as an alternative therapeutic choice for IDD.",[29,30,31],"Temporomandibular Disorders (TMD)","Internal Derangement of the Tempromandibular Joint","Anterior Disc Displacement",[33,34,35,36,37],"Temporomandibular disorder","Concentrated growth factor","Anterior disc displacement with reduction","Anterior disc displacement without reduction","Arthrocentesis","RECRUITING","2026-08-14",{"date":41,"type":42},"2026-08-17","ACTUAL",{"date":44,"type":42},"2025-10-01",{"date":46,"type":23},"2026-12-01",{"name":48,"class":49},"Horus University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":24,"phases":61,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":50},"100651522","comparison-of-conventional3d-printed-and-novel-hybrid-stabilization-splints-in-the-management-of-temporomandibular-joint-disorders-100651522","NCT07760428","Comparison of Conventional,3D Printed and Novel Hybrid Stabilization Splints in the Management of Temporomandibular Joint Disorders","Comparative Efficacy of Conventional, 3D-Printed, and Novel Hybrid Stabilization Splints in the Management of Temporomandibular Joint Disorders: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients presenting with clinical symptoms of TMJ pain disorders were diagnosed using the DC\u002FTMD criteria.\n* Age between 18 and 60.\n* The same number of original molars was used to avoid affecting periodontal proprioception and bite force.\n* The Patient's consent to participate in the study.\n\nExclusion Criteria:\n\n* Pregnancy\n* Not willing to participate in the study\n* Healing disorders or systemic diseases where healing is compromised.\n* Allergic to PMMA, TPU, PETG or any other 3D printing or conventional prosthetic material.\n* Patients with epilepsy or any other neurological disorders.\n* Systemic Arthritis or any other osteo-degenerative disorder.\n* Acute TMJ trauma or fracture in \\\u003C 30 days.\n* Any obvious dental decay or periodontal disease to which fascial pain could be attributed.\n* Patient with psychiatric disorder or on anti-anxiety or anti-depressant drugs.\n* Patients with dental implants.\n* Any systemic condition associated with widespread pain such as in fibromyalgia.","60 Years",{"count":60,"type":23},36,[26],"Occlusal splint therapy is a well-established conservative approach for the management of temporomandibular disorders (TMDs); however, variability in clinical outcomes suggests that no single splint design is universally optimal. Conventional chairside stabilization splints are widely used and allow immediate intraoral adjustments; however, they are technique-sensitive and may compromise long-term fit and patient comfort. Conversely, 3D-printed occlusal splints provide superior precision, reproducibility, and material stability; however, their uniformly rigid structure may limit initial comfort and patient compliance, particularly in patients with acute pain or muscle tenderness.\n\nTo address these limitations, the researchers intend to develop an innovative hybrid occlusal splint i.e. Dual material 3D printed stabilization splint, that integrates both hard and soft components. This design aims to combine the biomechanical stability and occlusal precision characteristic of rigid splints with the cushioning effect and enhanced comfort provided by soft splints. The objective is to improve adaptation, compliance, and the sustained therapeutic efficacy of the splint.",[64,65,66,31],"Temporomandibular Disorders (TMDs)","Myofascial Pain - Dysfunction Syndrome of TMJ","Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint",[68,69,70,71,72,73,74],"occlusal splints","temporomandibular disorders","temporomandibular joint disorders","muscle pain","myofascial pain","3d printed occlusal splints","FDM","NOT_YET_RECRUITING","2026-08-07",{"date":78,"type":42},"2026-08-12",{"date":80,"type":23},"2026-08-16",{"date":82,"type":23},"2027-12-31",{"name":84,"class":49},"Postgraduate Institute of Dental Sciences Rohtak"]