[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"antiemetic-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:antiemetic-therapy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100649737","phase-4-routine-antiemetic-prophylaxis-for-nonfasted-parturients-undergoing-cesarean-sections-under-spinal-anesthesia-100649737",false,"NCT07740577","Routine Antiemetic Prophylaxis for Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia","Comparative Effectiveness of Routine Antiemetic Prophylaxis in Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women scheduled for emergency cesarean delivery under spinal anesthesia\n* Non-fasted (full-stomach) parturients\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Age ≥ 18 years\n* Singleton pregnancy\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* ASA physical status III or higher\n* Refusal to participate\n* Elective cesarean delivery (non-emergency cases)\n* Preoperative antiemetic use within 24 hours before surgery\n* Known allergy or contraindication to study drugs (ondansetron or metoclopramide)\n* Pre-existing gastrointestinal disorders (e.g., severe GERD, gastroparesis, bowel obstruction)\n* Psychiatric illness or current use of psychotropic medications\n* Preoperative anemia (as defined by institutional threshold, e.g., Hb \\\u003C 10 g\u002FdL)\n* Intraoperative conversion to general anesthesia\n* Massive intraoperative hemorrhage (\\>1000-1500 mL or requiring transfusion, depending on your protocol definition)\n* Intraoperative administration of additional sedative or antiemetic agents outside study protocol\n* Multiple gestation pregnancies","FEMALE","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The aim of this prospective randomized double-blind study is to compare the effectiveness of routine antiemetic prophylaxis for the prevention of intraoperative nausea and vomiting (IONV) in non-fasted parturients undergoing emergency cesarean section under spinal anesthesia.\n\nNausea and vomiting are common complications during cesarean delivery performed under spinal anesthesia and may negatively affect maternal comfort and perioperative safety. The incidence of these symptoms may be particularly increased in emergency cesarean sections involving non-fasted (full-stomach) parturients. This study compares two commonly used antiemetic strategies, namely 5-hydroxytryptamine-3 (5-HT3) receptor antagonists and dopamine receptor antagonists, to determine their relative effectiveness in preventing IONV during surgery.\n\nThe findings are expected to contribute to optimization of antiemetic prophylaxis protocols, improvement of maternal comfort, and reduction of perioperative complications associated with nausea and vomiting during emergency cesarean delivery.",[26,27,28,29,30,31],"Intraoperative Nausea-retching-vomiting Episodes","Spinal Aneshtesia","Ceserean Section","Antiemetic Therapy","Ondansetron","Metoclopramide",[33,34,35,36,37,38,39,40,41],"Cesarean Section","Emergency Cesarean Delivery","Non-fasted Parturients","Full Stomach","Spinal Anesthesia","Antiemetic Prophylaxis","Intraoperative Nausea and Vomiting","Obstetric Anesthesia","Maternal Outcomes","RECRUITING","2026-08-16",{"date":45,"type":46},"2026-08-18","ACTUAL",{"date":48,"type":46},"2026-07-30",{"date":50,"type":20},"2027-01-02",{"name":52,"class":53},"Sanliurfa Education and Research Hospital","OTHER_GOV",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":5},"100587395","frequency-of-occurrence-and-risk-factors-of-postoperative-nausea-and-vomiting-during-elective-c-section-under-spinal-anesthesia-with-preventive-medication-100587395","NCT06927830","Frequency of Occurrence and Risk Factors of Postoperative Nausea and Vomiting During Elective C-section Under Spinal Anesthesia With Preventive Medication","Incidence and Risk Factors of Postoperative Nausea and Vomiting (PONV) During Elective C-Section Under Spinal Anesthesia With Multimodal Antiemetic Prophylaxis","Inclusion Criteria:\n\nAny patient requiring elective caesarean section under spinal anesthesia, at a gestational age \\>37 weeks of amenorrhea in the context of a single-fetal pregnancy.\n\nExclusion Criteria:\n\nFailure to understand the French language; Contraindication to locoregional anesthesia; Nausea and\u002For vomiting in the 24 hours preceding the procedure; Type 1 or type 2 insulin-requiring non-gestational diabetes; Allergy or contraindication to one of the products used in the usual management protocol; Severe preeclampsia; Height \\\u003C150 cm",{"count":63,"type":20},400,"OBSERVATIONAL","The aim of this study is to learn about the incidence and risk factors of nausea and vomiting during planned caesarean section under spinal anesthesia.\n\nThe main question it aims to answer is : What are the incidence and risks factors of postoperative nausea and vomiting (NV) during planned caesarean section under spinal anesthesia with administration of intrathecal morphine and multimodal antiemetic prophylaxis ?\n\nPatients who will be managed according to the standard protocol in use in the department will have to answer specific questions about NV in the post-interventional recovery room and on 2 further visits in the first 24 hours post-caesarean section.",[67,68,37,29],"Nausea and Vomiting, Postoperative","Cesarean Delivery","2025-04-14",{"date":71,"type":46},"2025-04-15",{"date":73,"type":46},"2025-03-19",{"date":75,"type":20},"2026-04",{"name":77,"class":78},"University of Liege","OTHER"]