[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anxiety-and-fear-related-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anxiety-and-fear-related-disorders":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100654559","personalized-and-accelerated-transcranial-magnetic-stimulation-for-treatment-resistant-anxiety-related-disorders-100654559",false,"NCT07801391","Personalized and Accelerated Transcranial Magnetic Stimulation for Treatment-resistant Anxiety Related Disorders","I2Start","Inclusion Criteria:\n\n* Male\u002F female aged ≥ 21 years and ≤ 70 years\n* Diagnosis of an anxiety-related disorder as validated by the MINI (Specifically, the types of anxiety-related disorders are: generalized anxiety disorder; panic disorderl social anxiety disorder; obsessive compulsive disorder; post-traumatic stress disorder; agoraphobia; anxiety disorder due to another medical condition; other specified anxiety disorders; and unspecified anxiety disorder.)\n* Non-response to adequate trial (4 weeks) of at least two anxiety medication as verified by the study clinician, or psychotherapy for anxiety\n* BAI score of 16 or above\n* Able to give informed consent\n* Able to understand English\n\nExclusion Criteria:\n\n* DSM-5 psychotic disorder\n* Significant personality disorder which may hinder the progress of this study\n* Drug or alcohol abuse or dependency (preceding 3 months)\n* Rapid clinical response required, e.g., high suicide risk\n* Significant neurological disorder, which may pose increased risks with TMS, e.g., epilepsy\n* Metal in the cranium, skull defects, pacemaker, cochlear implant, medication infusion pumps or any other electronic implants\u002F devices\n* Tattoos containing derromagnetic ink or permanent piercings\n* Currently wearing dental braces\n* Pregnancy\n* Unsuitable for MRI or TMS for any other reasons\n* With recent TMS or ECT treatment within the past 3 months\n* Currently on multiple stimulant medications (2 or more)\n* Participant does not have the capacity to provide consent","ALL","21 Years","70 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","This proposal seeks to carry out an open-label single arm study to examine the neurobehavioral changes induced by personalized, causal network mapping guided accelerated intermittent theta burst stimulation (aiTBS) in patients with treatment-resistant anxiety-related disorders.",[27],"Anxiety and Fear-Related Disorders",[29,30,31,32],"Anxiety","Neuronavigated","iTBS","Accelerated","NOT_YET_RECRUITING","2026-08-31",{"date":36,"type":37},"2026-09-03","ACTUAL",{"date":39,"type":21},"2026-09",{"date":41,"type":21},"2029-12",{"name":43,"class":44},"National University Hospital, Singapore","OTHER"]